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Intervention decision-making in MAV/UAV cooperative engagement based on human factors engineering 被引量:9
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作者 ZHONG Yun YAO Peiyang +1 位作者 WAN Lujun YANG Juan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2018年第3期530-538,共9页
Aiming at the intervention decision-making problem in manned/unmanned aerial vehicle(MAV/UAV) cooperative engagement, this paper carries out a research on allocation strategy of emergency discretion based on human f... Aiming at the intervention decision-making problem in manned/unmanned aerial vehicle(MAV/UAV) cooperative engagement, this paper carries out a research on allocation strategy of emergency discretion based on human factors engineering(HFE).Firstly, based on the brief review of research status of HFE, it gives structural description to emergency in the process of cooperative engagement and analyzes intervention of commanders. After that,constraint conditions of intervention decision-making of commanders based on HFE(IDMCBHFE) are given, and the mathematical model, which takes the overall efficiency value of handling emergencies as the objective function, is established. Then, through combining K-best and variable neighborhood search(VNS) algorithm, a K-best optimization variable neighborhood search mixed algorithm(KBOVNSMA) is designed to solve the model. Finally,through three groups of simulation experiments, effectiveness and superiority of the proposed algorithm are verified. 展开更多
关键词 manned/unmanned aerial vehicle(MAV/UAV) intervention decision-making human factors engineering structural description K-best algorithm variable neighborhood search algorithm
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Hydro-Meteorological Trends in Southwest Coastal Bangladesh: Perspectives of Climate Change and Human Interventions 被引量:4
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作者 M. Shahjahan Mondal Mohammad Rashed Jalal +3 位作者 M. Shah Alam Khan Uthpal Kumar Rezaur Rahman Hamidul Huq 《American Journal of Climate Change》 2013年第1期62-70,共9页
The southwest coastal region of Bangladesh, being under tidal influence and dependent on sweet water supplies from upstream, has a unique brackish water ecosystem. The region, having vast low-lying areas enclosed by m... The southwest coastal region of Bangladesh, being under tidal influence and dependent on sweet water supplies from upstream, has a unique brackish water ecosystem. The region, having vast low-lying areas enclosed by man-made polders, is considered to be highly vulnerable to climate change induced hazards. In this study, linear trends in hydro-climatic variables, such as temperature, rainfall, sunshine, humidity, sweet water inflow and tidal water level in the region are assessed using secondary data and following both parametric and nonparametric statistical techniques. Correlation between the sweet water flow from the Gorai River, a major distributary of the Ganges River, and the salinity level in the Rupsa-Pasur River near Khulna, a southern metropolis, is also investigated. The results reveal that the temperature in the Khulna region is increasing at a significant rate, particularly in recent years. The number of extremely cold nights is decreasing and the heat index is increasing. The sunshine duration has a decreasing trend and the humidity has an increasing trend. Rainfall is increasing in terms of both magnitude and number of rainy days. However, the annual maximum rainfall and the number of days with high intensity rainfall have remained almost static. The annual maximum tidal high water level is increasing and the annual minimum low water level is decreasing at a rate of 7 - 18 mm and 4 - 8 mm per year, respectively. There is a negative correlation between the Gorai flow and the river water salinity around Khulna. Dredging of the Gorai during 1998-2001 resulted in an improvement of the salinity situation in the Khulna region. The variation in water salinity, tidal water level and sweet water flows in different time periods indicates that the human interventions through upstream diversion and coastal polders have contributed more in hydro-morphological changes in the southwest than the climate change. However, there are some evidences of climate change in the meteorological variables at Khulna. 展开更多
关键词 Trend Hydro-Meteorology SOUTHWEST Coastal BANGLADESH Salinity TIDAL Water Level human interventions
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Path Breakthrough of Medical Humanities Education From the Perspective of“All-Staff,Whole-Process,and All-Round Education”
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作者 Li Ruoxue Zhang Jun +1 位作者 Jiang Li Jiang Xianwen 《Contemporary Social Sciences》 2023年第4期142-155,共14页
Medical education is an important cornerstone for the development of healthcare,and medical humanities education,as an integral part of medical education,plays an irreplaceable role in cultivating people’s health gua... Medical education is an important cornerstone for the development of healthcare,and medical humanities education,as an integral part of medical education,plays an irreplaceable role in cultivating people’s health guardians with high medical ethics.We adopted the method of stratified random sampling to select 309 students and 107 faculty members from three independent medical colleges in Sichuan province as the research subjects and distributed questionnaire surveys investigating in three dimensions:overall cognition of medical humanities,evaluation of medical humanistic qualities,and the current situation of medical humanities education,supplemented by an in-depth literature review and interviews with subject matter experts.We found that“tech-centrism”still has a great influence,the self-evaluation of medical students’humanistic quality is generally not high,the educational concept of“emphasizing professional skills over morality”of faculty and staff is still quite prevalent,and there is still the“last mile”phenomenon in medical humanities education.In order to promote the integrated development of“new medicine”and“new liberal arts”and break the barriers of“tech-centrism”and“instrumental rationality,”it is necessary to change the educational concept and strengthen the education of all employees,break through the bottleneck of internships and strengthen the whole process of education,integrate educational resources and strengthen all-round education,improve the incentive mechanisms,strengthen the assessment methods,and provide Chinese wisdom and Chinese solutions for the development of medical humanities education. 展开更多
关键词 all-staff whole-process and all-round medical humanities education thorough the people’s health tech-centrism
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Human Factors/Ergonomics (HFE) in Leadership and Management: Organizational Interventions to Reduce Stress in Healthcare Delivery 被引量:1
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作者 Michael R. Privitera 《Health》 2020年第9期1262-1278,共17页
<p align="justify"> <span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span>Clinician Burnout is a personal and public health iss... <p align="justify"> <span style="font-family:Verdana;"></span><span style="font-family:Verdana;"></span>Clinician Burnout is a personal and public health issue. Most occupational stressors contributing to clinician burnout are systemic. The combination of organizational interventions along with individual interventions is necessary to make significant lasting difference in reducing burnout, improving clinician and patient satisfaction and reducing latent error in healthcare delivery. Application of Human Factors/Ergonomics (HFE) science in healthcare leadership and management is a gap in current training for leaders. HFE uses concepts from organizational, educational and cognitive science, systems science and industrial engineering. HFE application is especially necessary in a fast changing highly stressful healthcare environment which impacts the wellbeing of clinicians and the safety of patients under care. Practical suggestions for working with various healthcare leadership styles and organizational dynamics, while aligning wellness efforts with institutional mission are discussed. Concrete examples of decreasing extraneous mental load on clinicians to preserve their brainpower to achieve quality patient care are illustrated. Organizational interventions in combination with individual interventions to reduce and manage burnout have enormous potential to improve clinician wellbeing and satisfaction in taking care of patients, reduce costs, risk of error and create the safe working environment needed to sustainably give high quality care to patients. </p> 展开更多
关键词 LEADERSHIP MANAGEMENT BURNOUT human Factors ERGONOMICS Occupational Stress Organizational interventions
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Human Rights in China:Exploration and Development of Whole-process People’s Democracy
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作者 李君如 《The Journal of Human Rights》 2023年第4期709-721,共13页
Whole-process people’s democracy represents a new exploration of socialism with Chinese characteristics for a new era as well as a novel and important method for protecting the human rights of the Chinese people.It i... Whole-process people’s democracy represents a new exploration of socialism with Chinese characteristics for a new era as well as a novel and important method for protecting the human rights of the Chinese people.It is conducive to solving a multitude of problems hindering the protection of civil rights and political rights.The greatest highlight of whole-process people’s democracy is that the people are the masters of their own country and exercise the power to govern the state through“extensive participation and consultation.”China’s experience and approaches in advancing whole-process people’s democracy provide a reference for other countries. 展开更多
关键词 whole-process people’s democracy human rights in China the 20th National Congress of the Communist Party of China
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Effectiveness of onsite and online education in enhancing knowledge and use of human immunodeficiency virus pre-and postexposure prophylaxis
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作者 Ying Shao Mei Zhang +10 位作者 Li-Jun Sun Hong-Wei Zhang An Liu Xi Wang Ruo-Lei Xin Jian-Wei Li Jiang-Zhu Ye Yue Gao Zhang-Li Wang Zai-Cun Li Tong Zhang 《World Journal of Clinical Cases》 SCIE 2024年第22期5042-5050,共9页
BACKGROUND Enhancing awareness and use of pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)is vital to curb human immunodeficiency virus(HIV)spread.High-risk behaviors prevalent among sexually transmitte... BACKGROUND Enhancing awareness and use of pre-exposure prophylaxis(PrEP)and postexposure prophylaxis(PEP)is vital to curb human immunodeficiency virus(HIV)spread.High-risk behaviors prevalent among sexually transmitted infection clinic outpatients underscore the need for increased PrEP/PEP education in this group.AIM To investigate the effects of both onsite and online health education on the knowledge of,and willingness to use,PrEP and PEP among individuals receiving PEP services.METHODS Participants were drawn from a cohort study on PEP service intervention at an STD/AIDS outpatient clinic in designated HIV/AIDS hospitals in Beijing,conducted from January 1 to June 30,2022.Health education was provided both onsite and online during follow-up.Surveys assessing knowledge of,and willingness to use,PrEP/PEP were administered at baseline and again at 24 wk post-intervention.RESULTS A total of 112 participants were enrolled in the study;105 completed the follow-up at week 24.The percentage of participants with adequate knowledge of,and willingness to use,PrEP significantly increased from 65.2%and 69.6%at baseline to 83.8%and 82.9%at the end of the intervention(both P<0.05).Similarly,those with adequate knowledge of,and willingness to use,PEP increased from 74.1%and 77.7%at baseline to 92.4%and 89.5%at week 24(P<0.05).Being between 31 years and 40 years of age,having a postgraduate degree or higher,and reporting a monthly expenditure of RMB 5000 or more were found to be significantly associated with knowledge of PrEP and PEP(both P<0.05).CONCLUSION The findings show that both onsite and online health education significantly improved the knowledge of,and increased willingness to use,PrEP and PEP in individuals utilizing PEP services. 展开更多
关键词 human immunodeficiency virus Pre-exposure prophylaxis Post-exposure prophylaxis Health education intervention
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Surgical intervention combined with weight-bearing walking training improves neurological recoveries in 320 patients with clinically complete spinal cord injury:a prospective self-controlled study 被引量:4
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作者 Yansheng Liu Jia-Xin Xie +12 位作者 Fang Niu Zhexi Xu Pengju Tan Caihong Shen Hongkun Gao Song Liu Zhengwen Ma Kwok-Fai So Wutian Wu Chen Chen Sujuan Gao Xiao-Ming Xu Hui Zhu 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第5期820-829,共10页
Although a large number of trials in the SCI field have been conducted,few proven gains have been realized for patients.In the present study,we determined the efficacy of a novel combination treatment involving surgic... Although a large number of trials in the SCI field have been conducted,few proven gains have been realized for patients.In the present study,we determined the efficacy of a novel combination treatment involving surgical intervention and long-term weight-bearing walking training in spinal cord injury(SCI)subjects clinically diagnosed as complete or American Spinal Injury Association Impairment Scale(AIS)Class A(AIS-A).A total of 320 clinically complete SCI subjects(271 male and 49 female),aged 16–60 years,received early(≤7 days,n=201)or delayed(8–30 days,n=119)surgical interventions to reduce intraspinal or intramedullary pressure.Fifteen days post-surgery,all subjects received a weight-bearing walking training with the“Kunming Locomotion Training Program(KLTP)”for a duration of 6 months.The neurological deficit and recovery were assessed using the AIS scale and a 10-point Kunming Locomotor Scale(KLS).We found that surgical intervention significantly improved AIS scores measured at 15 days post-surgery as compared to the pre-surgery baseline scores.Significant improvement of AIS scores was detected at 3 and 6 months and the KLS further showed significant improvements between all pair-wise comparisons of time points of 15 days,3 or 6 months indicating continued improvement in walking scores during the 6-month period.In conclusion,combining surgical intervention within 1 month post-injury and weight-bearing locomotor training promoted continued and statistically significant neurological recoveries in subjects with clinically complete SCI,which generally shows little clinical recovery within the first year after injury and most are permanently disabled.This study was approved by the Science and Research Committee of Kunming General Hospital of PLA and Kunming Tongren Hospital,China and registered at ClinicalTrials.gov(Identifier:NCT04034108)on July 26,2019. 展开更多
关键词 American Spinal Injury Association Impairment Scale–A functional recovery human intramedullary decompression spinal cord injury surgical intervention walking training
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Effect of a 12-Week Dietary Intervention with Folic Acid or Folate-Enhanced Foods on Folate Status in Healthy Egyptian Women
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作者 Mohammed E. Hefni Mohamed T. Shalaby +2 位作者 Rasha A. Mohamed Ahmad M. Elwa Cornelia M. Witthöft 《Food and Nutrition Sciences》 2016年第14期1339-1351,共13页
The Egyptian government introduced wheat-flour fortification with iron and folic acid to reduce the incidence of neural tube defects, but suspended it for technical reasons. We previously developed novel legume foods ... The Egyptian government introduced wheat-flour fortification with iron and folic acid to reduce the incidence of neural tube defects, but suspended it for technical reasons. We previously developed novel legume foods with enhanced folate content. In this study, we investigated the efficacy of 12-week intervention with folate-enhanced foods versus folic acid supplement in improving folate status in Egyptian women. A randomized, parallel intervention trial with two active groups (n = 19, n = 18) and one blinded control group (n = 20) was executed over 12 weeks. Volunteers received either germinated legume foods and orange juice (≈250 μg/d folate) or folic acid supplement (500 μg/d) or apple juice (0 μg/d folate). Folate status was assessed by erythrocyte and plasma folate and total homocysteine (tHcy) at day 0, and after 8 and 12 weeks of intervention. After 12 weeks, mean plasma folate increased by 14 (P < 0.0001) and 12 (P < 0.0001) nmoL in the folic acid and food group, respectively. Erythrocyte folate concentration increased in the folic acid group from 614 to 912 (P < 0.0001) and in the food group from 631 to 914 nmoL (P < 0.0001). After 12 weeks, 90% of subjects in the folic acid group and 70% in the food group had erythrocyte folate concentrations exceeding 906 nmol/L. tHcy concentration was decreased by 20% (P = 0.007) and 18% (P = 0.006) in the folic acid and food group, respectively, but remained unchanged in the control group during intervention. Folate-enhanced foods effectively improve folate status in women of reproductive age. These foods could be used as a complement to folic acid fortification. 展开更多
关键词 Folic Acid Folate-Enhanced Legume Foods human intervention Folate Status
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On the Human Rights Implications of the Whole-process People’s Democracy
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作者 尹奎杰 HU Genfu 《The Journal of Human Rights》 2022年第1期91-100,共10页
The whole-process people’s democracy is a prerequisite for the people’s democracy.It is the organic unity of process and outcome democracy,procedural and substantive democracy,direct and indirect democracy,as well a... The whole-process people’s democracy is a prerequisite for the people’s democracy.It is the organic unity of process and outcome democracy,procedural and substantive democracy,direct and indirect democracy,as well as the people’s democracy and the will of the state.The whole-process people’s democracy is the latest theoretical expression of the concept of socialist human rights with Chinese characteristics,a new achievement in the practice of socialist human rights with Chinese characteristics,a new development of the system of the socialist human rights with Chinese characteristics,and a new contribution to the development path of human rights in the world. 展开更多
关键词 whole-process people’s democracy concept of human rights practice of human rights system of human rights path of human rights
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The Core of the Chinese Democracy Is to Respect and Protect Human Rights——A Summary of the Academic Seminar on Chinese Democracy and Human Rights Protection
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作者 毛俊响 毛成毅 JIANG Yu 《The Journal of Human Rights》 2023年第3期684-695,共12页
On March 26,2023,a Seminar on Chinese Democracy and Human Rights Protection was held,jointly organized by the National Human Rights Education and Training Base and the Human Rights Research Center of Central South Uni... On March 26,2023,a Seminar on Chinese Democracy and Human Rights Protection was held,jointly organized by the National Human Rights Education and Training Base and the Human Rights Research Center of Central South University under the guidance of the Chinese Society for Human Rights Studies.The event adopted a combination of online and offline channels.Over 30 experts and scholars from universities,research institutions,and practical departments across the country participated in extensive discussions on“Theoretical and Practical Aspects of Chinese Democracy and Protection of Human Rights.”The seminar aimed to focused on the essence,characteristics,advantages,and human rights implications of Chinese democracy and interpreted the concept of Chinese democracy and the protection of human rights through academic and theoretical methods. 展开更多
关键词 Chinese democracy protection of human rights the whole-process people’s democracy
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冠状动脉内注射重组人TNK组织型纤溶酶原激活剂及腺苷注射液对急性ST段抬高型心肌梗死的疗效分析
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作者 李柳 郑庆厚 +3 位作者 战吟戈 王乐 陈勤聪 王硕 《西安交通大学学报(医学版)》 CAS CSCD 北大核心 2024年第5期794-800,共7页
目的评价急诊直接经皮冠脉介入(PPCI)治疗中经指引导管冠状动脉内注射重组人TNK组织型纤溶酶原激活剂及腺苷注射液对急性ST段抬高型心肌梗死(ASTEMI)的疗效。方法选择行急诊PPCI的ASTEMI患者,按照随机数字表法分为对照组和治疗组。对照... 目的评价急诊直接经皮冠脉介入(PPCI)治疗中经指引导管冠状动脉内注射重组人TNK组织型纤溶酶原激活剂及腺苷注射液对急性ST段抬高型心肌梗死(ASTEMI)的疗效。方法选择行急诊PPCI的ASTEMI患者,按照随机数字表法分为对照组和治疗组。对照组给予PPCI术常规治疗,若PPCI后梗死相关动脉(IRA)达到TIMI血流3级,则终止手术;若TIMI血流≤2级,则应用指引导管于冠脉内注射硝普钠、硝酸甘油、替罗非班改善冠状动脉微循环功能障碍(CMD),直到IRA达到TIMI血流3级。治疗组是在PPCI术常规治疗基础上,术中开通IRA后应用指引导管于冠状动脉内注射重组人TNK组织型纤溶酶原激活剂8 mg及腺苷注射液200μg,若IRA达到TIMI血流3级,则终止手术;若TIMI血流≤2级,则再次注射腺苷注射液改善CMD,直到IRA达到TIMI血流3级。观察指标,①心肌损伤指标:术前及术后12、24、36、48 h的血浆肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、N端B型脑钠肽(NT-pro BNP)水平;②心肌灌注指标:术后校正的TIMI帧数(CTFC)、术后90 min IRA导联ST段回落值(STR);③心肌缺血的程度:术后3 d行静息D-SPECT+腺苷负荷D-SPECT检查,观察心肌17节段分布下心肌灌注总积分、心肌缺血总节段数情况;④术后30 d的药物不良反应:皮下瘀斑、牙龈出血、消化道出血、泌尿系出血、血红蛋白下降、脑出血;⑤术后30 d的主要不良心血管事件(MACE):心脏死亡、心肌梗死、心力衰竭、靶血管再次血运重建情况。结果①心肌损伤指标:术前的cTnI、CK-MB、NT-pro BNP水平两组患者差异均无统计学意义(均P>0.05),心肌损伤指标治疗组均在术后12 h显著低于对照组(均P<0.05),之后均趋势下降,术后48 h两组差异均无统计学意义(均P>0.05)。②心肌灌注指标:治疗组术后CTFC均显著优于对照组(P<0.05)。应用秩和检验,治疗组术后90 min STR显著优于对照组(Z=2.437,P=0.014)。③心肌缺血的程度:两组患者在术后3 d行静息D-SPECT+腺苷负荷D-SPECT检查,在心肌17节段分布下心肌灌注总积分、心肌缺血总节段数情况,治疗组在负荷缺血节段数、静息灌注总评分、负荷灌注总评分均显著优于对照组(均P<0.05)。④术后30 d的药物不良反应:两组患者在皮下瘀斑、牙龈出血、消化道出血、泌尿系出血、血红蛋白下降、脑出血发生率均无统计学差异(P>0.05)。⑤术后30 d的MACE情况:两组患者在心脏死亡、心肌梗死、心力衰竭、靶血管再次血运重建情况以及总MACE发生率均无统计学差异(P>0.05)。结论急诊PPCI中经指引导管冠状动脉内注射重组人TNK组织型纤溶酶原激活剂及腺苷注射液对ASTEMI患者安全、有效,可改善心肌损伤、心肌灌注和心肌缺血。 展开更多
关键词 重组人TNK组织型纤溶酶原激活剂 腺苷注射液 直接经皮冠状动脉介入治疗 冠状动脉微循环功能障碍(CMD)
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生成式AI在科技文献信息检索中的信息偏差及干预策略
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作者 严一梅 夏杰 张进 《计算机应用文摘》 2024年第10期125-129,132,共6页
生成式AI对科技文献信息检索产生了重大影响。文章探讨了ChatGPT在科技文献检索中的重要价值,通过具体案例对ChatGPT与文献数据库系统进行了比较,分析了ChatGPT在文献检索中可能出现的信息偏差问题,并从用户角度提出了信息偏差应对策略... 生成式AI对科技文献信息检索产生了重大影响。文章探讨了ChatGPT在科技文献检索中的重要价值,通过具体案例对ChatGPT与文献数据库系统进行了比较,分析了ChatGPT在文献检索中可能出现的信息偏差问题,并从用户角度提出了信息偏差应对策略,旨在提高使用ChatGPT检索科技文献的准确性和可靠性。 展开更多
关键词 ChatGPT 信息检索 应用偏差 人工干预
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浅谈自然恢复在安徽省矿山生态修复中的应用
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作者 管政亭 赵国红 +1 位作者 宋阳 费雅洁 《安徽地质》 2024年第3期241-245,共5页
自然恢复已作为生态修复的一种常用方法,应用于安徽省历史遗留废弃矿山生态修复工作中,但人们对自然恢复方法的认知却不够深入。本文通过对四个采用自然恢复方法进行修复的废弃矿山案例进行分析研究,发现自然恢复需具备一定条件,同时人... 自然恢复已作为生态修复的一种常用方法,应用于安徽省历史遗留废弃矿山生态修复工作中,但人们对自然恢复方法的认知却不够深入。本文通过对四个采用自然恢复方法进行修复的废弃矿山案例进行分析研究,发现自然恢复需具备一定条件,同时人工干预和技术支持能够提高生态系统的自我修复能力,为自然恢复提供辅助作用。自然恢复具有经济投入小、再次干扰破坏小等优势,对安徽省矿山生态修复工作具有非常重要的现实意义。 展开更多
关键词 自然恢复 生态系统 矿山生态修复 人工干预
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人性化护理对胃癌患者全胃切除术后的干预效果
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作者 蒋丹丹 陈美铃 江美燕 《中外医疗》 2024年第1期136-139,共4页
目的探究胃癌患者行全胃切除术后应用人性化护理的临床效果。方法随机选取2019年1月—2021年2月福建医科大学附属协和医院收治的100例接受全胃切除术治疗的胃癌患者为研究对象,按随机数表法分为对照组(n=50)和研究组(n=50),分别在术后... 目的探究胃癌患者行全胃切除术后应用人性化护理的临床效果。方法随机选取2019年1月—2021年2月福建医科大学附属协和医院收治的100例接受全胃切除术治疗的胃癌患者为研究对象,按随机数表法分为对照组(n=50)和研究组(n=50),分别在术后给予常规护理和人性化护理,对比护理干预效果。结果护理后,研究组患者的躯体功能、认知功能、社会功能、角色功能和情绪功能评分分别为(78.45±8.99)分、(85.43±8.22)分、(86.34±7.33)分、(87.31±7.11)分和(87.34±5.33)分,均显著高于对照组,差异有统计学意义(t=10.353、7.172、6.822、4.378、8.548,P均<0.05)。同时,研究组患者的护理满意度和不良反应发生率分别为96.00%和4.00%,均优于对照组,差异有统计学意义(χ^(2)=4.000、5.005,P均<0.05)。结论在胃癌患者全胃切除术后开展人性化护理,可降低不良反应发生率,提高护理满意度并改善患者生活质量。 展开更多
关键词 人性化护理 胃癌患者 全胃切除术 术后 干预效果
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三种冠状动脉内灌注用药方案对高血栓负荷急性ST段抬高型心肌梗死患者经皮冠状动脉介入术后心肌灌注及短期预后的影响 被引量:1
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作者 晋辉 郑献召 +9 位作者 沈玲 曾辉 王中明 韩风杰 杭晓阳 刘静 周庆庆 朱艳霞 王晓飞 郑海军 《中国心血管杂志》 北大核心 2024年第2期143-151,共9页
目的探讨三种冠状动脉内灌注用药方案对高血栓负荷急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心肌灌注及短期预后的影响。方法前瞻性、单中心、随机对照研究。纳入2017年3月至2021年8月焦作市人民医院心内科高血栓负... 目的探讨三种冠状动脉内灌注用药方案对高血栓负荷急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入(PCI)术后心肌灌注及短期预后的影响。方法前瞻性、单中心、随机对照研究。纳入2017年3月至2021年8月焦作市人民医院心内科高血栓负荷STEMI患者150例,按照分层区组随机化原则等分为三组各50例。A组:尼可地尔+替罗非班靶血管灌注;B组:尿激酶原+替罗非班靶血管灌注;C组:尼可地尔+尿激酶原+替罗非班靶血管灌注。于PCI术前、术后即刻检测记录梗死相关动脉(IRA)的心肌梗死溶栓试验(TIMI)血流分级、TIMI心肌灌注分级(TMPG)、校正的TIMI血流帧数(CTFC);于PCI术前、术后24 h记录心电图的ST段回落幅度;记录IRA开通后24 h内Curtis-Walker评分及恶性心律失常例数;于PCI术前、术后0 h、12 h、24 h、3 d及7 d检测血清高敏肌钙蛋白I(hs-cTnI);于PCI术前、术后24 h及7 d检测丙二醛(MDA)、超氧化物歧化酶(SOD);于PCI术前、术后7 d、术后1个月、术后6个月及术后12个月检测左心室射血分数(LVEF)。随访记录患者住院期间及出院后30 d内的出血事件及术后12个月内主要不良心血管事件(MACE)。结果(1)PCI术后即刻,C组患者的TIMI血流分级、TMPG均优于A组(Z=-16.610,P=0.023;Z=-18.400,P=0.015)和B组(Z=-15.130,P=0.046;Z=16.550,P=0.035);C组患者的CTFC帧数低于A组(P<0.001)和B组(P=0.001)。(2)PCI术后,C组患者的血清hs-cTnI水平低于A组和B组(均为P<0.001)。(3)PCI术后,C组患者的MDA水平低于A组和B组(均为P<0.001),SOD水平高于A组(P=0.004)和B组(P=0.024)。(4)PCI术后24 h,C组患者的ST段回落幅度大于A组(P=0.003)和B组(P=0.012),Curtis-Walker评分及恶性心律失常发生率低于A组(P=0.008、0.015)和B组(P=0.014、0.034)。(5)PCI术后,C组患者的LVEF水平高于A组和B组(均为P<0.001)。(6)住院期间及出院后30 d内,三组患者均未发生大出血,少量出血和微量出血的发生率比较无统计学差异(χ^(2)=1.385,P=0.500);术后12个月内,C组患者的MACE发生率低于A组和B组(χ^(2)=7.400,P=0.025)。结论尼可地尔+尿激酶原+替罗非班靶血管灌注具有协同作用,可有效改善STEMI患者PCI术后的心肌灌注,减轻术后心肌损伤和氧化应激损伤,促进ST段回落,降低恶性心律失常发生率,有效促进心功能恢复,减少心血管不良事件,且不增加术后出血。 展开更多
关键词 急性ST段抬高型心肌梗死 高血栓负荷 经皮冠状动脉介入 尼可地尔 重组人尿激酶原 心肌灌注
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基于人文环境改善方案的综合护理干预在包皮环切术患者中的应用效果
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作者 徐艳 汪洁 邢晓黎 《中国医药导报》 CAS 2024年第17期168-170,共3页
目的 探讨基于人文环境改善方案的综合护理干预用于包皮环切术患者的效果。方法 选取合肥市第三人民医院2020年1月至2023年3月收治的100例行包皮环切术患者,按随机数字表法分为对照组和观察组,每组50例。对照组采取常规护理,观察组采取... 目的 探讨基于人文环境改善方案的综合护理干预用于包皮环切术患者的效果。方法 选取合肥市第三人民医院2020年1月至2023年3月收治的100例行包皮环切术患者,按随机数字表法分为对照组和观察组,每组50例。对照组采取常规护理,观察组采取基于人文环境改善方案的综合护理干预。比较两组干预前后的焦虑自评量表(SAS)评分,术中视觉模拟评分法(VAS)评分,术前和术中的收缩压、心率,及切口并发症。结果 干预前,两组SAS评分比较,差异无统计学意义(P>0.05);干预后,两组SAS评分均较干预前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组术中VAS评分低于对照组,差异有统计学意义(P<0.05)。术前,两组心率与收缩压比较,差异无统计学意义(P>0.05);术中,两组心率、收缩压均高于术前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组切口并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论 基于人文环境改善方案的综合护理干预能改善包皮环切术患者的心理状态,减轻应激与疼痛,减少切口并发症。 展开更多
关键词 包皮环切术 人文环境 综合护理干预 焦虑 切口并发症
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PDCA监管机制对人血白蛋白合理使用监管的效果评价
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作者 沈盼 林莹 庄燕琴 《海峡药学》 2024年第4期109-115,共7页
目的探索人血白蛋白在PDCA循环监管机制下是否促进其合理安全使用。方法采取PDCA循环的管理方法,建立人血白蛋白合理使用管理体系。分阶段分析调查白蛋白的临床使用状况,参考美国大学医院联合会推荐的《人血白蛋白,非蛋白液体及晶体溶... 目的探索人血白蛋白在PDCA循环监管机制下是否促进其合理安全使用。方法采取PDCA循环的管理方法,建立人血白蛋白合理使用管理体系。分阶段分析调查白蛋白的临床使用状况,参考美国大学医院联合会推荐的《人血白蛋白,非蛋白液体及晶体溶液使用指南》、药品说明书以及相关文献,结合临床实际情况,探索和建立适应实际工作需要的“人血白蛋白临床合理应用规范”“人血白蛋白临床合理用药动态监测与分析系统”,并分析实施PDCA循环管理前后各项用药指标和效果。结果2019年至2022年,合理性比例分别为34.65%、41.07%、47.35%和48.74%(P<0.001)。人血白蛋白的平均使用量从(88.59±54.6)g逐渐下降到(49.35±41.6)g(P=0.038)。在监管干预后大部分科室,特别是ICU、心胸手术和肝胆外科,白蛋白的临床使用量显著下降。除11~20 d组以外,各组均显著减少,长疗程(>20 d)从2019年至2022年的比例显著降低。此外,血清白蛋白水平<25 g的患者比例从15.43%增加到39.31%(P<0.001)。高血压或肾功能不全患者有监测血压或肌酐清除率的比例轻微增加(P=0.039)。结论通过PDCA监管机制,对人血白蛋白的监管取得一定效果,推进了人血白蛋白的合理安全使用,在一定程度上促进了医疗资源合理分配。 展开更多
关键词 人血白蛋白 合理用药 PDCA循环 药学干预
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直接经皮冠状动脉介入治疗联合冠状动脉内注射重组人尿激酶原或替罗非班对ST段抬高型心肌梗死患者疗效与安全性的Meta分析
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作者 杜淑珍 剡冬冬 张钲 《中国介入心脏病学杂志》 CSCD 2024年第9期516-527,共12页
目的直接经皮冠状动脉介入治疗(PPCI)期间冠状动脉内注射重组人尿激酶原(rhPro-UK)或替罗非班有助于改善冠状动脉微循环灌注。本研究旨在探索ST段抬高型心肌梗死(STEMI)患者PPCI期间冠状动脉内注射rhPro-UK或替罗非班的有效性和安全性... 目的直接经皮冠状动脉介入治疗(PPCI)期间冠状动脉内注射重组人尿激酶原(rhPro-UK)或替罗非班有助于改善冠状动脉微循环灌注。本研究旨在探索ST段抬高型心肌梗死(STEMI)患者PPCI期间冠状动脉内注射rhPro-UK或替罗非班的有效性和安全性。方法计算机检索PubMed,Ovid-MEDLINE,Embase,Web of Science,Cochrane Library,clinical trials.gov,中国知网(CNKI),维普网(VIP),中国生物医学文献服务系统(SinoMed),万方数据知识服务平台(WANFANG)数据库,纳入STEMI患者PPCI期间冠状动脉内注射rhPro-UK或替罗非班的随机对照试验(RCT)及队列研究。检索时间为从建库至2023年11月27日。文献筛选、资料提取及偏倚风险评估均由2名研究者独立完成。采用RevMan 5.4软件对数据进行Meta分析。结果共纳入12项研究,包括1721例患者,冠状动脉内注射rhPro-UK 864例(试验组),注射替罗非班857例(对照组)。Meta分析显示,与对照组相比,试验组可改善PPCI术后冠状动脉微循环灌注,包括心肌梗死溶栓治疗试验(TIMI)血流分级Ⅲ级及TIMI心肌灌注分级(TMPG)Ⅲ级比例显著高于对照组(OR 1.83,95%CI 1.36~2.46,P<0.0001;OR 2.38,95%CI 1.22~4.66,P=0.010);校正TIMI帧计数(cTFC)显著低于对照组(MD–2.43,95%CI–2.94~–1.92,P<0.00001);ST段回落率(STR)≥70%高于对照组(OR 1.93,95%CI 1.01~3.68,P=0.050)。显著降低术后1个月主要不良心血管事件(MACE)发生率(OR 0.54,95%CI 0.35~0.82,P=0.004)。改善心功能,术后1个月左心室射血分数(LVEF)高于对照组(MD1.71,95%CI0.04~3.38,P=0.050)。缩小心肌梗死面积,术后肌酸激酶同工酶MB型(CK-MB)峰值低于对照组(MD–74.16,95%CI–83.59~–64.74,P<0.00001)。两组间出血事件发生率比较(OR1.18,95%CI0.64~2.16,P=0.600),差异无统计学意义。结论STEMI患者PPCI期间,冠状动脉内注射rhPro-UK较替罗非班可有效改善患者冠状动脉微循环灌注、心功能,缩小心肌梗死面积,降低术后1个月MACE发生率,同时两组间出血事件差异无统计学意义。 展开更多
关键词 ST段抬高型心肌梗死 重组人尿激酶原 替罗非班 直接经皮冠状动脉介入治疗 META分析
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急性STEMI患者直接PCI时经球囊尾部于冠状动脉内注射小剂量尿激酶原的疗效
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作者 李亚楠 张红雨 《临床荟萃》 CAS 2024年第6期518-523,共6页
目的探讨直接经皮冠状动脉介入术(percutaneous coronary intervention,PCI)时,经球囊尾部于冠状动脉内注射小剂量尿激酶原对急性重度血栓负荷ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者的临床疗效。... 目的探讨直接经皮冠状动脉介入术(percutaneous coronary intervention,PCI)时,经球囊尾部于冠状动脉内注射小剂量尿激酶原对急性重度血栓负荷ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者的临床疗效。方法纳入2022年6月至2023年7月就诊于天津市宝坻区人民医院胸痛中心、发病时间<12 h、直接PCI时梗死相关动脉为重度血栓负荷(血栓积分≥4分)的急性STEMI患者122例,采用随机数字表法将患者分为经球囊尾部于冠状动脉内注射尿激酶原+替罗非班组(研究组,61例)和单纯经球囊尾部于冠状动脉内注射替罗非班组(对照组,61例)。比较两组临床资料。结果①两组年龄、性别、吸烟史、高血压病史、糖尿病病史、冠心病家族史、陈旧性心肌梗死病史、高脂血症病史、心功能分级、术前TIMI血流分级、TMPG血流分级、术前化验(肌酸激酶同工酶、超敏肌钙蛋白T、CRP、D-二聚体、B型脑钠肽、肌酐、血红蛋白)、梗死相关动脉、病变血管支数、症状至再灌注时间和血栓负荷等差异均无统计学意义(P>0.05)。②PCI后两组TIMI血流分级、TMPG血流分级、主要心血管不良事件及出血率差异均无统计学意义(P>0.05)。③术后研究组2 h心电图ST段回降率≤50%占比、超敏肌钙蛋白T峰值浓度、肌酸激酶同工酶峰值浓度、术后24 h B型脑钠肽均低于对照组,术后1周左心室射血分数高于对照组,差异均有统计学意义(P<0.05)。结论经球囊尾部于冠状动脉内注射小剂量尿激酶原能够减少重度血栓负荷急性STEMI患者的心肌损害,改善心脏功能,并且不增加患者住院期间出血风险。 展开更多
关键词 ST段抬高型心肌梗死 经皮冠状动脉介入治疗 重组人尿激酶原 替罗非班 冠脉内注射
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人性化服务理念下的全方位干预在初产妇围产期护理中的应用
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作者 董卫卫 《河南医学研究》 CAS 2024年第9期1700-1703,共4页
目的探讨人性化服务理念下的全方位干预在初产妇围产期护理中的应用效果。方法选取郑州大学第二附属医院2022年5月至2023年5月收入的126例初产妇为研究对象,通过随机数字表法分为观察组(63例)与对照组(63例)。给予对照组常规护理,观察... 目的探讨人性化服务理念下的全方位干预在初产妇围产期护理中的应用效果。方法选取郑州大学第二附属医院2022年5月至2023年5月收入的126例初产妇为研究对象,通过随机数字表法分为观察组(63例)与对照组(63例)。给予对照组常规护理,观察组在常规护理基础上接受人性化服务理念下的全方位干预,两组干预均于产妇入院待产时开始,干预至产妇分娩后7 d。统计两组分娩方式(自然分娩、中转剖宫产、产钳助产),并比较两组阴道分娩产妇产程时间及产妇分娩后7 d时爱丁堡产后抑郁量表(EPDS)评分。结果两组分娩方式对比,差异有统计学意义(P<0.05)。观察组中自然分娩产妇第一产程、第二产程及第三产程时间均短于对照组(P<0.05)。分娩后7 d时,观察组EPDS评分低于对照组(P<0.001)。结论人性化服务理念下的全方位干预在初产妇围产期中的应用效果显著,可缩短产程时间,提高自然分娩率,预防产后抑郁。 展开更多
关键词 初产妇 人性化服务理念 全方位干预 围产期 产程时间 自然分娩 产后抑郁
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