Aiming at the decision-making problem of construction programme choice,this paper advanced a new group expandable optimization decision-making model.Various factors were comprehensively considered,and the new multi-at...Aiming at the decision-making problem of construction programme choice,this paper advanced a new group expandable optimization decision-making model.Various factors were comprehensively considered,and the new multi-attribute evaluation index system was established.Based on the assumption that decision-makers were rational,this paper formed a group of rational preferences through extracting the personal preferences pertinently,so the decision-makers position matrix was determined.The decision-makers position matrix integrated values given by group decision-makers to construction programme comprised a matrix,of which the entropy theory for datamining was adopted in this paper to determine the attribute weights.A decision was made by using the extension decision method.Eventually,the feasibility and practicability of the model were verified by the example.展开更多
The representation method of heterogeneous material information is one of the key technologies of heterogeneous object modeling, but almost all the existing methods cannot represent non-uniform rational B-spline （NU...The representation method of heterogeneous material information is one of the key technologies of heterogeneous object modeling, but almost all the existing methods cannot represent non-uniform rational B-spline （NURBS） entity. According to the characteristics of NURBS, a novel data structure, named NURBS material data structure, is proposed, in which the geometrical coordinates, weights and material coordinates of NURBS heterogene- ous objects can be represented simultaneously. Based on this data structure, both direct representation method and inverse construction method of heterogeneous NURBS objects are introduced. In the direct representation method, three forms of NURBS heterogeneous objects are introduced by giving the geometry and material information of con- trol points, among which the homogeneous coordinates form is employed for its brevity and easy programming. In the inverse construction method, continuous heterogeneous curves and surfaces can he obtained by interpolating discrete points and curves with specified material information. Some examples are given to show the effectiveness of the pro- posed methods.展开更多
The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of ...The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of active targeting liposomes.Combining multiscale computational simulation and experimental verification,we established a computational model of RVGP modified PEGylated liposomes(RVGP-PEG-L)and investigated the role of PEG and molecular interaction mechanism of carrier-ligand-receptor.The result indicated that the complex network conformation formed by PEG with 42 monomers(42 PEG)above the density of 8%was the molecular basis for PEG-L to achieve long-circulation function.The lowest monomer number of PEG linker to ensure the targeting ability of RVGP was 42.However,the pose of RVGP binding to nAChR changed after it was linked with PEG-L due to the restraint of PEG chain,leading to a decrease of binding free energy.Increasing the monomer number of PEG linker or improving the non-polarity of polymers was a potential strategy to enhance the combination of RVGP-PEG-L with nAChR on the targeting cell.展开更多
A new approach for NURBS(Non-uniform rational B-spline) curve and surface fitting for measured points was presented which employs a fairing method applied to digitized point data with discrete curvature. If measured p...A new approach for NURBS(Non-uniform rational B-spline) curve and surface fitting for measured points was presented which employs a fairing method applied to digitized point data with discrete curvature. If measured points are used as control points to construct an NURBS curve, then the curvature of each data point corresponding to control point of the constructed curve can be computed. According to the convex hull and local properties of NURBS, based on the curvatures obtained, the measured points can be faired. If faired measured points are used as target points to modify, the constructed curve passing through these faired points can produce a smooth NURBS curve. This paper also presented the justification for utilizing the curvatures of constructed NURBS curve instead of the conventional interpolated curve to fair the measured points. Based on the presented algorithms, some qualities of the constructed curves can be improved.展开更多
基金Project of Hunan Fund in Social Science (No.11YBB060)
文摘Aiming at the decision-making problem of construction programme choice,this paper advanced a new group expandable optimization decision-making model.Various factors were comprehensively considered,and the new multi-attribute evaluation index system was established.Based on the assumption that decision-makers were rational,this paper formed a group of rational preferences through extracting the personal preferences pertinently,so the decision-makers position matrix was determined.The decision-makers position matrix integrated values given by group decision-makers to construction programme comprised a matrix,of which the entropy theory for datamining was adopted in this paper to determine the attribute weights.A decision was made by using the extension decision method.Eventually,the feasibility and practicability of the model were verified by the example.
基金Supported by National Natural Science Foundation of China (No. 60973079)Natural Science Foundation of Hebei Province (No. E2006000039)
文摘The representation method of heterogeneous material information is one of the key technologies of heterogeneous object modeling, but almost all the existing methods cannot represent non-uniform rational B-spline （NURBS） entity. According to the characteristics of NURBS, a novel data structure, named NURBS material data structure, is proposed, in which the geometrical coordinates, weights and material coordinates of NURBS heterogene- ous objects can be represented simultaneously. Based on this data structure, both direct representation method and inverse construction method of heterogeneous NURBS objects are introduced. In the direct representation method, three forms of NURBS heterogeneous objects are introduced by giving the geometry and material information of con- trol points, among which the homogeneous coordinates form is employed for its brevity and easy programming. In the inverse construction method, continuous heterogeneous curves and surfaces can he obtained by interpolating discrete points and curves with specified material information. Some examples are given to show the effectiveness of the pro- posed methods.
基金National Natural Science Foundation of China(Grant No.81202469)
文摘The rational construction of active targeting liposomes will provide an important structural support for its effective brain targeting.However,there is no clear understanding of the structure-activity relationship of active targeting liposomes.Combining multiscale computational simulation and experimental verification,we established a computational model of RVGP modified PEGylated liposomes(RVGP-PEG-L)and investigated the role of PEG and molecular interaction mechanism of carrier-ligand-receptor.The result indicated that the complex network conformation formed by PEG with 42 monomers(42 PEG)above the density of 8%was the molecular basis for PEG-L to achieve long-circulation function.The lowest monomer number of PEG linker to ensure the targeting ability of RVGP was 42.However,the pose of RVGP binding to nAChR changed after it was linked with PEG-L due to the restraint of PEG chain,leading to a decrease of binding free energy.Increasing the monomer number of PEG linker or improving the non-polarity of polymers was a potential strategy to enhance the combination of RVGP-PEG-L with nAChR on the targeting cell.
基金The Rising Star Project of Shanghai (No.06QA14026) The International Coopera-tion Project of Shanghai (No.41107049)
文摘A new approach for NURBS(Non-uniform rational B-spline) curve and surface fitting for measured points was presented which employs a fairing method applied to digitized point data with discrete curvature. If measured points are used as control points to construct an NURBS curve, then the curvature of each data point corresponding to control point of the constructed curve can be computed. According to the convex hull and local properties of NURBS, based on the curvatures obtained, the measured points can be faired. If faired measured points are used as target points to modify, the constructed curve passing through these faired points can produce a smooth NURBS curve. This paper also presented the justification for utilizing the curvatures of constructed NURBS curve instead of the conventional interpolated curve to fair the measured points. Based on the presented algorithms, some qualities of the constructed curves can be improved.
