Zinc alpha 2 glycoprotein(ZAG)is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum,saliva,sweat,breast milk,and urine.It is also found in tissues like the testis,epididymis,kidney,s...Zinc alpha 2 glycoprotein(ZAG)is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum,saliva,sweat,breast milk,and urine.It is also found in tissues like the testis,epididymis,kidney,spleen,liver,lungs,heart,and brain.ZAG is an adipokine with multiple roles,including lipid mobilization,modulating glucose metabolisms,improving insulin sensitivity,inhibiting tumor proliferation through RNAse activity,and suppressing inflammation.Low levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential biomarkers for diabetic nephropathy.Interestingly zinc has been found to regulate the binding of ZAG to fatty acids.Based on very few reports on the vitreous ZAG and based on its known functions,we speculate that ZAG has a potential role in diabetic retinopathy.In this article,we discuss the structural component of the protein,its secretion from various tissues,and its distribution in multiple tissues in normal and disease conditions,especially in diabetes and its complications.展开更多
基于zig-zag板壳假设和哈密顿原理建立了压电阻尼层合结构的机电耦合动力学有限元模型,实现了结构自然频率和损耗系数的准确计算。有限元模型采用八节点的七自由度(degrees of freedom,DOFs)四边形单元,且考虑阻尼层的复弹性模量。通过...基于zig-zag板壳假设和哈密顿原理建立了压电阻尼层合结构的机电耦合动力学有限元模型,实现了结构自然频率和损耗系数的准确计算。有限元模型采用八节点的七自由度(degrees of freedom,DOFs)四边形单元,且考虑阻尼层的复弹性模量。通过对文献算例的计算与仿真,验证建立的有限元模型的正确性。研究了材料增强角度、阻尼层厚度和结构曲率对压电阻尼层合结构频率和损耗系数的影响,为压电阻尼层合结构的减振及结构优化提供参考。展开更多
基金the Indian Council of Medical Research(ICMR—(5/4/6/1/OPH/2020-NCD-II)).
文摘Zinc alpha 2 glycoprotein(ZAG)is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum,saliva,sweat,breast milk,and urine.It is also found in tissues like the testis,epididymis,kidney,spleen,liver,lungs,heart,and brain.ZAG is an adipokine with multiple roles,including lipid mobilization,modulating glucose metabolisms,improving insulin sensitivity,inhibiting tumor proliferation through RNAse activity,and suppressing inflammation.Low levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential biomarkers for diabetic nephropathy.Interestingly zinc has been found to regulate the binding of ZAG to fatty acids.Based on very few reports on the vitreous ZAG and based on its known functions,we speculate that ZAG has a potential role in diabetic retinopathy.In this article,we discuss the structural component of the protein,its secretion from various tissues,and its distribution in multiple tissues in normal and disease conditions,especially in diabetes and its complications.
文摘基于zig-zag板壳假设和哈密顿原理建立了压电阻尼层合结构的机电耦合动力学有限元模型,实现了结构自然频率和损耗系数的准确计算。有限元模型采用八节点的七自由度(degrees of freedom,DOFs)四边形单元,且考虑阻尼层的复弹性模量。通过对文献算例的计算与仿真,验证建立的有限元模型的正确性。研究了材料增强角度、阻尼层厚度和结构曲率对压电阻尼层合结构频率和损耗系数的影响,为压电阻尼层合结构的减振及结构优化提供参考。
