The traditional Chinese medicine concepts of "Xinxueyuzuzheng (heart blood stasis obstruction pattern)" and "Qiyinliangxuzheng (qi and yin deficiency pattern)" for myocardial ischemia rat models we...The traditional Chinese medicine concepts of "Xinxueyuzuzheng (heart blood stasis obstruction pattern)" and "Qiyinliangxuzheng (qi and yin deficiency pattern)" for myocardial ischemia rat models were constructed in the present study. Endogenous metabolites in rat plasma were analyzed using the GC/TOF-MS-based metabonomic method. Significant metabolic differences were observed between the control and two model groups, and the three groups were distinguished clearly by pattern recognition. Compared with those of the control, the levels of hydroxyproline, threonic acid, glutamine and citric acid were strikingly up or down-regulated in model rats. The metabolites contributing most to the classification between the two "pattern" rats were identified, such as valine, serine, threonine, ornithine, hydroxyproline, lysine, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, galactofuranose and inositol. These compounds were indicated as the potential biomarkers. The results suggested that the two "patterns" are involved in dysfunction in oxidative stress, energy metabolism and amino acid metabolism. These findings also provided the substantial foundation for exploring the scientific connotation of these two "Zhengxing (pattern types)" of myocardial ischemia, and "Bianzheng (pattern identification)".展开更多
目的:探讨知柏地黄汤联合二甲双胍片对阴虚火旺型2型糖尿病患者血糖的影响。方法:选取2型糖尿病属阴虚火旺型患者100例,采用前瞻性随机单盲对照试验方法,2组各50例,其中单用二甲双胍片的为对照组,剂量随血糖结果调整;治疗组为知柏地黄...目的:探讨知柏地黄汤联合二甲双胍片对阴虚火旺型2型糖尿病患者血糖的影响。方法:选取2型糖尿病属阴虚火旺型患者100例,采用前瞻性随机单盲对照试验方法,2组各50例,其中单用二甲双胍片的为对照组,剂量随血糖结果调整;治疗组为知柏地黄汤联合二甲双胍片治疗。分别于2个月的观察周期前后测定空腹血糖、餐后2 h血糖及糖化血红蛋白。结果:2组均能改善阴虚火旺型2型糖尿病患者的糖代谢情况。血糖疗效评定对照组总有效率为73.91%,治疗组为93.33%,在降糖疗效方面治疗组优于对照组。2组均能有效降低空腹血糖(FBG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(Hb A1c),经统计学处理显示降低FBG、2 h PBG及Hb A1c方面治疗组优于对照组。结论:知柏地黄汤联合二甲双胍片在改善阴虚火旺型2型糖尿病患者糖代谢方面有显著疗效。展开更多
基金Supported by the National Natural Science Foundation of China (Grant Nos 30630076 and 30572228)the National 11th 5 Year Technology Support Program (Grant No 2006BAI08B04-05)
文摘The traditional Chinese medicine concepts of "Xinxueyuzuzheng (heart blood stasis obstruction pattern)" and "Qiyinliangxuzheng (qi and yin deficiency pattern)" for myocardial ischemia rat models were constructed in the present study. Endogenous metabolites in rat plasma were analyzed using the GC/TOF-MS-based metabonomic method. Significant metabolic differences were observed between the control and two model groups, and the three groups were distinguished clearly by pattern recognition. Compared with those of the control, the levels of hydroxyproline, threonic acid, glutamine and citric acid were strikingly up or down-regulated in model rats. The metabolites contributing most to the classification between the two "pattern" rats were identified, such as valine, serine, threonine, ornithine, hydroxyproline, lysine, 2-hydroxybutanoic acid, 3-hydroxybutanoic acid, galactofuranose and inositol. These compounds were indicated as the potential biomarkers. The results suggested that the two "patterns" are involved in dysfunction in oxidative stress, energy metabolism and amino acid metabolism. These findings also provided the substantial foundation for exploring the scientific connotation of these two "Zhengxing (pattern types)" of myocardial ischemia, and "Bianzheng (pattern identification)".
文摘目的:探讨知柏地黄汤联合二甲双胍片对阴虚火旺型2型糖尿病患者血糖的影响。方法:选取2型糖尿病属阴虚火旺型患者100例,采用前瞻性随机单盲对照试验方法,2组各50例,其中单用二甲双胍片的为对照组,剂量随血糖结果调整;治疗组为知柏地黄汤联合二甲双胍片治疗。分别于2个月的观察周期前后测定空腹血糖、餐后2 h血糖及糖化血红蛋白。结果:2组均能改善阴虚火旺型2型糖尿病患者的糖代谢情况。血糖疗效评定对照组总有效率为73.91%,治疗组为93.33%,在降糖疗效方面治疗组优于对照组。2组均能有效降低空腹血糖(FBG)、餐后2 h血糖(2 h PBG)及糖化血红蛋白(Hb A1c),经统计学处理显示降低FBG、2 h PBG及Hb A1c方面治疗组优于对照组。结论:知柏地黄汤联合二甲双胍片在改善阴虚火旺型2型糖尿病患者糖代谢方面有显著疗效。
