Adopting prospective, multi-center, random, single-blind and equal rank-control methods,226 patients with rlieumatoid arthritis (RA) were divided into two groups. The 114 patients ot the test groupwere treated with or...Adopting prospective, multi-center, random, single-blind and equal rank-control methods,226 patients with rlieumatoid arthritis (RA) were divided into two groups. The 114 patients ot the test groupwere treated with oral sustained release tablets of Tripterygium Wiltordii (TW-SR) , 2 tablets twice a day for4 weeks, 112 patients of the control group received tablets of Tripterygium Wiltordii(TW) orally 2 tablets 3times per day for 4 weeks. Testing results showed thetotal effective rates of the two groups were 92 . 11%and 90. 65 % , respectively (P >0. 05) . The adverse reaction rate of TW-SR was 20 . 18% , which was low-er than that of TW group of 70. 54% (P < 0. 01 ) . Results of pre-clinical pharmacologic experimental studydemonstrated that TW-SR has obvious anti-inflammatory , analgesic and immunosuppressive actions the sameas TW, while the toxicity of TW-SR was less than that of TW significantly.展开更多
Abstract: Schisandra rubriflora Rehd. et Wils. is a traditional Chinese medicine. To search for new and bioactive components from traditional Chinese medicines and provide scientific evidence for taxonomy, the chemica...Abstract: Schisandra rubriflora Rehd. et Wils. is a traditional Chinese medicine. To search for new and bioactive components from traditional Chinese medicines and provide scientific evidence for taxonomy, the chemical constituents of the plant were investigated by various column chromatography methods (silica gel, Sephadex LH-20, and RP-18). From the aerial parts of S. rubriflora, three new megastigmane glycosides, namely (3S, 5R, 6S, 9R)-megastigmane-3, 9-diol 3-O-[α-L-arabionfuranosyl-(1→6)-β-D-glucopyranoside] (1), 7-megastigmene-3-ol-9-one 3-O-[α-L-arabionfuranosyl-(1→6)-β-D-glucopyranoside] (2), and megastigmane-3α, 4β, 9σ-triol 3-O-β-D-glucopyranoside (3), along with 14 known compounds, were isolated. The structures of the new compounds were elucidated by a combination of spectroscopic and chemical methods.展开更多
文摘Adopting prospective, multi-center, random, single-blind and equal rank-control methods,226 patients with rlieumatoid arthritis (RA) were divided into two groups. The 114 patients ot the test groupwere treated with oral sustained release tablets of Tripterygium Wiltordii (TW-SR) , 2 tablets twice a day for4 weeks, 112 patients of the control group received tablets of Tripterygium Wiltordii(TW) orally 2 tablets 3times per day for 4 weeks. Testing results showed thetotal effective rates of the two groups were 92 . 11%and 90. 65 % , respectively (P >0. 05) . The adverse reaction rate of TW-SR was 20 . 18% , which was low-er than that of TW group of 70. 54% (P < 0. 01 ) . Results of pre-clinical pharmacologic experimental studydemonstrated that TW-SR has obvious anti-inflammatory , analgesic and immunosuppressive actions the sameas TW, while the toxicity of TW-SR was less than that of TW significantly.
文摘Abstract: Schisandra rubriflora Rehd. et Wils. is a traditional Chinese medicine. To search for new and bioactive components from traditional Chinese medicines and provide scientific evidence for taxonomy, the chemical constituents of the plant were investigated by various column chromatography methods (silica gel, Sephadex LH-20, and RP-18). From the aerial parts of S. rubriflora, three new megastigmane glycosides, namely (3S, 5R, 6S, 9R)-megastigmane-3, 9-diol 3-O-[α-L-arabionfuranosyl-(1→6)-β-D-glucopyranoside] (1), 7-megastigmene-3-ol-9-one 3-O-[α-L-arabionfuranosyl-(1→6)-β-D-glucopyranoside] (2), and megastigmane-3α, 4β, 9σ-triol 3-O-β-D-glucopyranoside (3), along with 14 known compounds, were isolated. The structures of the new compounds were elucidated by a combination of spectroscopic and chemical methods.
