A PRELIMINARY STUDY OF THE EFFECTS OF CHEMOTHERAPEUTICAGENTS IN COMBINATION WITH CHINESE HERBAL COMPOUNDS AS IMMUNOMODULATORS IN MOUSE S_(180)

The effect of the Chinese herbal compound (CHC) on solid sarcoma 180 (S180) in Swiss mice was studied either alone or in combination with 5-fluorouracil (5FU), cyclophosphamide (CYT) or mitomycin C (MMC). The preliminary results indicated that combination treatment seemed to possess better antitumor activity than chemotherapy alone. The treatment with CHC alone however had neither an obvious antitumor effect in tumor bearing mice nor toxicity in normal mice. These results show that CHC may stimulate organs of the immune system such as the spleen to be im-munomodulators and enhance the antitumor activity of some chemotherapeutic agents.

Clinical study of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia with overactive bladder

Objective To evaluate the efficacy and safety of combination therapy of tamsulosin and solifenacin for benign prostatic hyperplasia ( BPH) with overactive bladder ( OAB) . Methods 82 patients with OAB and coexisting BPH were randomly divided into tamsulosin group ( n

Experimental Study on Bubble Pulse Features Under the Combined Action of Horizontal and Vertical Walls

The pulse features of a bubble have a close connection with the boundary condition. When a bubble moves near a rigid wall, it will be attracted by the Bjerknes force of the wall, and a jet pointing at the wall will be generated. In real application, the bubble may move under the combined action of walls in different directions when it forms at the corner of a pipe or at the bottom of a dam. The motion of the bubble shows complex and nonlinear characteristics under these conditions. In order to investigate the bubble pulse features near complex walls, a horizontal wall and a vertical wall are put into the experimental water tank synchronously, and an electric circuit with 200 voltages is designed to generate discharge bubbles, and then experimental study on the bubble pulse features under the combined action of horizontal and vertical walls is carried out. The influences of the combined action of two walls on the bubble shape, pulse period, moving trace and inside jet are obtained by changing the distances from bubble center to the two walls. It aims at providing references for the relevant theoretical and numerical research.

Combined Effect of Smoking and Obesity on Coronary Heart Disease Mortality in Male Veterans:A 30-year Cohort Study

Objective Evidence is lacking regarding the combined effects of smoking and obesity on mortality from coronary heart disease in male veterans.This study aimed to explore the combined effect of smoking and obesity on coronary heart disease mortality in male veterans in China.Methods A cohort of 1,268 male veterans from 22 veteran centers in Xi’an(Shaanxi Province,China)were followed up once every 2 years from February 1,1987 to October 30,2016.The endpoint was death from any cause.The hazard ratio(HR)of each risk factor and the 95%confidence interval(CI)were calculated using a multivariate Cox proportional hazard model.Results The total follow-up was 24394.21 person-years;each subject was followed up for a mean duration of 19.24 years.By the end of the study,of the 1,268 veterans,889 had died,363 were alive,and 16 were lost to follow-up.Cox regression analysis results revealed that current smoking(HR:1.552,95%CI:1.074–2.243),obesity(HR:1.625,95%CI:1.024–2.581),and the combined effect of the two factors(HR:2.828,95%CI:1.520–5.262)were associated with coronary heart disease mortality.Conclusion Our results suggest that obese veterans who smoke might be an important target population for coronary heart disease mortality control.

Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes:A Population-based Prospective Cohort Study of Inner Mongolians in China

This prospective study was designed to examine the combined influence of insulin resistance（IR）and inflammatory biomarker levels on type 2 diabetes mellitus（T2DM）among 1,903Inner Mongolians.

Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)

BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.RESULTS In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study.

A COMBINED MEASUREMENT SYSTEM FOR UV/V IN SITU SPECTROELECTROCHEMICAL STUDY

A microcomputer-based UV/V in situ spectroelectrochemical measurement system has been developed.This paper presents a description of the experimental details regarding the methods and equipment.

A Biochemical Study on Combined Treatment of Experimental Silicosis with Tetradrine-PVNO and Tetradrine-QOHP in Rats

A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monoamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats

The study on the mechanism of Sodium aescinate combined with Xuesaitong for cerebral thrombosis treatment

Objective:To observe the mechanism of Sodium aescinate combined with Xuesaitong for cerebral thrombosis treatment and offer clinical help to cerebral thrombosis treatment. Methods:A total of 92 patients with cerebral thrombosis were selected and randomly divided into groups: the observation group (46 people) and the control group (46 people).The patient in the control group were treated with conventional therapy and the patients in the observation group were treated with Sodium aescinate combined with Xuesaitong on the basis of conventional therapy. Inflammatory factors (IL-6, IL-10, TNF-α and CRP), Nerve cell factor (NSE, NGF and NTF) and blood rheology indexes (Fg, BVH, BVL and PV) were detected and analyzed before and after treatment.Results:The comparison of inflammatory factors, Nerve cell factor and blood rheology indexes in the two groups before treatment were not statistically significant. Inflammatory factors (IL-6, TNF-α and CRP), Nerve cell factor (NSE) and blood rheology indexes (Fg, BVH, BVL and PV) in both groups after treatment significantly decreased compared with that before treatment. Inflammatory factors (IL-10), Nerve cell factor (GF and NTF) in both groups after treatment significantly increased compared with that before treatment. The changes were statistically significant. Inflammatory factors (IL-6, TNF-α and CRP), Nerve cell factor (NSE) and blood rheology indexes (Fg, BVH, BVL and PV) in observation group after treatment decreased more significantly than that in control group, and inflammatory factors (IL-10), Nerve cell factor (GF and NTF) increased more significantly than that in control group. The difference between two groups was considered statistically significant.Conclusion:Sodium aescinate combined with Xuesaitong could inhibit the inflammatory reaction, improve the blood flow condition and promote rehabilitation in patients with cerebral thrombosis. So it has a very important clinical significance of the treatment to cerebral hemorrhage.

Accuracy of combined PET/CT in image-guided interventions of liver lesions: An ex-vivo study

AIM： Positioning of interventional devices in liver lesions is a challenging task if only CT is available. We investigated the potential benefit of combined PET/CT images for localization of interventional devices in interventional liver studies. METHODS： Thirty lesions each of hyperdense, isodense and hypodense attenuation compared to normal liver parenchyma were injected into 15 ex-vivo pig livers. All lesions were composed of the same amounts of gelatine containing 0.5 MBq of ^18F-FDG. Following lesion insertion, an interventional needle was placed in each lesion under CT-guidance solely. After that, a PET/CT study was performed. The localization of the needle within the lesion was assessed for CT alone and PET/CT and the root mean square （RMS） was calculated. Results were compared with macroscopic measurements after lesion dissection serving as the standard of reference. RESULTS： In hypo- and isodense lesions PET/CT proved more accurate in defining the position of the interventional device when compared with CT alone. The mean RMS for CT and PET/CT differed significantly in isodense and hypodense lesions. No significant difference was found for hyperdense lesions. CONCLUSION： Combined FDG-PET/CT imaging provides more accurate information than CT alone concerning the needle position in FDG-PET positive liver lesions. Therefore combined PET/CT might be potentially beneficial not only for localization of an interventional device, but may also be beneficial for guidance in interventional liver procedures.

A comparative study of pancreatic endocrine function and related metabolism after long-term survival between the patients with combined kidneypancreas transplantation vs those with combined en bloc ' liver-pancreas transplantation

Objective To compare the effects of combined en bloc liver - pancreas transplantation ( LPT) with portal vein drainage and simultaneous combined kidney - pancreas transplantation ( KPT) with systemic venous drainage on the pancreatic endocrine function and related me-

三部配穴法针刺治疗慢性中心性浆液性脉络膜视网膜病变的临床效果

目的 观察三部配穴法针刺治疗慢性中心性浆液性脉络膜视网膜病变(CSC)的临床效果。方法 将2022年1月至12月于上海市第一人民医院就诊的84例慢性CSC患者按随机数字表法分为对照组(42例)与治疗组(42例),对照组予维生素B1片、肌苷片、三磷酸腺苷二钠片的基础治疗(40 d),治疗组在对照组的基础上联合三部配穴法针刺,隔天针刺1次,共20次(40 d)。比较两组临床疗效,比较两组治疗前后美国国立眼科研究院视功能问卷-25(NEI-VFQ-25)、中医症状证候量表、最佳矫正视力(BCVA)变化。结果 对照组脱落3例,治疗组脱落4例。治疗组临床疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组NEI-VFQ-25评分、BCVA均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组中医症状证候量表评分低于本组治疗前及对照组,差异有统计学意义(P<0.05)。结论 三部配穴法针刺联合基础治疗慢性CSC效果显著,具有较高的临床推广及应用价值。

基于COMET职业评价模型的工学结合课程职业能力内涵及评价探索

为实现“培养什么人,怎样培养人,为谁培养人”的教育价值回归,积极推进职业教育的“提质培优”建设,分析培养对象作为“学习者、社会人、职业人、岗位者、筑梦人”五类属性的职业能力要求。基于COMET职业评价模型建立基于职业能力发展逻辑顺序的工学结合学习领域课程体系,以及专业能力加关键能力的项目任务型课程与课程职业能力评价规范性操作文件并例证。构建工学结合课程职业能力培养与评价体系,为高职课程教学质量提升提供了新参考。

含新药口服短程方案治疗耐多药/利福平耐药结核病三例并文献复习

目的:探讨含新药口服短程方案治疗耐多药/利福平耐药结核病的疗效和安全性,为临床医师应用该方案治疗提供更多的依据。方法:回顾性分析2023年12月北京胸科医院收治的3例应用含新药口服短程方案(贝达喹啉、康替唑胺、德拉马尼)治疗的耐多药/利福平耐药结核病患者的相关临床资料,通过查阅中国知网、万方数据库及PubMed数据库,以“耐多药结核、康替唑胺”和“耐多药结核、贝达喹啉、德拉马尼”为中文关键词,以“contezolid、multidrug-resistant tuberculosis”及“multidrug-resistant tuberculosis、bedaquiline、delamanid”为英文关键词进行文献检索,共搜索到国内外相关文献11篇,本研究主要选取含新药康替唑胺、德拉马尼、贝达喹啉短程治疗的文献8篇,结合本组3例患者的病历资料进行有效性和安全性分析。结果:有效性分析显示,含康替唑胺方案治疗的患者中,84%的患者痰培养和(或)涂片结核分枝杆菌阴性,且持续为阴性。治疗期间胸部CT检查显示病灶缩小,停药后胸部CT检查提示病灶稳定。含贝达喹啉、德拉马尼方案治疗的患者中,91%的患者获得了良好的结果。在治疗第8周,痰结核分枝杆菌培养阴转率为95%,第24周时为95%。贝达喹啉联合德拉马尼组的痰涂片和培养阴转中位时间均快于贝达喹啉组。安全性分析显示,含康替唑胺方案治疗的患者未发生骨髓抑制、周围神经病变和视神经病变等在内的利奈唑胺常见不良反应。而在含贝达喹啉和德拉马尼治疗的患者中,QTcF间期相比基线延长了20.7ms(平均16.1~25.3ms),2例患者出现QT间期延长大于500ms,4例患者发生6次QTcF间期延长超过基线值60ms,在治疗期间没有发生3级或4级不良QTc延长事件,未发生心律失常,没有一例永久停药,也没有发生死亡。贝达喹啉联合德拉马尼组QTc间期延长少于贝达喹啉组。在治疗过程中,52%的患者出现骨髓抑制,42%的患者出现周围神经病变。在48周随访时,大多数不良事件得到解决。结论:含新药贝达喹啉、德拉马尼、康替唑胺的全口服方案在耐药结核病短程治疗中取得了较好的效果。治疗期间仅出现轻度药物不良反应,经对症治疗后均缓解,未出现严重药物不良反应。

起始联合降脂策略对心内科门诊“极高危ASCVD”患者疗效及安全性观察——真实世界的前瞻性队列研究

目的:在真实世界的前瞻性队列研究中观察心内科门诊“极高危ASCVD”患者在治疗起始阶段采用联合降脂策略的疗效与安全性。方法:连续入组2021年1月至6月在湘雅医院心内科高脂血症专病门诊就诊的“极高危ASCVD”患者,根据其实际降脂策略分为三组:阿托伐他汀单药组;阿托伐他汀联合依折麦布组;阿托伐他汀联合依洛尤单抗组。主要观察终点为治疗一个月后低密度脂蛋白胆固醇(LDL-C)、脂蛋白a[Lp(a)]、非-HDL-C变化,次要终点为总胆固醇(TC)、甘油三酯(TG)、LDL-C、超敏C反应蛋白(hs-CRP)变化及安全性指标。结果:无论哪种联合方式,在“极高危ASCVD”患者降脂起始阶段联合降脂治疗的疗效均显著优于阿托伐他汀单药组:LDL-C、Log[Lp(a)]、非-HDL-C、TC的降幅更大,差异均有统计学意义(均P<0.05)。在两种联合降脂方案中,阿托伐他汀联合依洛尤单抗与联合依折麦布相比,LDL-C、Log[Lp(a)]的降幅更大,差异均有统计学意义(P<0.05),TC、TG有一定的降幅,差异无统计学意义(P>0.05)。以“LDL-C<1.4 mmol/L或<1.8 mmol/L”作为降脂达标的标准时,两组联合降脂治疗的LDL-C达标率均高于阿托伐他汀单药组,差异均有统计学意义(均P<0.05);阿托伐他汀联合依洛尤单抗组的LDL-C达标率高于阿托伐他汀联合依折麦布组,差异均有统计学意义(均P<0.05)。单独或联合“LDL下降超过50%”的降幅为达标标准,三组均无人能达标。治疗后三组间的肝脏转氨酶水平变化差异均无统计学意义(均P<0.05);三组间心肌酶同工酶(CK-MB)均下降,但差异无统计学意义(P<0.05)。与阿托伐他汀单药组相比,两联合降脂组治疗组的血糖均下降,差异具有统计学意义(P<0.05);阿托伐他汀联合依折麦布组的血糖比阿托伐他汀联合依洛尤单抗组的降幅更大,差异有统计学意义(P<0.05)。结论:起始联合降脂治疗1个月对心内科门诊“极高危ASCVD”患者的降脂效果及LDL-C的达标率优于阿托伐他汀单药组。以LDL-C<1.4 mmol/L或<1.8 mmol/L为降脂达标目标时,阿托伐他汀联合依洛尤单抗组治疗1个月后LDL-C达标率高于联合依折麦布组;以“LDL下降超过50%”的降幅作为降脂达标标准时,1个月内很难达标。门诊“极高危ASCVD”患者采用起始联合的降脂治疗1个月无不良反应。起始联合降脂策略可用于心内科门诊“极高危ASCVD”患者中LDL-C数值需早期达标的人群,阿托伐他汀联合依洛尤单抗可用于需在1个月内LDL-C<1.4 mmol/L或<1.8 mmol/L的人群。

金匮肾气丸联用cART对HIV-1感染者的疗效及不良反应分析

获得性免疫缺陷综合征(acquired immunodeficiency syndrome,AIDS)的主要治疗方法为联合抗逆转录病毒治疗(combined antiretroviral therapy,cART),但部分患者由于免疫功能重建不全和不良反应,可能出现药物性肝损伤、消化功能下降、神经系统毒性和代谢紊乱等,严重影响了抗病毒疗效和患者生存质量,已成为AIDS治疗领域的瓶颈[1]。部分国家资助的中医药防治AIDS科研课题提出正虚(主要为肾虚)是AIDS发生发展的内在病理基础,以肾气与肾阴肾阳的功能下降为主要特征[2-3]。补肾制剂可能是缓解人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染患者病情和不良反应的可靠方式。金匮肾气丸是由地黄、山药、茯苓、牡丹皮、山茱萸、牛膝、泽泻等多味中药制成的综合制剂[4],具有温补肾阳、化气行水的作用。本研究首次采用金匮肾气丸与cART联用治疗HIV-1感染者,比较了金匮肾气丸与cART联用、单用cART对HIV-1感染者抗病毒疗效和不良反应的差异,试图为探索HIV-1感染者治疗的新途径提供参考。

基于浊毒理论针刺结合通滞苏润江胶囊治疗腰椎间盘突出症临床研究

目的:探究浊毒理论针刺结合通滞苏润江胶囊治疗腰椎间盘突出症(lumbar disc herniation,LDH)的临床效果。方法:将湿浊瘀阻型LDH患者120例按照随机数字表法分为针药结合组、针刺组、中药组各40例。3组患者均接受常规康复护理训练,在此基础上,针刺组给予《神应经》腰痛十二穴针刺治疗;中药组给予通滞苏润江胶囊;针药结合组给予通滞苏润江胶囊+《神应经》腰痛十二穴针刺,均连续治疗4周。比较3组治疗前后疼痛视觉模拟评分(visual analogue scale,VAS)、日本骨科学会评估治疗评分(Japanese orthopaedic association scores,JOA)、Oswestry功能障碍指数(oswestry disability index,ODI)、临床症状及椎间盘退变等级改善率和安全性。结果:针药结合组临床症状改善率为97.50%(39/40),高于针刺组的80.00%(32/40)及中药组的82.50%(33/40)(P<0.05);针药结合组椎间盘退变等级改善率为92.50%(37/40),高于针刺组的75.00%(30/40)及中药组的70.00%(28/40)(P<0.05);治疗后,3组患者VAS、JOA、ODI评分与治疗前比较差异具有统计学意义(P<0.05),针药结合组VAS、ODI评分低于针刺组及中药组(P<0.05),JOA评分高于针刺组及中药组(P<0.05);3组不良反应发生率较低。结论:将基于浊毒理论的针药结合治疗应用于LDH,可有效缓解疼痛,提高患者生活质量及腰椎功能恢复率,改善椎间盘退变程度,且安全性较高。

光电信息类应用型人才“学研训赛”协同育人探索与实践

针对工科高校光电信息类专业创新应用型人才普遍存在的“工科偏理化”“学生实践与创新能力不足”等问题,开展多层次、多维度应用型人才培养模式的教学改革与实践。更新教学方法和手段等措施,构建具有特色的光电信息类专业理实融通、学研对接、训赛结合的“学研训赛”实践育人模式,在课程教学中融入课程思政教育,凝练出“一体系、三层次、六结合”理论课程体系,造就一支基础厚、能力强、素质高且全面发展的应用型创新人才队伍。该成果为地方工科院校培养光电信息类应用型人才提供经验和范例。

“岗课赛证”融通背景下高职院校教学改革探析——以“直播电商运营实务”课程为例

以“直播电商运营实务”课程教学项目为例,从教学设计、教学特色与创新、教学实施与效果、教学反思四个维度开展课堂教学实践与分析,基于直播电商运营的真实工作过程构建以技能培训为核心的“岗课赛证+工学结合”一体化教学模式,浸润“一线二融三式”思政元素,提出人才培养方案的具体改革措施,探索可实现价值引领、知识传授、能力培养和全面发展为一体的教学实践路径。

两边连接木盖板屈曲约束钢板剪力墙抗侧力性能试验研究

从环保角度提出一种钢木组合形式的两边连接防屈曲钢板剪力墙。基于已有的研究成果,设计两个试件,一个是没有木盖板约束的钢板剪力墙,另一个是覆盖木板作为钢板面外屈曲约束的钢板剪力墙。对试件采用位移控制加载方式进行拟静力试验,得到试件的滞回曲线。根据试验结果,分析了试件的骨架曲线、刚度退化和耗能能力。试验结果表明,木盖板抑制钢板屈曲效果较好,能够有效减小鼓曲声音;与无木盖板试件相比,有木盖板试件具有更高的承载力和更强的耗能能力。在试件破坏后,对试件进行拆卸,发现钢板腹部木盖板覆盖区域能够保持平整,拆卸后的木盖板在加载后也能保持完整。采用软件ABAQUS进行有限元分析,模拟结果和试验结果吻合,验证了模型的可行性。