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Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study 被引量:1
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作者 Wei Ding Min-Zhong Wang +8 位作者 Xian-Wei Zeng Zhen-Hua Liu Yao Meng Hui-Ting Hu Yuan Zhang Yu-Guang Guan Fan-Gang Meng Jian-Guo Zhang Shu Wang 《World Journal of Psychiatry》 SCIE 2024年第5期704-714,共11页
BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and insomnia.These problems can persist for a long period,even afte... BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and insomnia.These problems can persist for a long period,even after the pandemic.However,less is known about this topic.AIM To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 pandemic.METHODS This multicenter cross-sectional,hospital-based study was conducted from June 1,2023 to June 30,2023,which was a half-year after the end of the COVID-19 emergency.Region-stratified population-based cluster sampling was applied at the provincial level for Chinese HCWs.Symptoms such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity Index.Factors influencing the symptoms were identified by multivariable logistic regression.RESULTS A total of 2000 participants were invited,for a response rate of 70.6%.A total of 1412 HCWs[618(43.8%)doctors,583(41.3%)nurses and 211(14.9%)nonfrontline],254(18.0%),231(16.4%),and 289(20.5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the participants.Nurses,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia symptoms.During the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological education.Only 102(7.2%)of the HCWs received individual counseling from COVID-19.CONCLUSION Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general population.Identifying risk factors would help in providing targeted interventions.In addition,although a major proportion of HCWs have received public psychological education,individual interventions are still insufficient. 展开更多
关键词 COVID-19 Mental health Psychological symptoms INSOMNIA Sleep disorders Cross-sectional study Epidemiological study
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Formulation of Work-Study Combined and Result-Oriented Integrated Curriculum Standards
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作者 Lianfang LI Chunhua DU +2 位作者 Fen YANG Yun LI Yanfei NIU 《Medicinal Plant》 2024年第3期79-83,共5页
According to the Annex Technical Regulations for Integrated Curriculum Development(Trial)in Document No.30 of the General Office of the Ministry of Human Resources and Social Security(2012),this paper studies the form... According to the Annex Technical Regulations for Integrated Curriculum Development(Trial)in Document No.30 of the General Office of the Ministry of Human Resources and Social Security(2012),this paper studies the formulation of the curriculum standards for the integration of Chinese medicinal materials production.We focus on the formulation ideas of the curriculum standards for the integration of Chinese medicinal materials production,the formulation process of the curriculum standards for the integration of Chinese medicinal materials production,including the description of typical work tasks,the determination of curriculum objectives,the analysis of study content,the description of referential study tasks,teaching implementation suggestions,assessment and evaluation suggestions,which can provide a reference for the development and research of other related integrated courses. 展开更多
关键词 Integration of work and study work process Curriculum STANDARDS Production of Chinese MEDICINAL materials Typical work TASKS REFERENTIAL study TASKS
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Exploring the Path of Shantytown Renewal Based on the Theory of Environment-behavior Studies: A Case Study of the Northwest Area of Saihantala in Baotou City
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作者 ZHANG Miao TIAN Jiaqi GONG Rui 《Journal of Landscape Research》 2024年第2期61-65,68,共6页
The application of environment-behavior studies plays an important role in studying the renewal of shantytowns.One of the most humane ways of renewal is designing and constructing the necessary urban spatial environme... The application of environment-behavior studies plays an important role in studying the renewal of shantytowns.One of the most humane ways of renewal is designing and constructing the necessary urban spatial environment from the perspective of human daily behavior.Most of the shantytown renovation projects currently carried out in China are mainly focused on demolition and reconstruction,which not only incurs high costs but also damages the original social structure and economic model.During the process of shantytown renewal,it should improve the urban landscape,living environment,and life quality of residents,and ensure the daily life of shantytown residents without increasing their economic burden,and preserve the traces of urban development.In order to achieve this goal,it should explore the renewal strategies of shantytowns from the perspective of environment-behavior studies through behavior maps,on-site research,and literature review.Updating and design from a human perspective often achieve faster and better development;the renewal of shantytowns should be a bottom-up approach and start from a grassroots perspective,completing the renovation design through the composition of the population and behavioral patterns. 展开更多
关键词 Environment-behavior studies Shantytown renewal Economic type Bottom view BOTTOM-UP
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Study on the Impact of Massive Refracturing on the Fracture Network in Tight Oil Reservoir Horizontal Wells
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作者 Jianchao Shi Yanan Zhang +2 位作者 Wantao Liu Yuliang Su Jian Shi 《Fluid Dynamics & Materials Processing》 EI 2024年第5期1147-1163,共17页
Class III tight oil reservoirs have low porosity and permeability,which are often responsible for low production rates and limited recovery.Extensive repeated fracturing is a well-known technique to fix some of these ... Class III tight oil reservoirs have low porosity and permeability,which are often responsible for low production rates and limited recovery.Extensive repeated fracturing is a well-known technique to fix some of these issues.With such methods,existing fractures are refractured,and/or new fractures are created to facilitate communication with natural fractures.This study explored how different refracturing methods affect horizontal well fracture networks,with a special focus on morphology and related fluid flow changes.In particular,the study relied on the unconventional fracture model(UFM).The evolution of fracture morphology and flow field after the initial fracturing were analyzed accordingly.The simulation results indicated that increased formation energy and reduced reservoir stress differences can promote fracture expansion.It was shown that the length of the fracture network,the width of the fracture network,and the complexity of the fracture can be improved,the oil drainage area can be increased,the distance of oil and gas seepage can be reduced,and the production of a single well can be significantly increased. 展开更多
关键词 Type III tight oil reservoirs refracturing methods horizontal wells fracture network study fracture network evolution
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Violence study of healthcare workers and systems in the Caribbean:ViSHWaS-Caribbean study
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作者 Reshon Hadmon Daniella Myriam Pierre +12 位作者 Akshat Banga Jacques W Clerville Hans Mautong Precious Akinsanya Rajat Das Gupta Sama Soliman Tolupe M Hunjah Bamidele A Hunjah Hafeez Hamza Ruman Khurshid Qasba Faisal A Nawaz Salim Surani Rahul Kashyap 《World Journal of Methodology》 2024年第3期106-118,共13页
BACKGROUND Violence against healthcare workers(HCWs)in the Caribbean continues to prevail yet remains underreported.Our aim is to determine the cause,traits,and consequences of violence on HCWs in the Caribbean.AIM To... BACKGROUND Violence against healthcare workers(HCWs)in the Caribbean continues to prevail yet remains underreported.Our aim is to determine the cause,traits,and consequences of violence on HCWs in the Caribbean.AIM To determine the cause,traits,and consequences of violence on HCWs in the Caribbean.METHODS This research adopted an online cross-sectional survey approach,spanning over eight weeks(between June 6th and August 9th,2022).The survey was generated using Research Electronic Data Capture forms and followed a snowballing strategy to contact individuals using emails,social media,text messages,etc.Logistic regression analysis was performed to evaluate the variables that influence violence,including gender,age,years of experience,institution type,and night shift frequency.RESULTS The survey was completed by 225 HCWs.Females comprised 61%.Over 51%of respondents belonged to the 21 to 35 age group.Dominica(n=61),Haiti(n=50),and Grenada(n=31)had the most responses.Most HCWs(49%)worked for government academic institutions,followed by community hospitals(23%).Medical students(32%),followed by attending physicians(22%),and others(16%)comprised the most common cadre of respondents.About 39%of the participants reported experiencing violence themselves,and 18%reported violence against colleague(s).Verbal violence(48%),emotional abuse(24%),and physical misconduct(14%)were the most common types of violence.Nearly 63%of respondents identified patients or their relatives as the most frequent aggressors.Univariate logistic regression analyses demonstrated that female gender(OR=2.08;95%CI:1.16-3.76,P=0.014)and higher frequency of night shifts(OR=2.22;95%CI:1.08-4.58,P=0.030)were associated with significantly higher odds of experiencing violence.More than 50%of HCWs felt less motivated and had decreased job satisfaction post-violent conduct.CONCLUSION A large proportion of HCWS in the Caribbean are exposed to violence,yet the phenomenon remains underreported.As a result,HCWs’job satisfaction has diminished. 展开更多
关键词 ViSHWaS Healthcare workers VIOLENCE SURVEY workplace violence Caribbean Cross-sectional study
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Benefits of Dielectric Oil Regeneration Systems in Power Transmission Networks: A Case Study
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作者 Emmanouil D. Fylladitakis Savvas Katemliadis Ioanna Pantelaki 《Journal of Power and Energy Engineering》 2024年第4期20-29,共10页
The criticality of transformers and reactors in the power transmission network and the paramount importance of ensuring their reliability through maintenance of the insulating oil is known. This paper presents a compr... The criticality of transformers and reactors in the power transmission network and the paramount importance of ensuring their reliability through maintenance of the insulating oil is known. This paper presents a comprehensive examination of the efficacy and economic viability of a dielectric oil regeneration system, as implemented by the Transmission System Maintenance Department (TSMD) of the Independent Power Transmission Operator (IPTO), Greece’s sole transmission operator. Through a detailed chemical analysis and performance evaluation, we assess the impact of the regeneration system on treated insulating oil quality over multiple cycles. The study reveals that the electrical properties of the insulating oil are fully restored after regeneration, negating the need to fully replace it, while the investment becomes cost-neutral within weeks from the commissioning of the regeneration system. This economic analysis, coupled with the system’s environmental benefits of reducing waste oil generation, positions the dielectric oil regeneration system as a compelling solution for the maintenance of power transmission assets. 展开更多
关键词 Insulating Oil Regeneration Transformer Maintenance Economic Analysis Preventive Maintenance Case study
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Exploring influences and risk of bias of studies on return to sport and work after lateral ankle sprain:A systematic review and metaanalysis
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作者 Priscilla A Maria Gwendolyn Vuurberg Gino MMJ Kerkhoffs 《World Journal of Meta-Analysis》 2024年第1期11-25,共15页
BACKGROUND Lateral ankle sprains are the most common traumatic musculoskeletal injuries of the lower extremity,with an incidence rate of 15%-20%.The high incidence and prevalence highlights the economic impact of this... BACKGROUND Lateral ankle sprains are the most common traumatic musculoskeletal injuries of the lower extremity,with an incidence rate of 15%-20%.The high incidence and prevalence highlights the economic impact of this injury.Ankle sprains lead to a high socioeconomic burden due to the combination of the high injury incidence and high medical expenses.Up to 40%of patients who suffer from an ankle sprain develop chronic ankle instability.Chronic instability can lead to prolonged periods of pain,immobility and injury recurrence.Identification of factors that influence return to work(RTW)and return to sports(RTS)after a lateral ankle sprain(LAS)may help seriously reduce healthcare costs.AIM To explore which factors may potentially affect RTW and RTS after sustaining an LAS.METHODS EMBASE and PubMed were systematically searched for relevant studies published until June 2023.Inclusion criteria were as follows:(1)Injury including LAS or chronic ankle instability;(2)Described any form of treatment;(3)Assessment of RTW or RTS;(4)Studies published in English;and(5)Study designs including randomized controlled clinical trials,clinical trials or cohort studies.Exclusion criteria were:(1)Studies involving children(age<16 year);or(2)Patients with concomitant ankle injury besides lateral ankle ligament damage.A quality assessment was performed for each of the included studies using established risk of bias tools.Additionally quality of evidence was assessed using the GRADEpro tool in cases where outcomes were included in the quantitative analysis.A best evidence synthesis was performed in cases of qualitative outcome analysis.For all studied outcomes suitable for quantitative analysis a forest plot was created to calculate the effect on RTW and RTS.RESULTS A total of 8904 patients were included in 21 studies,10 randomized controlled trials,7 retrospective cohort studies and 4 prospective cohort studies.Fifteen studies were eligible for meta-analysis.The overall RTS rate ranged were 80%and 83%in the all treatments pool and surgical treatments pool,respectively.The pooled mean days to RTS ranged from 23-93 d.The overall RTW rate was 89%.The pooled mean time to RTW ranged from 5.8-8.1 d.For patients with chronic ankle instability,higher preoperative motivation was the sole factor significantly and independently(P=0.001)associated with the rate of and time to RTS following ligament repair or reconstruction.Higher body mass index was identified as a significant factor(P=0.04)linked to not resuming sports or returning at a lower level(median 24,range 20-37),compared to those who resumed at the same or higher level(median 23,range 17-38).Patients with a history of psychological illness or brain injury,experienced a delay in their rehabilitation process for sprains with fractures and unspecified sprains.The extent of the delayed rehabilitation was directly proportional to the increased likelihood of experiencing a recurrence of the ankle sprain and the number of ankle-related medical visits.We also observed that 10%of athletes who did return to sport after lateral ankle sprain without fractures described non-ankle-related reasons for not returning.CONCLUSION All treatments yielded comparable results,with each treatment potentially offering unique advantages or benefits.Preoperative motivation may influence rehabilitation after LAS.Grading which factor had a greater impact was not possible due to the lack of comparability among the included patients. 展开更多
关键词 Ankle sprain Prognostic factors BIAS Return to work Return to sport Preoperative motivation
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A Study on the Work Process-Based Practical Training Model for Basic Nursing Skills in Vocational Colleges
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作者 Dan Li Huan Wei 《Journal of Clinical and Nursing Research》 2024年第9期128-132,共5页
Objective:To explore and analyze the work process-based practical training teaching model for basic nursing skills in vocational colleges and its implementation effects.Methods:A total of 82 nursing students from our ... Objective:To explore and analyze the work process-based practical training teaching model for basic nursing skills in vocational colleges and its implementation effects.Methods:A total of 82 nursing students from our school were selected for the study,which was conducted from April 2023 to April 2024.Using a random number table method,the students were divided into an observation group and a control group,each with 41 students.The control group received conventional practical training teaching,while the observation group followed the work process-based practical training model for basic nursing skills.The assessment scores and teaching satisfaction of the two groups were compared.Results:The comparison of assessment scores showed that the observation group performed significantly better than the control group(P<0.05).The comparison of teaching satisfaction also indicated that the observation group had significantly higher satisfaction than the control group(P<0.05).Conclusion:The work process-based practical training teaching model for basic nursing skills in vocational colleges can improve students’assessment scores and enhance teaching satisfaction,demonstrating its value for wider application. 展开更多
关键词 work processes Vocational colleges Basic nursing skills Practical training teaching model
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Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine
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作者 Jiang-Yu Bian Yu-Fang Feng +1 位作者 Wen-Ting He Tong Zhang 《World Journal of Clinical Oncology》 2025年第1期25-33,共9页
BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohor... BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment. 展开更多
关键词 Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study
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Network Connection and Energy Radiation through Grassroots Master Teacher Studios--A Case Study Based on Distributed Perspective
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作者 Panjing Feng 《Journal of Contemporary Educational Research》 2021年第2期33-42,共10页
Distributed leadership is a collective leadership mode in which multiple members of the organization dynamically share leadership roles according to changes in capability and environment,so as to achieve leadership sh... Distributed leadership is a collective leadership mode in which multiple members of the organization dynamically share leadership roles according to changes in capability and environment,so as to achieve leadership sharing and leadership energy radiation.Facing the distributed leadership practice of Master Teacher Studio that really occur in education management can make our understanding and description of its original ecological and endogenous construction process more objectively,meticulously and deeply.Through the generation and expansion of the case studio with the characteristics of"grassroots",the empowerment and differentiation of leaders,the stimulation and radiation of members leadership,the generation process of"grassroots"Master Teacher Studio from the initial construction of"uniline"mode to"network"distribution connection,and the radiation process of Master Teacher Studio members'energy from"uninuclear transmission"to"multinuclear connection".Thus,it will realize the organic integration of Western distributed leadership theory and localized grassroots master teachers'studio practice. 展开更多
关键词 Master Teacher Studio Distributed leadership Social network Energy radiation Case study
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Studies on Benign Working Pairs for Adsorption Refrigeration 被引量:1
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作者 崔群 陈海军 姚虎卿 《Journal of Southeast University(English Edition)》 EI CAS 2002年第3期283-288,共6页
Water and ethanol were selected as refrigerants, 13x molecular sieve, silica gel, activated carbon and adsorbents NA and NB prepared by authors were selected as adsorbents, and the performance of adsorption working pa... Water and ethanol were selected as refrigerants, 13x molecular sieve, silica gel, activated carbon and adsorbents NA and NB prepared by authors were selected as adsorbents, and the performance of adsorption working pairs in adsorption refrigeration system was studied. The adsorption isotherms of adsorbents (NA and NB) were obtained by high vacuum gravimetric method. Desorption properties of adsorbents were analyzed and compared by thermal analysis method. The performance parameters of adsorption refrigerat... 展开更多
关键词 adsorption refrigeration working pairs ISOTHERM refrigeration volume
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On the Study of Translation Approaches of Culture-loaded Words in Literary Works 被引量:1
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作者 李福珍 《海外英语》 2016年第23期143-144,147,共3页
Culture-loaded words refer to expressions and idioms that carry typically culture messages. The peculiarity of one culture cannot be understood or accepted by readers from another culture. The uniqueness very likely m... Culture-loaded words refer to expressions and idioms that carry typically culture messages. The peculiarity of one culture cannot be understood or accepted by readers from another culture. The uniqueness very likely makes misunderstanding and may lead to cultural vacancy in other cultures. Due to the culture differences between Chinese and English, it is hard for a translator to achieve complete equivalence at the level of word. This paper discusses the translation approaches of Chinese cultureloaded words in literary works. 展开更多
关键词 Culture-loaded Words Translation Approaches Literary works
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Comparative Studies on Tourist Satisfaction of World Heritage Sites——A Case Study of Huangshan Mountain,Lushan Mountain and Wuyi Mountain
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作者 顾晓艳 《Journal of Landscape Research》 2009年第4期85-90,共6页
Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the... Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the problems in tourism services of three scenic areas and then put forward relevant countermeasures for the management of scenic areas. 展开更多
关键词 World HERITAGE SITES TOURIST SATISFACTION COMPARATIVE study Huangshan MOUNTAIN Lushan MOUNTAIN Wuyi MOUNTAIN
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How Work Organization Affects the Prevalence of WMSDs: A Case-control Study 被引量:11
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作者 LIU Lu CHEN Song Gen +6 位作者 TANG Shi Chuan WANG Sheng HE Li Hua GUO Ze Hua LI Jing Yun YU Shan Fa WANG Zhong Xu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2015年第9期627-633,共7页
Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders(WMSDs) and work organization based on a case-control study. Methods A total of 1938 workers who claimed t... Objective In this study, we aimed at exploring the association between work-related musculoskeletal disorders(WMSDs) and work organization based on a case-control study. Methods A total of 1938 workers who claimed to suffer from WMSDs were selected from Beijing, Henan, Hubei, and the Guangdong province. The control group consisted of 2009 workers employed in similar industries without severe disease or musculoskeletal discomforts. We used a modified version of the questionnaire developed by the NMQ and the DMQ to investigate individual and work-related factors. Results A total of 13 variables(P〈0.1) were selected by the chi-square test and finally, 7 variables entered into the equation, with 6 variables reaching statistical significance(P〈0.05). The odds ratios(OR) of 'work changing with season' and 'sufficient rest time' did not reach 1(0.749 and 0.441, respectively). In addition, 'sufficient rest time' seemed to be the stronger protective factor according to its higher standardized coefficient. And 'repetitive work every minute', 'constantly repetitive work'(every day), 'shortage of site personnel', and 'often switching shifts with others' seemed to be the risk factors. Conclusion Work organization may have comprehensive effects on the occurrence of WMSDs. This pattern of associations suggests that further investigation into the mechanism of how work organization affects the prevalence of WMSDs is required. 展开更多
关键词 WMSDs work organization Case-control study Prevalence Risk factors
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IMPROVING ELEVATOR MAINTENANCE PERFORMANCE: WORK STUDY APPROACH
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作者 陆雪芬 曾庆才 梁浩池 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 1998年第1期53-59,共7页
Strategic quality management is implemented in a local elevator company. Quality strategies, policies and goals focusing on customers′ needs are clearly established. Continuous quality improvement has been adopted as... Strategic quality management is implemented in a local elevator company. Quality strategies, policies and goals focusing on customers′ needs are clearly established. Continuous quality improvement has been adopted as the corporate strategy to improve its performance and competitive edge. This paper presents the successful implementation of a quality improvement project using the work study approach. On the completion of the project, the rate of serious defects which may lead to an accident is reduced by 55%, i.e., from 2% ̄0.9% over a period of two years. A total of HK$ 1.1 million spent on the project is justified when compared with the reduction of financial risks involved. The success of the project demonstrates that the work study approach could be an effective tool for improving the performance of maintenance work. 展开更多
关键词 quality management quality improvement maintenance performance work study
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TNF-α and IL-1RA Polymorphisms and Silicosis Susceptibility in Chinese Workers Exposed to Silica Particles:A Case-Control Study 被引量:12
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作者 WANG Yong Wei LAN Ya Jia +2 位作者 YANG Yue Lin WANG De Jun KUANG Jie 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2012年第5期517-525,共9页
Abstract Objective To assess the association of TNF-α and IL-1RA SNPs with the risk of silicosis in Chinese workers exposed to silica particles. Methods Case-control study design was used to enroll 68 silicotic patie... Abstract Objective To assess the association of TNF-α and IL-1RA SNPs with the risk of silicosis in Chinese workers exposed to silica particles. Methods Case-control study design was used to enroll 68 silicotic patients induced by silica particles and 68 healthy workers matched for length of silica particle exposure as controls. Both cases and controls were from the same company in southwest China, and each of them was requested to complete a questionnaire. Blood samples were drawn for genomic DNA extraction from each participant. The genotyping of TNF-α (-238 and -308) and IL-1RA (+2018) was performed using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) and SYBR green-based quantitative polymerase chain reaction {qPCR), respectively. Unconditional logistic regression model was used to estimate odds ratios (ORs) and their 95% confidential intervals (Cl) for SNPs. Results No significant differences were found between cases and controls in particles exposure length, body mass index (BMI), and status of smoking and alcohol consumption except for age (P=O.O01) and blood type (P=0.042). The frequencies of TNF-c((-238) and IL-1RA (+2018) genotypes in cases were significantly different from those in controls, (P=O.O01 and P=0.O02, respectively), while a borderline significant difference was found in the frequencies of TNF-α(-308) between cases and controls (P=0.063). The variants of three SNPs increased the risk of silicosis in the Chinese workers exposed to silica particles. The adjusted ORs of TNFα(-308), TNF-α(-238) and IL-1RA (+2018) were 2.8 (95% Ch 2.1-7.5), 20.9 (95% Ch 2.8-236.4) and 4.0 (95% CI: 2.6-10.2), respectively. Conclusion It is suggested that cytokine polymorphisms of TNF-ct (-238, -308) and IL-1RA (+2018) are associated with the risk of silicosis in the Chinese workers exposed to silica particles. Further independent studies on the interaction between SNPs and exposure to silica particles with a larger sample size are therefore warranted. 展开更多
关键词 TNF-α IL-1RA POLYMORPHISM SILICOSIS Case-control study
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Risk of Active Pulmonary Tuberculosis among Patients with Coal Workers'Pneumoconiosis:A Case-control Study in China 被引量:9
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作者 JIN Yan FAN Jing Guang +4 位作者 PANG Jing WEN Ke ZHANG Pei Ying WANG Huan Qiang LI Tao 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2018年第6期448-453,共6页
The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis(PTB) among coal workers' pneumoconiosis(CWP) patients. A match... The aim of this study was to estimate the association between occupational, environmental, behavioral risk factors, and active pulmonary tuberculosis(PTB) among coal workers' pneumoconiosis(CWP) patients. A matched case-control study was conducted in 86 CWP patients with active PTB and 86 CWP controls without TB. A standardized questionnaire was used for risk factors assessment. Conditioned logistic regression analysis was used to identify associations between the risk factors and active PTB among CWP patients. The results showed that the stage of CWP, poor workplace ventilation, family history of TB, and exposure to TB were independent risk factors for active PTB in patients with CWP with which recommendations for improving work environments, and for case finding activities in patients with CWP could be made. 展开更多
关键词 Pulmonary tuberculosis Coal workers' pneumoconiosis RISK Case-control study
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Silicosis in Automobile Foundry Workers: A 29-Year Cohort Study 被引量:11
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作者 MIN ZHANG YING-DONG ZHENG +4 位作者 XIE-YI DU YANG LU WEN-JIE LI CHENG QI ZHENG-LAI WU 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2010年第2期121-129,共9页
Objectives The purposes were to determine the relationship between silicosis among foundry workers and their cumulative exposure to silica dust, and to establish a regression model to predict the risk for developing s... Objectives The purposes were to determine the relationship between silicosis among foundry workers and their cumulative exposure to silica dust, and to establish a regression model to predict the risk for developing silicosis by a given length of employment and air concentrations of silica at worksites. Methods A 29-year cohort study was conducted, including all those employed for more than one year during January 1, 1980 to December 31, 1996 and all members of the cohort were followed-up to December 3 1, 2008. In total, 2 009 workers of an automobile foundry in Shiyan, Hubei province were recruited in the study, 1 300 at eight worksites including sand preparation, cast shakeout, and finishing, melting, moulding, core-making, overhead crane operation and pouring as exposed group, and the other 709 auxiliary workers at the same factory, such as electricians, inspectors, fitters, and so on, as control group. Person-years of observation were calculated by persons observed and years followed-up for each of them. Person-year incidence of silicosis and its relative risk (RR) or odds ratio (OR) and 95% confidence intervals (CI) among the workers were estimated, adjusted for relevant factors with logistic regression model using SPSS version 15.0 software. Results Totally, 2 009 workers were followed-up for 37 151 person-years and 48 cases of silicosis were found, with an overall incidence of 1.34 per thousand, 2.02 per thousand in exposed group, and 0.15 per thousand in control one. Risk of silicosis was significantly higher in the exposed group than that in the control one (RR=13.13, 95% CI 3.18-54.13), higher in men than that in women (RR=13.92, 95% CI 1.92-100.93). Risks of silicosis varied by job, highest in those exposed to cast shakeout and finishing (RR=28.14, 95% CI 6.43-123.11), followed by those exposed to pouring (RR-22.23, 95% CI 5.01-98.55) in the foundry. Average length of employment at onset of silicosis was 25.94 years, and silicosis incidence increased with length of employment. Average age at onset of silicosis was 47.83 years old. The risk of silicosis in workers with pulmonary tuberculosis was 2.57 folds as those without it (P〈0.01). Ten deaths were recorded in those with silicosis, with a case-fatality rate of 20.83 percent three of them died of lung cancer, three of liver cancer, two of ischemic heart disease, and two of other diseases as their immediate causes of death. Incidence of silicosis in foundry workers positively correlated with their cumulative silica exposure (OR-3.00, 95% CI 2.34-3.83). Risks of silicosis increased by 4.38 folds with an increase of 1 mg/m^3-year of cumulative silica exposure, and by 3.79 folds with smoking, respectively, adjusted for alcohol drinking and age. Based on a logistic regression model fitted, incidence of silicosis is expected to be 44.6 per thousand for those with daily exposure to silica of 4.18 mg/m^3 in average for 30 years, and if incidence of silicosis is expected to be less than 1 per thousand, daily exposure to silica should be controlled below 0.2 mg/m^3 for those with 20 years of employment, or below 0.1 mg/m^3 for those with 30 or 40 years of silica exposure. Conclusions At present, foundry workers in China still face high risk of developing silicosis. For lowering occurrence of silicosis in exposed workers, it seems necessary that current occupational exposure limits for silica at worksites in China should be reexamined and silica dust control measures be strengthend. 展开更多
关键词 FOUNDRY SILICA SILICOSIS Occupational exposure limit Cohort study INCIDENCE Person-year Relative risk (RR) Odds ratio (OR)
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Demands, Resources and the Three Dimensions of Flow at Work. A Study among Professional Nurses 被引量:3
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作者 Lara Colombo Margherita Zito 《Open Journal of Nursing》 2014年第4期255-264,共10页
Within the healthcare context is very important to foster the dynamics leading to positive experiences at work, in order to promote work motivation and well-being. This study investigated the influence of some persona... Within the healthcare context is very important to foster the dynamics leading to positive experiences at work, in order to promote work motivation and well-being. This study investigated the influence of some personal and job resources and of some job demands on the three dimensions (absorption, work enjoyment, intrinsic work motivation) of flow at work, on the basis of Job Demands-Resources Model. Flow at work is an inner experience arising during an activity in which people are immersed, feel motivated and enjoy it. Studies suggest that resources are the main antecedents of the flow experience. Respondents to the questionnaire were 197 nurses. Multiple regressions were performed to detect the resources and the demands that influence the three dimensions of flow at work. As expected, resources positively influenced the dimensions of flow at work, particularly work enjoyment. Job demands positively influenced absorption and negatively influenced the other two dimensions of flow at work. Human resources managers should promote flow at work supporting the availability of resources and monitoring the job demands. 展开更多
关键词 FLOW at work work Motivation Positive PSYCHOLOGY JOB Demands-Resources Model Healthcare Context
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Nickel-exposed Workers in China: A Cohort Study 被引量:20
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作者 BAI Ya Na YAGN Ai Min +7 位作者 PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2014年第3期208-211,共4页
There are more than S0 000 workers in Jinchuan Group Co, Ltd (JNMC). Since all staff in JNMC are eligible for a medical examination every two years, only 23 484 nickel-exposed subjects who participated in medical ex... There are more than S0 000 workers in Jinchuan Group Co, Ltd (JNMC). Since all staff in JNMC are eligible for a medical examination every two years, only 23 484 nickel-exposed subjects who participated in medical examination were included in this study. Their data, collected from June 22, 2011 to September 28, 2012, in a comprehensive epidemiological survey and during medical examinations, permitted an extensive evaluation of the relation between metal exposure, gene, epigenetics and risk of human diseases. Their lifestyle investigation showed that the overall prevalence of current smokers, alcohol drinkers, and tea drinkers was 39.1%, 19.7%, and 55.2%, respectively. The prevalence of hypertension, allergic rhinitis and cholecystitis, the top 3 prevalent diseases, was 11.7%, 11.0%, and 8.9%, respectively. 展开更多
关键词 CO A Cohort study Nickel-exposed workers in China
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