Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are a...Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.展开更多
The number of children with Severe Motor and Intellectual Disabilities (SMID) receiving medical treatment/recovering at home is rising yearly. Although benefits of this care are emphasized, the stress and duties of fa...The number of children with Severe Motor and Intellectual Disabilities (SMID) receiving medical treatment/recovering at home is rising yearly. Although benefits of this care are emphasized, the stress and duties of family members in the household are extremely great, especially because Japan is becoming a society of nuclear families. In this study, we described the lifestyles of nuclear families providing in-home medical care for children with SMID, focusing on family members’ roles. Roles of mothers, fathers, and siblings of children with SMID were summarized from semi-structured inter-views. As a result, for “the roles of each family member living with a child with SMID”, mothers had five roles, fathers seven, and siblings five. For “the hopes of each family member living with a child with SMID”, parents desired the whole family collaboration in care for children with SMID, and as caregivers, parents’ common thoughts included wanting siblings in order to help care for the child with SMID and wanting siblings to treasure their own lives. Siblings wanted their mother to have some time for rest and expected their fathers to have two main roles. They also expected their grandparents and other siblings to fulfill roles.展开更多
Purpose: The objective of the present study was to identify the type of experiences that parents and their children have with each other when late-school age children take on roles in family routines related to daily ...Purpose: The objective of the present study was to identify the type of experiences that parents and their children have with each other when late-school age children take on roles in family routines related to daily meals. Methods: A grounded theory approach was used. The participants were children in the 4th, 5th, and 6th grades of elementary school and their main caregivers. First, 10 parent and child dyads were interviewed using a semi-structured schedule. Next, online group interviews were conducted for 17 parent and child dyads to deductively confirm the categories. Results: The average age of the subjects was 41.9 years for parents and 10.4 years for children in parent-child interviews, and 41.1 years for parents and 9.6 years for children in group interviews. Six categories emerged with nineteen subcategories. Conclusions: Experiences mutually nurtured by parents and their children included experiences in which children used negotiation and conversation skills to consensually engage in family routines related to meals. It also included experiences that socialized the children in family life and fostered good communication. The six categories will be useful for healthcare professionals and school authorities in providing health guidance that addresses health functions of late school-age children and their families.展开更多
The oxysterol-binding protein-related protein(ORP)family is a group of proteins that mediate oxysterol metabolism and bioactivity in cells.ORPs constitute a large family of lipid transfer proteins.Much of the current ...The oxysterol-binding protein-related protein(ORP)family is a group of proteins that mediate oxysterol metabolism and bioactivity in cells.ORPs constitute a large family of lipid transfer proteins.Much of the current evidence indicates that certain members of the family of oxysterol-binding proteins(OSBPs)can lead to cancer.Many studies have revealed the putative roles of OSBPs in various cancer types.However,the exact effects and mechanisms of action of members of the OSBP/ORP family in cancer initiation and progression are currently unclear.This review focuses on ORP family members that can accelerate human tumour cell proliferation,migration,and invasion.The mechanisms and functions of various ORPs are introduced in detail.We also attempt to identify the roles of these proteins in malignant tumours with the ultimate aim of determining the exact role of the OSBP/ORP family in human tumour cells.展开更多
BACKGROUND This research demonstrates that nurses feel pain because the pandemic process has separated them from their family and children.AIM To examine the family relationship situation of nurses in the coronavirus ...BACKGROUND This research demonstrates that nurses feel pain because the pandemic process has separated them from their family and children.AIM To examine the family relationship situation of nurses in the coronavirus disease 2019(COVID-19)pandemic.METHODS The research adopted a descriptive qualitative design.Participants were selected by the snowball method.An individual in-depth interview technique was used while the participants were away.In-depth interviews were made with a total of 27 nurses.Nine of these nurses were excluded from the study due to communication problems and device problems during the interview.RESULTS This research showed that nurses suffered from family relationship breakdown and insufficiency in intrafamilial coping.The nurses stayed away from their families due to overtime and fear of COVID-19.They cannot meet the needs of their children and spouses for whom they are responsible,and they cannot spare time for them.They were living a tiring life with great responsibility and faced with mental problems such as burnout syndrome and depression.This study was conducted in three cities with a high number of COVID-19 cases in Turkey.We investigated three themes:Breakdown in continuity of intrafamilial relationship,ineffectiveness in role performance,and ineffective individual coping.CONCLUSION The nurses suffer from conditions such as change in parent-infant/child relation and insufficiency in intrafamilial process coping.展开更多
The United Kingdom’s Custody of Infants Act of 1839 is generally regarded as a signature instrument for women to gain guardianship of a child, and widely considered a product of the equal rights movement launched by ...The United Kingdom’s Custody of Infants Act of 1839 is generally regarded as a signature instrument for women to gain guardianship of a child, and widely considered a product of the equal rights movement launched by women in England. It has played an important role in promoting women’s equal rights and breaking patriarchal absolutism. However, there was much compromise in the legal basis for the legislation and the legal provisions, resulting in debates on the legislation that have greatly diluted the revolutionary significance of the Act. Starting with the Marxist argument on bourgeois family legislation, this paper analyzes the legislative and judicial practice of guardianship of minors before and after the promulgation of the Act in the United Kingdom. In view of its impact on the United Nations Convention on the Rights of the Child, this paper attempts to re-evaluate the historical status of this act.展开更多
For needed changes to occur, we need to do gender in higher education and tenure differently. The way that tenure is established and reviews for tenure are conducted need to be based more on a system that allows for t...For needed changes to occur, we need to do gender in higher education and tenure differently. The way that tenure is established and reviews for tenure are conducted need to be based more on a system that allows for the development of the whole individual. The future health of academia rests on the development and refinement of a system that creates a healthy environment for all members of that system. All faculty members cannot and should not be held to standards that were created in another time, which constructed the academic role as a gendered role. Individuals need to consider how we do gender, and how that creates an impact on our organization, academia. A process for equitable review of all participants in the system requires that all individuals be involved in the process of defining the standards for a tenurable professor. Then all voices should and must be represented when we construct how we do tenure so that even minority voices still have their chance to speak. There is a better way to perform the roles we take in academia, there is a better way to perform our gender in this setting, and from recognizing this we can then move to a better way to do all this that is academia.展开更多
目的探讨家庭社会支持对甲状腺微波消融术后患者睡眠质量和负性情绪的链式中介作用。方法前瞻性方便选取2023年7—12月南宁市第二人民医院接受甲状腺微波消融术治疗的157例患者作为研究对象,术后采用家庭支持自评量表(Perceived Social ...目的探讨家庭社会支持对甲状腺微波消融术后患者睡眠质量和负性情绪的链式中介作用。方法前瞻性方便选取2023年7—12月南宁市第二人民医院接受甲状腺微波消融术治疗的157例患者作为研究对象,术后采用家庭支持自评量表(Perceived Social Support From Family,PSS-Fa)、社会支持评定量表(Social Support Rating Scale,SSRS)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)、焦虑自评量表(Self-rating Anxiety Scale,SAS)与抑郁自评量表(Self-rating Depression Scale,SDS)为调查工具。分析患者家庭支持水平、社会支持水平、睡眠质量及负性情绪之间的相关性,并分析家庭社会支持对甲状腺微波消融术后患者睡眠质量和负性情绪的链式中介作用。结果最终回收有效问卷153份。不同年龄、婚姻状况、文化程度、消融范围甲状腺微波消融术后患者的PSS-Fa评分、SSRS评分、PSQI评分、SAS评分、SDS评分比较,差异有统计学意义(P均<0.05);不同性别的甲状腺微波消融术后患者的PSQI评分比较,差异有统计学意义(P<0.05),PSS-Fa评分、SSRS评分、SAS评分、SDS评分比较,差异无统计学意义(P均>0.05)。患者PSQI总分与PSS-Fa、SSRS总分呈负相关,与负性情绪评分呈正相关;PSS-Fa总分与SSRS总分呈正相关,与负性情绪评分呈负相关;SSRS总分与负性情绪评分呈负相关。“睡眠质量→家庭支持→负性情绪”路径的间接效应为0.436,bootstrap 95%CI为0.143~0.739;“睡眠质量→社会支持→负性情绪”路径的间接效应为0.261,bootstrap 95%CI为0.046~0.532;“睡眠质量→家庭支持→社会支持→负性情绪”路径的间接效应为0.088,bootstrap 95%CI为0.009~0.207。差异有统计学意义(P均<0.05)。结论家庭社会支持在甲状腺微波消融术后患者睡眠质量和负性情绪之间起链式中介作用。展开更多
基金funded by a Medical Research Council(UK)Experimental Medicine grant[MR/M006646/1]
文摘Autosomal recessive mutations in the PARK7 gene,which encodes for the protein DJ-1,result in a loss of function and are a cause of familial Parkinson’s disease（PD）,while increased wild-type DJ-1protein levels are associated with some forms of cancer.Several functions of DJ-1 have been described,with the greatest evidence indicating that DJ-1 is a redox-sensitive protein involved in the regulation of oxidative stress and cell survival.
文摘The number of children with Severe Motor and Intellectual Disabilities (SMID) receiving medical treatment/recovering at home is rising yearly. Although benefits of this care are emphasized, the stress and duties of family members in the household are extremely great, especially because Japan is becoming a society of nuclear families. In this study, we described the lifestyles of nuclear families providing in-home medical care for children with SMID, focusing on family members’ roles. Roles of mothers, fathers, and siblings of children with SMID were summarized from semi-structured inter-views. As a result, for “the roles of each family member living with a child with SMID”, mothers had five roles, fathers seven, and siblings five. For “the hopes of each family member living with a child with SMID”, parents desired the whole family collaboration in care for children with SMID, and as caregivers, parents’ common thoughts included wanting siblings in order to help care for the child with SMID and wanting siblings to treasure their own lives. Siblings wanted their mother to have some time for rest and expected their fathers to have two main roles. They also expected their grandparents and other siblings to fulfill roles.
文摘Purpose: The objective of the present study was to identify the type of experiences that parents and their children have with each other when late-school age children take on roles in family routines related to daily meals. Methods: A grounded theory approach was used. The participants were children in the 4th, 5th, and 6th grades of elementary school and their main caregivers. First, 10 parent and child dyads were interviewed using a semi-structured schedule. Next, online group interviews were conducted for 17 parent and child dyads to deductively confirm the categories. Results: The average age of the subjects was 41.9 years for parents and 10.4 years for children in parent-child interviews, and 41.1 years for parents and 9.6 years for children in group interviews. Six categories emerged with nineteen subcategories. Conclusions: Experiences mutually nurtured by parents and their children included experiences in which children used negotiation and conversation skills to consensually engage in family routines related to meals. It also included experiences that socialized the children in family life and fostered good communication. The six categories will be useful for healthcare professionals and school authorities in providing health guidance that addresses health functions of late school-age children and their families.
文摘The oxysterol-binding protein-related protein(ORP)family is a group of proteins that mediate oxysterol metabolism and bioactivity in cells.ORPs constitute a large family of lipid transfer proteins.Much of the current evidence indicates that certain members of the family of oxysterol-binding proteins(OSBPs)can lead to cancer.Many studies have revealed the putative roles of OSBPs in various cancer types.However,the exact effects and mechanisms of action of members of the OSBP/ORP family in cancer initiation and progression are currently unclear.This review focuses on ORP family members that can accelerate human tumour cell proliferation,migration,and invasion.The mechanisms and functions of various ORPs are introduced in detail.We also attempt to identify the roles of these proteins in malignant tumours with the ultimate aim of determining the exact role of the OSBP/ORP family in human tumour cells.
文摘BACKGROUND This research demonstrates that nurses feel pain because the pandemic process has separated them from their family and children.AIM To examine the family relationship situation of nurses in the coronavirus disease 2019(COVID-19)pandemic.METHODS The research adopted a descriptive qualitative design.Participants were selected by the snowball method.An individual in-depth interview technique was used while the participants were away.In-depth interviews were made with a total of 27 nurses.Nine of these nurses were excluded from the study due to communication problems and device problems during the interview.RESULTS This research showed that nurses suffered from family relationship breakdown and insufficiency in intrafamilial coping.The nurses stayed away from their families due to overtime and fear of COVID-19.They cannot meet the needs of their children and spouses for whom they are responsible,and they cannot spare time for them.They were living a tiring life with great responsibility and faced with mental problems such as burnout syndrome and depression.This study was conducted in three cities with a high number of COVID-19 cases in Turkey.We investigated three themes:Breakdown in continuity of intrafamilial relationship,ineffectiveness in role performance,and ineffective individual coping.CONCLUSION The nurses suffer from conditions such as change in parent-infant/child relation and insufficiency in intrafamilial process coping.
文摘The United Kingdom’s Custody of Infants Act of 1839 is generally regarded as a signature instrument for women to gain guardianship of a child, and widely considered a product of the equal rights movement launched by women in England. It has played an important role in promoting women’s equal rights and breaking patriarchal absolutism. However, there was much compromise in the legal basis for the legislation and the legal provisions, resulting in debates on the legislation that have greatly diluted the revolutionary significance of the Act. Starting with the Marxist argument on bourgeois family legislation, this paper analyzes the legislative and judicial practice of guardianship of minors before and after the promulgation of the Act in the United Kingdom. In view of its impact on the United Nations Convention on the Rights of the Child, this paper attempts to re-evaluate the historical status of this act.
文摘For needed changes to occur, we need to do gender in higher education and tenure differently. The way that tenure is established and reviews for tenure are conducted need to be based more on a system that allows for the development of the whole individual. The future health of academia rests on the development and refinement of a system that creates a healthy environment for all members of that system. All faculty members cannot and should not be held to standards that were created in another time, which constructed the academic role as a gendered role. Individuals need to consider how we do gender, and how that creates an impact on our organization, academia. A process for equitable review of all participants in the system requires that all individuals be involved in the process of defining the standards for a tenurable professor. Then all voices should and must be represented when we construct how we do tenure so that even minority voices still have their chance to speak. There is a better way to perform the roles we take in academia, there is a better way to perform our gender in this setting, and from recognizing this we can then move to a better way to do all this that is academia.
文摘目的探讨家庭社会支持对甲状腺微波消融术后患者睡眠质量和负性情绪的链式中介作用。方法前瞻性方便选取2023年7—12月南宁市第二人民医院接受甲状腺微波消融术治疗的157例患者作为研究对象,术后采用家庭支持自评量表(Perceived Social Support From Family,PSS-Fa)、社会支持评定量表(Social Support Rating Scale,SSRS)、匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)、焦虑自评量表(Self-rating Anxiety Scale,SAS)与抑郁自评量表(Self-rating Depression Scale,SDS)为调查工具。分析患者家庭支持水平、社会支持水平、睡眠质量及负性情绪之间的相关性,并分析家庭社会支持对甲状腺微波消融术后患者睡眠质量和负性情绪的链式中介作用。结果最终回收有效问卷153份。不同年龄、婚姻状况、文化程度、消融范围甲状腺微波消融术后患者的PSS-Fa评分、SSRS评分、PSQI评分、SAS评分、SDS评分比较,差异有统计学意义(P均<0.05);不同性别的甲状腺微波消融术后患者的PSQI评分比较,差异有统计学意义(P<0.05),PSS-Fa评分、SSRS评分、SAS评分、SDS评分比较,差异无统计学意义(P均>0.05)。患者PSQI总分与PSS-Fa、SSRS总分呈负相关,与负性情绪评分呈正相关;PSS-Fa总分与SSRS总分呈正相关,与负性情绪评分呈负相关;SSRS总分与负性情绪评分呈负相关。“睡眠质量→家庭支持→负性情绪”路径的间接效应为0.436,bootstrap 95%CI为0.143~0.739;“睡眠质量→社会支持→负性情绪”路径的间接效应为0.261,bootstrap 95%CI为0.046~0.532;“睡眠质量→家庭支持→社会支持→负性情绪”路径的间接效应为0.088,bootstrap 95%CI为0.009~0.207。差异有统计学意义(P均<0.05)。结论家庭社会支持在甲状腺微波消融术后患者睡眠质量和负性情绪之间起链式中介作用。
