目的探讨Yes关联蛋白1(Yes-associated protein 1,YAP1)在食管鳞状细胞癌组织中的表达情况及临床意义。方法采用免疫组化技术检测439例食管鳞状细胞癌患者癌组织中YAP1的表达,分析YAP1阳性组与阴性组患者的临床病理参数差异。采用Kaplan...目的探讨Yes关联蛋白1(Yes-associated protein 1,YAP1)在食管鳞状细胞癌组织中的表达情况及临床意义。方法采用免疫组化技术检测439例食管鳞状细胞癌患者癌组织中YAP1的表达,分析YAP1阳性组与阴性组患者的临床病理参数差异。采用Kaplan-Meier生存曲线分析YAP1对患者生存的影响。结果食管鳞状细胞癌中,YAP1的阳性率为30.52%(134/439)。YAP1阳性组患者肿瘤浸润更深(P<0.001)。Kaplan-Meier生存曲线分析显示,在生存期长于30个月的患者中,YAP1阳性者无瘤生存期(disease-free survival,DFS)和总生存期(overall survival,OS)更长(P<0.05)。Cox多因素回归分析显示,浸润深度是影响患者DFS(HR=1.371,95%CI 0.993~1.894,P=0.035)和OS(HR=1.489,95%CI 1.066~2.080,P=0.020)的独立因素。结论YAP1在部分食管鳞状细胞癌中表达;对于生存期大于30个月的患者,YAP1表达阳性提示预后更好。展开更多
Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular...Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre- or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.展开更多
文摘Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre- or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.
