More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and deaths.Overall,colorectal ranks third in incidence,but s...More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and deaths.Overall,colorectal ranks third in incidence,but second in mortality.More than half of the patients are in advanced stages at diagnosis.Treatment options are complex because of the heterogeneity of the patient population,including different molecular subtypes.Treatments have included conventional fluorouracil-based chemotherapy,targeted therapy,immunotherapy,etc.In recent years,with the development of genetic testing technology,more and more targeted drugs have been applied to the treatment of CRC,which has further prolonged the survival of metastatic CRC patients.展开更多
植物光系统Ⅰ反应中心亚基Ⅴ(photosystemⅠreaction center subunitⅤ,简称PSAG或PSⅠ-G)是光合系统Ⅰ的主要组件,具有维持PSⅠ复合体稳定性的重要作用,并与抗盐密切相关。本研究以福州宦溪野生蕉(Musa spp.AB group)叶片为材料,采用...植物光系统Ⅰ反应中心亚基Ⅴ(photosystemⅠreaction center subunitⅤ,简称PSAG或PSⅠ-G)是光合系统Ⅰ的主要组件,具有维持PSⅠ复合体稳定性的重要作用,并与抗盐密切相关。本研究以福州宦溪野生蕉(Musa spp.AB group)叶片为材料,采用同源克隆的方法 ,首次分离到PSAG基因的2个成员:PSAG1、PSAG2(GenBank登录号分别为JX317082、JX317083),分别为800、827 bp,分别编码150、160个氨基酸;PSAG1、PSAG2的基因组序列分析表明2个成员均没有内含子。生物信息学分析表明:PSAG1、PSAG2具有PSⅠ的Ⅹ亚基超家族(photosystemⅠreaction center subunitⅩpsaK)保守结构域,是不具有信号肽的跨膜蛋白,具有亲水性;PSAG1、PSAG2均有4个位点发生磷酸化。宦溪野生蕉PSAG在进化过程中形成了特殊的结构特征,即PSAG1和PSAG2没有内含子,并且在不同物种间保守区具有高度的一致性,为保持PSAG功能的稳定性提供了重要保证。展开更多
文摘More than 1.9 million new colorectal cancer(CRC)cases and 935000 deaths were estimated to occur worldwide in 2020,representing about one in ten cancer cases and deaths.Overall,colorectal ranks third in incidence,but second in mortality.More than half of the patients are in advanced stages at diagnosis.Treatment options are complex because of the heterogeneity of the patient population,including different molecular subtypes.Treatments have included conventional fluorouracil-based chemotherapy,targeted therapy,immunotherapy,etc.In recent years,with the development of genetic testing technology,more and more targeted drugs have been applied to the treatment of CRC,which has further prolonged the survival of metastatic CRC patients.
文摘植物光系统Ⅰ反应中心亚基Ⅴ(photosystemⅠreaction center subunitⅤ,简称PSAG或PSⅠ-G)是光合系统Ⅰ的主要组件,具有维持PSⅠ复合体稳定性的重要作用,并与抗盐密切相关。本研究以福州宦溪野生蕉(Musa spp.AB group)叶片为材料,采用同源克隆的方法 ,首次分离到PSAG基因的2个成员:PSAG1、PSAG2(GenBank登录号分别为JX317082、JX317083),分别为800、827 bp,分别编码150、160个氨基酸;PSAG1、PSAG2的基因组序列分析表明2个成员均没有内含子。生物信息学分析表明:PSAG1、PSAG2具有PSⅠ的Ⅹ亚基超家族(photosystemⅠreaction center subunitⅩpsaK)保守结构域,是不具有信号肽的跨膜蛋白,具有亲水性;PSAG1、PSAG2均有4个位点发生磷酸化。宦溪野生蕉PSAG在进化过程中形成了特殊的结构特征,即PSAG1和PSAG2没有内含子,并且在不同物种间保守区具有高度的一致性,为保持PSAG功能的稳定性提供了重要保证。
