Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted...Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted was the multi-centered, randomized, positive parallel controlled method, 448 patients with CHD-AP-XBSS were enrolled and divided into two groups, 336 in the tested group treated with SYI and 112 in the control group treated with Salvia injection by intravenous dripping once a day for 14 days, so as to observe the conditions of angina, electrocardiogram, and therapeutic effect on traditinal Chinese medicine （TCM） symptoms as well as the safety of the treatment. Results： The significantly effective rate and total effective rate in the tested group were 60.06% （194/323） and 91.02 % （294/323） respectively; those in improvement of TOM symptoms were 40. 18% （129/321） and 75.23% （243/323） respectively, which were better than those in the control group （P〈0.01）. Conclusion： SYI Injection is effective and safe in treating OHD-AP-XBSS.展开更多
目的:观察三黄泻心汤联合常规西药治疗脓毒症所致急性肾损伤患者的临床疗效。方法:将81例脓毒症所致肾损伤患者按照随机数字表法分为观察组42例和对照组39例。对照组给予常规西药治疗,观察组在对照组治疗的基础上给予三黄泻心汤加味治...目的:观察三黄泻心汤联合常规西药治疗脓毒症所致急性肾损伤患者的临床疗效。方法:将81例脓毒症所致肾损伤患者按照随机数字表法分为观察组42例和对照组39例。对照组给予常规西药治疗,观察组在对照组治疗的基础上给予三黄泻心汤加味治疗。比较两组患者的临床疗效及治疗前后全身性感染相关性器官功能衰竭评分(sepsis related organ failure assessment,SOFA)、急性生理与慢性健康量表(acute physiology and chronic health evaluation,APACHEⅡ)评分、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-18(interleukin-18,IL-18)、胱抑素C(cystatin C,CYS-C)、中性粒细胞明胶相关脂质运载蛋白(neutrophil gelatinase associated lipocali,NGAL)、尿肾损伤因子-1(kidney injury molecule-1,KIM-1)水平变化情况。结果:两组患者治疗后APACHEⅡ、SOFA评分、TNF-α、IL-18、NGAL、KIM-1及Cys-C水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。观察组有效率为85.71%,对照组有效率为66.67%,两组患者有效率比较,差异具有统计学意义(P<0.05)。结论:三黄泻心汤加味联合常规西药治疗脓毒症所致急性肾损伤,可改善患者肾脏损伤程度,降低炎症因子水平。展开更多
文摘Objective： To evaluate the clinical effect and safety of Safflower Yellow injection （SYI） in treating coronary heart disease angina pectoris （OHD-AP） with Xin-blood stagnation syndrome （XBSS）. Methods： Adopted was the multi-centered, randomized, positive parallel controlled method, 448 patients with CHD-AP-XBSS were enrolled and divided into two groups, 336 in the tested group treated with SYI and 112 in the control group treated with Salvia injection by intravenous dripping once a day for 14 days, so as to observe the conditions of angina, electrocardiogram, and therapeutic effect on traditinal Chinese medicine （TCM） symptoms as well as the safety of the treatment. Results： The significantly effective rate and total effective rate in the tested group were 60.06% （194/323） and 91.02 % （294/323） respectively; those in improvement of TOM symptoms were 40. 18% （129/321） and 75.23% （243/323） respectively, which were better than those in the control group （P〈0.01）. Conclusion： SYI Injection is effective and safe in treating OHD-AP-XBSS.
文摘目的:观察三黄泻心汤联合常规西药治疗脓毒症所致急性肾损伤患者的临床疗效。方法:将81例脓毒症所致肾损伤患者按照随机数字表法分为观察组42例和对照组39例。对照组给予常规西药治疗,观察组在对照组治疗的基础上给予三黄泻心汤加味治疗。比较两组患者的临床疗效及治疗前后全身性感染相关性器官功能衰竭评分(sepsis related organ failure assessment,SOFA)、急性生理与慢性健康量表(acute physiology and chronic health evaluation,APACHEⅡ)评分、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-18(interleukin-18,IL-18)、胱抑素C(cystatin C,CYS-C)、中性粒细胞明胶相关脂质运载蛋白(neutrophil gelatinase associated lipocali,NGAL)、尿肾损伤因子-1(kidney injury molecule-1,KIM-1)水平变化情况。结果:两组患者治疗后APACHEⅡ、SOFA评分、TNF-α、IL-18、NGAL、KIM-1及Cys-C水平低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。观察组有效率为85.71%,对照组有效率为66.67%,两组患者有效率比较,差异具有统计学意义(P<0.05)。结论:三黄泻心汤加味联合常规西药治疗脓毒症所致急性肾损伤,可改善患者肾脏损伤程度,降低炎症因子水平。
