Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In thi...Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In this research, t he embolization results and pathological reactions after embolization of canine aneurysmal models with EDC or CAP were observed and compared. Methods. The canine aneurysmal models constructed by anastomosis of venous pouch es were randomly grouped. The aneurysms were respectively occluded with CAP and electrolytic detachable coils that was named by Wu electrolytic detachable coil (WEDC) and made by us. Angiogram follow ups were performed at 24 hour, 2 week , and 2 month after embolization. The occluded aneurysms were dissected in each stage for light microscopic, electron microscopic, and histochemical research. Results. The effect of embolization was significantly better with WEDC than that with CAP . Post embolized complications such as aneurysm rupture and stenosis of parent arteries could only be found in CAP group. Pathol ogical research showed that CAP mass could packed the aneurysms more densely tha n coils. Acute chemical damage of aneurysmal wall and inflammatory cell infiltra tion was prominently found in early stage after CAP embolization. Organization of thrombus inside aneurysms and formation of endothelial tissue over the orific es of aneurysmal necks could be found in both groups 2 months after embolization . But parts of coils might be exposed outside endothelial layer. Conclusions. EDC are still the most safe, efficient, and reliable instruments to embolize aneurysm. CAP should be improved further to solve the problem of stron g chemical corrosion and difficulty in control before it is widely used.展开更多
目的探讨溶栓结合抗凝治疗次大面积肺栓塞的疗效及对凝血及纤溶系统的影响。方法选择我院2012年2月至2013年12月收治的75例次大面积肺栓塞患者为研究对象,按入院先后顺序随机分为实验组(n=38)、对照组(n=37),对照组患者给予单纯抗凝治疗...目的探讨溶栓结合抗凝治疗次大面积肺栓塞的疗效及对凝血及纤溶系统的影响。方法选择我院2012年2月至2013年12月收治的75例次大面积肺栓塞患者为研究对象,按入院先后顺序随机分为实验组(n=38)、对照组(n=37),对照组患者给予单纯抗凝治疗,观察组患者则行溶栓联合序贯抗凝治疗,对两组临床疗效、治疗前后血液凝血及纤溶系统变化进行比较。结果观察组治疗总有效率97.37%,明显高于对照组的78.38%,差异显著(P<0.05)。两组治疗后PAI-1活性[(7.2±1.1)AU·m L VS(8.7±1.2)AU·m L]、tPA活性[(1.2±0.2)IU·m L VS(1.5±0.1)IU·m L]、D-D含量[(0.35±0.05)mg·L VS(0.55±0.08)mg·L]及PLT[(256.9±72.8)×109VS(212.6±62.4)×109]比较差异显著(P<0.05)。结论溶栓结合抗凝治疗次大面积肺栓塞疗效明确,能有效改善患者凝血及纤溶系统功能。展开更多
文摘Electrolytic detachable coils (EDC) have been the main embolic materi als for intracranial aneurysms. Liquid aneurysmal embolic materials represented by cellulose acetate polymer (CAP) are still in controversy. In this research, t he embolization results and pathological reactions after embolization of canine aneurysmal models with EDC or CAP were observed and compared. Methods. The canine aneurysmal models constructed by anastomosis of venous pouch es were randomly grouped. The aneurysms were respectively occluded with CAP and electrolytic detachable coils that was named by Wu electrolytic detachable coil (WEDC) and made by us. Angiogram follow ups were performed at 24 hour, 2 week , and 2 month after embolization. The occluded aneurysms were dissected in each stage for light microscopic, electron microscopic, and histochemical research. Results. The effect of embolization was significantly better with WEDC than that with CAP . Post embolized complications such as aneurysm rupture and stenosis of parent arteries could only be found in CAP group. Pathol ogical research showed that CAP mass could packed the aneurysms more densely tha n coils. Acute chemical damage of aneurysmal wall and inflammatory cell infiltra tion was prominently found in early stage after CAP embolization. Organization of thrombus inside aneurysms and formation of endothelial tissue over the orific es of aneurysmal necks could be found in both groups 2 months after embolization . But parts of coils might be exposed outside endothelial layer. Conclusions. EDC are still the most safe, efficient, and reliable instruments to embolize aneurysm. CAP should be improved further to solve the problem of stron g chemical corrosion and difficulty in control before it is widely used.
文摘目的探讨溶栓结合抗凝治疗次大面积肺栓塞的疗效及对凝血及纤溶系统的影响。方法选择我院2012年2月至2013年12月收治的75例次大面积肺栓塞患者为研究对象,按入院先后顺序随机分为实验组(n=38)、对照组(n=37),对照组患者给予单纯抗凝治疗,观察组患者则行溶栓联合序贯抗凝治疗,对两组临床疗效、治疗前后血液凝血及纤溶系统变化进行比较。结果观察组治疗总有效率97.37%,明显高于对照组的78.38%,差异显著(P<0.05)。两组治疗后PAI-1活性[(7.2±1.1)AU·m L VS(8.7±1.2)AU·m L]、tPA活性[(1.2±0.2)IU·m L VS(1.5±0.1)IU·m L]、D-D含量[(0.35±0.05)mg·L VS(0.55±0.08)mg·L]及PLT[(256.9±72.8)×109VS(212.6±62.4)×109]比较差异显著(P<0.05)。结论溶栓结合抗凝治疗次大面积肺栓塞疗效明确,能有效改善患者凝血及纤溶系统功能。
