目的:观察不同频次铜砭循经刮痧对痰浊阻肺型肺胀患者肺功能的影响。方法:选取台州市中医院2022年7月至2023年7月诊治的痰浊阻肺型肺胀患者144例,按随机数字表法分为常规组、观察1组和观察2组,每组各48例。常规组给予常规西医治疗,观察...目的:观察不同频次铜砭循经刮痧对痰浊阻肺型肺胀患者肺功能的影响。方法:选取台州市中医院2022年7月至2023年7月诊治的痰浊阻肺型肺胀患者144例,按随机数字表法分为常规组、观察1组和观察2组,每组各48例。常规组给予常规西医治疗,观察1组在常规组治疗的基础上加用铜砭循经刮痧治疗,每周1次,观察2组在常规组治疗的基础上加用铜砭循经刮痧治疗,具体操作方法同观察1组,变更刮痧频次为每周2次。观察3组患者治疗前后生活质量[慢性阻塞性肺疾病评估测试(COPD Assessment test,CAT)]、中医证候积分、肺功能[第1秒用力呼吸容积(Forced expiratory volume in one second,FEV1)和第1秒用力呼吸容积占用力肺活量之比值(percentage of forced expiratory volume in first second to forced vital capacity,FEV1/FVC)]、6min步行距离试验(6 minute walking distance,6MWD)变化情况及不良反应发生情况。结果:3组治疗后CAT评分、中医证候积分均低于治疗前,且观察1组治疗后CAT评分、中医证候积分低于常规组,观察2组CAT评分、中医证候积分低于观察1组、常规组,差异有统计学意义(P<0.05)。3组治疗后FEV1、FEV1/FVC、6MWD均高于治疗前,且观察1组FEV1、FEV1/FVC、6MWD高于常规组,观察2组FEV1、FEV1/FVC、6MWD高于观察1组、常规组,差异有统计学意义(P<0.05)。3组患者治疗期间均未出现明显不良反应。结论:痰浊阻肺型肺胀患者采用铜砭循经刮痧治疗均有效,每周2次的铜砭循经刮痧治疗方案效果优于每周1次的治疗方案,可缓解患者临床症状,改善其肺功能和生活质量,且安全性良好。展开更多
Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with c...Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with chronic obstructive pulmonary disease(COPD) by means of the "syndrome?efficacy?biological sample analysis" method and then to explore its meridian tropism. Methods: Wistar rats were given nasal drops of 200-μL lipopolysaccharide and smoke 30 min two times a day, then put the appropriate dose of ice water, and freeze for an hour to build model rats. On the 16 th day, the drug group was orally administered of DG(500 mg/mL) until the 30 th day. Blood samples and biological tissues were collected from the orbital venous plexus into heparinized hemostasis tubes at 5, 10, 15, 30, 45, 60, 90, 120, 180, 240, and 360 min after the last administration. Using ultraviolet-high-performance liquid chromatography(Waters, USA) method, the effective components were tested, and DAS 3.0 software(Mathematical Pharmacology Professional Committee of China, Shanghai, China) was used to analyze the results. Results: The compounds of DG entering into blood were 6-gingerol, 6-shogaol, and 8-gingerol. Tissue distribution analysis indicates that three active ingredients are widely present in the lung, spleen, kidney, liver, heart, large intestine, stomach, small intestine, and other organs of rats with COPD. Conclusions: 6?gingerol, 6?shogaol, and 8?gingerol belong to effective components of DG in curing the syndrome of cold fluid retained in lung of rats with COPD and mainly distributed in organs including the spleen, stomach, lung, kidney, liver, and heart.展开更多
目的:观察疏风通络方治疗支气管哮喘风痰阻肺证的临床疗效及对血清白细胞介素-6(interleukin-6,IL-6)、IL-8、γ-干扰素(interferon-γ,IFN-γ)的影响。方法:选取天津中医药大学第一附属医院2019年6月至2021年7月治疗的支气管哮喘急性...目的:观察疏风通络方治疗支气管哮喘风痰阻肺证的临床疗效及对血清白细胞介素-6(interleukin-6,IL-6)、IL-8、γ-干扰素(interferon-γ,IFN-γ)的影响。方法:选取天津中医药大学第一附属医院2019年6月至2021年7月治疗的支气管哮喘急性发作期风痰阻肺证患者为研究对象,共128例,按照随机数字表法分为对照组和观察组各64例。对照组采用雾化吸入布地奈德混悬液、硫酸特布他林治疗,观察组在对照组治疗的基础上采用疏风通络方治疗,两组患者均连续治疗7 d。比较两组患者临床疗效和治疗前后中医证候积分、哮喘控制情况、肺功能、血清IL-6、IL-8、IFN-γ水平。结果:对照组有效率为64.06%,观察组有效率为89.06%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后中医证候积分和哮喘控制测试(asthma control test,ACT)评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后第1秒用力呼气容积(forced expiratory volume in the first second,FEV_(1))、呼气流量峰值(peak expiratory flow,PEF)升高,用力肺活量(forced vital capacity,FVC)降低,且组间比较,差异有统计学意义(P<0.05)。两组患者治疗后血清IL-6、IL-8、IFN-γ水平均降低,且组间比较,差异有统计学意义(P<0.05)。结论:疏风通络方治疗支气管哮喘急性发作期风痰阻肺证,可有效改善哮喘症状,改善肺功能,其机制可能与降低血清IL-6、IL-8、IFN-γ表达有关。展开更多
文摘目的:观察不同频次铜砭循经刮痧对痰浊阻肺型肺胀患者肺功能的影响。方法:选取台州市中医院2022年7月至2023年7月诊治的痰浊阻肺型肺胀患者144例,按随机数字表法分为常规组、观察1组和观察2组,每组各48例。常规组给予常规西医治疗,观察1组在常规组治疗的基础上加用铜砭循经刮痧治疗,每周1次,观察2组在常规组治疗的基础上加用铜砭循经刮痧治疗,具体操作方法同观察1组,变更刮痧频次为每周2次。观察3组患者治疗前后生活质量[慢性阻塞性肺疾病评估测试(COPD Assessment test,CAT)]、中医证候积分、肺功能[第1秒用力呼吸容积(Forced expiratory volume in one second,FEV1)和第1秒用力呼吸容积占用力肺活量之比值(percentage of forced expiratory volume in first second to forced vital capacity,FEV1/FVC)]、6min步行距离试验(6 minute walking distance,6MWD)变化情况及不良反应发生情况。结果:3组治疗后CAT评分、中医证候积分均低于治疗前,且观察1组治疗后CAT评分、中医证候积分低于常规组,观察2组CAT评分、中医证候积分低于观察1组、常规组,差异有统计学意义(P<0.05)。3组治疗后FEV1、FEV1/FVC、6MWD均高于治疗前,且观察1组FEV1、FEV1/FVC、6MWD高于常规组,观察2组FEV1、FEV1/FVC、6MWD高于观察1组、常规组,差异有统计学意义(P<0.05)。3组患者治疗期间均未出现明显不良反应。结论:痰浊阻肺型肺胀患者采用铜砭循经刮痧治疗均有效,每周2次的铜砭循经刮痧治疗方案效果优于每周1次的治疗方案,可缓解患者临床症状,改善其肺功能和生活质量,且安全性良好。
文摘Objective: This study aimed to investigate effective components of dried ginger(DG) in warming lung to reduce watery phlegm and in vivo tissue distribution on the syndrome of cold fluid retained in lung of rats with chronic obstructive pulmonary disease(COPD) by means of the "syndrome?efficacy?biological sample analysis" method and then to explore its meridian tropism. Methods: Wistar rats were given nasal drops of 200-μL lipopolysaccharide and smoke 30 min two times a day, then put the appropriate dose of ice water, and freeze for an hour to build model rats. On the 16 th day, the drug group was orally administered of DG(500 mg/mL) until the 30 th day. Blood samples and biological tissues were collected from the orbital venous plexus into heparinized hemostasis tubes at 5, 10, 15, 30, 45, 60, 90, 120, 180, 240, and 360 min after the last administration. Using ultraviolet-high-performance liquid chromatography(Waters, USA) method, the effective components were tested, and DAS 3.0 software(Mathematical Pharmacology Professional Committee of China, Shanghai, China) was used to analyze the results. Results: The compounds of DG entering into blood were 6-gingerol, 6-shogaol, and 8-gingerol. Tissue distribution analysis indicates that three active ingredients are widely present in the lung, spleen, kidney, liver, heart, large intestine, stomach, small intestine, and other organs of rats with COPD. Conclusions: 6?gingerol, 6?shogaol, and 8?gingerol belong to effective components of DG in curing the syndrome of cold fluid retained in lung of rats with COPD and mainly distributed in organs including the spleen, stomach, lung, kidney, liver, and heart.
文摘目的:观察疏风通络方治疗支气管哮喘风痰阻肺证的临床疗效及对血清白细胞介素-6(interleukin-6,IL-6)、IL-8、γ-干扰素(interferon-γ,IFN-γ)的影响。方法:选取天津中医药大学第一附属医院2019年6月至2021年7月治疗的支气管哮喘急性发作期风痰阻肺证患者为研究对象,共128例,按照随机数字表法分为对照组和观察组各64例。对照组采用雾化吸入布地奈德混悬液、硫酸特布他林治疗,观察组在对照组治疗的基础上采用疏风通络方治疗,两组患者均连续治疗7 d。比较两组患者临床疗效和治疗前后中医证候积分、哮喘控制情况、肺功能、血清IL-6、IL-8、IFN-γ水平。结果:对照组有效率为64.06%,观察组有效率为89.06%,两组有效率比较,差异有统计学意义(P<0.05)。两组患者治疗后中医证候积分和哮喘控制测试(asthma control test,ACT)评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后第1秒用力呼气容积(forced expiratory volume in the first second,FEV_(1))、呼气流量峰值(peak expiratory flow,PEF)升高,用力肺活量(forced vital capacity,FVC)降低,且组间比较,差异有统计学意义(P<0.05)。两组患者治疗后血清IL-6、IL-8、IFN-γ水平均降低,且组间比较,差异有统计学意义(P<0.05)。结论:疏风通络方治疗支气管哮喘急性发作期风痰阻肺证,可有效改善哮喘症状,改善肺功能,其机制可能与降低血清IL-6、IL-8、IFN-γ表达有关。
