The extracts of yew tree have showed unique anti-tumor and anti-leakematic activities. Taxol extracted from it is effective against a variety of cancers, such as ovarian cancer and breast cancer. However the hypoglyce...The extracts of yew tree have showed unique anti-tumor and anti-leakematic activities. Taxol extracted from it is effective against a variety of cancers, such as ovarian cancer and breast cancer. However the hypoglycemic efficacy of the extract has not been reported yet, so the effects of oral administration of yew tree extracts on streptozotocin-induced diabetic rats were examined. Administration of shah tang ping （STP）, a fraction from the column separation of extract （450 mg/kg body weight）, for 14 days reduced the serum glucose concentrations of fasted diabetic rats by 52.4%. In addition, it also decreased the concentrations of triglyceride （TG）, total cholesterol （TC）, and low density lipoprotein cholesterol （LDL-C）. An oral glucose tolerance test （OGTT） was performed, a significant improvement in glucose tolerance was observed in rats treated with STP. These results suggest that STP has hypoglycemic properties and hypolipidemic action on streptozotocin-induced diabetic rats.展开更多
Paclitaxel in southern yew tree was quantitatively determined by high performance liquid chromatography(HPLC) with ODS-C18 column. A mixture of CH3OH-H2O-CH3COOH(volume ratio: 55 : 44: 1) is used as mo-bile phase and ...Paclitaxel in southern yew tree was quantitatively determined by high performance liquid chromatography(HPLC) with ODS-C18 column. A mixture of CH3OH-H2O-CH3COOH(volume ratio: 55 : 44: 1) is used as mo-bile phase and UV detection is carried out at 227 nm, and the column temperature is 20℃. The results show thatthere is a good linear relationship between the area of paclitaxel and the concentration of the sample in the range 50-500 mg/L for paclitaxel. The corresponding regression equation is Y=13 021.7+ 1.01 × 106 X, r=0. 999 0. The av-erage recovery is 95. 3% and the relative standard deviation is 2.08%.展开更多
文摘The extracts of yew tree have showed unique anti-tumor and anti-leakematic activities. Taxol extracted from it is effective against a variety of cancers, such as ovarian cancer and breast cancer. However the hypoglycemic efficacy of the extract has not been reported yet, so the effects of oral administration of yew tree extracts on streptozotocin-induced diabetic rats were examined. Administration of shah tang ping （STP）, a fraction from the column separation of extract （450 mg/kg body weight）, for 14 days reduced the serum glucose concentrations of fasted diabetic rats by 52.4%. In addition, it also decreased the concentrations of triglyceride （TG）, total cholesterol （TC）, and low density lipoprotein cholesterol （LDL-C）. An oral glucose tolerance test （OGTT） was performed, a significant improvement in glucose tolerance was observed in rats treated with STP. These results suggest that STP has hypoglycemic properties and hypolipidemic action on streptozotocin-induced diabetic rats.
基金Project (00KNY1010 ) supported by the Key Program of Science and Technology Office of Hunan Province
文摘Paclitaxel in southern yew tree was quantitatively determined by high performance liquid chromatography(HPLC) with ODS-C18 column. A mixture of CH3OH-H2O-CH3COOH(volume ratio: 55 : 44: 1) is used as mo-bile phase and UV detection is carried out at 227 nm, and the column temperature is 20℃. The results show thatthere is a good linear relationship between the area of paclitaxel and the concentration of the sample in the range 50-500 mg/L for paclitaxel. The corresponding regression equation is Y=13 021.7+ 1.01 × 106 X, r=0. 999 0. The av-erage recovery is 95. 3% and the relative standard deviation is 2.08%.
