BACKGROUND When herpes zoster is complicated with paralytic ileus,this mostly involves acute intestinal pseudo-obstruction of Ogilvie’s syndrome manifesting as obvious dilatation of the cecum and right colon;small in...BACKGROUND When herpes zoster is complicated with paralytic ileus,this mostly involves acute intestinal pseudo-obstruction of Ogilvie’s syndrome manifesting as obvious dilatation of the cecum and right colon;small intestinal obstruction is rare.Here,we present a patient with a very rare case of small bowel pseudo-obstruction.CASE SUMMARY A 76-year-old female patient complained of right upper quadrant pain.Two days later,a blistering,right-sided rash of the thoracoabdominal dermatome(T5-T10) emerged in conjunction with small intestinal dilatation and the inability to defecate.Computed tomography of the abdomen confirmed small bowel pseudoobstruction.Antiviral therapy,gastrointestinal decompression,and enemas proved unproductive.After 4 d of stagnation,an epidural block was performed for pain relief and prompted the passage of gas and stool,resolving the obstructive problem.Three days later,the rash appeared dry and crusted,and the pain diminished.After 5 d,no abnormality was visible by gastroenteroscopy,and the patient was discharged on day 7.CONCLUSION This case shows that herpes zoster may induce small bowel pseudo-obstruction in addition to colonic pseudo-obstruction.Epidural block can not only treat intercostal neuralgia but also resolve small bowel pseudo-obstruction caused by herpes zoster.展开更多
It was not until 1979 that Bayes de Ltma described atrial conduction blocks and classified them as interatrial and intra- atrial.Interatrial blocks refer to conduction disorders lo- cated between the atria, while intr...It was not until 1979 that Bayes de Ltma described atrial conduction blocks and classified them as interatrial and intra- atrial.Interatrial blocks refer to conduction disorders lo- cated between the atria, while intraalxial blocks occur within the same atrium. This work motivated several authors, in- cluding Bayes himself, to further investigate atrial conduc- tion and interatrial block （IAB）.展开更多
The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resista...The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance. This capacity is evaluated using Kirsten's index, which was initially developed to evaluate the excavatability of earth materials. For rocky material, this index is determined according to certain geomechanical factors related to intact rock and rock mass, such as compressive strength of intact rock, rock block size, discontinuity shear strength and relative block structure. To quantify the relative block structure, Kirsten(1982) developed a mathematical expression that accounts for the shape and orientation of the blocks relative to the direction of flow. Kirsten's initial concept for assessing the relative block structure considers that the geological formation is mainly fractured by two joint sets forming an orthogonally fractured system. An adjusted concept is proposed to determine the relative block structure when the fractured system is non-orthogonal where the angle between the planes of the two joint sets is greater or less than 90°. An analysis of the proposed relative block structure rating shows that considering a non-orthogonally fractured system has a significant effect on Kirsten's index and, as a consequence, on the assessment of the hydraulic erodibility of rock.展开更多
Using pure S wave fitting method, we studied the shear wave velocity structures under the Ordos block and its eastern and southern marginal areas. The results show that the velocity structure beneath Yulin station in ...Using pure S wave fitting method, we studied the shear wave velocity structures under the Ordos block and its eastern and southern marginal areas. The results show that the velocity structure beneath Yulin station in the interior of Ordos block is relatively stable, where no apparent change between high and low velocity layers exists and the shear wave velocity increases steadily with the depth. There is a 12km thick layer at the depth of 25km under this station, with an S wave velocity (V S=3.90km/s) lower than that at the same depth in its eastern and southern areas (V S≥4.00km/s). The crust under the eastern margin of Ordos block is thicker than that of the Yulin station, and the velocity structures alternate between the high and low velocity layers, with more low velocity layers. It has the same characteristic as having a 10km-thick low velocity layer (V S=3.80km/s) in the lower crust but buried at a depth of about 35km. Moreover, we studied the V P/V S ratio under each station in combination with the result of P wave velocity inversion. The results show that, the average velocity ratio of the Yulin station at the interior of Ordos block is only 1.68, with a very low ratio (about 1.60) in the upper crust and a stable ratio of about 1.73 in the mid and lower crust, which indicates the media under this station is homogenous and stable, being in a state of rigidity. But at the stations in the eastern and southern margins of the Ordos block, several layers of high velocity ratio (about 1.80) have been found, in which the average velocity ratio under Kelan and Lishi stations at the eastern margin is systemically higher than that of the general elastical body waves (1.732). This reflects that the crust under the marginal areas is more active relatively, and other materials may exist in these layers. Finally, we discussed the relationship among earthquakes, velocity structures beneath stations and faults.展开更多
The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical ind...The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).展开更多
Pelagic copepods play an important role in the marine food web. However, a full understanding of the ecological status of this zooplankton group depends on the careful study of their natural diets. In previous PCR-bas...Pelagic copepods play an important role in the marine food web. However, a full understanding of the ecological status of this zooplankton group depends on the careful study of their natural diets. In previous PCR-based copepod diet studies, we found many apostome ciliates that live symbiotically under the exoskeleton of the copepods, and their sequences were often over-represented in the 18S rRNA gene （18S rDNA） libraries. As a first step to address this issue, we designed three apostome ciliate 18S rDNA blocking primers, and tested their blocking efficiency against apostome ciliate 18S rDNA under various PCR conditions. Using a semi-quantitative PCR method, we optimized the conditions to efficiently amplify the 18S rDNA of the prey while simultaneously excluding the symbiotic apostome ciliates. This technique will facilitate PCR-based diet studies of copepods and other zooplankton in their natural environments.展开更多
BACKGROUND Neuralgia is frequently noted in patients with Kummell’s disease,and its mechanism is complex,rendering it challenging to treat.Percutaneous kyphoplasty(PKP)has been widely used to treat osteoporotic verte...BACKGROUND Neuralgia is frequently noted in patients with Kummell’s disease,and its mechanism is complex,rendering it challenging to treat.Percutaneous kyphoplasty(PKP)has been widely used to treat osteoporotic vertebral compression fractures with satisfactory outcomes.However,it is not optimal for managing severely collapsed vertebrae,as cement injection may not be feasible.This report describes the use of a selective nerve block for the treatment of neuralgia caused by severely collapsed vertebrae in a patient with Kummell’s disease.CASE SUMMARY In our patient,three vertebrae were involved.The collapse of T11 was particularly severe.After managing T8 and T9 using PKP,these two segments were effectively strengthened;consequently,back pain was significantly relieved.However,the structure and strength of T11 could not be effectively restored using a minimally invasive surgical method because there was little room for cement injection.This caused obvious neuralgia according to the postoperative status of the PKP.Thus,we performed selective nerve blocks for the treatment of neuralgia,which resulted in satisfactory outcomes.CONCLUSION Selective nerve block may be a possible therapeutic strategy for neuralgia due to severely collapsed vertebrae in Kummell’s disease.展开更多
Necrotizing scleritis is the most severe form of scleritis with a significant threat to vision and globe integrity. It can be infectious, surgically induced necrotizing scleritis (SINS) or systemic autoimmune associat...Necrotizing scleritis is the most severe form of scleritis with a significant threat to vision and globe integrity. It can be infectious, surgically induced necrotizing scleritis (SINS) or systemic autoimmune associated. We report a case of necrotizing scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of necrotizing scleritis associated with 5-FU. This may implicate alternative approaches to local anaesthetic techniques when using adjunctive 5-FU.展开更多
The objective of this research paper is to study numerical relationships between a block of a finite group and a defect group of such block. We define a new notion which is called a strongly k(D)- block and give a nec...The objective of this research paper is to study numerical relationships between a block of a finite group and a defect group of such block. We define a new notion which is called a strongly k(D)- block and give a necessary and sufficient condition of a block with a cyclic defect group to be a k(D) -block in term of its inertial index. We believe that the notion and the results in this work will contribute to the developments of the theory of blocks of finite groups.展开更多
Writer identity in academic writing has long been ignored by developing L2 writers.Moreover,research has much focused on the reader in shaping writing,and treated the role of the writer as unproblematic.In this essay,...Writer identity in academic writing has long been ignored by developing L2 writers.Moreover,research has much focused on the reader in shaping writing,and treated the role of the writer as unproblematic.In this essay,the construction of writer identity in developing writers’academic writing practice will be explored through a review of some relevant literature research and gain insights for the development of writer apprentices and writing instruction.展开更多
Amphiphilic block copolymers poly(LysAA-b-DMS) consisting of a hydrophilic poly(N-α-acrylamide-L-lysine) [poly(LysAA)] segment with different molecular weights and a hydrophobic polydimethylsiloxane (PDMS) segment we...Amphiphilic block copolymers poly(LysAA-b-DMS) consisting of a hydrophilic poly(N-α-acrylamide-L-lysine) [poly(LysAA)] segment with different molecular weights and a hydrophobic polydimethylsiloxane (PDMS) segment were prepared as follows. The precursor copolymer poly(Boc-LysAA-OtBu-b-PDMS) was obtained from radical polymerization of N-α-acrylamide-N-ε-tert-butoxycarbonyl-L-lysine-tert-butylester (Boc-LysAA-OtBu) initiated with 4,4’-azobis(polydimethylsiloxane 4-cyanopentanoate) (azo-PDMS) with the molecular weight of PDMS Mw = 4.3 × 103 in the presence of 2-mercaptoethanol (2-ME) as a chain-transfer agent. Removal of the protecting groups of the precursor copolymer was carried out in 80% trifluoroacetic acid aqueous solution to give poly(LysAA-b-DMS)-1-3. The weight average molecular weight of poly(LysAA-b-DMS)-1-3 was Mw = 1.02 × 104 – 2.52 × 104. From the 1H-NMR and fluorescence spectra measurements, poly(LysAA-b-DMS)-1-3 was determined to self-organize and form core-shell micelles in water. The critical micelle concentration (CMC) increased to 1000 - 4000 mg·L–1 with increasing molar ratio of the poly(LysAA) segment from 0.42 to 0.65. From morphological analysis with a scanning probe microscope (SPM), poly(LysAA-b-DMS) has microphase-separated structures made up of hydrophilic and hydrophobic regions with the domain size ranging from several tens to several hundreds of nanometers. Inhibition of thrombin activity of poly(LysAA-b-DMS) was evaluated from the Michaelis constant (KM) and catalytic activity (kcat) for the enzymatic reaction of thrombin and synthetic substrate S-2238 in the presence of poly(LysAA-b-DMS). The KM and kcat were 0.10 - 0.11 mM and 4.04 × 105 – 4.26 × 105 min–1, respectively. Fibrinolytic activity was also verified from the transformation of plasminogen to plasmin by tissue plasminogen activator (t-PA) using synthetic substrate S-2251 in the presence of poly(LysAA-b-DMS). The KM and kcat were 0.07 mM and 5.73 × 106 –5.95 × 106 min–1, respectively.展开更多
文摘BACKGROUND When herpes zoster is complicated with paralytic ileus,this mostly involves acute intestinal pseudo-obstruction of Ogilvie’s syndrome manifesting as obvious dilatation of the cecum and right colon;small intestinal obstruction is rare.Here,we present a patient with a very rare case of small bowel pseudo-obstruction.CASE SUMMARY A 76-year-old female patient complained of right upper quadrant pain.Two days later,a blistering,right-sided rash of the thoracoabdominal dermatome(T5-T10) emerged in conjunction with small intestinal dilatation and the inability to defecate.Computed tomography of the abdomen confirmed small bowel pseudoobstruction.Antiviral therapy,gastrointestinal decompression,and enemas proved unproductive.After 4 d of stagnation,an epidural block was performed for pain relief and prompted the passage of gas and stool,resolving the obstructive problem.Three days later,the rash appeared dry and crusted,and the pain diminished.After 5 d,no abnormality was visible by gastroenteroscopy,and the patient was discharged on day 7.CONCLUSION This case shows that herpes zoster may induce small bowel pseudo-obstruction in addition to colonic pseudo-obstruction.Epidural block can not only treat intercostal neuralgia but also resolve small bowel pseudo-obstruction caused by herpes zoster.
文摘It was not until 1979 that Bayes de Ltma described atrial conduction blocks and classified them as interatrial and intra- atrial.Interatrial blocks refer to conduction disorders lo- cated between the atria, while intraalxial blocks occur within the same atrium. This work motivated several authors, in- cluding Bayes himself, to further investigate atrial conduc- tion and interatrial block （IAB）.
基金the organizations that have funded this project:the Natural Sciences and Engineering Research Council of Canada(Grant No.498020-16)Hydro-Quebec(NC-525700)Mitacs Accelerate Program(Grant Ref.IT10008)
文摘The most commonly used method for assessing the hydraulic erodibility of rock is Annandale's method.This method is based on a correlation between the erosive force of flowing water and the capacity of rock resistance. This capacity is evaluated using Kirsten's index, which was initially developed to evaluate the excavatability of earth materials. For rocky material, this index is determined according to certain geomechanical factors related to intact rock and rock mass, such as compressive strength of intact rock, rock block size, discontinuity shear strength and relative block structure. To quantify the relative block structure, Kirsten(1982) developed a mathematical expression that accounts for the shape and orientation of the blocks relative to the direction of flow. Kirsten's initial concept for assessing the relative block structure considers that the geological formation is mainly fractured by two joint sets forming an orthogonally fractured system. An adjusted concept is proposed to determine the relative block structure when the fractured system is non-orthogonal where the angle between the planes of the two joint sets is greater or less than 90°. An analysis of the proposed relative block structure rating shows that considering a non-orthogonally fractured system has a significant effect on Kirsten's index and, as a consequence, on the assessment of the hydraulic erodibility of rock.
文摘Using pure S wave fitting method, we studied the shear wave velocity structures under the Ordos block and its eastern and southern marginal areas. The results show that the velocity structure beneath Yulin station in the interior of Ordos block is relatively stable, where no apparent change between high and low velocity layers exists and the shear wave velocity increases steadily with the depth. There is a 12km thick layer at the depth of 25km under this station, with an S wave velocity (V S=3.90km/s) lower than that at the same depth in its eastern and southern areas (V S≥4.00km/s). The crust under the eastern margin of Ordos block is thicker than that of the Yulin station, and the velocity structures alternate between the high and low velocity layers, with more low velocity layers. It has the same characteristic as having a 10km-thick low velocity layer (V S=3.80km/s) in the lower crust but buried at a depth of about 35km. Moreover, we studied the V P/V S ratio under each station in combination with the result of P wave velocity inversion. The results show that, the average velocity ratio of the Yulin station at the interior of Ordos block is only 1.68, with a very low ratio (about 1.60) in the upper crust and a stable ratio of about 1.73 in the mid and lower crust, which indicates the media under this station is homogenous and stable, being in a state of rigidity. But at the stations in the eastern and southern margins of the Ordos block, several layers of high velocity ratio (about 1.80) have been found, in which the average velocity ratio under Kelan and Lishi stations at the eastern margin is systemically higher than that of the general elastical body waves (1.732). This reflects that the crust under the marginal areas is more active relatively, and other materials may exist in these layers. Finally, we discussed the relationship among earthquakes, velocity structures beneath stations and faults.
文摘The traditional combinatorial designs can be used as basic designs for constructing designs of computer experiments which have been used successfully till now in various domains such as engineering, pharmaceutical industry, etc. In this paper, a new series of generalized partially balanced incomplete blocks PBIB designs with m associated classes (m = 4, 5 and 7) based on new generalized association schemes with number of treatments v arranged in w arrays of n rows and l columns (w ≥ 2, n ≥ 2, l ≥ 2) is defined. Some construction methods of these new PBIB are given and their parameters are specified using the Combinatory Method (s). For n or l even and s divisor of n or l, the obtained PBIB designs are resolvable PBIB designs. So the Fang RBIBD method is applied to obtain a series of particular U-type designs U (wnl;) (r is the repetition number of each treatment in our resolvable PBIB design).
基金Supported by the National Natural Science Foundation of China(No.41076085)
文摘Pelagic copepods play an important role in the marine food web. However, a full understanding of the ecological status of this zooplankton group depends on the careful study of their natural diets. In previous PCR-based copepod diet studies, we found many apostome ciliates that live symbiotically under the exoskeleton of the copepods, and their sequences were often over-represented in the 18S rRNA gene （18S rDNA） libraries. As a first step to address this issue, we designed three apostome ciliate 18S rDNA blocking primers, and tested their blocking efficiency against apostome ciliate 18S rDNA under various PCR conditions. Using a semi-quantitative PCR method, we optimized the conditions to efficiently amplify the 18S rDNA of the prey while simultaneously excluding the symbiotic apostome ciliates. This technique will facilitate PCR-based diet studies of copepods and other zooplankton in their natural environments.
文摘BACKGROUND Neuralgia is frequently noted in patients with Kummell’s disease,and its mechanism is complex,rendering it challenging to treat.Percutaneous kyphoplasty(PKP)has been widely used to treat osteoporotic vertebral compression fractures with satisfactory outcomes.However,it is not optimal for managing severely collapsed vertebrae,as cement injection may not be feasible.This report describes the use of a selective nerve block for the treatment of neuralgia caused by severely collapsed vertebrae in a patient with Kummell’s disease.CASE SUMMARY In our patient,three vertebrae were involved.The collapse of T11 was particularly severe.After managing T8 and T9 using PKP,these two segments were effectively strengthened;consequently,back pain was significantly relieved.However,the structure and strength of T11 could not be effectively restored using a minimally invasive surgical method because there was little room for cement injection.This caused obvious neuralgia according to the postoperative status of the PKP.Thus,we performed selective nerve blocks for the treatment of neuralgia,which resulted in satisfactory outcomes.CONCLUSION Selective nerve block may be a possible therapeutic strategy for neuralgia due to severely collapsed vertebrae in Kummell’s disease.
文摘Necrotizing scleritis is the most severe form of scleritis with a significant threat to vision and globe integrity. It can be infectious, surgically induced necrotizing scleritis (SINS) or systemic autoimmune associated. We report a case of necrotizing scleritis associated with 5-fluorouracil (5-FU) at the site of sub tenon’s block in a patient with previous trabeculectomy. To our knowledge, this is the first reported case of necrotizing scleritis associated with 5-FU. This may implicate alternative approaches to local anaesthetic techniques when using adjunctive 5-FU.
文摘The objective of this research paper is to study numerical relationships between a block of a finite group and a defect group of such block. We define a new notion which is called a strongly k(D)- block and give a necessary and sufficient condition of a block with a cyclic defect group to be a k(D) -block in term of its inertial index. We believe that the notion and the results in this work will contribute to the developments of the theory of blocks of finite groups.
文摘Writer identity in academic writing has long been ignored by developing L2 writers.Moreover,research has much focused on the reader in shaping writing,and treated the role of the writer as unproblematic.In this essay,the construction of writer identity in developing writers’academic writing practice will be explored through a review of some relevant literature research and gain insights for the development of writer apprentices and writing instruction.
文摘Amphiphilic block copolymers poly(LysAA-b-DMS) consisting of a hydrophilic poly(N-α-acrylamide-L-lysine) [poly(LysAA)] segment with different molecular weights and a hydrophobic polydimethylsiloxane (PDMS) segment were prepared as follows. The precursor copolymer poly(Boc-LysAA-OtBu-b-PDMS) was obtained from radical polymerization of N-α-acrylamide-N-ε-tert-butoxycarbonyl-L-lysine-tert-butylester (Boc-LysAA-OtBu) initiated with 4,4’-azobis(polydimethylsiloxane 4-cyanopentanoate) (azo-PDMS) with the molecular weight of PDMS Mw = 4.3 × 103 in the presence of 2-mercaptoethanol (2-ME) as a chain-transfer agent. Removal of the protecting groups of the precursor copolymer was carried out in 80% trifluoroacetic acid aqueous solution to give poly(LysAA-b-DMS)-1-3. The weight average molecular weight of poly(LysAA-b-DMS)-1-3 was Mw = 1.02 × 104 – 2.52 × 104. From the 1H-NMR and fluorescence spectra measurements, poly(LysAA-b-DMS)-1-3 was determined to self-organize and form core-shell micelles in water. The critical micelle concentration (CMC) increased to 1000 - 4000 mg·L–1 with increasing molar ratio of the poly(LysAA) segment from 0.42 to 0.65. From morphological analysis with a scanning probe microscope (SPM), poly(LysAA-b-DMS) has microphase-separated structures made up of hydrophilic and hydrophobic regions with the domain size ranging from several tens to several hundreds of nanometers. Inhibition of thrombin activity of poly(LysAA-b-DMS) was evaluated from the Michaelis constant (KM) and catalytic activity (kcat) for the enzymatic reaction of thrombin and synthetic substrate S-2238 in the presence of poly(LysAA-b-DMS). The KM and kcat were 0.10 - 0.11 mM and 4.04 × 105 – 4.26 × 105 min–1, respectively. Fibrinolytic activity was also verified from the transformation of plasminogen to plasmin by tissue plasminogen activator (t-PA) using synthetic substrate S-2251 in the presence of poly(LysAA-b-DMS). The KM and kcat were 0.07 mM and 5.73 × 106 –5.95 × 106 min–1, respectively.
