Vitamin C (ascorbic acid) plays an important role in maintaining skin health, and topical vitamin C supplementation can counteract oxidative stress induced by UVA, due to excellent reducibility. To clarify the efficac...Vitamin C (ascorbic acid) plays an important role in maintaining skin health, and topical vitamin C supplementation can counteract oxidative stress induced by UVA, due to excellent reducibility. To clarify the efficacy of vitamin C on the skin in the carrier of lotion, we studied its permeability, irritation and anti-aging effect in vitro and in vivo, using Franz cell system, cell model and clinical test. The permeability test showed that vitamin C with 10%, 15%, 20% and 25% mass ratio could effectively penetrate skin. The 20% of vitamin C lotion (VCL-20%) had the highest efficiency of transdermal penetration and the diffusion percentage reached 84.707% after 24 h. Besides, the permeation quantity of VCL-20% was 1.43 times that of the control group. Irritation test showed that the cytotoxicity of vitamin C lotion was low. And no allergic reaction happened in the occlusive patch test. Compared with the control group, using vitamin C lotion for 28 days could significantly improve subjects’ skin gloss of 10.53% and improve skin color, enhance facial skin elasticity and tightness of 9.20% and reduce wrinkle area of 12.27% (p < 0.05).展开更多
Metformin is a first-line medication for type II diabetes.Numerous studies have shown that metformin not only has hypoglycemic effects,but also modulates many physiological and pathological processes ranging from agin...Metformin is a first-line medication for type II diabetes.Numerous studies have shown that metformin not only has hypoglycemic effects,but also modulates many physiological and pathological processes ranging from aging and cancer to fracture healing.During these different physiological activities and pathological changes,stem cells usually play a core role.Thus,many studies have investigated the effects of metformin on stem cells.Metformin affects cell differentiation and has promising applications in stem cell medicine.It exerts anti-aging effects and can be applied to gerontology and regenerative medicine.The potential anticancer stem cell effect of metformin indicates that it can be an adjuvant therapy for cancers.Furthermore,metformin has beneficial effects against many other diseases including cardiovascular and autoimmune diseases.In this review,we summarize the effects of metformin on stem cells and provide an overview of its molecular mechanisms and clinical prospects.展开更多
The skin's normal color is primarily determined by the quantity and distribution of pigment,the level of hemoglobin in the skin's blood vessels,and various optical factors.Additionally,mechanical damage from c...The skin's normal color is primarily determined by the quantity and distribution of pigment,the level of hemoglobin in the skin's blood vessels,and various optical factors.Additionally,mechanical damage from clothing renders certain areas of the body more susceptible to hyperpigmentation,such as the elbows and knees.According to research,various factors such as gender and weight have been found to influence skin color.The mechanism of body skin pigmentation has been extensively studied with a particular focus on melanogenesis and related signaling pathways.Therefore,this article primarily focuses on elucidating the mechanisms governing body pigmentation while discussing strategies for managing skin whitening,encompassing influential factors and whitening methods.展开更多
文摘Vitamin C (ascorbic acid) plays an important role in maintaining skin health, and topical vitamin C supplementation can counteract oxidative stress induced by UVA, due to excellent reducibility. To clarify the efficacy of vitamin C on the skin in the carrier of lotion, we studied its permeability, irritation and anti-aging effect in vitro and in vivo, using Franz cell system, cell model and clinical test. The permeability test showed that vitamin C with 10%, 15%, 20% and 25% mass ratio could effectively penetrate skin. The 20% of vitamin C lotion (VCL-20%) had the highest efficiency of transdermal penetration and the diffusion percentage reached 84.707% after 24 h. Besides, the permeation quantity of VCL-20% was 1.43 times that of the control group. Irritation test showed that the cytotoxicity of vitamin C lotion was low. And no allergic reaction happened in the occlusive patch test. Compared with the control group, using vitamin C lotion for 28 days could significantly improve subjects’ skin gloss of 10.53% and improve skin color, enhance facial skin elasticity and tightness of 9.20% and reduce wrinkle area of 12.27% (p < 0.05).
基金Supported by National Natural Science Foundation of China,No.81670951.
文摘Metformin is a first-line medication for type II diabetes.Numerous studies have shown that metformin not only has hypoglycemic effects,but also modulates many physiological and pathological processes ranging from aging and cancer to fracture healing.During these different physiological activities and pathological changes,stem cells usually play a core role.Thus,many studies have investigated the effects of metformin on stem cells.Metformin affects cell differentiation and has promising applications in stem cell medicine.It exerts anti-aging effects and can be applied to gerontology and regenerative medicine.The potential anticancer stem cell effect of metformin indicates that it can be an adjuvant therapy for cancers.Furthermore,metformin has beneficial effects against many other diseases including cardiovascular and autoimmune diseases.In this review,we summarize the effects of metformin on stem cells and provide an overview of its molecular mechanisms and clinical prospects.
文摘The skin's normal color is primarily determined by the quantity and distribution of pigment,the level of hemoglobin in the skin's blood vessels,and various optical factors.Additionally,mechanical damage from clothing renders certain areas of the body more susceptible to hyperpigmentation,such as the elbows and knees.According to research,various factors such as gender and weight have been found to influence skin color.The mechanism of body skin pigmentation has been extensively studied with a particular focus on melanogenesis and related signaling pathways.Therefore,this article primarily focuses on elucidating the mechanisms governing body pigmentation while discussing strategies for managing skin whitening,encompassing influential factors and whitening methods.
