目的:研究胃癌前病变(Precancerous lesion of gastric cancer,PLGC)虚实关联证患者的癌变趋向及演变规律。方法:多中心临床协作,选择324例PLGC属虚实关联证者进行为期两年的临床跟踪,同步检测血清肿瘤相关物质(tumor supplied group of...目的:研究胃癌前病变(Precancerous lesion of gastric cancer,PLGC)虚实关联证患者的癌变趋向及演变规律。方法:多中心临床协作,选择324例PLGC属虚实关联证者进行为期两年的临床跟踪,同步检测血清肿瘤相关物质(tumor supplied group of factors,TSGF)或癌胚抗原(carcino-embryonic antigen,CEA)。结果:324例PLGC患者7类证型中两年内发生癌变29例,癌变率为9%。癌变率最高的证型依次是:湿热藴胃并/兼脾胃虚寒证16.7%,胃络瘀阻并/兼气阴两虚证13.2%,肝胃气滞并/兼脾胃虚寒证8%。TSGF水平高峰值出现在前两类证型上。癌变患者癌变前半年证候呈虚实多证兼夹态势,其虚证涉气血虚、肾虚占48%。结论:PLGC癌变证候具有虚实兼夹的多态性及虚涉气血虚、肾阴阳虚的特征性。展开更多
BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndrome...BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostridium increased in PXSY patients.The differential functional pathways of the gut microbiome between the PXSY and DCSR groups mainly included lipid metabolism,immunity,and the metabolism of polypeptides.CONCLUSION Our study suggests that the gut microbiota contributes to the distinction between the two TCM syndromes of UC.展开更多
"虚实"是中医学理论体系中的核心概念,是中医典籍论述中的关键术语。世界卫生组织(WHO)《西太平洋地区传统医学名词术语国际标准》将"虚实"译为deficiency and excess,这与全国通用的中医基础理论教材中定义的"..."虚实"是中医学理论体系中的核心概念,是中医典籍论述中的关键术语。世界卫生组织(WHO)《西太平洋地区传统医学名词术语国际标准》将"虚实"译为deficiency and excess,这与全国通用的中医基础理论教材中定义的"虚乃正不足,实乃邪过剩"相吻合。对"虚实"英文译名的标准化有助于中医学在海外的传播,但教条式地照搬标准化译名则会导致僵化甚至歪曲的译文效果。本文以《黄帝内经》中涉及"虚实"的部分英语译文为例证,通过译文对比、分析及所提出的改进译文,指出译例中的翻译得失,并由此提出中医典籍中的"虚实"具有空间、哲学、身体状态、病证、脉象、治法等多层面的含义,其英译文当根据文本语境而定,不能千篇一律、机械式地套用WHO的标准化译文。展开更多
文摘目的:研究胃癌前病变(Precancerous lesion of gastric cancer,PLGC)虚实关联证患者的癌变趋向及演变规律。方法:多中心临床协作,选择324例PLGC属虚实关联证者进行为期两年的临床跟踪,同步检测血清肿瘤相关物质(tumor supplied group of factors,TSGF)或癌胚抗原(carcino-embryonic antigen,CEA)。结果:324例PLGC患者7类证型中两年内发生癌变29例,癌变率为9%。癌变率最高的证型依次是:湿热藴胃并/兼脾胃虚寒证16.7%,胃络瘀阻并/兼气阴两虚证13.2%,肝胃气滞并/兼脾胃虚寒证8%。TSGF水平高峰值出现在前两类证型上。癌变患者癌变前半年证候呈虚实多证兼夹态势,其虚证涉气血虚、肾虚占48%。结论:PLGC癌变证候具有虚实兼夹的多态性及虚涉气血虚、肾阴阳虚的特征性。
基金Supported by the National Natural Science Foundation of China,No.81704009,No.81873253,No.81573892,and No.81770571the Project of Shanghai Municipal Health and Family Planning Commission,No.201640122
文摘BACKGROUND Ulcerative colitis(UC)is considered to be closely associated with alteration of intestinal microorganisms.According to the traditional Chinese medicine(TCM)theory,UC can be divided into two disease syndromes called Pi-Xu-Shi-Yun(PXSY)and Da-Chang-Shi-Re(DCSR).The relationships among gut microbiota,TCM syndromes,and UC pathogenesis have not been well investigated.AIM To investigate the role of gut microbiota in UC and the distinction of microbiota dysbiosis between PXSY and DCSR syndromes.METHODS From May 2015 to February 2016,UC patients presenting to LongHua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study.Fresh stool specimens of UC patients with PXSY or DCSR were collected.The feces of the control group came from the health examination population of Longhua Hospital.The composition of gut bacterial communities in stool samples was determined by the pyrosequencing of 16S ribosomal RNA.The high-throughput sequencing reads were processed with QIIME,and biological functions were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.RESULTS The composition of gut bacterial communities in 93 stool samples(30 healthy controls,32 patients with PXSY syndrome,and 31 patients with DCSR syndrome)was determined by the pyrosequencing of 16S ribosomal RNA.Beta diversity showed that the composition of the microbiota was different among the three groups.At the family level,Porphyromonadaceae,Rikeneliaceae,and Lachnospiraceae significantly decreased while Enterococcus,Streptococcus,and other potential pathogens significantly increased in UC patients compared to healthy subjects.At the genus level,Parabacteroides,Dorea,and Ruminococcus decreased while Faeca-libacterium showed increased abundance in UC compared to healthy controls.Five differential taxa were identified between PXSY and DCSR syndromes.At the genus level,a significantly increased abundance of Streptococcus was observed in DCSR patients,while Lachnoclostridium increased in PXSY patients.The differential functional pathways of the gut microbiome between the PXSY and DCSR groups mainly included lipid metabolism,immunity,and the metabolism of polypeptides.CONCLUSION Our study suggests that the gut microbiota contributes to the distinction between the two TCM syndromes of UC.
文摘"虚实"是中医学理论体系中的核心概念,是中医典籍论述中的关键术语。世界卫生组织(WHO)《西太平洋地区传统医学名词术语国际标准》将"虚实"译为deficiency and excess,这与全国通用的中医基础理论教材中定义的"虚乃正不足,实乃邪过剩"相吻合。对"虚实"英文译名的标准化有助于中医学在海外的传播,但教条式地照搬标准化译名则会导致僵化甚至歪曲的译文效果。本文以《黄帝内经》中涉及"虚实"的部分英语译文为例证,通过译文对比、分析及所提出的改进译文,指出译例中的翻译得失,并由此提出中医典籍中的"虚实"具有空间、哲学、身体状态、病证、脉象、治法等多层面的含义,其英译文当根据文本语境而定,不能千篇一律、机械式地套用WHO的标准化译文。
