Introduction: Breast cancer is the most common cancer in women worldwide, with an increasing incidence. Although it is rare and no much studied in young women, it represents 7% of cases worldwide and often appears mor...Introduction: Breast cancer is the most common cancer in women worldwide, with an increasing incidence. Although it is rare and no much studied in young women, it represents 7% of cases worldwide and often appears more aggressive with a poor prognosis compared to its counterpart in older women. The main objective of our study was to describe the histological and phenotypic aspects of breast cancer in women of age under 40. Methodology: We conducted a descriptive and analytical cross-sectional study, with retrospective collection of data over a period of 05 years. All women diagnosed with breast cancer were included and divided into 2 study groups: under 40 years old and over 40 years old. Data were analyzed using SPSS version 23.0 software, compared using the Chi square or Fisher exact test. A p value Results: We retained 196 files, either 89 for those under 40 and 107 for those over 40. Young patients with breast cancer had a higher stage, grade and tumor size. Lymph node involvement was more observed in women under 40 years (69.6% vs 53.2%). Older women were more likely to be hormone receptor positive (54.2% vs 38.2%);p = 0.018. HER-2 overexpression was higher in women younger than 40 years (39.32% vs 25.23%);p = 0.080 with a high Ki67 proliferation index (30.3% versus 2.8%);p 0.001. Triple-negative and Her-2 tumors were much more frequent in young women (48.3% vs. 36.4%;p = 0.063) and (17.97% vs. 10.3%;p = 0.125). Conclusion: Breast cancer in young women remains more aggressive and is dominated by triple negative and Her-2 phenotypes.展开更多
Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most...Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most common malignancy among younger patients. Advancement in the treatment and earlier detection gives excellent 5 years of survival. However, the standard treatment that comprises surgical-chemo radiation therapy or hormonal treatment often results in an increased incidence of treatment-induced infertility. Therefore, adding fertility preservation to primary cancer treatment may offer the best opportunity for future fertility. However, despite advancements in Assisted Reproductive Technology (ART), the uptake of fertility services in this group remains low. In this review, we highlighted the effect of all breast cancer treatments on women’s fertility, the effectiveness and safety of ART in breast cancer patients as well as the safety of pregnancy in breast cancer survivors. Our aim is to improve awareness of fertility preservation for breast cancer to ensure all women diagnosed with breast cancer have multidisciplinary approaches with early referral to fertility specialists to discuss regarding potential risks and benefits of fertility preservation to improve the uptake of fertility preservation among this group of patients.展开更多
Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Ma...Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Materials and Methods:We reviewed the records of 406 breast cancer patients≤35 years old from 2008 to 2017 in southwest China,investigating their biological characteristics and prognosis.Results:In southwest China,8.77%of breast cancer patients were young women.Although the number of breast cancer cases increased over time,the proportion of young women declined.Patients in stages III and IV accounted for 32%of cases.Young women with breast cancer often experienced local and regional recurrence and had a poor prognosis(5-year disease-free survival rate of 54.9%and 5-year overall survival rate of 71.3%).T and N stages were significantly related to disease-free survival and overall survival.Hormone receptor status was associated with overall survival.Conclusions:In southwest China,young women with breast cancer tend to present with late-stage clinical features,and the prognosis remains poor.展开更多
Objectives: To explore attitudes to cervical cancer screening and sexual behaviour among human papillomavirus (HPV)-vaccinated young women in southern Sweden. Methods: Sixteen women aged 17-26 years who had received t...Objectives: To explore attitudes to cervical cancer screening and sexual behaviour among human papillomavirus (HPV)-vaccinated young women in southern Sweden. Methods: Sixteen women aged 17-26 years who had received the HPV vaccine were submitted to an individual semi-structured interview. Interviews were recorded and transcribed verbatim. The data were analysed qualitatively by means of latent content analysis. Results: The interviewees had a poor understanding of cervical cancer screening. After it was explained to them, they stated that they were willing to participate in the screening. The young women thought their future sexual behaviour would not be affected by the vaccination. They considered themselves to be more aware of it and less likely to engage in risky behaviour than their peers. They knew little about the relation among HPV, sexual transmission and cervical cancer, and they expressed a desire for more information. Conclusions: These young women who recently had been administered HPV vaccine had a limited understanding of the importance of participating in future cervical cancer screening. It is necessary that more and more appropriate information of cervical cancer screening be given on the occasion of the HPV vaccination.展开更多
Objective: To describe the epidemiological, clinical and therapeutic characteristics of women under 40 years followed for breast cancer. Method: This is a retrospective and cohort study with descriptive purpose conduc...Objective: To describe the epidemiological, clinical and therapeutic characteristics of women under 40 years followed for breast cancer. Method: This is a retrospective and cohort study with descriptive purpose conducted over 10 years on the management of breast cancer in 105 patients under 40 years in the Gynecology Service of the University and Hospital Center of Treichville. Results: The incidence of breast cancer in women under 40 years was 8.4%, and the majority of patients were over 35 years old (64.8%) and had a low socioeconomic level (61.7%). Some patients had classic risk factors for breast cancer: menarche before 12 years (48.6%), nulliparity (20%), family history of breast cancer (1.9%). The discovery of a breast abnormality was made by patients in 97.1% of the cases. Cancers were either isolated (92.4%) or associated with pregnancy (5.7%) or bilateral (1.9%). The majority of cancers were infiltrating ductal carcinomas (86.7%), of SBR II grade (69%). Patients generally benefited from a mastectomy with axillary dissection, framed by chemotherapy. The global survival at 10 years was 5%. Conclusion: This study allowed us to confirm that breast cancers in younger women were a reality in our country and posed us enormous difficulties in their management.展开更多
Background:Differentiated thyroid cancer(DTC)is commonly diagnosed in women of child-bearing age,but whether pregnancy influences the prognosis of DTC remains controversial.This study aimed to summarize existing evide...Background:Differentiated thyroid cancer(DTC)is commonly diagnosed in women of child-bearing age,but whether pregnancy influences the prognosis of DTC remains controversial.This study aimed to summarize existing evidence regarding the association of pregnancy with recurrence risk in patients previously treated for DTC.Methods:We searched PubMed,Embase,Web of Science,Cochrane,and Scopus based on the prespecified protocol registered at PROSPERO(CRD42022367896).After study selection,two researchers independently extracted data from the included studies.For quantitative data synthesis,we used random-effects meta-analysis models to pool the proportion of recurrence(for pregnant women only)and odds ratio(OR;comparing the risk of recurrence between the pregnancy group and the nonpregnancy group),respectively.Then we conducted subgroup analyses to explore whether risk of recurrence differed by response to therapy status or duration of follow-up time.We also assessed quality of the included studies.Results:A total of ten studies were included.The sample size ranged from 8 to 235,with participants’age at pregnancy or delivery ranging from 28 to 35 years.The follow-up time varied from 0.1 to 36.0 years.The pooled proportion of recurrence in all pregnant patients was 0.13(95%confidence intervals[CI]:0.06-0.25;I^(2):0.58).Among six included studies reporting response to therapy status before pregnancy,we observed a trend for increasingly higher risk of recurrence from excellent,indeterminate,and biochemically incomplete to structurally incomplete response to therapy(P trend<0.05).The pooled risk of recurrence in the pregnancy group showed no evidence of a significant difference from that in the nonpregnancy group(OR:0.75;95%CI:0.45-1.23;I^(2):0).The difference in follow-up time(below/above five years)was not associated with either the proportion of recurrence in all pregnant patients(P>0.05)or the OR of recurrence in studies with a comparison group(P>0.05).Two included studies that focused on patients with distant metastasis also did not show a significant difference in disease recurrence between pregnancy and nonpregnancy groups(OR:0.51[95%CI:0.14-1.87;I^(2):59%]).Conclusion:In general,pregnancy appears to have a minimal association with the disease recurrence of DTC with initial treatment.Clinicians should pay more attention to progression of DTC among pregnant women with biochemical and/or structural persistence.Registration:PROSPERO,https://www.crd.york.ac.uk/PROSPERO/;No.CRD42022367896.展开更多
OBJECTIVE To explore molecular markers for cervical cancer in female patients below thirty-five years of age, so that the markers may be used to formulate a prognosis and to provide some useful targets for improving t...OBJECTIVE To explore molecular markers for cervical cancer in female patients below thirty-five years of age, so that the markers may be used to formulate a prognosis and to provide some useful targets for improving therapy. METHODS Pathological data were collected from 64 cervical cancer patients under the age of 35 from June, 1995 to June, 2000 in our institution. The data were retrospectively analyzed as a study group, and compared to data obtained from 90 cervical cancer cases over the age of 35 as controls who underwent treatment during the same time period. Immuno-histochemical and quantified image analyses were conducted to look for differences between the two groups in expression of survivin, p27, CD44v6, MMP-2 and TIMP-2. RESULTS The overall 5-year survival rate (65.6%) of the study group was significantly lower (P<0.05) compared to the control group (84.4%). The expression of survivin, MMP -2 and CD44v6 was much higher in the younger study group compared to the older control group, but TIMP-2 displayed higher expression in the control group (P<0.05). There was no significant difference in p27 expression between the two groups (P>0.05). CONCLUSION Young women patients with cervical cancer have a poorer prognosis compared to old women. Our study reveals that survivin, MMP-2, TIMP-2 and CD44v6 expression have a correlation with shorter 5-year survival. Improvement in the prognosis for young cervical cancer patients can be expected using biomedical therapy which targets these molecular markers.展开更多
We aimed to investigate risk factors of local and distant recurrence in small-sized, node negative breast cancer in women 〈35 years in a Chinese cohort. Between January 1994 and January 2007, 107 patients with pathol...We aimed to investigate risk factors of local and distant recurrence in small-sized, node negative breast cancer in women 〈35 years in a Chinese cohort. Between January 1994 and January 2007, 107 patients with pathologically confirmed small-sized （E1 cm）, node negative breast cancer who did not receive neoadjuvant or adjuvant chemotherapy were included. The 5-year recurrence-free survival （RFS） was estimated according to different prognostic variables. With a median time of 60 months （range, 8-60 months） follow-up, local and distant recurrence were observed in 25 cases （23.4%）. By univariate analysis, HER-2 positivity, triple negative （TN）, and high Ki-67 index （~14%） were risk factors of a lower RFS （hazard ratio （HR） 6.680, 95% confidence interval （CI） 2.350-18.985, P〈0.0001 for HER-2 positive; HR 4.769, 95%CI 1.559-14.591, P=0.006 for TN; HR 6.030, 95%CI 2.659-13.674, P〈0.0001 for high Ki-67 index）. Patients with grade 3 tumors had a lower RFS （HR 2.922, 95%CI 1.096-7.791, P=0.032） compared with those with grade 1 or grade 2 tumors. By multivariate analysis, HER-2 positivity （HR 10.204, 95%CI 3.391-30.704, P〈0.0001）, TN （HR 10.521, 95% CI 3.152-35.113, P〈0.0001） and high Ki-67 index （HR 10.820, 95%CI 4.338-27.002, P〈0.0001） remained risk factors of RFS. In this cohort, HER-2 positivity, triple neg- ative and high Ki-67 index were independent risk factors of RFS in young patients with Tla,bN0 breast cancer. Subsequent pregnancy did not affect RFS.展开更多
For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative treatment.Progestin based therapy with ...For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative treatment.Progestin based therapy with regular assessment of treatment efficacy can achieve a promising outcome.After complete remission patients are suggested with assisted reproductive technology or maintenance therapy depending on their immediate pregnancy plan.Hysterectomy is recommended for patients who have finished reproduction while re-treatment for recurrent cases should be carefully informed.展开更多
文摘Introduction: Breast cancer is the most common cancer in women worldwide, with an increasing incidence. Although it is rare and no much studied in young women, it represents 7% of cases worldwide and often appears more aggressive with a poor prognosis compared to its counterpart in older women. The main objective of our study was to describe the histological and phenotypic aspects of breast cancer in women of age under 40. Methodology: We conducted a descriptive and analytical cross-sectional study, with retrospective collection of data over a period of 05 years. All women diagnosed with breast cancer were included and divided into 2 study groups: under 40 years old and over 40 years old. Data were analyzed using SPSS version 23.0 software, compared using the Chi square or Fisher exact test. A p value Results: We retained 196 files, either 89 for those under 40 and 107 for those over 40. Young patients with breast cancer had a higher stage, grade and tumor size. Lymph node involvement was more observed in women under 40 years (69.6% vs 53.2%). Older women were more likely to be hormone receptor positive (54.2% vs 38.2%);p = 0.018. HER-2 overexpression was higher in women younger than 40 years (39.32% vs 25.23%);p = 0.080 with a high Ki67 proliferation index (30.3% versus 2.8%);p 0.001. Triple-negative and Her-2 tumors were much more frequent in young women (48.3% vs. 36.4%;p = 0.063) and (17.97% vs. 10.3%;p = 0.125). Conclusion: Breast cancer in young women remains more aggressive and is dominated by triple negative and Her-2 phenotypes.
文摘Breast cancer is the most common cancer in women worldwide, constituting 25% of all cancer diagnoses. Even though it is only affecting 4% - 6% of women under the age of 40, it remains the most common malignancy among younger patients. Advancement in the treatment and earlier detection gives excellent 5 years of survival. However, the standard treatment that comprises surgical-chemo radiation therapy or hormonal treatment often results in an increased incidence of treatment-induced infertility. Therefore, adding fertility preservation to primary cancer treatment may offer the best opportunity for future fertility. However, despite advancements in Assisted Reproductive Technology (ART), the uptake of fertility services in this group remains low. In this review, we highlighted the effect of all breast cancer treatments on women’s fertility, the effectiveness and safety of ART in breast cancer patients as well as the safety of pregnancy in breast cancer survivors. Our aim is to improve awareness of fertility preservation for breast cancer to ensure all women diagnosed with breast cancer have multidisciplinary approaches with early referral to fertility specialists to discuss regarding potential risks and benefits of fertility preservation to improve the uptake of fertility preservation among this group of patients.
文摘Background:Breast cancer is more common among young women in China than in developed countries.This study analyzes the clinicopathological features and prognosis of young women with breast cancer in southwest China.Materials and Methods:We reviewed the records of 406 breast cancer patients≤35 years old from 2008 to 2017 in southwest China,investigating their biological characteristics and prognosis.Results:In southwest China,8.77%of breast cancer patients were young women.Although the number of breast cancer cases increased over time,the proportion of young women declined.Patients in stages III and IV accounted for 32%of cases.Young women with breast cancer often experienced local and regional recurrence and had a poor prognosis(5-year disease-free survival rate of 54.9%and 5-year overall survival rate of 71.3%).T and N stages were significantly related to disease-free survival and overall survival.Hormone receptor status was associated with overall survival.Conclusions:In southwest China,young women with breast cancer tend to present with late-stage clinical features,and the prognosis remains poor.
文摘Objectives: To explore attitudes to cervical cancer screening and sexual behaviour among human papillomavirus (HPV)-vaccinated young women in southern Sweden. Methods: Sixteen women aged 17-26 years who had received the HPV vaccine were submitted to an individual semi-structured interview. Interviews were recorded and transcribed verbatim. The data were analysed qualitatively by means of latent content analysis. Results: The interviewees had a poor understanding of cervical cancer screening. After it was explained to them, they stated that they were willing to participate in the screening. The young women thought their future sexual behaviour would not be affected by the vaccination. They considered themselves to be more aware of it and less likely to engage in risky behaviour than their peers. They knew little about the relation among HPV, sexual transmission and cervical cancer, and they expressed a desire for more information. Conclusions: These young women who recently had been administered HPV vaccine had a limited understanding of the importance of participating in future cervical cancer screening. It is necessary that more and more appropriate information of cervical cancer screening be given on the occasion of the HPV vaccination.
文摘Objective: To describe the epidemiological, clinical and therapeutic characteristics of women under 40 years followed for breast cancer. Method: This is a retrospective and cohort study with descriptive purpose conducted over 10 years on the management of breast cancer in 105 patients under 40 years in the Gynecology Service of the University and Hospital Center of Treichville. Results: The incidence of breast cancer in women under 40 years was 8.4%, and the majority of patients were over 35 years old (64.8%) and had a low socioeconomic level (61.7%). Some patients had classic risk factors for breast cancer: menarche before 12 years (48.6%), nulliparity (20%), family history of breast cancer (1.9%). The discovery of a breast abnormality was made by patients in 97.1% of the cases. Cancers were either isolated (92.4%) or associated with pregnancy (5.7%) or bilateral (1.9%). The majority of cancers were infiltrating ductal carcinomas (86.7%), of SBR II grade (69%). Patients generally benefited from a mastectomy with axillary dissection, framed by chemotherapy. The global survival at 10 years was 5%. Conclusion: This study allowed us to confirm that breast cancers in younger women were a reality in our country and posed us enormous difficulties in their management.
基金funded by National Natural Science Foundation of China(No.82373694)Young Elite Scientists Sponsorship Program by CAST(No.2023QNRC001)+1 种基金the Beijing Ofce for Education Sciences Planning(No.BECA23111)the Fundamental Research Funds for the Central Universities(No.BMU2021YJ030).
文摘Background:Differentiated thyroid cancer(DTC)is commonly diagnosed in women of child-bearing age,but whether pregnancy influences the prognosis of DTC remains controversial.This study aimed to summarize existing evidence regarding the association of pregnancy with recurrence risk in patients previously treated for DTC.Methods:We searched PubMed,Embase,Web of Science,Cochrane,and Scopus based on the prespecified protocol registered at PROSPERO(CRD42022367896).After study selection,two researchers independently extracted data from the included studies.For quantitative data synthesis,we used random-effects meta-analysis models to pool the proportion of recurrence(for pregnant women only)and odds ratio(OR;comparing the risk of recurrence between the pregnancy group and the nonpregnancy group),respectively.Then we conducted subgroup analyses to explore whether risk of recurrence differed by response to therapy status or duration of follow-up time.We also assessed quality of the included studies.Results:A total of ten studies were included.The sample size ranged from 8 to 235,with participants’age at pregnancy or delivery ranging from 28 to 35 years.The follow-up time varied from 0.1 to 36.0 years.The pooled proportion of recurrence in all pregnant patients was 0.13(95%confidence intervals[CI]:0.06-0.25;I^(2):0.58).Among six included studies reporting response to therapy status before pregnancy,we observed a trend for increasingly higher risk of recurrence from excellent,indeterminate,and biochemically incomplete to structurally incomplete response to therapy(P trend<0.05).The pooled risk of recurrence in the pregnancy group showed no evidence of a significant difference from that in the nonpregnancy group(OR:0.75;95%CI:0.45-1.23;I^(2):0).The difference in follow-up time(below/above five years)was not associated with either the proportion of recurrence in all pregnant patients(P>0.05)or the OR of recurrence in studies with a comparison group(P>0.05).Two included studies that focused on patients with distant metastasis also did not show a significant difference in disease recurrence between pregnancy and nonpregnancy groups(OR:0.51[95%CI:0.14-1.87;I^(2):59%]).Conclusion:In general,pregnancy appears to have a minimal association with the disease recurrence of DTC with initial treatment.Clinicians should pay more attention to progression of DTC among pregnant women with biochemical and/or structural persistence.Registration:PROSPERO,https://www.crd.york.ac.uk/PROSPERO/;No.CRD42022367896.
文摘OBJECTIVE To explore molecular markers for cervical cancer in female patients below thirty-five years of age, so that the markers may be used to formulate a prognosis and to provide some useful targets for improving therapy. METHODS Pathological data were collected from 64 cervical cancer patients under the age of 35 from June, 1995 to June, 2000 in our institution. The data were retrospectively analyzed as a study group, and compared to data obtained from 90 cervical cancer cases over the age of 35 as controls who underwent treatment during the same time period. Immuno-histochemical and quantified image analyses were conducted to look for differences between the two groups in expression of survivin, p27, CD44v6, MMP-2 and TIMP-2. RESULTS The overall 5-year survival rate (65.6%) of the study group was significantly lower (P<0.05) compared to the control group (84.4%). The expression of survivin, MMP -2 and CD44v6 was much higher in the younger study group compared to the older control group, but TIMP-2 displayed higher expression in the control group (P<0.05). There was no significant difference in p27 expression between the two groups (P>0.05). CONCLUSION Young women patients with cervical cancer have a poorer prognosis compared to old women. Our study reveals that survivin, MMP-2, TIMP-2 and CD44v6 expression have a correlation with shorter 5-year survival. Improvement in the prognosis for young cervical cancer patients can be expected using biomedical therapy which targets these molecular markers.
文摘We aimed to investigate risk factors of local and distant recurrence in small-sized, node negative breast cancer in women 〈35 years in a Chinese cohort. Between January 1994 and January 2007, 107 patients with pathologically confirmed small-sized （E1 cm）, node negative breast cancer who did not receive neoadjuvant or adjuvant chemotherapy were included. The 5-year recurrence-free survival （RFS） was estimated according to different prognostic variables. With a median time of 60 months （range, 8-60 months） follow-up, local and distant recurrence were observed in 25 cases （23.4%）. By univariate analysis, HER-2 positivity, triple negative （TN）, and high Ki-67 index （~14%） were risk factors of a lower RFS （hazard ratio （HR） 6.680, 95% confidence interval （CI） 2.350-18.985, P〈0.0001 for HER-2 positive; HR 4.769, 95%CI 1.559-14.591, P=0.006 for TN; HR 6.030, 95%CI 2.659-13.674, P〈0.0001 for high Ki-67 index）. Patients with grade 3 tumors had a lower RFS （HR 2.922, 95%CI 1.096-7.791, P=0.032） compared with those with grade 1 or grade 2 tumors. By multivariate analysis, HER-2 positivity （HR 10.204, 95%CI 3.391-30.704, P〈0.0001）, TN （HR 10.521, 95% CI 3.152-35.113, P〈0.0001） and high Ki-67 index （HR 10.820, 95%CI 4.338-27.002, P〈0.0001） remained risk factors of RFS. In this cohort, HER-2 positivity, triple neg- ative and high Ki-67 index were independent risk factors of RFS in young patients with Tla,bN0 breast cancer. Subsequent pregnancy did not affect RFS.
基金supported by the National Key R&D Program of China(No.2019YFC1005200 and 2019YFC1005204)National Key Technology R&D Program(No.2015BAI13B06).
文摘For young women with early stage well differentiated endometrial cancer who have fertility desire,it is import to give comprehensive assessment before initiation of conservative treatment.Progestin based therapy with regular assessment of treatment efficacy can achieve a promising outcome.After complete remission patients are suggested with assisted reproductive technology or maintenance therapy depending on their immediate pregnancy plan.Hysterectomy is recommended for patients who have finished reproduction while re-treatment for recurrent cases should be carefully informed.
