Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the...Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the problems in tourism services of three scenic areas and then put forward relevant countermeasures for the management of scenic areas.展开更多
BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not bee...BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.RESULTS In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study.展开更多
This paper reconstructs,based on American and Chinese primary sources,the visits of Chinese mathematicians Shiing-shen Chern陈省身(Chen Xingshen)and Hua Luogeng华罗庚(Loo-Keng Hua)4 to the Institute for Advanced Study...This paper reconstructs,based on American and Chinese primary sources,the visits of Chinese mathematicians Shiing-shen Chern陈省身(Chen Xingshen)and Hua Luogeng华罗庚(Loo-Keng Hua)4 to the Institute for Advanced Study in Princeton in the United States in the 1940s,especially their interactions with Oswald Veblen and Hermann Weyl,two leading mathematicians at the IAS.It argues that Chern’s and Hua’s motivations and choices in regard to their transnational movements between China and the US were more nuanced and multifaceted than what is presented in existing accounts,and that socio-political factors combined with professional-personal ones to shape their decisions.The paper further uses their experiences to demonstrate the importance of transnational scientific interactions for the development of science in China,the US,and elsewhere in the twentieth century.展开更多
Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Trans...Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Transdermal Rotigotine User Surveillance Study＂ （TRUST） trial represents such a real-world study. It investigated long-term treatment with different dopamine substituting treatment regimens in 2195 PD patients （Mfiller et al., 2018）. Participation in TRUST meant that the treating neurologists were only asked to document and modify the dopaminergic drug regimen without any prior PD patient selection criteria. Thus this unique trial design reflects the real world of patient maintenance.展开更多
11 September 2014, Hong Kong： Smartphones will account for two out of every, three mobile connections globally by 2020, according to a major new report by GSMA In- telligence, the research arm of the GSMA. The new st...11 September 2014, Hong Kong： Smartphones will account for two out of every, three mobile connections globally by 2020, according to a major new report by GSMA In- telligence, the research arm of the GSMA. The new study, ＂Smartphone forecasts and assumptions, 2007- 2020＂, finds that smartphones account for one in three mobile conneetions today, representing more than two billion mobile connections. It forecasts that the number of smartphone connections will grow three-fold over the next six years,展开更多
As we know,new criticism is the post—world school of critical theory insists onthe intrinsic value of work of art and focusses on the individual work alone asan independent unit of meaning.It is opposed to the critic...As we know,new criticism is the post—world school of critical theory insists onthe intrinsic value of work of art and focusses on the individual work alone asan independent unit of meaning.It is opposed to the critical practice of bringing histori-cal of brographical data to bear on the anterpretation of a work.To the new critocs,poet-.ry was a special kind of discourse,a means of communicating feeling and thought thatwould not be expressed in any other kind of language.It differed qualitatively from thelanguage of science,or philosophy,but it converyed valid meanings.Such critics set outto define and formalize the qualities of poetic thought and languagege,using the techniqueof close reading with special emphasis on the implicative values of works and on the vari-ous function of figurative language—imagery,metaphor and symbol—in the work.展开更多
Tibetan drama, called"Ache Lhamo"in Tibetan, is a comprehensive performing art evolved from Tibetan folk oral art, music, dance and religious rituals.For a long time, Ache Lhamo has attracted worldwide atten...Tibetan drama, called"Ache Lhamo"in Tibetan, is a comprehensive performing art evolved from Tibetan folk oral art, music, dance and religious rituals.For a long time, Ache Lhamo has attracted worldwide attention, it not only is one of the hot topics of Tibetan studies in China, but also attracts many scholars in other countries, including scholars in English world. In the early nineteenth century, in the western world, some scholars had mentioned Ache Lhamo in their research, Ache Lhamo story texts'translation has gradually ap- peared and recently scholars conduct academic research on Ache Lhamo, whose research findings are fruitful and meaningful. There- fore, the author chooses Ache Lhamo study in the Anglophone world as the research object. This thesis studies on the translation works and research of Ache Lhamo produced in English world based on more than 30 relevant articles and translation works. With the advan- tages of western scholars drawing on exotic cultural backgrounds and rich theoretical knowledge, they inevitably adopt western academic perspectives and methodologies. For these reasons above, this thesis attempts to utilize the variation theory to explore Ache Lhamo study in the English world.展开更多
A history of the Islamic studies in China,not only includes studies on world Islam,it also includes research on Islam and Muslims in China.Before the Reform and Opening Up,China did not achieve much in this field,sinc...A history of the Islamic studies in China,not only includes studies on world Islam,it also includes research on Islam and Muslims in China.Before the Reform and Opening Up,China did not achieve much in this field,since then,the research field of Islam and Muslim in China has been expanding and the results have been published,forming a new trend.In this field,scholars such as Jin Yijiu,Li Xinghua,Qin Huibin,Zhou Guoli,Sha Qiuzhen,Zhou Xiefan,Wu Yungui,and Yang Huaizhong have made the most outstanding achievements.Especially in the collation of reference books and historical materials,in the past 20 years,The Encyclopedia of the history of Islam,The Chinese Encyclopedia of Islam have emerged,and the Chinese and World Encyclopedia of Islamic Law and other important historical books have been published.This paper focuses on the field of historical research and divided into academic research history at home and abroad,which is discussed from several fields such as general history,special history,national history,and regional history.展开更多
Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter stu...Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced NSCLC.Methods: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved survival.Conclusions: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib.展开更多
In this paper, the content of rockery protection was discussed through the analysis of a series of documents such as the convention, declaration, and regulations concerning heritage protection in accordance with the p...In this paper, the content of rockery protection was discussed through the analysis of a series of documents such as the convention, declaration, and regulations concerning heritage protection in accordance with the principles of authenticity and integrity. Through the analysis of the influence factors of the rockery and its environment, it is proposed that the rockery protection should strengthen environmental protection on the basis of the protection of the body of a rockery. From the perspectives of structure, skill, materials and function, the contents of the rockery protection and the human settlement environment where the rockery is located, the external environment and internal environment of the rockery space were analyzed, and the contents of the rockery protection were preliminarily proposed.展开更多
This year highlights the centenary of the outbreak of World War I and this paper aims at comparing and contrasting multicultural views on the First World War in Virginia Woolf＇s Mrs. Dalloway （1925）. The views on t...This year highlights the centenary of the outbreak of World War I and this paper aims at comparing and contrasting multicultural views on the First World War in Virginia Woolf＇s Mrs. Dalloway （1925）. The views on the First War are portrayed by a plurality of voices, most of which are women＇s, and they allow readers to think of the war experience in a more subjective but also more plural way. In this novel, voices from both sides of the First War resonate, i.e., the hegemonic side of the war--the Allies--is compared and contrasted to the subjectivity of the voices of the ＂others＂--the Axis, although they do not necessarily work in harmony. Such innovation in point of view has, in great part, contributed to converging story and history, allowing this literary work to partake in the production of historical knowledge and cultural memory of the War.展开更多
The series A Study on Ethical Literary Criticism exhibits key achievements in the major program of national social sciences by scholars headed by Professor Nie Zhenzhao,who are devoted to the research of foreign liter...The series A Study on Ethical Literary Criticism exhibits key achievements in the major program of national social sciences by scholars headed by Professor Nie Zhenzhao,who are devoted to the research of foreign literatures,studies in philosophy and social sciences,and interdisciplinary study of world literature,who dedicated themselves to the construction of the ethical literary critical theory and methodology with the application of ethical literary criticism in practice.This series organically combine the generality of ethical literary criticism with the individuality of specific writers and combine the theoretical guidance with realistic practicality in academic research,which will be conducive to the development of world literary criticism and region and country-specific studies in the new era.展开更多
Sponsored by scholars and experts concerned with human rights at nine Beijing-based schools of higher learning and research institutes, the All-China Federation of Trade Unions and the All-China Women’s Federation, t...Sponsored by scholars and experts concerned with human rights at nine Beijing-based schools of higher learning and research institutes, the All-China Federation of Trade Unions and the All-China Women’s Federation, the China Society for Human Rights Studies (CSHRS) was founded in January 1993. It is the largest academic organization specializing in human rights studies in China, and a non-government organization that is in consultative status with the United Nations Economic and Social Council. A non-profit organization, CSHRS relies on financial aid and donations to maintain its operations.展开更多
文摘Through the questionnaire survey and comparative studies on tourist satisfaction of tourism services among three world heritage sites,i.e.Huangshan Mountain,Lushan Mountain and Wuyi Mountain,this study pointed out the problems in tourism services of three scenic areas and then put forward relevant countermeasures for the management of scenic areas.
基金supported by the China Cardiovascular Health Alliance-Advanced Fund (2019CCA-ACCESS-054)the Beijing Lisheng Cardiovascular Health Foundation Pilot Fund Key Projects。
文摘BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.RESULTS In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study.
文摘This paper reconstructs,based on American and Chinese primary sources,the visits of Chinese mathematicians Shiing-shen Chern陈省身(Chen Xingshen)and Hua Luogeng华罗庚(Loo-Keng Hua)4 to the Institute for Advanced Study in Princeton in the United States in the 1940s,especially their interactions with Oswald Veblen and Hermann Weyl,two leading mathematicians at the IAS.It argues that Chern’s and Hua’s motivations and choices in regard to their transnational movements between China and the US were more nuanced and multifaceted than what is presented in existing accounts,and that socio-political factors combined with professional-personal ones to shape their decisions.The paper further uses their experiences to demonstrate the importance of transnational scientific interactions for the development of science in China,the US,and elsewhere in the twentieth century.
文摘Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Transdermal Rotigotine User Surveillance Study＂ （TRUST） trial represents such a real-world study. It investigated long-term treatment with different dopamine substituting treatment regimens in 2195 PD patients （Mfiller et al., 2018）. Participation in TRUST meant that the treating neurologists were only asked to document and modify the dopaminergic drug regimen without any prior PD patient selection criteria. Thus this unique trial design reflects the real world of patient maintenance.
文摘11 September 2014, Hong Kong： Smartphones will account for two out of every, three mobile connections globally by 2020, according to a major new report by GSMA In- telligence, the research arm of the GSMA. The new study, ＂Smartphone forecasts and assumptions, 2007- 2020＂, finds that smartphones account for one in three mobile conneetions today, representing more than two billion mobile connections. It forecasts that the number of smartphone connections will grow three-fold over the next six years,
文摘As we know,new criticism is the post—world school of critical theory insists onthe intrinsic value of work of art and focusses on the individual work alone asan independent unit of meaning.It is opposed to the critical practice of bringing histori-cal of brographical data to bear on the anterpretation of a work.To the new critocs,poet-.ry was a special kind of discourse,a means of communicating feeling and thought thatwould not be expressed in any other kind of language.It differed qualitatively from thelanguage of science,or philosophy,but it converyed valid meanings.Such critics set outto define and formalize the qualities of poetic thought and languagege,using the techniqueof close reading with special emphasis on the implicative values of works and on the vari-ous function of figurative language—imagery,metaphor and symbol—in the work.
文摘Tibetan drama, called"Ache Lhamo"in Tibetan, is a comprehensive performing art evolved from Tibetan folk oral art, music, dance and religious rituals.For a long time, Ache Lhamo has attracted worldwide attention, it not only is one of the hot topics of Tibetan studies in China, but also attracts many scholars in other countries, including scholars in English world. In the early nineteenth century, in the western world, some scholars had mentioned Ache Lhamo in their research, Ache Lhamo story texts'translation has gradually ap- peared and recently scholars conduct academic research on Ache Lhamo, whose research findings are fruitful and meaningful. There- fore, the author chooses Ache Lhamo study in the Anglophone world as the research object. This thesis studies on the translation works and research of Ache Lhamo produced in English world based on more than 30 relevant articles and translation works. With the advan- tages of western scholars drawing on exotic cultural backgrounds and rich theoretical knowledge, they inevitably adopt western academic perspectives and methodologies. For these reasons above, this thesis attempts to utilize the variation theory to explore Ache Lhamo study in the English world.
文摘A history of the Islamic studies in China,not only includes studies on world Islam,it also includes research on Islam and Muslims in China.Before the Reform and Opening Up,China did not achieve much in this field,since then,the research field of Islam and Muslim in China has been expanding and the results have been published,forming a new trend.In this field,scholars such as Jin Yijiu,Li Xinghua,Qin Huibin,Zhou Guoli,Sha Qiuzhen,Zhou Xiefan,Wu Yungui,and Yang Huaizhong have made the most outstanding achievements.Especially in the collation of reference books and historical materials,in the past 20 years,The Encyclopedia of the history of Islam,The Chinese Encyclopedia of Islam have emerged,and the Chinese and World Encyclopedia of Islamic Law and other important historical books have been published.This paper focuses on the field of historical research and divided into academic research history at home and abroad,which is discussed from several fields such as general history,special history,national history,and regional history.
文摘Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced NSCLC.Methods: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved survival.Conclusions: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib.
基金Sponsored by 2018 Talented Young People Nourishment Program of North China University of Technology(18XN012-025)2017 Scientific Research Project of Beijing Municipal Education Commission(KM201710009013)
文摘In this paper, the content of rockery protection was discussed through the analysis of a series of documents such as the convention, declaration, and regulations concerning heritage protection in accordance with the principles of authenticity and integrity. Through the analysis of the influence factors of the rockery and its environment, it is proposed that the rockery protection should strengthen environmental protection on the basis of the protection of the body of a rockery. From the perspectives of structure, skill, materials and function, the contents of the rockery protection and the human settlement environment where the rockery is located, the external environment and internal environment of the rockery space were analyzed, and the contents of the rockery protection were preliminarily proposed.
文摘This year highlights the centenary of the outbreak of World War I and this paper aims at comparing and contrasting multicultural views on the First World War in Virginia Woolf＇s Mrs. Dalloway （1925）. The views on the First War are portrayed by a plurality of voices, most of which are women＇s, and they allow readers to think of the war experience in a more subjective but also more plural way. In this novel, voices from both sides of the First War resonate, i.e., the hegemonic side of the war--the Allies--is compared and contrasted to the subjectivity of the voices of the ＂others＂--the Axis, although they do not necessarily work in harmony. Such innovation in point of view has, in great part, contributed to converging story and history, allowing this literary work to partake in the production of historical knowledge and cultural memory of the War.
文摘The series A Study on Ethical Literary Criticism exhibits key achievements in the major program of national social sciences by scholars headed by Professor Nie Zhenzhao,who are devoted to the research of foreign literatures,studies in philosophy and social sciences,and interdisciplinary study of world literature,who dedicated themselves to the construction of the ethical literary critical theory and methodology with the application of ethical literary criticism in practice.This series organically combine the generality of ethical literary criticism with the individuality of specific writers and combine the theoretical guidance with realistic practicality in academic research,which will be conducive to the development of world literary criticism and region and country-specific studies in the new era.
文摘Sponsored by scholars and experts concerned with human rights at nine Beijing-based schools of higher learning and research institutes, the All-China Federation of Trade Unions and the All-China Women’s Federation, the China Society for Human Rights Studies (CSHRS) was founded in January 1993. It is the largest academic organization specializing in human rights studies in China, and a non-government organization that is in consultative status with the United Nations Economic and Social Council. A non-profit organization, CSHRS relies on financial aid and donations to maintain its operations.
