Three new lactones,xylanilyticolides A-C(1-3),were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515.Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunctio...Three new lactones,xylanilyticolides A-C(1-3),were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515.Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis.Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60,A-549,SMMC-7721,MCF-7 and SW480 with the IC_(50) values of 3.9,15.2,11.2,5.9,and 4.7 pM,respectively.展开更多
基金supported by National Natural Science Foundation of China(81561148013,21502239)the Key Projects of Technological Innovation of Hubei Province(No.2016ACA138)the Fundamental Research Funds for the Central University,South-Central University for Nationalities(CZZ17006,CZQ17008).
文摘Three new lactones,xylanilyticolides A-C(1-3),were isolated from cultures of the actinomycete Promicromonospora xylanilytica YIM 61515.Their structures were elucidated by 1D and 2D NMR spectroscopic data in conjunction with HRESIMS analysis.Compound 1 exhibited potent cytotoxicities against five human cancer cell lines HL-60,A-549,SMMC-7721,MCF-7 and SW480 with the IC_(50) values of 3.9,15.2,11.2,5.9,and 4.7 pM,respectively.
