The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte C...The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.展开更多
The investigation on fatigue lives of reinforced concrete (RC) structures strength- ened with fiber laminate under random loading is important for the repairing or the strengthening of bridges and the safety of the ...The investigation on fatigue lives of reinforced concrete (RC) structures strength- ened with fiber laminate under random loading is important for the repairing or the strengthening of bridges and the safety of the traffic. In this paper, two methods are developed for predicting the fatigue lives of RC structures strengthened with carbon fiber [aminate (CFL) under random loading based on a residual life and a residual strength model. To discuss the efficiency of the model, 12 RC beams strengthened with CFL are tested under random loading by the MTS810 testing system. The predicted residual strength approximately agrees with test results.展开更多
Extensive 3-D model tests have been performed to study the effects of wave obliquity and multi-directionality on the wave loads acting on vertical breakwaters. The variation of horizontal and uplift forces acting on a...Extensive 3-D model tests have been performed to study the effects of wave obliquity and multi-directionality on the wave loads acting on vertical breakwaters. The variation of horizontal and uplift forces acting on an unit length of a breakwater with wave direction, the longitudinal distribution of wave forces, as well as the longitudinal load reduction are analyzed. Some empirical formulae of the longitudinal distribution coefficient and the longitudinal load reduction factor are presented for practical use.展开更多
A bounded optimal control strategy for strongly non-linear systems under non-white wide-band random excitation with actuator saturation is proposed. First, the stochastic averaging method is introduced for controlled ...A bounded optimal control strategy for strongly non-linear systems under non-white wide-band random excitation with actuator saturation is proposed. First, the stochastic averaging method is introduced for controlled strongly non-linear systems under wide-band random excitation using generalized harmonic functions. Then, the dynamical programming equation for the saturated control problem is formulated from the partially averaged Itō equation based on the dynamical programming principle. The optimal control consisting of the unbounded optimal control and the bounded bang-bang control is determined by solving the dynamical programming equation. Finally, the response of the optimally controlled system is predicted by solving the reduced Fokker-Planck-Kolmogorov (FPK) equation associated with the completed averaged Itō equation. An example is given to illustrate the proposed control strategy. Numerical results show that the proposed control strategy has high control effectiveness and efficiency and the chattering is reduced significantly comparing with the bang-bang control strategy.展开更多
In this study, the coupled heave-pitch motion equations of a spar platform were established by considering lst-order and 2nd-order random wave loads and the effects of time-varying displacement volume and transient wa...In this study, the coupled heave-pitch motion equations of a spar platform were established by considering lst-order and 2nd-order random wave loads and the effects of time-varying displacement volume and transient wave elevation. We generated random wave loads based on frequency-domain wave load transfer functions and the Joint North Sea Wave Project (JONSWAP) wave spectrum, designed program codes to solve the motion equations, and then simulated the coupled heave-pitch motion responses of the platform in the time domain. We then calculated and compared the motion responses in different sea conditions and separately investigated the effects of 2nd-order random wave loads and transient wave elevation. The results show that the coupled heave-pitch motion responses of the platform are primarily dominated by wave height and the characteristic wave period, the latter of which has a greater impact. 2nd-order mean wave loads mainly affect the average heave value. The platform's pitch increases after the 2nd-order low frequency wave loads are taken into account. The platform's heave is underestimated if the transient wave elevation term in the motion equations is neglected.展开更多
The pseudo-excitation method combined with the integral transform method (PEM-ITM) is presented to investigate the ground vibration of a coupled track-soil system induced by moving random loads. Commonly in the track ...The pseudo-excitation method combined with the integral transform method (PEM-ITM) is presented to investigate the ground vibration of a coupled track-soil system induced by moving random loads. Commonly in the track model, the rail, sleepers, rail pads, and ballast are modelled as an infinite Euler beam, discretely distributed masses, discretely distributed vertical springs, and a viscoelastic layer, respectively. The soil is regarded as a homogenous isotropic half-space coupled with the track using the boundary condition at the surface of the ground. By introducing a pseudo-excitation, the random vibration analysis of the coupled system is converted into a harmonic analysis. The analytical form of evolutionary power spectral density responses of the simplified coupled track-soil system under a random moving load is derived in the frequency/wavenumber domain by PEM-ITM. In the numerical examples, the effects of different parameters, such as the moving speed, the soil properties, and the coherence of moving loads, on the ground response are investigated.展开更多
AIM:To assess the efficacy and advantages of 4-wk pegylated interferon a-2a(peg-IFN-a2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response(SVR).METHODS:Patients(n = 33...AIM:To assess the efficacy and advantages of 4-wk pegylated interferon a-2a(peg-IFN-a2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response(SVR).METHODS:Patients(n = 33) with genotype 2 and low viral load(< 100 KIU/mL),who became HCV RNA negative after 1 wk of IFN treatment,were randomly allocated to receive a 4-or 12-wk treatment course at a ratio of 2:1,respectively,with a subsequent 24-wk follow-up period.Peg-IFN-a2a was administered subcutaneously at a dose of 180 μg or 90 μg once weekly.SVR was defined as absence of serum HCV RNA at the end of the follow-up period.RESULTS:All patients completed the treatment schedule,and more than half were symptom-free during the treatment.In the 4-wk treatment group,20 of 22(91%) patients achieved SVR.Two patients relapsed,but achieved SVR following re-treatment with peg-IFN-a2a alone.In the 12-wk treatment group,11 of 11(100%) patients attained SVR.CONCLUSION:Our results show that a 4-wk course of peg-IFN-a2a monotherapy can achieve a high SVR rate in "IFN-sensitive" patients,without negatively affecting outcome.展开更多
Fatigue damage of materials includes static damage and cyclic damage.Static damage is a ratio of the plastic energy in first static loading to the statictoughness, while cyclic damage is the ratio of the cyclic plasti...Fatigue damage of materials includes static damage and cyclic damage.Static damage is a ratio of the plastic energy in first static loading to the statictoughness, while cyclic damage is the ratio of the cyclic plastic hysteresis energy to thefatigue toughness. In the calculation, cyclic hardening (or softening) of a material istaken into account, which results in the increase (or decrease) of the yield stress. Forsimplification, it is assumed that stress and strain in cyclic loading vary in accordancewith the hysteresis loop. Fatigue toughness of a material can be detennined bysymmetric cyclic stress controlled fatigue test. A method, rational and convenient forengineering, is proposed to estimate the fatigue life under random loading based onplastic hysteresis energy theorem. Preliminary verification by test is satisfactory.展开更多
In order to employ cost effective frequency domain analysis for off-shore structures treatment of hydrodynamic loading is essential. Drag and inertia dominated, resonating and antiresonating cases under random sea sta...In order to employ cost effective frequency domain analysis for off-shore structures treatment of hydrodynamic loading is essential. Drag and inertia dominated, resonating and antiresonating cases under random sea states are analyzed to highlight the implications and relative merits of four salient linearization techniques.展开更多
This paper discussed the random distribution of the loading and unloading response ratio(LURR) of different definitions(Y<sub>1</sub>~Y<sub>5</sub>)using the assumptions that the earthquak...This paper discussed the random distribution of the loading and unloading response ratio(LURR) of different definitions(Y<sub>1</sub>~Y<sub>5</sub>)using the assumptions that the earthquakes occurfollowing the Poisson process and their magnitudes obey the Gutenberg-Richter law.Theresults show that Y<sub>1</sub>~Y<sub>5</sub> are quite stable or concentrated when the expected number of eventsin the calculation time window is relatively large(】40);but when this occurrence ratebecomes very small,Y<sub>2</sub>~Y<sub>5</sub> become quite variable or unstable.That is to say,a high value ofthe LURR can be produced not only from seismicity before a large earthquake,but also from arandom sequence of earthquakes that obeys a Poisson process when the expected number ofevents in the window is too small.To check the influence of randomness in the catalogue tothe LURR,the random distribution of the LURR under Poisson models has been calculated bysimulation.90%,95% and 99% confidence ranges of Y<sub>1</sub> and Y<sub>3</sub> are given in this paper,which is helpful to quantify the random展开更多
This paper presents a Monte-Carlo simulation method to calculate intensity reliability for a missile tank under random loading. The cumulative damage mathematical model is established , and it adopts a direct simulati...This paper presents a Monte-Carlo simulation method to calculate intensity reliability for a missile tank under random loading. The cumulative damage mathematical model is established , and it adopts a direct simulation method to present random loading and o-riginal intensity for a missile tank. It can effectively predict intensity reliability for a missile tank in the environment of transport and flight.展开更多
An uncertainty analysis method is proposed for the assessment of the residual strength of a casing subjected to wear and non-uniform load in a deep well.The influence of casing residual stress,out-of-roundness and non...An uncertainty analysis method is proposed for the assessment of the residual strength of a casing subjected to wear and non-uniform load in a deep well.The influence of casing residual stress,out-of-roundness and non-uniform load is considered.The distribution of multi-source parameters related to the residual anti extrusion strength and residual anti internal pressure strength of the casing after wear are determined using the probability theory.Considering the technical casing of X101 well in Xinjiang Oilfield as an example,it is shown that the randomness of casing wear depth,formation elastic modulus and formation Poisson’s ratio are the main factors that affect the uncertainty of residual strength.The wider the confidence interval is,the greater the uncertainty range is.Compared with the calculations resulting from the proposed uncertainty analysis method,the residual strength obtained by means of traditional single value calculation method is either larger or smaller,which leads to the conclusion that the residual strength should be considered in terms of a range of probabilities rather than a single value.展开更多
BACKGROUND Hepatitis B virus(HBV)and hepatitis C virus(HCV)viral load(VL)estimation is essential for the management of both HBV and HCV infections.Due to a longer turnaround time for VL estimation,many patients drop o...BACKGROUND Hepatitis B virus(HBV)and hepatitis C virus(HCV)viral load(VL)estimation is essential for the management of both HBV and HCV infections.Due to a longer turnaround time for VL estimation,many patients drop out from the cascade of care.To achieve the global goals of reducing morbidity and mortality due to HBV/HCV and moving towards their elimination by 2030,molecular diagnostic platforms with faster and random(i.e.single sample)access are needed.AIM To evaluate the performance of the recently launched NeuMoDx 96 random access system with the conventional COBAS^(■)AmpliPrep/COBAS TaqMan system for HBV and HCV VL estimation.METHODS Archived once-thawed plasma samples were retrieved and tested on both platforms.Correlation between the assays was determined by linear regression and Bland-Altman analysis.The study included samples from 186 patients,99 for HBV of which 49 were true infected HBV cases(hepatitis B surface antigen,antihepatitis B core antibody,and HBV DNA-positive)and 87 for HCV assay in which 39 were true positives for HCV infection(anti-HCV and HCV RNA-positive).RESULTS The median VL detected by NeuMoDx for HBV was 2.9(interquartile range[IQR]:2.0-4.3)log_(10)IU/mL and by COBAS it was 3.70(IQR:2.28-4.56)log_(10)IU/mL,with excellent correlation(R2=0.98).In HCV,the median VL detected by NeuMoDx was 4.9(IQR:4.2-5.4)log_(10)IU/mL and by COBAS it was 5.10(IQR:4.07-5.80)log_(10)IU/mL with good correlation(R2=0.96).CONCLUSION The overall concordance between both the systems was 100%for both HBV and HCV VL estimation.Moreover,no genotype-specific bias for HBV/HCV VL quantification was seen in both the systems.Our findings reveal that NeuMoDx HBV and HCV quantitative assays have shown overall good clinical performance and provide faster results with 100%sensitivity and specificity compared to the COBAS AmpliPrep/COBAS TaqMan system.展开更多
文摘The article introduces a finite element procedure using the bilinear quadrilateral element or four-node rectangular element(namely Q4 element) based on a refined first-order shear deformation theory(rFSDT) and Monte Carlo simulation(MCS), so-called refined stochastic finite element method to investigate the random vibration of functionally graded material(FGM) plates subjected to the moving load.The advantage of the proposed method is to use r-FSDT to improve the accuracy of classical FSDT, satisfy the stress-free condition at the plate boundaries, and combine with MCS to analyze the vibration of the FGM plate when the parameter inputs are random quantities following a normal distribution. The obtained results show that the distribution characteristics of the vibration response of the FGM plate depend on the standard deviation of the input parameters and the velocity of the moving load.Furthermore, the numerical results in this study are expected to contribute to improving the understanding of FGM plates subjected to moving loads with uncertain input parameters.
基金supported by the National Natural Science Foundation of China(No.10672060)the Guangdong Provincial Nature Science Foundation of China(No.07006538).
文摘The investigation on fatigue lives of reinforced concrete (RC) structures strength- ened with fiber laminate under random loading is important for the repairing or the strengthening of bridges and the safety of the traffic. In this paper, two methods are developed for predicting the fatigue lives of RC structures strengthened with carbon fiber [aminate (CFL) under random loading based on a residual life and a residual strength model. To discuss the efficiency of the model, 12 RC beams strengthened with CFL are tested under random loading by the MTS810 testing system. The predicted residual strength approximately agrees with test results.
文摘Extensive 3-D model tests have been performed to study the effects of wave obliquity and multi-directionality on the wave loads acting on vertical breakwaters. The variation of horizontal and uplift forces acting on an unit length of a breakwater with wave direction, the longitudinal distribution of wave forces, as well as the longitudinal load reduction are analyzed. Some empirical formulae of the longitudinal distribution coefficient and the longitudinal load reduction factor are presented for practical use.
基金the National Natural Science Foundation of China(Nos.10332030 and 10772159)Research Fund for Doctoral Program of Higher Education of China(No.20060335125).
文摘A bounded optimal control strategy for strongly non-linear systems under non-white wide-band random excitation with actuator saturation is proposed. First, the stochastic averaging method is introduced for controlled strongly non-linear systems under wide-band random excitation using generalized harmonic functions. Then, the dynamical programming equation for the saturated control problem is formulated from the partially averaged Itō equation based on the dynamical programming principle. The optimal control consisting of the unbounded optimal control and the bounded bang-bang control is determined by solving the dynamical programming equation. Finally, the response of the optimally controlled system is predicted by solving the reduced Fokker-Planck-Kolmogorov (FPK) equation associated with the completed averaged Itō equation. An example is given to illustrate the proposed control strategy. Numerical results show that the proposed control strategy has high control effectiveness and efficiency and the chattering is reduced significantly comparing with the bang-bang control strategy.
基金Foundation item: Supported by the National Natural Science Foundation of China under Grant No. 51279130 and No. 51239008
文摘In this study, the coupled heave-pitch motion equations of a spar platform were established by considering lst-order and 2nd-order random wave loads and the effects of time-varying displacement volume and transient wave elevation. We generated random wave loads based on frequency-domain wave load transfer functions and the Joint North Sea Wave Project (JONSWAP) wave spectrum, designed program codes to solve the motion equations, and then simulated the coupled heave-pitch motion responses of the platform in the time domain. We then calculated and compared the motion responses in different sea conditions and separately investigated the effects of 2nd-order random wave loads and transient wave elevation. The results show that the coupled heave-pitch motion responses of the platform are primarily dominated by wave height and the characteristic wave period, the latter of which has a greater impact. 2nd-order mean wave loads mainly affect the average heave value. The platform's pitch increases after the 2nd-order low frequency wave loads are taken into account. The platform's heave is underestimated if the transient wave elevation term in the motion equations is neglected.
基金the National Basic Research Program of China (Grant 2014CB046803)the National Natural Science Foundation of China (Grant 11772084).
文摘The pseudo-excitation method combined with the integral transform method (PEM-ITM) is presented to investigate the ground vibration of a coupled track-soil system induced by moving random loads. Commonly in the track model, the rail, sleepers, rail pads, and ballast are modelled as an infinite Euler beam, discretely distributed masses, discretely distributed vertical springs, and a viscoelastic layer, respectively. The soil is regarded as a homogenous isotropic half-space coupled with the track using the boundary condition at the surface of the ground. By introducing a pseudo-excitation, the random vibration analysis of the coupled system is converted into a harmonic analysis. The analytical form of evolutionary power spectral density responses of the simplified coupled track-soil system under a random moving load is derived in the frequency/wavenumber domain by PEM-ITM. In the numerical examples, the effects of different parameters, such as the moving speed, the soil properties, and the coherence of moving loads, on the ground response are investigated.
基金Supported by Clinical Research Funds from Department of Gastroenterology and Hepatology,Kashiwa Hospital,Jikei University School of Medicine
文摘AIM:To assess the efficacy and advantages of 4-wk pegylated interferon a-2a(peg-IFN-a2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response(SVR).METHODS:Patients(n = 33) with genotype 2 and low viral load(< 100 KIU/mL),who became HCV RNA negative after 1 wk of IFN treatment,were randomly allocated to receive a 4-or 12-wk treatment course at a ratio of 2:1,respectively,with a subsequent 24-wk follow-up period.Peg-IFN-a2a was administered subcutaneously at a dose of 180 μg or 90 μg once weekly.SVR was defined as absence of serum HCV RNA at the end of the follow-up period.RESULTS:All patients completed the treatment schedule,and more than half were symptom-free during the treatment.In the 4-wk treatment group,20 of 22(91%) patients achieved SVR.Two patients relapsed,but achieved SVR following re-treatment with peg-IFN-a2a alone.In the 12-wk treatment group,11 of 11(100%) patients attained SVR.CONCLUSION:Our results show that a 4-wk course of peg-IFN-a2a monotherapy can achieve a high SVR rate in "IFN-sensitive" patients,without negatively affecting outcome.
文摘Fatigue damage of materials includes static damage and cyclic damage.Static damage is a ratio of the plastic energy in first static loading to the statictoughness, while cyclic damage is the ratio of the cyclic plastic hysteresis energy to thefatigue toughness. In the calculation, cyclic hardening (or softening) of a material istaken into account, which results in the increase (or decrease) of the yield stress. Forsimplification, it is assumed that stress and strain in cyclic loading vary in accordancewith the hysteresis loop. Fatigue toughness of a material can be detennined bysymmetric cyclic stress controlled fatigue test. A method, rational and convenient forengineering, is proposed to estimate the fatigue life under random loading based onplastic hysteresis energy theorem. Preliminary verification by test is satisfactory.
文摘In order to employ cost effective frequency domain analysis for off-shore structures treatment of hydrodynamic loading is essential. Drag and inertia dominated, resonating and antiresonating cases under random sea states are analyzed to highlight the implications and relative merits of four salient linearization techniques.
基金This project was sponsored by the National Soience Foundation of China(19702060)
文摘This paper discussed the random distribution of the loading and unloading response ratio(LURR) of different definitions(Y<sub>1</sub>~Y<sub>5</sub>)using the assumptions that the earthquakes occurfollowing the Poisson process and their magnitudes obey the Gutenberg-Richter law.Theresults show that Y<sub>1</sub>~Y<sub>5</sub> are quite stable or concentrated when the expected number of eventsin the calculation time window is relatively large(】40);but when this occurrence ratebecomes very small,Y<sub>2</sub>~Y<sub>5</sub> become quite variable or unstable.That is to say,a high value ofthe LURR can be produced not only from seismicity before a large earthquake,but also from arandom sequence of earthquakes that obeys a Poisson process when the expected number ofevents in the window is too small.To check the influence of randomness in the catalogue tothe LURR,the random distribution of the LURR under Poisson models has been calculated bysimulation.90%,95% and 99% confidence ranges of Y<sub>1</sub> and Y<sub>3</sub> are given in this paper,which is helpful to quantify the random
文摘This paper presents a Monte-Carlo simulation method to calculate intensity reliability for a missile tank under random loading. The cumulative damage mathematical model is established , and it adopts a direct simulation method to present random loading and o-riginal intensity for a missile tank. It can effectively predict intensity reliability for a missile tank in the environment of transport and flight.
基金supported by the National Natural Science Foundation of China[51804061,51974052,51774063]the Academician Led Special Project of Chongqing Science and Technology Commission[cstc2017zdcy-yszxX0009]+1 种基金the Chongqing Research Program of Basic Research and Frontier Technology[cstc2019jcyj-msxmX0199,cstc2018jcyjAX0417]the Chongqing Education Committee foundation[KJQN201901544,KJZD-K201801501].
文摘An uncertainty analysis method is proposed for the assessment of the residual strength of a casing subjected to wear and non-uniform load in a deep well.The influence of casing residual stress,out-of-roundness and non-uniform load is considered.The distribution of multi-source parameters related to the residual anti extrusion strength and residual anti internal pressure strength of the casing after wear are determined using the probability theory.Considering the technical casing of X101 well in Xinjiang Oilfield as an example,it is shown that the randomness of casing wear depth,formation elastic modulus and formation Poisson’s ratio are the main factors that affect the uncertainty of residual strength.The wider the confidence interval is,the greater the uncertainty range is.Compared with the calculations resulting from the proposed uncertainty analysis method,the residual strength obtained by means of traditional single value calculation method is either larger or smaller,which leads to the conclusion that the residual strength should be considered in terms of a range of probabilities rather than a single value.
文摘BACKGROUND Hepatitis B virus(HBV)and hepatitis C virus(HCV)viral load(VL)estimation is essential for the management of both HBV and HCV infections.Due to a longer turnaround time for VL estimation,many patients drop out from the cascade of care.To achieve the global goals of reducing morbidity and mortality due to HBV/HCV and moving towards their elimination by 2030,molecular diagnostic platforms with faster and random(i.e.single sample)access are needed.AIM To evaluate the performance of the recently launched NeuMoDx 96 random access system with the conventional COBAS^(■)AmpliPrep/COBAS TaqMan system for HBV and HCV VL estimation.METHODS Archived once-thawed plasma samples were retrieved and tested on both platforms.Correlation between the assays was determined by linear regression and Bland-Altman analysis.The study included samples from 186 patients,99 for HBV of which 49 were true infected HBV cases(hepatitis B surface antigen,antihepatitis B core antibody,and HBV DNA-positive)and 87 for HCV assay in which 39 were true positives for HCV infection(anti-HCV and HCV RNA-positive).RESULTS The median VL detected by NeuMoDx for HBV was 2.9(interquartile range[IQR]:2.0-4.3)log_(10)IU/mL and by COBAS it was 3.70(IQR:2.28-4.56)log_(10)IU/mL,with excellent correlation(R2=0.98).In HCV,the median VL detected by NeuMoDx was 4.9(IQR:4.2-5.4)log_(10)IU/mL and by COBAS it was 5.10(IQR:4.07-5.80)log_(10)IU/mL with good correlation(R2=0.96).CONCLUSION The overall concordance between both the systems was 100%for both HBV and HCV VL estimation.Moreover,no genotype-specific bias for HBV/HCV VL quantification was seen in both the systems.Our findings reveal that NeuMoDx HBV and HCV quantitative assays have shown overall good clinical performance and provide faster results with 100%sensitivity and specificity compared to the COBAS AmpliPrep/COBAS TaqMan system.