Objective： To study the efficacy of modified Wuzhuyu Decoction Granule （加减吴茱萸汤颗粒剂, MWDG） in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. Methods： This study was a...Objective： To study the efficacy of modified Wuzhuyu Decoction Granule （加减吴茱萸汤颗粒剂, MWDG） in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. Methods： This study was a randomized, double-blind, placebo-controlled trial. A total of 78 migraine patients with cold and stasis obstructing meridian syndrome were recruited and randomly assigned by a ratio of 2：1 into a treatment group （51 cases） and a placebo group （27 cases）. Patients in the treatment group were treated with MWDG while placebo granules were applied in the control group. The treatment course lasted for 12 weeks with a follow-up of 4 weeks. The primary outcome measures included frequency and days of migraine attacks and the secondary outcome measures were analgesics consumption and visual analogue scale （VAS） scores. All outcome assessments were conducted respectively at baseline, the 4th, 8th and 12th week, and the end of follow-up. Results： In the treatment group, significant decrease in frequency of migraine attacks were observed since the 4th week and that of analgesics consumption since the 8th week （both P〈0.05）. While, in the placebo group, significant decrease in frequency of migraine attacks were observed since the 8th week and that of analgesics consumption since the 12th week （both P〈0.05）. No significant decrease in days of migraine attacks and VAS scores of migraine pain were observed in both groups. Between the two groups, there were significant differences in VAS scores and intensity of pain appeared in the 8th week （P〈0.05）. However, no significant differences were found in days and frequency of migraine attacks and analgesics consumption （P〉0.05）. Conclusions： MWDG was probably effective in the treatment of migraine especially for alleviating pain intensity. Furthermore, MWDG could reduce the frequency of migraine attacks and analgesics consumption sooner than the placebo.展开更多
目的:观察半夏白术天麻汤加减联合康复训练对风痰瘀阻型急性脑梗死合并H型高血压患者神经功能及生活质量的影响。方法:将182例风痰瘀血型急性脑梗死合并H型高血压患者按照随机数字表法分为对照组和观察组,每组各91例。两组均接受西医基...目的:观察半夏白术天麻汤加减联合康复训练对风痰瘀阻型急性脑梗死合并H型高血压患者神经功能及生活质量的影响。方法:将182例风痰瘀血型急性脑梗死合并H型高血压患者按照随机数字表法分为对照组和观察组,每组各91例。两组均接受西医基础治疗,对照组给予康复训练治疗,观察组在对照组治疗的基础上联合半夏白术天麻汤加减。比较两组患者的临床疗效及治疗前后中医证候积分、美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分、世界卫生组织生活质量评定简表(world health organization quality of life-bref,WHOQOL-BREF)评分、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、同型半胱氨酸(homocysteine,Hcy)水平变化情况。结果:观察组有效率为94.51%,明显高于对照组的75.82%,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分、NIHSS评分低于本组治疗前,WHOQOL-BREF评分高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后HCY、SBP、DBP水平低于本组治疗前,且观察组治疗后低于对照组(P<0.05)。结论:半夏白术天麻汤加减结合康复训练治疗风痰瘀阻型急性脑梗死合并H型高血压,临床疗效确切,可促进患者神经功能的恢复,提高患者的生活质量。展开更多
基金Supported by the "Eleventh Five-Year Plan" of China State Science&Technology Ministry(No.2007BAI20B053)National Natural Science Foundation of China(No.81273688)
文摘Objective： To study the efficacy of modified Wuzhuyu Decoction Granule （加减吴茱萸汤颗粒剂, MWDG） in the treatment of migraine patients with cold and stasis obstructing meridian syndrome. Methods： This study was a randomized, double-blind, placebo-controlled trial. A total of 78 migraine patients with cold and stasis obstructing meridian syndrome were recruited and randomly assigned by a ratio of 2：1 into a treatment group （51 cases） and a placebo group （27 cases）. Patients in the treatment group were treated with MWDG while placebo granules were applied in the control group. The treatment course lasted for 12 weeks with a follow-up of 4 weeks. The primary outcome measures included frequency and days of migraine attacks and the secondary outcome measures were analgesics consumption and visual analogue scale （VAS） scores. All outcome assessments were conducted respectively at baseline, the 4th, 8th and 12th week, and the end of follow-up. Results： In the treatment group, significant decrease in frequency of migraine attacks were observed since the 4th week and that of analgesics consumption since the 8th week （both P〈0.05）. While, in the placebo group, significant decrease in frequency of migraine attacks were observed since the 8th week and that of analgesics consumption since the 12th week （both P〈0.05）. No significant decrease in days of migraine attacks and VAS scores of migraine pain were observed in both groups. Between the two groups, there were significant differences in VAS scores and intensity of pain appeared in the 8th week （P〈0.05）. However, no significant differences were found in days and frequency of migraine attacks and analgesics consumption （P〉0.05）. Conclusions： MWDG was probably effective in the treatment of migraine especially for alleviating pain intensity. Furthermore, MWDG could reduce the frequency of migraine attacks and analgesics consumption sooner than the placebo.
文摘目的:观察半夏白术天麻汤加减联合康复训练对风痰瘀阻型急性脑梗死合并H型高血压患者神经功能及生活质量的影响。方法:将182例风痰瘀血型急性脑梗死合并H型高血压患者按照随机数字表法分为对照组和观察组,每组各91例。两组均接受西医基础治疗,对照组给予康复训练治疗,观察组在对照组治疗的基础上联合半夏白术天麻汤加减。比较两组患者的临床疗效及治疗前后中医证候积分、美国国立卫生研究院卒中量表(national institutes of health stroke scale,NIHSS)评分、世界卫生组织生活质量评定简表(world health organization quality of life-bref,WHOQOL-BREF)评分、收缩压(systolic blood pressure,SBP)、舒张压(diastolic blood pressure,DBP)、同型半胱氨酸(homocysteine,Hcy)水平变化情况。结果:观察组有效率为94.51%,明显高于对照组的75.82%,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分、NIHSS评分低于本组治疗前,WHOQOL-BREF评分高于本组治疗前,且治疗后组间比较,差异具有统计学意义(P<0.05)。两组患者治疗后HCY、SBP、DBP水平低于本组治疗前,且观察组治疗后低于对照组(P<0.05)。结论:半夏白术天麻汤加减结合康复训练治疗风痰瘀阻型急性脑梗死合并H型高血压,临床疗效确切,可促进患者神经功能的恢复,提高患者的生活质量。
