Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression

Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

Profile of Peanut Sensitization in Children Attending a Pneumo-Allergology Consultation at the Teaching Hospital Campus of Lomé, Togo

Introduction: Food allergies are on the constant increase worldwide. Among them is peanut allergy, which also affects children. The aim of this study was to determine the profile of peanut sensitization in children attending a pneumo-allergology consultation. Methods: This was a cross-sectional study, which ran from January 1, 2018, to December 31, 2022, on children sensitized to peanuts seen in pneumo-allergology consultations at the Teaching Hospital Campus of Lomé. Results: The sample included 137 children aged 3 months to 18 years. The frequency of peanut sensitization was 25.3%. The mean age of patients was 6.3 ± 4.3 years (minimum 6 months and maximum 18 years). The 6 months to 5 years age group was the most represented (43.1%). The sex ratio was 1.3. The main reasons for consultation were rhinorrhea (67.9%), sneezing (36.5%) and cough (35.8%). Allergic rhinitis was identified as a personal history in 75.2% of patients. Peanut allergy was manifested as rhinorrhea (62.5%), asthma (26.8%) and eczema (8.9%). The risk of onset of symptoms within 15 - 30 minutes was 1.87 times (p = 0.001, CI = [1.2 - 2.1]) for peanuts consumed in roasted form with shell. Severe clinical signs such as Quincke’s Edema and anaphylactic shock were found in 1.4% of cases. Conclusion: Peanut allergy was common in children. Severe clinical signs were rare.

Management of Acute Diarrhoea in Children Aged 0 - 59 Months in the Paediatric Ward of the Ratoma CMC (Guinea)

Introduction: Acute diarrhoea is a real public health problem worldwide and is responsible for considerable mortality in developing countries. The aim of this study was to evaluate the management of acute diarrhoea in children aged 0 - 59 months hospitalised in the paediatric ward of the Ratoma CMC. Material and Methods: This was a descriptive cross-sectional study lasting 6 months, from 01 July to 31 December 2023, including all children aged 0-59 months admitted for diarrhoea lasting no more than 14 days and whose parents agreed to take part in the study. Sociodemographic, clinical, therapeutic and evolutionary data were studied. Results: 79 children were seen for acute diarrhoea out of 330 consulted, i.e., a frequency of 23.9%. The age group 0 - 11 months was the most represented, at 54.4%. Males predominated: 62% with a sex ratio of 1.6. The average consultation time was 3 days, with extremes of 0 to 10 days. The number of bowel movements per day varied from 3 to 12. The stools were liquid in 82.27% of cases. All hospitalised children were dehydrated, with 68.4% suffering from moderate dehydration, 21.5% from mild dehydration and 10.1% from severe dehydration. Malaria was the condition most frequently associated with diarrhoea (27.8%). Malnutrition was found in only 2.5%. 82% of the children had received oral rehydration with ORS and 18% intravenous rehydration. Almost all the children (93.67%) had a favourable outcome. We recorded one case of death, a rate of 1.26%. Conclusion: Acute diarrhoea in children is one of the most frequent reasons for consultation in the paediatric department of the Ratoma CMC. Often accompanied by fever and vomiting, it is frequently observed in children aged 0 to 11 months, with a predominance of males. The overall management of acute diarrhoea in children involves improving people’s standard of living, combating faecal peril, drinking water consumption, promoting vaccination, the use of oral rehydration solutions and zinc, and training healthcare staff.

Obstacles to the Integrated Care of Children Aged 6 to 59 Months Suffering from Acute and Severe Malnutrition at the Chu-Me and HATC of N’Djamena/Chad

Introduction: the problem of Severe Acute Malnutrition (SAM) and its consequences concern and challenge all social actors worldwide. The objective of the study was to identify the real obstacles that actors face in the integrated management of children aged 6 - 59 months suffering from SAM at the University Hospital of Mother and Child (CHUME) and the Chad-China Friendship Hospital (HATC) of N’Djamena. Methodology: this is a cross-sectional descriptive and interpretative study conducted from January to October 2023 at the CHUME and HATC of N’Djamena. It is based on questionnaires and direct observation of two hundred and thirty-six (236) parents or guardians of malnourished children admitted to these health facilities. All 236 agreed to participate freely in this study. Results: it appears from this study that the obstacles to the integrated management of malnourished children were: poor care-care relationship (26.7%) permanent product breaks (22.9%), the direct costs of services ranged from 30,000 to 60,000 FCFA (41.53%), drugs used for the treatment of patients came from the street (66.10%), malaria and anemia occupy an important place (27.5%), 57.2% respondents had monthly income below 60,000 CFAF. Conclusion: the present study carried out has identified the real bottlenecks to the integrated management of children suffering from SAM in the therapeutic nutritional units of the city of N’Djamena. .

Mother-to-Child Transmission of Human Papillomavirus in Burkina Faso

Introduction: Human papillomavirus (HPV) infection is the most widespread sexually transmitted infection in the world. Today, there is growing evidence that HPV can be transmitted early in life, and one potential route is mother-to-child transmission. Data on this route of HPV transmission are scarce in Africa and particularly in Burkina Faso, where no data on the subject are yet available. The aim of our study was to estimate the rate of mother-to-child transmission of HPV infection and to identify circulating genotypes. Methodology: Cervico-uterine samples were collected from 100 full-term pregnant women and, buccal samples were obtained from their newborns at Hopital Saint Camille de Ouagadougou (HOSCO) by the specialist physician. HPV DNA amplification and genotyping were performed by PCR followed by hybridization using the HPV Direct Flow Chips kit, detecting 36 genotypes including 18 high-risk and 18 low-risk. Results: The prevalence of HPV in newborns was 8% (8/100). Six (6) HPV-positive neonates had HPV-positive mothers, while 2 HPV-positive neonates had HPV-negative mothers. The vertical transmission rate was 26.09% (6/23). Mother-newborn genotypes were concordant. However, the genotype profile of the newborns was more restricted than that of the mothers. Conclusion: HPV DNA was found in 8% of newborns in our study. The genotype profile of the mother-newborn pair was concordant. Asymptomatic HPV infection in a pregnant woman could constitute a risk factor for vertical transmission.

Evolution of Mother-to-Child HIV-1 Transmission Rate in Mali from 2009 to 2018

Despite enormous efforts to achieve the goal of eliminating mother-to-child transmission of HIV-1, it remains a major challenge for many countries in sub-Saharan Africa, particularly Mali. Our objective is to assess changes in the rate of mother-to-child transmission of HIV-1. We conducted a cross-sectional study between January 1, 2009 to December 31, 2018 (10 years) of early diagnosis activity in newborns and children born to HIV-1-positive mothers at the National Institute for Public Health (INSP). The samples came from health and referral centers in mali. All samples were received at the Laboratory of Molecular Biology at the INSP. Proviral DNA extraction was performed from a blood spot sample with a Roche DNA kit, Cobas AmpliPrep/Cobas TaqMan HIV-1 qualitative Test, V2.0 (Roche Molecular System, Inc, USA) following the company procedures. Molecular diagnosis was performed using the same kits using an algorithm of three identical PCRs. The Epi Info version 7 software was used for data analysis with a significance threshold of 5%. A total of 10,714 samples of infants and children born to HIV-positive mothers were analyzed by PCR. Ninety-six percent of mothers were on ARV prophylaxis (AZT 3TC NVP and AZT NVP) and 60% of newborns received the same ARV prophylaxis. Of these children, 956 tested positive with an overall transmission rate of 8.92%, varying between 7.27% in 2009 and 08.01% in 2018. This rate was relatively low among children receiving prophylaxis at 2.04% and remained high for children who received breastfeeding at 5.62%. However, the transmission rate remains low for those who have benefited from mixed and artificial breastfeeding at 1.58% and 1.27% respectively. A significant proportion of children remained infected by their mothers during pregnancy, childbirth or breastfeeding. This study shows the importance of early diagnosis of HIV in children using molecular technology.

Experiences of Mothers on the Utilization of Elimination of Mother to Child Transmission of HIV Services at Mtendere Clinic, Lusaka

Introduction: Acquired immunodeficiency syndrome is one of the leading causes of mortality among women of reproductive age and Mother to Child Transmission of Human immunodeficiency virus is still a challenge affecting many countries. Globally, an estimation of 180,000 children under 15 years acquire the Human immunodeficiency virus every day, and more than 90% of those infections are due to Mother to Child Transmission. The study sought to explore the experiences of mothers on the Elimination of Mother to Child Transmission-HIV services at Mtendere Clinic, Lusaka. Materials and Methods: Qualitative interpretive phenomenology study design was employed using in-depth interviews to collect data from a sample that was selected using purposive sampling technique. Thirteen participants were recruited, and these were HIV-positive mothers at least between the ages of 15 and 49 years and enrolled in the Elimination of Mother To Child Transmission-HIV program. The in-depth interviews were audiotape recorded and transcribed verbatim. Data was analyzed using thematic method. Findings: Three main themes that emerged are;living with HIV, support system and barriers to utilization of Elimination of Mother To Child Transmission-HIV services. Most of the participants expressed having acquired knowledge from the program, and received counselling and support from spouses, family as well as health personnel at Mtendere health facility which culminated into a positive experience and enhanced their uptake of the Elimination of Mother to Child Transmission-HIV services. However, barriers to service utilization were identified and these included fear of stigma, negative attitudes from health workers, long waiting times, lack of support and lack of transport to the health facility. Conclusion: Interventions such as community awareness campaigns on Elimination of Mother To Child Transmission-HIV, male involvement and implementing mother-to-mother peer support strategies in Elimination of Mother To Child Transmission-HIV service utilization should be prioritized so as to alleviate stigma and enhancing a positive experience for these mothers thus reducing on the Mother to Child HIV Transmission burden and mortality rates.

Assessment of the Willingness to Buy and the Use of Insecticide Treated Nets (ITN) among Caregivers of Under-Five Children Attending Immunization Clinics in a Private Tertiary Hospital in Plateau State, Nigeria

Introduction: Malaria control becomes effective if countries adopt the World Health Organization & Global Malaria Programme (WHO/GMP) recommendation with includes diagnosis of malaria cases and treatment with effective medicines, distribution of insecticide-treated nets (ITNs) and indoor residual spraying (IRS). Ownership and utilization of mosquito nets for malaria prevention is still sub-optimal with only 62% ownership of at least one mosquito net and only 37% of children using the nets. This seeks to investigate the willingness to buy and the use ITN use among caregivers of under five children attending immunization clinic in Bingham University Teaching Hospital. Methodology: A descriptive cross sectional study design carried out among 242 caregivers of all ages and sex of under-five children attending immunization clinic at Bingham University Teaching Hospital (BHUTH) in Jos North Local Government Area of Plateau State, Nigeria. A Simple Random Sampling technique was used to select respondents. Findings: Two hundred and sixteen 216 (89.3%) of the children use ITNs, majority of the children 190 (78.5%) slept under ITN the night before the interview, 226 (93.4%) owned ITNs, 156 (64.5%) got the ITNs for free while 60 (24.8%) paid for it and majority 172 (71.1%) of the children use ITN every night. Tertiary education, having much younger children (less than 3 years) and perception as a means of malaria prevention were associated with higher use of ITNs. Majority 220 (90.9%) the caregivers were willing to buy ITN and also recommend ITN to others. Caregivers who were traders and civil servants were willing to buy ITN than farmers, tertiary education, having children 1 - 3 months old, and owning 3 or more ITNs was associated with willingness to buy ITNs. Conclusion: About 90% of the children of caregivers use ITNs and over three quarters slept under ITN the night before the interview and majority use it every night. Majority the caregivers were willing to buy ITN and also recommend ITN to others. The government and health care workers should continue to encourage and enlighten caregivers to keep using ITNs for their children and sustain mass free distribution of ITNs to improve ownership and utilization of ITNs.

Study on the Rual Migrant Workers＇ Willingness to Have Urban Hukou and the Choice of Urbanization Path of China in Recent Years

Based on the empirically analysis of the data from a nationwide survey in 2010 in China, the study found. （1） The overwhelming majority of rural migrant workers in China were not willing to convert their rural household registration （nongye hukou） to an urban or non-rural registration Orei nong hukou）. If they were required to return the rural land contract rights as precondition, only lOper cent were willing to be urban citizens. （2） For the small proportion of migrant workers who were willing to convert their rural household registration to urban household registration, ＇obtaining access to better education and more opportunities for the continuation of education for their children＇ is the major incentive. （3） The primary reason for retaining a rural hukou, on the other hand, is to keep their rural contract land. （4） Finally, there is no significant difference between the rural migrant workers who were born before 1980 and those after 1980, in term of the attitude toward converting rural hukou to urban hukou. The policy recommendations drew from the findings are as follows： 1） In order to promote the urbanization process, the government should choose the path of ＇urbanization based on the long term residence in the towns and cities＇ instead of the path of ＂urbanization based on household registration ＇. 2） The rural migrant workers should be converted into urban citizens without being forced to give up their contact land. 3） The government should give equal weight in policy making to the migrant workers born before 1980 and those born after 1980. Therefore, the policy emphasis of deepening the urbanization of China should focus on the ＇equalization of the resource allocation of the public services and social welfare＂ while the characteristics of the separation of the household registration system should not be strengthened any longer.

Study on Influencing Factors of Childbearing-Aged Women’s Willingness to Have Multiple Children in China

The fertility rate of China has shown an overall decline trend,so the fully understanding of the factors affecting China’s fertility intention has become the focus of the research.Based on CFPS2020 data,the study subjects were women of age between 20 and 49,who were born after the 1970s and were influenced by the family planning policy.Then,SMOTE-Catboost algorithm was used to construct a model.The results show that:(1)For the women’s willingness to have multiple children,the SMOTE-Catboost algorithm is more effective than the Catboost algorithm,and the classification accuracy is improved by 8 percentage points.(2)The factors influencing women’s willingness to have multiple children were ranked by social status,intergenerational care,education level and age.Women with high social status are more willing to have multiple children;All-day intergenerational care has a positive effect on women’s willingness to have multiple children.And women’s willingness to have multiple children declines with the rise of education level but increases with age.(3)Combined with the CFPS2018 data,the influencing factors changed over time.In 2018,the important factors related to women’s willingness to have multiple children were mainly related to economic,within which the income ranked locally is the most important one.In 2020,the most important factor changed to be social status while economic became less important.

How to Strengthen Child Learners' Self-confidence

Self-confidence is closely related to L2 learning.In order to make their learners enjoy English learning,English teach ers need to strengthen the learners’English learning confidence.This article is to find out English teachers’role to strengthening learners’self-confidence in ELL by means of class observation.The writer concludes improving speaking ability;giving praise and offering gentle error correcting can help to strengthen the learners’confidence.

Efficiency of HAART in the prevention of mother to children HIV-1 transmission at Saint Camille medical centre in Burkina Faso,West Africa

Objective:To evaluate efficiency of HAART in the prevention of mother to child HIV transmission.Methods:A longitudinal study was conducted on 1 300 women attending the antenatal service at Saint Camille Medical Centre from September 2010 to July 2011.The HIV status of mothers was determined by rapid tests and EUSA.Discordant results were confirmed by real-time PCR.PCR was used to determine HIV status of children born from HIV-positive mothers.Results:Among 1 300 pregnant women tested for HIV,378 were seropositive.Mothers were predominantly housewives(69.7%),and their mean age was(28.32±0.15) years.The overall prevalence of HIV transmission from mother to child was 4.8%(18/378).This prevalence differed significantly from 0.0%(0/114) to 6.8%(18/264) in children born from mothers under HAART and those with mothers under New Prophylactic Protocol(ACT + 3TC + NVP),respectively(P【 0.01).Children’s mortality rate during the medical follow up was 1.3%(5/378).Among 16 women with HIV dubious status by ELISA,the Real Time PCR confirmed 2/16(12.5%) as HIV positive. Conclusions:The protocol of prevention of mother to children HIV transmission(PMTCT) is effective.The rate of HIV vertical transmission is significantly reduced.Early diagnosis determined by PCR of children born from HIV- positive mother is necessary and recommended in the context of PMTCT in Burkina Faso.We also found that PCR is an effective tool to confirm HIV status in pregnant women.

Willingness of farmers to participate in food traceability systems:improving the level of food safety

In order to solve frequently emerging food safety problems and adapt to the developing trends in the international food safety field, the Chinese government is establishing and developing food traceability systems. Whether or not food traceability sys- tems can guarantee food safety is a problem well worth discussing. Hence, we constructed a theoretical model to explore the effect of incentives in a food traceability system in order to improve food safety levels. The following results were obtained： enhancing the ef- fectiveness of a food traceability system, increasing the payment to farmers who supply safe agricultural products and strengthening the penalty for unsafe food supply actions are necessary conditions to improve the level of food safety. How to encourage farmers to use food traceability systems is another problem explored in our investigation. Based on a field survey on the willingness of vegetable growers to participate using a vegetable traceability system in Beijing, the first city in China to develop such a system, we used a de- scriptive statistics and a binary logistic regression model to investigate the factors which dominate the decision on the part of farmers to participate in a food safety system. The results indicate that i： younger farmers are more likely to get involved in a food traceability system than older farmers, ii： income from non-agricultural activities decreases the willingness of farmers to participate, iii： the high- er the cost-benefit ratio of growing vegetables, the more likely for farmers to engage in a food traceability system, iv： farmers with a great concern for food safety information have a high propensity to participate and v： increased penalties against unsafe food supply actions and high-risk expectation are adverse incentives. In contrast, high-price expectation is a positive incentive for farmers to par- ticipate, while agricultural training, government subsidies and being part of an industrial organization will significantly strengthen the confidence of farmers to participate in a food safety system.

Tuberculous peritonitis in children:Report of nine patients and review of the literature

AIM:To present our experience with tuberculous peritonitis treated in our hospital from 2002-2007. METHODS: We reviewed the medical records of 9 children with tuberculous peritonitis. RESULTS: Nine patients (5 boys, 4 girls) of mean age 14.2 years were diagnosed with peritoneal tuberculosis. All patients presented with abdominal distention. Abdominal pain was seen in 55.5% and fever in 44.4% of the patients. Four cases had coexisting pleural effusion and two had pulmonary tuberculosis with parenchymal consolidation. Ultrasonography found ascites with septation in 7 patients. Two patients had only ascites without septation. Ascitic fluid analysis of 8 patients yielded serum-ascite albumin gradients of less than 1.1 gr/dL. Laparoscopy and laparotomy showed that whitish tuberculi were the most common appearance. Adhesions were also seen in three cases. The diagnosis of peritoneal tuberculosis was confirmed histo-pathologically in 7 patients and microbiologically in two. Two patients had been diagnosed by ascitic fluid diagnostic features and a positive response to antituberculous treatment. All patients completed the antituberculous therapy without any complications. CONCLUSION: Tuberculous peritonitis has to be clinically suspected in all patients with slowly progressive abdominal distension, particularly when it is accompanied by fever and pain. Laparoscopy and peritoneal biopsy are still the most reliable, quick and safe methods for the diagnosis of tuberculous peritonitis.

Dynamic Characteristic Analysis of HIV Mother to Child Transmission in China

Objective to explore dynamic characteristics of the HIV mother to child transmission （MTCT） epidemic in China.Methods A deterministic dynamic transmission model was used to determine the effect of key parameters on the likely long-term trends of the HIV MTCT epidemic in China.Matlab 7.0 was used to develop the model.Results The number of the susceptibles （S）,the transmission rate （β）,and the screening proportion （α） of HIV positive pregnant women have the greatest impact on the HIV MTCT epidemic in China.The growth of the MTCT epidemic in China could not be controlled only by decreasing the MTCT transmission rate.The prevalence of HIV positive women should be reduced and more pregnant women should be tested for HIV.Conclusion Prevention of MTCT （PMTCT） should focus not only on the reduction of HIV transmission rates and incidences of HIV among women but also on the increase of HIV testing for pregnant women.The most cost-effective PMTCT means for China should be investigated in future studies.

Research on the Willingness to Accept Compensation and Compensation Sharing of Returning Land for Farming to Forestry in Zhangjiakou and Chengde Region

[Objective] The aim was to study the willingness to accept compensation and compensation sharing of returning land for farming to forestry in Zhangjiakou and Chengde region.[Method] Based on the investigation of farmers’ willingness to accept ecological compensation in Zhangjiakou and Chengde region,farmers’ willingness to accept compensation was quantized,and the calculation model of sharing rate of ecological compensation was established,finally the sharing rate of ecological compensation was calculated choosing water supply quantity as reference.[Result] Farmers’ willingness to accept compensation in Zhangjiakou and Chengde region was 2 740.5 yuan/(hm2·a),and returned farmland area was 429 700 hm2 in 2008,so the willingness to accept ecological compensation was up to 1.178 billion yuan/a.In addition,the ecological compensation sharing rate of government was 37.60% in Beijing,42.75% in Tianjing and 19.64% in Tangshan,and their ecological compensation funds were 443,504 and 231 million yuan,respectively.[Conclusion] The study could provide important foundation for the establishment of ecological compensation standard and implementation of ecological compensation in Zhangjiakou and Chengde region.

Willingness to Pay for Measures of Managing the Health Effects of Heat Wave in Beijing,China:a Cross-sectional Survey

Objective There are evidences that heat wave events cause deaths and emergency cases. This article used the contingent valuation method to find the willingness to pay for the protective measures and investigated the factors that influence the willingness to pay. Methods A cross-sectional face-to-face household survey was completed by 637 urban long-term residents and 591 rural long-term residents aged 15-79 in Beijing, China. Binary logistic regression was used to identify factors that influenced the payment rate or payment amount for the protective measures, including independent variables for district, gender, age, education, income, air conditioner ownership, heat wave experience, and chronic non-communicable disease. Results The payment rate was 41.1% for protective measures provided by the government and 39.5% by measures provided by the market. Most of the respondents were willing to pay 40 CNY per capita annually for measures provided by the government or the market. The factors influencing willingness to pay were district, gender, income, air conditioner ownership, heat wave experience, and chronic non-communicable disease. Conclusion Protective measures for heat waves need to be provided immediately. More attention should be paid to the situation of vulnerable groups, such as people who live in urban areas, those without air conditioning, and those who have experienced a heat wave in the past.

Assessment of Willingness to Pay as a Source of Financing for the Sustainable Development of Barobbob Watershed in Nueva Vizcaya, Philippines

This study employed the Contingent Valuation Method to assess the willingness to pay of water users, as a source of financing for the sustainable development of Barobbob Watershed. The WTP study was conducted among 345 waters users in 19 barangays in the municipalities of Solano and Bayombong. Uncensored data revealed that 63.8% (58.84% for the adjusted) of the respondents revealed willingness to pay for improved watershed management. The mean WTP amount, estimated through a logit model, Turnbull Distributor-Free Estimator and Lower Bound Estimate, is found to be PhP39.35, PhP27.80 and PhP25.90/month/household, respectively. Respondents WTP is influenced by bid amount, age, membership in environmental organization, experience with water-related problems, civil status, house ownership, and awareness on the concept of watershed. Respondents were willing to pay because they wanted a sustainable water supply for the present and future generations. A payment scheme is possible and it could provide a sustainable flow of fund, however, the willingness percentages still needed to be increased. Community education and public awareness (CEPA) campaign is necessary to enhance the water users’ knowledge and understand about the importance and values of watersheds. Ultimately, WTP percentage and WTP amounts would increase.

Factors influencing willingness to participate in ophthalmic clinical trials and strategies for effective recruitment

AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical trials.METHODS:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic Center,Sun Yat-sen University,in Guangzhou,China.The survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical trials.RESULTS:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical trials.Specific characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical trials.With the exception of age,these characteristics were significantly linked to a higher willingness.The primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key facilitator.CONCLUSION:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic factors.Variations in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment strategies.Importantly,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.

Pig farmers’ willingness to recover their production under COVID-19 pandemic shock in China-Empirical evidence from a farm survey

Pig farmers’willingness to recover production under the COVID-19 pandemic shock is significant to recover live pigs’supply in China in 2020.Increasing farmers’willingness to recover pig production contributes to enhance pig supply,stabilize the pig and pork market,and to improve pig farmers’income.This research studies the determinants of pig farmers’willingness to recover production under COVID-19 pandemic shock by applying survey data of 201 farmers in Huai’an City and Lin’an City and a logit regression model.The estimation results show that a farmer’s risk perception,the duration time of a farmer’s feed supply under COVID-19 pandemic shock,whether or not being a cooperative member,and a farmer’s knowledge on government’s policy designed to encourage pig production,a farmer’s education level and production experience are the key determinants to a farmer’s willingness to recover pig production.Thus,it’s important for policymakers to solve the problems for farmers to get access to feed during the pandemic,to encourage the development of cooperatives,as well as to issue and advocate policies to encourage pig production.The study contributes to the scant literature by providing fresh empirical evidences on determinants of farmers’willingness to recover pig production.It has significance to farmers and governments to enhance farmers’willingness to recover production,which contributes to secure pig supply in China after the COVID-19 pandemic.