Study on Mineralization Age of Xiaoban Gold Deposit, Fujian Province

The Xiaoban gold deposit is a large-size deposit recently found in middlearea of Fujian Province. It belongs to magmatic hydrothermal type occurred in Mayuan Groupmetamorphic rocks of Middle Proterozoic and is controlled by low angle fault (detachment)structures. The contents of Au in Mayuan Group metamorphic rocks, Caledonian-Indosinian deformedgranite and early Yanshanian granite are higher with Au enrichment coefficient of 2. 06-5.68, 5.11and 6.67 than those in other geological bodies. And the higher enrichment coefficients (>2) of Ag,S, Sn and Te are similar to those of gold ore. Meanwhile, the distribution of Au in Mayuan Groupmetamorphic rocks and early Yanshanian granite with a low D-value (0.58 and 0.67) is favorable togold mineralization. REE characteristics of gold ore, ratios of (LREE/HREE), (La/Sm)_n, (Yb/Lu)_n,(La/Tb)_n and (Sm/Nd)_n are similar to Mayuan Group metamorphic rocks, only non or little normal Euabnormal of ore is dissimilar to metamorphic rocks. The δ(^(34)S) of the gold ore, with a highhomogenization, is (-4.7X10^(-3) - (-2.7X 10^(-3)). The study of inclusion indicates 180-249℃ ofmineralization temperature, 3. 69 %-11. 81 % of salinities and 0. 869-0.991 g/cm^3 of densities ofmineralization fluid. Based on hydrogen and oxygen isotope (δ(^(18)O) = 11. 0 X 10^(-3) -11.7 X10^(-3), δ(D) = (-48 X 10^(-3)) - (-62 X 10^(-3))) and initial w(^(87)Sr)/w(^(86)Sr) =0. 715,combining to the analysis of geological history, regional metamorphism and magamtic activity, theauthors confirm that the source for the ore fluid was mainly from magmatic, partly from metamorphicwater, and with a little influence of meteoric water. Isotopic dating made on Rb-Sr isochron age of182 Ma, by using alteration minerals of gold-ores from the deposit, indicates that themineralization occurs in early Yanshanian epoch. This is close to the age of 187 Ma of the Anchunmagmatite with a similar alteration and gold mineralization to the Xiaoban gold deposit. The age ofearly Yanshanian epoch of the Xiaoban gold is indentical with the characteristics of southern Chinagold metal-logenic belt and the geotectonic evolution of the transition from paleo-Asian system andpaleo-Tethyan system to paleo-Pacific active continental margin in eastern Asia.

Liangxue Xiaoban decoction and its disassembled prescriptions ameliorate psoriasis-like skin lesions induced by imiquimod in mice via T cell regulation

Objective:To explore the therapeutic capacity of the Liangxue Xiaoban(LXXB)decoction and its disassembled prescriptions in the modulation of T cell subsets and recurrence-related indexes of psoriasis using a psoriasis-like mouse model.Methods:The psoriasis model was generated by the treatment of BALB/c mice(n=48)with imiquimod.Mice were divided into six groups:control,psoriasis model,tripterygium glycosides,LXXB decoction,Liangxue decoction,and Qingqi decoction.After the intervention period,the interleukin(IL)-17A,IL-22,and interferon-γ levels in mice were examined and hematoxylin and eosin staining was conducted to determine pathological changes in the skin tissues.T cell subset changes in the skin-draining lymph nodes were analyzed using flow cytometry,and the expression levels of the associated transcription factors and recurrence-related indexes in the skin tissues were determined using a polymerase chain reaction.Results:LXXB decoction attenuated the levels of CD8^(+)T,Th17,and Th1 cells and induced an increase in the Th2 and Treg cell levels.The disassembled prescriptions promoted or inhibited specific subsets of T cells to improve the symptoms of psoriasis.Notably,the LXXB and Liangxue decoctions suppressed the expression of IL-22 at both the gene and protein levels and restored the CD103 and IL-15 expressions in the skin tissue to the normal range.Conclusion:LXXB decoction exerted significant immunoregulatory effects on T cell subsets and improved the recurrence-related indexes.Interestingly,the Liangxue prescription appeared to have a therapeutic advantage in terms of Th17 modulation and psoriasis recurrence,while the Qingqi prescription performed better in Treg immunoregulation.

Efficacy of Jiangzhi Xiaoban tablet(降脂消斑片)on toll-like receptor 4/nuclear factor-kappa B/nod-like receptor protein 3 signaling pathway in mice with atherosclerosis induced by high-fat diet

OBJECTIVE:To study the effect of Jiangzhi Xiaoban tablet(降脂消斑片,JZXB)on toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/Nod-like receptor protein 3(NLRP3)signaling pathway expression in atherosclerosis(AS)mice by establishing a mouse model of AS,and to explore its mechanism of prevention and treatment of AS.METHODS:Sixty-four male C57BL/6J mice were randomly divided into two groups,12 in the normal control group and 52 in the model group(MOD).Seven weeks later,two mice in each of the above two groups were randomly sacrificed,and the whole aortic tissue of the mice was taken out for hematoxylin-eosin staining.After successful modeling,50 mice in the modeling group were randomly divided into 5 groups:MOD,atorvastatin group(ATO),low-dose group of JZXB(JZXB-L),middle-dose group of JZXB(JZXB-M),and high-dose group of JZXB(JZXB-H),10 mice in each group.The mice in each group were killed after 6 weeks of preventive administration.HE staining was used to observe the pathological changes of aorta in AS mice.The levels of serum triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were detected by automatic biochemical analyzer.The levels of inflammatory factor interleukin-1β(IL-1β)were detected by enzyme linked immunosorbent assay.The expression of TLR4,NF-κB and NLRP3 proteins in aortic tissue was detected by immunohistochemistry.RESULTS:Compared with the MOD,the levels of serum TC,TG and LDL-C in the JZXB-H and ATO were significantly decreased,while the level of HDL-C was significantly increased.The levels of serum TG,LDL-C in the JZXB-M were significantly decreased,and the level of HDL-C was significantly increased.Compared with the MOD,the levels of IL-1βwere significantly decreased,aortic lesions were significantly improved,and the expression of TLR4,NF-κB,and NLRP3 proteins in the aortic tissue was significantly decreased in the JZXB-H,JZXB-M,and ATO.CONCLUSION:JZXB has inhibitory effect on atherosclerosis in mice,and its mechanism may be through regulating the TLR4/NF-κB/NLRP3 signaling pathway and reducing the inflammatory response,so as to play a role in inhibiting atherosclerosis.

基于消斑通脉方抗动脉粥样硬化作用机制的网络药理学分析和体外实验验证

目的:利用网络药理学分析方法初步预测消斑通脉方抗动脉粥样硬化(AS)的潜在作用通路和靶点,联合体外细胞实验对其可能机制进行验证。方法:采用中药系统药理学数据库与分析平台(TCMSP)、GeneCards、Swiss Target Prediction和Uniprot等数据库,收集消斑通脉方中活性化合物及对应靶点信息,构建“成分-靶点-疾病”网络,通过蛋白-蛋白互作(PPI)网络预测可能的作用靶点和通路,对交集靶点进行基因本体论(GO)功能富集分析和京都基因与基因组百科全书(KEGG)信号通路富集分析。体外培养人主动脉血管平滑肌细胞(HA-VSMCs)并鉴定,采用氧化低密度脂蛋白(ox-LDL)诱导HA-VSMCs异常增殖并进行鉴定。MTT法检测不同浓度消斑通脉方作用后各组HA-VSMCs增殖活性,确定消斑通脉方安全性。HA-VSMCs分为空白组、模型组(诱导HA-VSMCs异常增殖)、瑞舒伐他汀组(诱导HA-VSMCs异常增殖后采用4μmol·L^(−1)瑞舒伐他汀干预)及低、中和高剂量消斑通脉方组(诱导HA-VSMCs异常增殖后分别采用0.025、0.050和0.100 mg·L^(−1)消斑通脉方干预)。酶联免疫吸附试验(ELISA)法检测各组HA-VSMCs培养上清中人单核细胞趋化蛋白1(MCP-1)、白细胞介素6(IL-6)和白细胞介素8(IL-8)水平,实时荧光定量PCR(RT-qPCR)法检测各组HA-VSMCs中核因子κB(NF-κB)p65 mRNA和成纤维细胞生长因子2(FGF2)mRNA表达水平,Western blotting法检测各组HA-VSMCs中NF-κB p65和FGF2蛋白表达水平。结果:消斑通脉方中含有103种活性成分,可通过作用于189个靶基因发挥抗AS作用,潜在作用靶点包括IL-6、IL-8、血管内皮生长因子A(VEGFA)、核因子κB1(NF-κB1)和RELA(NF-κB p65)等。GO功能分析和KEGG信号通路富集分析,消斑通脉方通过调节脂质、缺氧诱导因子1(HIF-1)、表皮生长因子(EGF)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)和NF-κB等信号通路发挥抗AS作用。细胞形态表现和免疫荧光染色结果证明细胞为HA-VSMCs。油红O染色,可观察到大量红色脂滴,表明造模成功。MTT法检测,在一定剂量范围内消斑通脉方对HA-VSMCs增殖率无明显影响,安全性良好。ELISA法检测,与模型组比较,瑞舒伐他汀组和不同剂量消斑通脉方组HA-VSMCs培养上清中MCP-1和IL-6水平降低(P<0.05或P<0.01),0.050和0.100 mg·L^(−1)消斑通脉方组HA-VSMC培养上清中IL-8降低(P<0.01);与瑞舒伐他汀组比较,不同剂量消斑通脉方组HA-VSMCs培养上清中MCP-1降低(P<0.01),0.050和0.100 mg·L^(−1)消斑通脉方组HA-VSMCs培养上清中IL-8降低(P<0.01)。与模型组比较,瑞舒伐他汀组和不同剂量消斑通脉方组HA-VSMCs中NF-κB p65 mRNA表达水平降低(P<0.01),瑞舒伐他汀组及0.050和0.100 mg·L^(−1)消斑通脉方组HA-VSMCs中FGF2 mRNA表达水平降低(P<0.01);与瑞舒伐他汀组比较,0.050和0.100 mg·L^(−1)消斑通脉方组HA-VSMCs中NF-κB p65和FGF2 mRNA表达水平降低(P<0.05或P<0.01)。与模型组比较,瑞舒伐他汀组和不同剂量消斑通脉方组HA-VSMCs中NF-κB p65和FGF2蛋白表达水平降低(P<0.01);与瑞舒伐他汀组比较,0.050和0.100 mg·L^(−1)消斑通脉方组HA-VSMCs中NF-κB p65蛋白表达水平降低(P<0.01),0.100 mg·L^(−1)消斑通脉方组HA-VSMCs中FGF2蛋白表达水平降低(P<0.01)。结论:消斑通脉方具有抗炎、抑制HA-VSMCs增殖和抗AS作用,其作用机制可能与NF-κB/FGF2通路失活有关。

散结消斑方联合八段锦治疗痰瘀互结型颈动脉易损斑块临床研究

目的:评价散结消斑方联合八段锦治疗痰瘀互结型颈动脉易损斑块临床价值。方法:将颈动脉易损斑块(痰瘀互结型)患者80例,随机分为治疗组(40例)及对照组(40例)。对照组患者予以西医规范化的抗血小板聚集及降脂稳定斑块治疗,治疗组在对照组基础治疗上加用散结消斑方联合八段锦。对比经过治疗后两组患者颈动脉斑块IMT的变化、斑块总数总斑块面积、Crouse积分及血清学指标。结果:治疗后两组患者颈动脉斑块IMT的变化、斑块总数总斑块面积、Crouse积分、双侧颈动脉中治疗前后最大斑块厚度及面积、总胆固醇、甘油三脂、低密度脂蛋白胆固醇均较治疗前显著降低(P<0.05),高密度脂蛋白胆固醇水平与上升时间值均较治疗前显著升高(P<0.05)。治疗后治疗组颈动脉斑块IMT的变化、斑块总数总斑块面积及Crouse积分、双侧颈动脉中治疗前后最大斑块厚度及面积、总胆固醇、甘油三脂、低密度脂蛋白胆固醇均与对照组比较明显降低(P<0.05),对比于对照组治疗后水平与上升时间值有了明显的升高,经过对于差异比较,均具有统计学意义(P<0.05)。结论:散结消斑方联合八段锦可有效减少痰瘀互结型患者的易损型斑块数目及面积、稳定颈动脉易损斑块、抑制颈动脉粥样硬化斑块进展,值得临床推广。

基于皮肤屏障功能、氧化应激指标评估疏肝消斑汤联合YAG激光治疗黄褐斑的临床效果

目的分析基于皮肤屏障功能、氧化应激指标评估疏肝消斑汤联合YAG激光治疗黄褐斑的可行性。方法选取108例信阳职业技术学院附属医院收治的黄褐斑患者,选例时间:2021年8月至2023年3月,分为对照组(54例)和研究组(54例),分为对照组和研究组,对照组接受YAG激光治疗,研究组接受疏肝消斑汤联合YAG激光治疗,两组均连续治疗20周。比较两组治疗后临床疗效,治疗前后皮损情况及皮肤屏障功能、血清超氧化物歧化酶(SOD)、丙二醛(MDA)、脂质过氧化物(LPO)水平、皮肤病生存质量指数(DLQI)、抑郁自评量表(SDS)、焦虑自评量表(SAS)和肝郁气滞证评分情况。结果研究组临床总有效率较高(两组治疗后相比);两组皮损面积、皮损颜色积分、皮损区经表皮水分流失值、黑色素含量、DLQI、SDS、SAS、肝郁气滞证评分、血清MDA、LPO水平均降低(治疗后相较于治疗前),且研究组处于较低水平(组间进行对比);两组角质层含水量、血清SOD水平均升高(治疗后相较于治疗前),且研究组处于较高水平(组间进行对比),P<0.05。结论黄褐斑患者应用疏肝消斑汤联合YAG激光治疗,可有助于改善皮肤屏障功能、心理状态,缓解临床症状,抑制氧化应激反应,提升生活质量,且临床疗效显著。

通脉消斑汤上调PPARα抑制NF-кB减轻缺氧复氧受损心肌细胞炎症反应

目的:探讨通脉消斑汤上调过氧化物酶体增生因子活化受体α(PPARα)抑制NF-кB保护缺氧复氧受损心肌细胞炎症反应。方法:建立大鼠H9C2细胞缺氧复氧模型,将细胞分为3组:对照组(Ⅰ组)、缺氧复氧组(Ⅱ组)、缺氧复氧加通脉消斑汤组(Ⅲ组)。CCK8检测不同浓度通脉消斑汤对大鼠H9C2活力影响;缺氧复氧以及加用通脉消斑汤对细胞活力的影响。免疫荧光观察PPAR缺氧复氧前后及加用通脉消斑汤后变化,NF-кB P65核转移以及磷酸化NF-κB P65(p-NF-κB P65)胞核内表达变化。Western Blot检测PPAR、p-NF-κB、NF-κB蛋白表达的变化。结果:与空白对照组比较,缺氧复氧组H9C2细胞活力降低,加用通脉消斑汤后,细胞活力升高(P﹤0.05)。免疫荧光显示缺氧复氧组细胞PPAR核内表达较空白对照组降低,加用通脉消斑汤组细胞,PPAR较前升高(P﹤0.05);缺氧复氧组细胞出现NF-κB P65核转移,通脉消斑汤组核转移减少;与空白对照组比较,磷酸化NF-κB在缺氧复氧组表达升高,加用通脉消斑汤组降低。Western Blot结果显示PPAR在缺氧复氧组表达较空白对照组降低,在通脉消斑汤升高;磷酸化NF-κB、细胞间粘附分子1(ICAM1)在缺氧复氧组表达升高,同样在通脉消斑汤组降低。结论:通脉消斑汤上调PPARα,抑制NF-κB,保护缺氧复氧受损心肌细胞。

Effects of Quyu Xiaoban Capsule (祛瘀消斑胶囊) on Vascular Endothelial Function in Patients with Atherosclerosis

Objective： To evaluate the therapeutic effects of Quyu Xiaoban Capsule （祛瘀消斑胶带）, QYXBC） on endothelial dependent vascular relaxation （EDVR） function in patients with atherosclerosis （AS） with ultrasonic technique. Methods： Tested were the endothelial function and blood lipids of 42 patients with AS in the treated group and 30 healthy volunteers in the control group. And re-examination of these parameters was carried out on the AS patients after they had been treated with QYXBC for 10 months. Results： Before treatment, the reactive hyperemia induced changes in artery diameter in the treated group was significantly lower than that in the control group （P〈0.01）, while insignificant difference was found between the two groups in response to nitroglycerin. In the treated group after treatment, with D%-R improved significantly （P〈0.01）, total cholesterol （TC）, triglyceride （TG） and low-density lipoprotein cholesterol （LDL-C） decreased by 16.3%, 5.6%, 10.2% respectively and high-density lipoprotein cholesterol （HDL-C） increased by 7.5%. EDVR was correlated negatively with the serum TC, LDL-C concentrations and the baseline brachial diameter （D0） （r = -0.41, -0.66, -0.59, respectively, all P〈0.01）, but correlated positively with HDL-C （r=0.62, P〈0.05）. The ameliorative extent of EDVR was correlated positively to the decreased magnitude of TC and LDL-C concentrations （r = 0.67,0.59, both P〈0.01）. Conclusion： QYXBC can lower the level of blood lipids and improve significantly EDVR function.

凉血解毒消斑汤治疗寻常型银屑病临床对照研究

本研究的目的是探究凉血解毒消斑汤治疗寻常型银屑病的临床应用效果。随机选取杭州医学院附属医院2023年6月-2023年12月来本院就诊的50例寻常型银屑病患者为研究对象,使用凉血解毒消斑汤治疗为观察组,对照组则采用传统治疗方法。结果显示,在治疗后的3个月内,观察组患者的病情得到了显著改善,平均病情评分由初始的6.8降至2.3,且无明显不良反应发生。而对照组患者的病情改善较慢,平均病情评分由初始的6.8降至4.5。统计学分析显示,观察组的治疗效果显著优于对照组(P<0.05)。此外,观察组患者的生活质量也有明显提高,皮肤瘙痒、脱屑等症状明显减轻,对疾病的认知和接受程度也有所增加。在随访期间,观察组患者的复发率较低,仅有10%的患者出现了病情反复,而对照组患者的复发率达到了30%。由此可见,凉血解毒消斑汤对于寻常型银屑病的治疗具有显著的临床应用效果,不仅可以改善患者的症状,提高生活质量,还能有效降低疾病的复发率,值得在临床中推广应用。

祛风消斑汤治疗过敏性紫癜风盛血热证患儿的效果及对免疫功能的影响

目的 探讨祛风消斑汤治疗过敏性紫癜风盛血热证患儿的效果及对免疫功能的影响。方法 选取2021年6月至2023年12月临朐县妇幼保健院收治的78例过敏性紫癜风盛血热证患儿为研究对象,以随机数字表法分为两组,每组39例。参照组给予常规西药治疗,联合组在参照组基础上联合祛风消斑汤治疗,比较两组治疗效果。结果 联合组治疗总有效率高于参照组,差异有统计学意义(P<0.05)。联合组关节肿痛、皮疹、肢体困重改善时间短于参照组,差异有统计学意义(P <0.05)。治疗前,两组免疫球蛋白(Ig) M、IgA、IgG水平以及各项中医证候评分比较,差异无统计学意义(P>0.05);治疗后,两组IgM、IgA、IgG水平及各项中医证候评分均降低,且联合组IgM、IgA、IgG水平及各项中医证候评分低于参照组,差异有统计学意义(P<0.05)。结论 祛风消斑汤治疗过敏性紫癜风盛血热证患儿的效果显著,能够调节免疫功能,促进症状缓解,值得推广应用。

美容消斑汤联合水光注射氨甲环酸治疗肝气郁结型黄褐斑的疗效及对皮肤屏障功能修复的影响

目的:观察美容消斑汤联合水光针治疗肝气郁结型黄褐斑的疗效及对皮肤屏障功能修复的影响。方法:分析笔者医院应用美容消斑汤联合水光针治疗的55例黄褐斑患者的病例资料,利用黄斑面积和严重指数(Melasma area and severity index,MASI)进行定量评价,评估患者疗效及皮损状况,使用多功能皮肤测试仪检测患者皮肤屏障功能,并采用皮肤病生活质量指数(Dermatology life quality index,DLQI)量表评价患者生活质量。结果:治疗后,患者治疗总有效率达90.91%;患者皮损情况(皮损面积、皮损颜色)评分和皮损区经表皮水分流失值、黑色素含量显著低于治疗前,角质层含水量显著高于治疗前,差异均有统计学意义(P<0.05);与治疗前比较,患者治疗后DLQI量表心理状态、生理状态、日常活动、社交娱乐评分均显著降低,差异均有统计学意义(P<0.05);治疗期间未出现严重不良反应。结论:美容消斑汤联合水光针治疗肝气郁结型黄褐斑具有显著疗效,能够改善患者皮损情况,促进皮肤屏障功能的恢复,并提高患者生活质量水平。

中医调冲消斑汤治疗对黄褐斑患者全身症状改善情况及皮肤病生活质量指数的影响

目的探讨中医调冲消斑汤治疗对黄褐斑患者全身症状改善情况及皮肤病生活质量指数的影响。方法选取我院2020年5月至2022年12月治疗的60例黄褐斑患者,按数字随机分组法将患者分为研究组和对照组,各30例。对照组采用外用氢醌乳膏联合口服氨甲环酸片(妥塞敏)、维生素C治疗,研究组在对照组的基础上加用中医调冲消斑汤治疗。对比两组总有效率和皮损面积、皮损颜色、皮肤病生活质量评分(Dermatology Life Quality Index,DLQI)以及血清雌激素和孕激素水平改善情况。结果研究组黄褐斑患者的总有效率显著高于对照组(P<0.05)。研究组的黄褐斑患者治疗前皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平与对照组治疗前相比无显著差异(P>0.05);干预之后两组黄褐斑患者皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平均显著改善(P<0.05),且研究组黄褐斑患者皮损面积、皮损颜色、DLQI评分和血清雌激素、孕激素水平改善情况显著优于对照组(P<0.05)。结论中医调冲消斑汤治疗方式能有效改善黄褐斑患者全身症状改善情况,并进一步改善患者的皮肤病生活质量指数和患者的激素水平,是一种高效的治疗方式。

加用自拟通脉消斑丸治疗湿热瘀阻型颈动脉硬化伴易损斑块疗效观察

目的:探讨加用自拟通脉消斑丸治疗湿热瘀阻型颈动脉硬化伴易损斑块临床效果及安全性。方法:将60例颈动脉硬化伴易损斑块患者按随机数字表法分为对照组30例与治疗组30例。对照组口服阿司匹林、瑞舒伐他汀钙片治疗,治疗组在对照组治疗的基础上应用自拟通脉消斑丸(由金银花20 g、黄柏10 g、麸炒苍术10 g、薏苡仁15 g、土茯苓15 g、黄芪20 g、玄参12 g、当归20 g、水蛭5 g、全蝎5 g、甘草6 g组成)治疗,两组均治疗3个月。比较两组患者治疗前后颈动脉中层内膜厚度、易损斑块面积、中医证候积分及同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平,并观察临床疗效及安全性。结果:与治疗前比较,两组治疗后颈动脉中层内膜厚度明显减少,易损斑块面积明显缩小,中医证候积分明显下降,Hcy、hs-CRP、Lp-PLA2水平显著下降(均P<0.01),且治疗组改善程度优于对照组(P<0.05或P<0.01);治疗组总有效率为76.67%,对照组总有效率为20.00%,两组比较差异有统计学意义(P<0.01)。两组患者治疗期间未见严重不良反应,安全性良好。结论:加用通脉消斑丸治疗颈动脉硬化伴易损斑块临床疗效确切,可显著缩小易损斑块面积,减少中层内膜厚度,同时降低中医证候积分,其机理可能与降低Hcy、hs-CRP、Lp-PLA2水平有关。

消斑方联合氨甲环酸对血管型黄褐斑RCM下皮损变化的影响

目的:观察消斑方联合氨甲环酸口服对血管型黄褐斑的临床疗效及其在反射式共聚焦显微镜(Reflectanceconfocal microscopy,RCM)下的影像学变化。方法:将2021年1月-2022年6月笔者医院收治的60例血管型黄褐斑患者(肝肾阴虚证)随机分为两组,对照组(n=30)予以氨甲环酸片口服;治疗组(n=30)在对照组的基础上予以消斑方治疗。12周后进行临床疗效评定及RCM监测其影像学的变化。结果:治疗12周后,两组疗效总体差异有统计学意义,治疗组疗效优于对照组(P<0.05);RCM监测下,两组患者树突状细胞形态改变,炎症细胞、黑素细胞、血管数量减少,且治疗组改善优于对照组(P<0.05);随访2个月后,对照组复发率为33.33%高于治疗组复发率为7.14%(P<0.05)。结论:使用消斑方联合氨甲环酸治疗血管型黄褐斑的临床疗效优于单纯口服氨甲环酸,且复发率明显降低。运用RCM能很好地评估其临床疗效。

祛瘀消斑胶囊消退动脉粥样硬化的临床研究

目的应用高频超声技术观察祛瘀消斑胶囊对动脉粥样硬化(AS)斑块的消退和稳定作用。方法80例AS患者按完全随机设计分为治疗组和对照组,对照组采用常规西药治疗,治疗组采用常规西药加祛瘀消斑胶囊治疗;治疗前两组超声检测动脉内膜-中层厚度(IMT)和图像平均回声强度的校正值(AI-Ic%),并测定其血脂水平,6个月后复查。结果治疗后治疗组TC及LDL-C较治疗前显著降低(P<0.05);治疗组脂质型斑块AIIc%为68.12±5.54,较治疗前61.43±5.37显著增大,且AIIc%变化率〔(10.9±5.1)%〕与对照组〔(2.5±5.5)%〕比较,差异有显著性(P<0.05)。结论祛瘀消斑胶囊能显著降低血脂水平,延缓AS斑块的进展,增加斑块的稳定性。

祛瘀消斑胶囊对易损斑块的稳定作用

目的应用血管内超声技术观察祛瘀消斑胶囊对易损斑块的稳定作用。方法23只兔给予球囊损伤腹主动脉加高脂饲料喂养,12周末20只造模兔随机分为自然消退组和中药组,每组10只。24周末在腹主动脉斑块处转染携带人野生型p53基因,两周后给予中国斑点蝰蛇毒和组胺触发斑块破裂。于12周末和26周末分别进行血脂和血管内超声检测,并和病理及电镜检测结果对比。结果治疗后中药组实验兔血清总胆固醇和低密度脂蛋白胆固醇均显著低于自然消退组(P<0.05或P<0.01);中药组实验兔血管外弹力膜面积、斑块面积和管腔面积狭窄百分率较造模后显著降低(P<0.05或P<0.01);造模后、自然消退组和中药组实验兔形态学检查有明显差异。结论祛瘀消斑胶囊能明显增加易损斑块的稳定性,血管内超声技术是定性和定量判断斑块易损性的可靠方法。

祛瘀消斑胶囊对高脂血症兔动脉硬化斑块的影响

目的观察祛瘀消斑胶囊对高脂血症兔动脉粥样硬化(AS)斑块发展和脂质沉积的干预效果。方法将45只AS模型兔分为中药组、西药组及对照组,检测血清氧化修饰低密度脂蛋白(ox-LDL)和低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(TC)、甘油三酯(TG)水平及HDL-C/LDL-C,测定斑块内脂质沉积面积。结果用药后兔血清ox-LDL、LDL- C、TC和TG的浓度较用药前显著降低,而HDL-C/LDL-C显著升高(P<0.05或P<0.01);与对照组比较,各项检测指标变化均有显著性意义(P<0.05或P<0.01);镜下观察到中药组和西药组脂质沉积面积显著小于对照组。结论祛瘀消斑胶囊能改善血脂异常,减少斑块脂质沉积,有良好的调脂作用。

肖板及其外围金矿成矿规律与找矿方向

肖板及外围地区是闽中“金三角”，矿点（床）众多。该区有利的成矿、控矿构造条件、麻源群变质岩以及燕山早期岩浆活动是金矿成矿的最重要因素，也是找矿的主要标志。金矿床以与燕山早期岩浆岩有关的岩浆热液型为主，矿化类型以构造蚀变岩型为主。肖板、龙门场、杨梅、徐州、岭头坪、葛坑是有利的找矿远景区，特别是火山拗陷区内的金矿点或小型金矿床集中区，应注意寻找盖层之下基底变质岩系中与肖坂类似的大。

降脂消斑片对兔动脉粥样硬化模型主动脉与冠状动脉粥样硬化斑块的影响

目的观察降脂消斑片对兔动脉粥样硬化(AS)模型主动脉与冠状动脉粥样硬化斑块的影响。方法采用免疫损伤(静脉注射牛血清白蛋白1次,剂量为250 mg/kg)加高脂饲料喂养方法复制兔AS模型。分别给予降脂消斑片高、中、低剂量及阳性对照药物治疗。比较对兔主动脉与冠状动脉粥样硬化斑块的影响。结果降脂消斑片能减轻兔主动脉与冠状动脉粥样硬化斑块及血管内膜脂质浸润程度,差异有统计学意义(P<0.01或P<0.05)。结论降脂消斑片能减轻兔AS模型的主动脉与冠状动脉粥样硬化斑块及血管内膜的脂质浸润程度。

祛瘀消斑胶囊消退动脉粥样硬化的实验研究

目的:应用高频超声显像技术观察动脉粥样硬化(AS)的自然消退及祛瘀消斑胶囊消退 AS 的作用。方法:20只兔喂以高胆固醇饲料,12周末16只造模兔随机分为自然消退组和中药组,每组8只。于实验开始、12周末和24周末分别进行血脂和高频超声检测,并和病理检测结果对比。结果:经过12周造模后,实验兔的血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)显著升高,腹主动脉内中膜厚度(IMT)显著增厚(P<0.05或 P<0.01)。24周末两组实验兔各项血脂指标均显著降低,中药组的 TC、TG 和 LDL-C 显著低于自然消退组(P<0.05或 P<0.01),IMT 显著小于自然消退组(P<0.05),腹主动脉超声图像平均回声强度的校正值(AIIc%)较造模后测量值显著增大(P<0.01)。造模后、自然消退组和中药组形态学检查有明显差异。结论:祛瘀消斑胶囊具有消退实验兔 AS 的作用,高频超声技术可作为定性和定量随访 AS 动态变化的可靠方法。