Summary: To investigate the effects of WIN 55,212-2 on I K in cultured rat trigeminal ganglion (TG) neurons, whole-cell patch clamp techniques were used to record the I K before and after WIN 55,212-2 perfusion at d...Summary: To investigate the effects of WIN 55,212-2 on I K in cultured rat trigeminal ganglion (TG) neurons, whole-cell patch clamp techniques were used to record the I K before and after WIN 55,212-2 perfusion at different concentrations. 30 μmol/L WIN 55,212-2 markedly (35 7 %± 7 3 %, P<0.01, n=8) inhibited I K currents, and the currents were partially recovered after washing. 30 μmol/L WIN 55,212-2 also induced a significant depolarizing shift in conductance-voltage parameters (control: V 0 5=10 43 ± 4.25 mV, k=16 27±3 86; WIN 55,212-2: V 0.5=24.71±3.91 mV, k =16.69±2.75; n = 8, P<0.01 for V 0.5). 0.01 μmol/L WIN 55,212-2 slightly (27.0 %± 7.9 %, P<0.05, n=7) increased I K currents, but had no significant change in conductance–voltage parameters (control: V 0.5=10.74±5.27 mV, k=17.33±2.96; WIN 55,212-2: V 0.5=11.06±2.05 mV, k=19.69±6.60; n=7, P>0.05 for V 0.5 and k). These results suggested that WIN 55,212-2 has dual action, which might be through different receptors.展开更多
Energy trade is the barometer of global trade in goods and plays an integral role international trade. As an important part of the implementation of the "Belt and Road"Initiative,multilateral partnership in ...Energy trade is the barometer of global trade in goods and plays an integral role international trade. As an important part of the implementation of the "Belt and Road"Initiative,multilateral partnership in energy trade is one of the most cooperative and promising areas for the countries along the "Belt and Road".Since the implementation of the initiative five years ago,cooperation in energy trade between China and the countries along the "Belt and Road"has been deepening.This development not only benefits the energy producers,energy consumers and energy corridors,but it also elevates China's influence and leadership in the regional energy market,contributing to the construction of a new international energy order.展开更多
Energy trade is the barometer of global trade in goods and plays an integral role international trade. As an important part of the implementation of the Belt and Road Initiative,multilateral partnership in energy trad...Energy trade is the barometer of global trade in goods and plays an integral role international trade. As an important part of the implementation of the Belt and Road Initiative,multilateral partnership in energy trade is one of the most cooperative and promising areas for the countries along the Belt and Road.Since the implementation of the initiative five years ago,cooperation in energy trade between China and the countries along the Belt and Road has been deepening.This development not only benefits the energy producers,energy consumers and energy corridors,but it also elevates China's influence and leadership in the regional energy market, contributing to the construction of a new international energy order.展开更多
基金his project was supported by a grant from National Natural Sciences Foundation of China (No. 30271500).
文摘Summary: To investigate the effects of WIN 55,212-2 on I K in cultured rat trigeminal ganglion (TG) neurons, whole-cell patch clamp techniques were used to record the I K before and after WIN 55,212-2 perfusion at different concentrations. 30 μmol/L WIN 55,212-2 markedly (35 7 %± 7 3 %, P<0.01, n=8) inhibited I K currents, and the currents were partially recovered after washing. 30 μmol/L WIN 55,212-2 also induced a significant depolarizing shift in conductance-voltage parameters (control: V 0 5=10 43 ± 4.25 mV, k=16 27±3 86; WIN 55,212-2: V 0.5=24.71±3.91 mV, k =16.69±2.75; n = 8, P<0.01 for V 0.5). 0.01 μmol/L WIN 55,212-2 slightly (27.0 %± 7.9 %, P<0.05, n=7) increased I K currents, but had no significant change in conductance–voltage parameters (control: V 0.5=10.74±5.27 mV, k=17.33±2.96; WIN 55,212-2: V 0.5=11.06±2.05 mV, k=19.69±6.60; n=7, P>0.05 for V 0.5 and k). These results suggested that WIN 55,212-2 has dual action, which might be through different receptors.
文摘Energy trade is the barometer of global trade in goods and plays an integral role international trade. As an important part of the implementation of the "Belt and Road"Initiative,multilateral partnership in energy trade is one of the most cooperative and promising areas for the countries along the "Belt and Road".Since the implementation of the initiative five years ago,cooperation in energy trade between China and the countries along the "Belt and Road"has been deepening.This development not only benefits the energy producers,energy consumers and energy corridors,but it also elevates China's influence and leadership in the regional energy market,contributing to the construction of a new international energy order.
文摘Energy trade is the barometer of global trade in goods and plays an integral role international trade. As an important part of the implementation of the Belt and Road Initiative,multilateral partnership in energy trade is one of the most cooperative and promising areas for the countries along the Belt and Road.Since the implementation of the initiative five years ago,cooperation in energy trade between China and the countries along the Belt and Road has been deepening.This development not only benefits the energy producers,energy consumers and energy corridors,but it also elevates China's influence and leadership in the regional energy market, contributing to the construction of a new international energy order.
