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Group Images of Korean Women on Douyin:Representation,Generation,and Identification
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作者 JIN Yihan CHEN Lu 《Cultural and Religious Studies》 2024年第2期95-103,共9页
Since 2023,the slogan“Question Korean women,understand Korean women,learn Korean women”has become popular in Chinese social networks.Previously,Chinese netizens have not paid such attention to women from other count... Since 2023,the slogan“Question Korean women,understand Korean women,learn Korean women”has become popular in Chinese social networks.Previously,Chinese netizens have not paid such attention to women from other countries.In response to this phenomenon,this paper combines neoliberal feminist theories with thematic analysis to obtain a total of 80 valid samples from the Douyin platform to analyze the image of Korean women disseminated on the Douyin platform.Finally,it is concluded that the image of Korean women’s strict self-discipline,internal and external cultivation,sobriety of thought,and the spirit of courageous struggle have to a certain extent promoted the awakening of self-consciousness of female netizens in China;on the other hand,it is also necessary to realize that the image of Korean women disseminated in Douyin is not completely true,and it is also necessary to be alert to the phenomenon that the gender dichotomy has been reduced to the attraction of network traffic and capital as a sharp weapon. 展开更多
关键词 Douyin Korean women FEMINIsM group images
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GAN-DIRNet:A Novel Deformable Image Registration Approach for Multimodal Histological Images
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作者 Haiyue Li Jing Xie +4 位作者 Jing Ke Ye Yuan Xiaoyong Pan Hongyi Xin Hongbin Shen 《Computers, Materials & Continua》 SCIE EI 2024年第7期487-506,共20页
Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of tissue.Convolutional neural network(CNN)and generative adversarial ne... Multi-modal histological image registration tasks pose significant challenges due to tissue staining operations causing partial loss and folding of tissue.Convolutional neural network(CNN)and generative adversarial network(GAN)are pivotal inmedical image registration.However,existing methods often struggle with severe interference and deformation,as seen in histological images of conditions like Cushing’s disease.We argue that the failure of current approaches lies in underutilizing the feature extraction capability of the discriminator inGAN.In this study,we propose a novel multi-modal registration approach GAN-DIRNet based on GAN for deformable histological image registration.To begin with,the discriminators of two GANs are embedded as a new dual parallel feature extraction module into the unsupervised registration networks,characterized by implicitly extracting feature descriptors of specific modalities.Additionally,modal feature description layers and registration layers collaborate in unsupervised optimization,facilitating faster convergence and more precise results.Lastly,experiments and evaluations were conducted on the registration of the Mixed National Institute of Standards and Technology database(MNIST),eight publicly available datasets of histological sections and the Clustering-Registration-Classification-Segmentation(CRCS)dataset on the Cushing’s disease.Experimental results demonstrate that our proposed GAN-DIRNet method surpasses existing approaches like DIRNet in terms of both registration accuracy and time efficiency,while also exhibiting robustness across different image types. 展开更多
关键词 Histological images registration deformable registration generative adversarial network cushing’s disease machine learning computer vision
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Women’s empowerment and food consumption:Evidence from female-headed households in Tanzania 被引量:1
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作者 Mosses Lufuke Xu Tian 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2024年第2期457-467,共11页
Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household... Despite the growing recognition of women’s increasing role in the household and corresponding empowerment programs in sub-Saharan Africa,intensive research on the relationship between women’s influence and household food consumption is minimal.Using the most recent(2017-2018)national household survey data from Tanzania,this study examined the influence of women’s empowerment on household food consumption.First,we compared the monthly consumption of eight food categories between female-headed households(FHHs)and male-headed households(MHHs)using both descriptive statistics and the propensity score matching(PSM)method.Furthermore,we adopted the two-stage Linear Expenditure System and Almost Ideal Demand System model(LES-AIDS)to estimate income and price elasticities for the two household types.The results show that FHHs consume bread and cereals,fish,oils and fats,vegetables,and confectionery(sugar,jam,honey,chocolate,etc.)more than MHHs.Moreover,FHHs have a significantly higher income elasticity of demand for all food groups than MHHs.They are also more price elastic than MHHs in meat,fish,oils,fats,sugar,jam,honey,chocolate,etc. 展开更多
关键词 women’s empowerment food consumption income elasticity price elasticity
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Pervasive Attentive Neural Network for Intelligent Image Classification Based on N-CDE’s
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作者 Anas W.Abulfaraj 《Computers, Materials & Continua》 SCIE EI 2024年第4期1137-1156,共20页
The utilization of visual attention enhances the performance of image classification tasks.Previous attentionbased models have demonstrated notable performance,but many of these models exhibit reduced accuracy when co... The utilization of visual attention enhances the performance of image classification tasks.Previous attentionbased models have demonstrated notable performance,but many of these models exhibit reduced accuracy when confronted with inter-class and intra-class similarities and differences.Neural-Controlled Differential Equations(N-CDE’s)and Neural Ordinary Differential Equations(NODE’s)are extensively utilized within this context.NCDE’s possesses the capacity to effectively illustrate both inter-class and intra-class similarities and differences with enhanced clarity.To this end,an attentive neural network has been proposed to generate attention maps,which uses two different types of N-CDE’s,one for adopting hidden layers and the other to generate attention values.Two distinct attention techniques are implemented including time-wise attention,also referred to as bottom N-CDE’s;and element-wise attention,called topN-CDE’s.Additionally,a trainingmethodology is proposed to guarantee that the training problem is sufficiently presented.Two classification tasks including fine-grained visual classification andmulti-label classification,are utilized to evaluate the proposedmodel.The proposedmethodology is employed on five publicly available datasets,including CUB-200-2011,ImageNet-1K,PASCAL VOC 2007,PASCAL VOC 2012,and MS COCO.The obtained visualizations have demonstrated that N-CDE’s are better appropriate for attention-based activities in comparison to conventional NODE’s. 展开更多
关键词 Differential equations neural-controlled DE image classification attention maps N-CDE’s
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Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease:A Data-Driven Meta-Analysis with N=3,118
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作者 Xiaopeng Kang Dawei Wang +24 位作者 Jiaji Lin Hongxiang Yao Kun Zhao Chengyuan Song Pindong Chen Yida Qu Hongwei Yang Zengqiang Zhang Bo Zhou Tong Han Zhengluan Liao Yan Chen Jie Lu Chunshui Yu Pan Wang Xinqing Zhang Ming Li Xi Zhang Tianzi Jiang Yuying Zhou Bing Liu Ying Han Yong Liu The Alzheimer’s Disease Neuroimaging Initiative The Multi-Center Alzheimer’s Disease Imaging(MCADI)Consortium 《Neuroscience Bulletin》 SCIE CAS CSCD 2024年第9期1274-1286,共13页
The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease(AD).We conducted data-driven meta-analyses to combine 3,118 structural magnetic res... The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease(AD).We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns.Then we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in AD.Our results showed that the hippocampus and amygdala exhibit the most severe atrophy,followed by the temporal,frontal,and occipital lobes in mild cognitive impairment(MCI)and AD.The extent of atrophy in MCI was less severe than that in AD.A series of biological processes related to the glutamate signaling pathway,cellular stress response,and synapse structure and function were investigated through gene set enrichment analysis.Our study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy,providing new insight for further clinical research on AD. 展开更多
关键词 Alzheimer’s disease structural magnetic resonance imaging META-ANALYsIs Brain atrophy Gene set enrichment analysis
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A Spectral Convolutional Neural Network Model Based on Adaptive Fick’s Law for Hyperspectral Image Classification
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作者 Tsu-Yang Wu Haonan Li +1 位作者 Saru Kumari Chien-Ming Chen 《Computers, Materials & Continua》 SCIE EI 2024年第4期19-46,共28页
Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convol... Hyperspectral image classification stands as a pivotal task within the field of remote sensing,yet achieving highprecision classification remains a significant challenge.In response to this challenge,a Spectral Convolutional Neural Network model based on Adaptive Fick’s Law Algorithm(AFLA-SCNN)is proposed.The Adaptive Fick’s Law Algorithm(AFLA)constitutes a novel metaheuristic algorithm introduced herein,encompassing three new strategies:Adaptive weight factor,Gaussian mutation,and probability update policy.With adaptive weight factor,the algorithmcan adjust theweights according to the change in the number of iterations to improve the performance of the algorithm.Gaussianmutation helps the algorithm avoid falling into local optimal solutions and improves the searchability of the algorithm.The probability update strategy helps to improve the exploitability and adaptability of the algorithm.Within the AFLA-SCNN model,AFLA is employed to optimize two hyperparameters in the SCNN model,namely,“numEpochs”and“miniBatchSize”,to attain their optimal values.AFLA’s performance is initially validated across 28 functions in 10D,30D,and 50D for CEC2013 and 29 functions in 10D,30D,and 50D for CEC2017.Experimental results indicate AFLA’s marked performance superiority over nine other prominent optimization algorithms.Subsequently,the AFLA-SCNN model was compared with the Spectral Convolutional Neural Network model based on Fick’s Law Algorithm(FLA-SCNN),Spectral Convolutional Neural Network model based on Harris Hawks Optimization(HHO-SCNN),Spectral Convolutional Neural Network model based onDifferential Evolution(DE-SCNN),SpectralConvolutionalNeuralNetwork(SCNN)model,and SupportVector Machines(SVM)model using the Indian Pines dataset and PaviaUniversity dataset.The experimental results show that the AFLA-SCNN model outperforms other models in terms of Accuracy,Precision,Recall,and F1-score on Indian Pines and Pavia University.Among them,the Accuracy of the AFLA-SCNN model on Indian Pines reached 99.875%,and the Accuracy on PaviaUniversity reached 98.022%.In conclusion,our proposed AFLA-SCNN model is deemed to significantly enhance the precision of hyperspectral image classification. 展开更多
关键词 Adaptive Fick’s law algorithm spectral convolutional neural network metaheuristic algorithm intelligent optimization algorithm hyperspectral image classification
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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
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作者 Yujie Yang Xinyi Li +7 位作者 Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 《Neural Regeneration Research》 SCIE CAS 2025年第1期93-106,共14页
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.... Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism.This review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest parkinsonism.We conducted a thorough literature search using reputable databases such as PubMed and Web of Science.Selection criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical applications.The findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting prognosis.Moreover,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo biomarker.This validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic depletion.In summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders. 展开更多
关键词 aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINsONIsM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2
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The Three Principles of Institutional Safeguards for Women's Participation in Legislation in China
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作者 刘睿 JIANG Yu(Translated) 《The Journal of Human Rights》 2024年第2期325-346,共22页
The participation of women in legislation is an important aspect and means of safeguarding women’s rights.Feminist theory,based on criticism of both the“citizenship identity theory as rights”and the“citizenship id... The participation of women in legislation is an important aspect and means of safeguarding women’s rights.Feminist theory,based on criticism of both the“citizenship identity theory as rights”and the“citizenship identity theory as responsibilities,”proposes the“citizenship identity theory as subjectivity.”Observing the current practice of women’s participation in legislation in China,two institutional safeguard principles can be summarized:the“minimum proportion”and the“influence evaluation.”However,each of these principles has its inherent limitations.Therefore,it is necessary to supplement them with the principle of“subjective participation”in a reflective manner.This principle requires women to participate substantively in the legislative process as subjects,express women’s needs and demands,input women’s perspectives and experiences,and reconstruct the distribution of rights and responsibilities in the existing legislation.The three principles complement each other and work together to comprehensively constitute the institutional structure of women’s participation in legislation,thereby promoting the reproduction of corresponding action structures. 展开更多
关键词 citizenship identity theory FEMINIsM women’s rights participation in legislation sUBJECTIVITY
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A Historical Review of the Development of Women’s Higher Education in China (1908-2020): Stages, Explanations, and Trends
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作者 TIAN Fen ZHENG Yaqian Ray Taheri 《Sociology Study》 2024年第1期39-53,共15页
The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work consid... The development of women’s higher education in China can be divided into four stages:emergence(1908-1948);foundation(1949-1976);accelerating development(1977-2008);and the qualitative leap(2009-2020).This work considers the principal institutional mechanisms that contributed to this development.First,flexibly planned parenthood gradually promoted gender equality and openness in society facilitated by systematic“awards,grants,and loans”initiatives to support women’s higher education economically.Second,compulsory education ensured that left-out and migrant children had access to higher education.Third,effective connectivity across different education types bridged education gaps between those with different levels of education.Fourth,China made great efforts to invite and integrate international experiences that promoted the development of women’s higher education.Looking beyond these achievements,we also discuss the future trends of women’s higher education in China. 展开更多
关键词 Chinese higher education women’s higher education educational equity development process
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Women's Images in Patriarchy Yoknapatawpha County --A Case Study of The Sundy and the Fury
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作者 Zhao Long 《International Journal of Technology Management》 2015年第8期101-103,共3页
William Faulkner is considered to be the most influential writers of America in the twentieth century. He has created a lot of great works in his lifetime, and The Sound and the Fury, which becomes the focus of study ... William Faulkner is considered to be the most influential writers of America in the twentieth century. He has created a lot of great works in his lifetime, and The Sound and the Fury, which becomes the focus of study and research among critics, is one of the outstanding representatives. As a famous southern writer, Faulkner' s concentrations not only just rely on the person' s inner world but also divergence into the broad external space. By observing male' s oppression and destruction toward female, Faulkner elaborates feminine crisis from another angle which reflects his strong humanistic concern. This paper tries to explore women' s images, which include Caddy, little Quentin, Dilsey and Mrs. Comoson. under the traditional patriarchy YoknaDatawoha County. 展开更多
关键词 The sOUND and the Fury PATRIARCHY Yoknapatawpha COUNTY women' s images
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Analysis of the Tragic Female Images in Eugene O'Neill's Plays 被引量:1
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作者 李琳 《海外英语》 2011年第8X期287-288,共2页
Ruth and Mary are two heroines in Eugene O'Neill's plays Beyond the Horizon, and Long Day's Journey into Night. They have some similarities: when they are young, they are beautiful, native and full of hope... Ruth and Mary are two heroines in Eugene O'Neill's plays Beyond the Horizon, and Long Day's Journey into Night. They have some similarities: when they are young, they are beautiful, native and full of hope towards the future life, but both make wrong choices; in the following years, both suffer a lot from these wrong choices, and feel regretful. This paper tries to explore these two tragic female images. 展开更多
关键词 female images Beyond the HORIZON Long Day’s JOURNEY into NIGHT
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基于轻量化YOLOX-S与多阈值分割的矿山遥感图像去噪算法
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作者 沈丹萍 赵爽 《金属矿山》 CAS 北大核心 2024年第9期175-180,共6页
矿山遥感图像普遍存在大量的噪点,给后续图像分析和处理带来了很大困难。提出了一种基于轻量化目标检测模型YOLOX-S和多阈值分割的矿山遥感图像去噪算法。首先使用YOLOX-S模型对矿山遥感图像进行目标检测,得到矿山目标的位置信息。然后... 矿山遥感图像普遍存在大量的噪点,给后续图像分析和处理带来了很大困难。提出了一种基于轻量化目标检测模型YOLOX-S和多阈值分割的矿山遥感图像去噪算法。首先使用YOLOX-S模型对矿山遥感图像进行目标检测,得到矿山目标的位置信息。然后针对矿山目标的特点,设计了一种多阈值分割方法消除图像中的噪声点。通过将图像分为若干个子区域,并对每个子区域采用不同的阈值进行二值化处理,最终将各子区域的二值化结果合并得到去噪后的图像。试验结果表明:该算法能够有效地去除矿山遥感图像中的噪声点,并且在保留目标特征的同时,大幅提升了图像质量。此外,由于采用了轻量化模型和多阈值分割算法,使得该算法具有较快的处理速度和较低的计算成本,适用于大规模图像数据的处理任务。 展开更多
关键词 矿山遥感图像 轻量化 YOLOX-s 阈值分割 图像去噪
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基于MRI影像组学构建PD-1/PD-L1抑制剂治疗dMMR/MSI-H直肠癌疗效的预测模型
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作者 张岚 周彦汝 +3 位作者 韩鼎盛 张嘉诚 何旭 刘鹏 《中国医学计算机成像杂志》 CSCD 北大核心 2024年第3期343-348,共6页
目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例... 目的:探讨MRI影像组学模型在程序性细胞死亡蛋白-1(PD-1)/程序性细胞死亡-配体1(PD-L1)抑制剂联合全程新辅助治疗(TNT)局部进展期直肠癌(LARC)的疗效预测价值。方法:收集河南中医药大学第一附属医院PD-1/PD-L1抑制剂联合TNT治疗的80例错配修复基因缺陷(dMMR)/微卫星高度不稳定(MSI-H)基因型中低位LARC患者的临床和影像资料。将入组患者按7∶3比例分为训练集和测试集,提取影像组学特征,从中筛选并构建影像组学模型。描绘影像组学模型的Rad-score与病理金标准之间的受试者工作特征(ROC)曲线,计算曲线下面积(AUC),并评价模型的诊断效能。采用决策曲线分析(DCA)计算风险阈值的范围,并评估临床获益情况。收集湖南省人民医院25例dMMR/MSI-H基因型LARC患者的影像资料作为外部验证集。结果:训练集、测试集及外部验证集三者之间的临床特征无统计学差异(P>0.05)。经过降维处理、t检验及一致性检验以及LASSO交叉验证后,筛选出一阶偏度特征和体积2个特征构建影像组学模型。训练集、测试集和外部验证集的影像组学预测模型ROC曲线的AUC、灵敏度、特异度、阳性预测值和阴性预测值分别为0.920、97.1%、85.7%、91.9%、94.7%;0.885、80.0%、88.9%、92.3%、72.7%;0.875、87.5%、88.9%、93.3%、80.0%。DCA曲线显示,当风险阈值范围为0%~82%时,采用影像组学模型预测LARC患者为病理完全缓解(pCR)的获益大于将所有患者都视为pCR或者无病理完全缓解(npCR)。结论:基于MRI影像组学构建的dMMR/MSI-H型局部进展期直肠癌PD-1/PD-L1抑制剂联合全程新辅助放化疗疗效预测模型,有较大潜力为不同基因分型的直肠癌患者制定个体化治疗策略提供量化依据。 展开更多
关键词 磁共振成像 影像组学 直肠肿瘤 局部进展期 程序性细胞死亡蛋白-1/程序性细胞死亡-配体1 全程新辅助放化疗
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Detection of Alzheimer’s disease onset using MRI and PET neuroimaging:longitudinal data analysis and machine learning 被引量:2
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作者 Iroshan Aberathne Don Kulasiri Sandhya Samarasinghe 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第10期2134-2140,共7页
The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectivene... The scientists are dedicated to studying the detection of Alzheimer’s disease onset to find a cure, or at the very least, medication that can slow the progression of the disease. This article explores the effectiveness of longitudinal data analysis, artificial intelligence, and machine learning approaches based on magnetic resonance imaging and positron emission tomography neuroimaging modalities for progression estimation and the detection of Alzheimer’s disease onset. The significance of feature extraction in highly complex neuroimaging data, identification of vulnerable brain regions, and the determination of the threshold values for plaques, tangles, and neurodegeneration of these regions will extensively be evaluated. Developing automated methods to improve the aforementioned research areas would enable specialists to determine the progression of the disease and find the link between the biomarkers and more accurate detection of Alzheimer’s disease onset. 展开更多
关键词 deep learning image processing linear mixed effect model NEUROimagING neuroimaging data sources onset of Alzheimer’s disease detection pattern recognition
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Image Segmentation of Brain MR Images Using Otsu’s Based Hybrid WCMFO Algorithm 被引量:6
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作者 A.Renugambal K.Selva Bhuvaneswari 《Computers, Materials & Continua》 SCIE EI 2020年第8期681-700,共20页
In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image slices.WCMFO constitutes a hybrid betwee... In this study,a novel hybrid Water Cycle Moth-Flame Optimization(WCMFO)algorithm is proposed for multilevel thresholding brain image segmentation in Magnetic Resonance(MR)image slices.WCMFO constitutes a hybrid between the two techniques,comprising the water cycle and moth-flame optimization algorithms.The optimal thresholds are obtained by maximizing the between class variance(Otsu’s function)of the image.To test the performance of threshold searching process,the proposed algorithm has been evaluated on standard benchmark of ten axial T2-weighted brain MR images for image segmentation.The experimental outcomes infer that it produces better optimal threshold values at a greater and quicker convergence rate.In contrast to other state-of-the-art methods,namely Adaptive Wind Driven Optimization(AWDO),Adaptive Bacterial Foraging(ABF)and Particle Swarm Optimization(PSO),the proposed algorithm has been found to be better at producing the best objective function,Peak Signal-to-Noise Ratio(PSNR),Standard Deviation(STD)and lower computational time values.Further,it was observed thatthe segmented image gives greater detail when the threshold level increases.Moreover,the statistical test result confirms that the best and mean values are almost zero and the average difference between best and mean value 1.86 is obtained through the 30 executions of the proposed algorithm.Thus,these images will lead to better segments of gray,white and cerebrospinal fluid that enable better clinical choices and diagnoses using a proposed algorithm. 展开更多
关键词 Hybrid WCMFO algorithm Otsu’s function multilevel thresholding image segmentation brain MR image
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Interplay between the glymphatic system and neurotoxic proteins in Parkinson’s disease and related disorders:current knowledge and future directions 被引量:1
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作者 Yumei Yue Xiaodan Zhang +2 位作者 Wen Lv Hsin-Yi Lai Ting Shen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1973-1980,共8页
Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired eli... Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired elimination of these neurotoxic protein.Atypical parkinsonism,which has the same clinical presentation and neuropathology as Parkinson’s disease,expands the disease landscape within the continuum of Parkinson’s disease and related disorders.The glymphatic system is a waste clearance system in the brain,which is responsible for eliminating the neurotoxic proteins from the interstitial fluid.Impairment of the glymphatic system has been proposed as a significant contributor to the development and progression of neurodegenerative disease,as it exacerbates the aggregation of neurotoxic proteins and deteriorates neuronal damage.Therefore,impairment of the glymphatic system could be considered as the final common pathway to neurodegeneration.Previous evidence has provided initial insights into the potential effect of the impaired glymphatic system on Parkinson’s disease and related disorders;however,many unanswered questions remain.This review aims to provide a comprehensive summary of the growing literature on the glymphatic system in Parkinson’s disease and related disorders.The focus of this review is on identifying the manifestations and mechanisms of interplay between the glymphatic system and neurotoxic proteins,including loss of polarization of aquaporin-4 in astrocytic endfeet,sleep and circadian rhythms,neuroinflammation,astrogliosis,and gliosis.This review further delves into the underlying pathophysiology of the glymphatic system in Parkinson’s disease and related disorders,and the potential implications of targeting the glymphatic system as a novel and promising therapeutic strategy. 展开更多
关键词 atypical parkinsonism glymphatic system magnetic resonance imaging neurotoxic proteins Parkinson’s disease
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Range anomaly suppression based on neighborhood pixels detection in ladar range images 被引量:2
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作者 Mingbo Zhao Jun He +1 位作者 Zaiqi Lu Qiang Fu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2013年第1期68-75,共8页
Research on the range anomaly suppression algorithm in laser radar (ladar) range images is significant in the application and development of ladar. But most of existing algorithms cannot protect the edge and linear ... Research on the range anomaly suppression algorithm in laser radar (ladar) range images is significant in the application and development of ladar. But most of existing algorithms cannot protect the edge and linear target well while suppressing the range anomaly. Aiming at this problem, the differences among the edge, linear target, and range anomaly are analyzed and a novel algo- rithm based on neighborhood pixels detection is proposed. Firstly, the range differences between current pixel and its neighborhood pixels are calculated. Then, the number of neighborhood pixels is detected by the range difference threshold. Finally, whether the current pixel is a range anomaly is distinguished by the neighbor- hood pixel number threshold. Experimental results show that the new algorithm not only has a better range anomaly suppression performance and higher efficiency, but also protects the edge and linear target preferably compared with other algorithms. 展开更多
关键词 image processing range anomaly suppression neigh-borhood p xe s detection linear target laser radar (ladar).
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Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease
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作者 Ting Shen Jia-Li Pu +7 位作者 Ya-Si Jiang Yu-Mei Yue Ting-Ting He Bo-Yi Qu Shuai Zhao Ya-Ping Yan Hsin-Yi Lai Bao-Rong Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第5期1154-1160,共7页
Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclea... Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclear. The aim of this study was to investigate the potential effects of multiple single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease. Forty-eight Parkinson’s disease patients and 39 matched healthy controls underwent genotyping and 7 T magnetic resonance imaging. A cognitive-weighted polygenic risk score model was designed, in which the effect sizes were determined individually for 36 single nucleotide polymorphisms. The correlations between polygenic risk score, neuroimaging features, and clinical data were analyzed. Furthermore, individual single nucleotide polymorphism analysis was performed to explore the main effects of genotypes and their interactive effects with Parkinson’s disease diagnosis. We found that, in Parkinson’s disease, the polygenic risk score was correlated with the neural activity of the hippocampus, parahippocampus, and fusiform gyrus, and with hippocampal-prefrontal and fusiform-temporal connectivity, as well as with gray matter alterations in the orbitofrontal cortex. In addition, we found that single nucleotide polymorphisms in α-synuclein(SNCA) were associated with white matter microstructural changes in the superior corona radiata, corpus callosum, and external capsule. A single nucleotide polymorphism in catechol-O-methyltransferase was associated with the neural activities of the lingual, fusiform, and occipital gyri, which are involved in visual cognitive dysfunction. Furthermore, DRD3 was associated with frontal and temporal lobe function and structure. In conclusion, imaging genetics is useful for providing a better understanding of the genetic pathways involved in the pathophysiologic processes underlying Parkinson’s disease. This study provides evidence of an association between genetic factors, cognitive functions, and multi-modality neuroimaging biomarkers in Parkinson’s disease. 展开更多
关键词 COGNITION imaging genetics magnetic resonance imaging MULTI-MODALITY Parkinson’s disease polygenic risk score single nucleotide polymorphism ultra-high field
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Influence of cultural factors on choice of childbirth place among women in Oyigbo Local Government Area,Rivers State,Nigeria
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作者 Ngozi Afulenu OBIKA-NDIRI Chizoma Millicent NDIKOM +1 位作者 Ogochukwu Immaculate OBIKA Omineokuma Tubonemi ASEMINASO 《Journal of Integrative Nursing》 2023年第1期37-42,共6页
Objectives:This study aims to ascertain if cultural factors influence the childbirth place choice of women in Oyigbo.Materials and Methods:The study used a cross‑sectional study design using a self‑structured question... Objectives:This study aims to ascertain if cultural factors influence the childbirth place choice of women in Oyigbo.Materials and Methods:The study used a cross‑sectional study design using a self‑structured questionnaire as the instrument to collect data from 384 volunteers through simple random sampling,and these data were analyzed using frequency and percentage for descriptive statistics while Chi‑square was used for inferential statistics at 0.05 level of significance.Results:The influence of cultural factors such as family traditions(χ^(2)=12.56,P=0.006),beliefs(χ^(2)=70.66,P=0.000),lack of confidence in health facilities(χ^(2)=367.83,P=0.000),and the presence of male skilled birth attendants(χ^(2)=50.85,P=0.000)were statistically significant to the choice of childbirth place,while patriarchal system(χ^(2)=2.99,P=0.393)was not statistically significant to the choices of childbirth places of women in Oyigbo.Religion had a statistically significant influence on childbirth place(χ^(2)=125.46,P=0.000).Conclusion:This study shows that religious and cultural factors have a significant influence on the childbirth place choices of women in Oyigbo Local Government Area of Rivers State. 展开更多
关键词 BIRTHPLACE CHILDBIRTH cultural factors maternal mortality Oyigbo women’s health
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Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease 被引量:1
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作者 Bo Li Yujie Chen +10 位作者 Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao Cheng Yawen Sun Yiming Zhang Jiahui Cheng Qi Zhang Wei Zhang Jianhui Liu 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1593-1601,共9页
Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheime... Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis. 展开更多
关键词 Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome sIRT1-PGC1α regional brain distribution whole brain clearing and imaging
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