Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one...Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. Methods： We have commenced a randomized phase III trial in December 2016 to evaluate S-I plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer. A total of 564 patients will be accrued from 13 Chinese institutions in two years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are 5-year overall survival, proportion of patients who complete the postoperative chemotherapy and incidence of adverse events. Ethic and dissemination： The trial has been approved by the institutional review board of each participating institution and it was activated on December, 2016. The enrollment will be finished in December, 2018. Patient＇s follow-up will be ended until December, 2023. Trial registration： ClinicalTrials.gov, identifier： NCT02867839. Registered on August 4, 2016.展开更多
As a third generation light source, Shanghai Synchrotron Radiation Facility (SSRF) has up to 140 beam position monitors (BPM) installed to monitor the beam dynamics on its storage ring. Once the operation mode is chos...As a third generation light source, Shanghai Synchrotron Radiation Facility (SSRF) has up to 140 beam position monitors (BPM) installed to monitor the beam dynamics on its storage ring. Once the operation mode is chosen, the betatron functions are determined. Since the sinusoidal betatron oscillation is the dominant component of the transverse motion, these BPMs can be used to measure the motion to get the betatron functions. Three methods are compared to calculate the phase advance among the BPMs in this paper, aiming to find one or more feasible ways to check the beam optics in SSRF. Some experiments have also been made to verify the practicality of the phase information.展开更多
Oscillatory behaviors can be ubiquitously observed in various systems. Biological rhythms are significant in governing living activities of all units. The emergence of biological rhythms is the consequence of large nu...Oscillatory behaviors can be ubiquitously observed in various systems. Biological rhythms are significant in governing living activities of all units. The emergence of biological rhythms is the consequence of large numbers of units. In this paper we discuss several important examples of sustained oscillations in biological media, where the unit composed in the system does not possess the oscillation behavior. The dominant phase-advanced driving method is applied to study the skeletons and oscillatory organizing motifs in excitable networks and gene regulatory networks.展开更多
Taking Au?Cu system as an example, three discoveries and two methods were presented. First, a new way for boosting sustainable progress of systematic metal materials science (SMMS) and alloy gene engineering (AGE) is ...Taking Au?Cu system as an example, three discoveries and two methods were presented. First, a new way for boosting sustainable progress of systematic metal materials science (SMMS) and alloy gene engineering (AGE) is to establish holographic alloy positioning design (HAPD) system, of which the base consists of measurement and calculation center, SMMS center, AGE center, HAPD information center and HAPD cybernation center; Second, the resonance activating-sychro alternating mechanism of atom movement may be divided into the located and oriented diffuse modes; Third, the equilibrium and subequilibrium holographic network phase diagrams are blueprints and operable platform for researchers to discover, design, manufacture and deploy advanced alloys, which are obtained respectively by the equilibrium lever numerical method and cross point numerical method of isothermal Gibbs energy curves. As clicking each network point, the holographic information of three structure levels for the designed alloy may be readily obtained: the phase constitution and fraction, phase arranging structure and properties of organization; the composition, alloy gene arranging structure and properties of each phase and the electronic structures and properties of alloy genes. It will create a new era for network designing advanced alloys.展开更多
Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemest...Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171).展开更多
As cyber threats keep changing and business environments adapt, a comprehensive approach to disaster recovery involves more than just defensive measures. This research delves deep into the strategies required to respo...As cyber threats keep changing and business environments adapt, a comprehensive approach to disaster recovery involves more than just defensive measures. This research delves deep into the strategies required to respond to threats and anticipate and mitigate them proactively. Beginning with understanding the critical need for a layered defense and the intricacies of the attacker’s journey, the research offers insights into specialized defense techniques, emphasizing the importance of timely and strategic responses during incidents. Risk management is brought to the forefront, underscoring businesses’ need to adopt mature risk assessment practices and understand the potential risk impact areas. Additionally, the value of threat intelligence is explored, shedding light on the importance of active engagement within sharing communities and the vigilant observation of adversary motivations. “Beyond Defense: Proactive Approaches to Disaster Recovery and Threat Intelligence in Modern Enterprises” is a comprehensive guide for organizations aiming to fortify their cybersecurity posture, marrying best practices in proactive and reactive measures in the ever-challenging digital realm.展开更多
Because of the special topography and large tidal range in the South Yellow Sea,the dynamic process of tide and storm surge is very complicated.The shallow water circulation model Advanced Circulation(ADCIRC)was used ...Because of the special topography and large tidal range in the South Yellow Sea,the dynamic process of tide and storm surge is very complicated.The shallow water circulation model Advanced Circulation(ADCIRC)was used to simulate the storm surge process during typhoon Winnie,Prapiroon,and Damrey,which represents three types of tracks attacking the South Yellow Sea,which are,moving northward after landing,no landing but active in offshore areas,and landing straightly to the coastline.Numerical experiments were carried out to investigate the effects of tidal phase on the tide-surge interaction as well as storm surge.The results show that the peak surge caused by Winnie and Prapiroon occurs 2-5 h before the high tide and its occurring time relative to high tide has little change with tidal phase variations.On the contrary,under the action of Damrey,the occurring time of the peak surge relative to high tide varies with tidal phase.The variation of tide-surge interaction is about 0.06-0.37 m,and the amplitude variations of interaction are smooth when tidal phase changes for Typhoon Winnie and Prapiroon.While the interaction is about 0.07-0.69 m,and great differences exists among the stations for Typhoon Damrey.It can be concluded that the tide-surge interaction of the former is dominated by the tidal phase modulation,and the time of surge peak is insensitive to the tidal phase variation.While the interaction of the latter is dominated by storm surge modulation due to the water depth varying with tide,the time of surge peak is significantly affected by tidal phase.Therefore,influence of tidal phase on storm surge is related to typhoon tracks which may provide very useful information at the design stage of coastal protection systems.展开更多
基金supported by the National Science Foundation of China (No. 81374016 and 81402308)Beijing Municipal Science & Technology Commission (No. D141100000414002)
文摘Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. Methods： We have commenced a randomized phase III trial in December 2016 to evaluate S-I plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer. A total of 564 patients will be accrued from 13 Chinese institutions in two years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are 5-year overall survival, proportion of patients who complete the postoperative chemotherapy and incidence of adverse events. Ethic and dissemination： The trial has been approved by the institutional review board of each participating institution and it was activated on December, 2016. The enrollment will be finished in December, 2018. Patient＇s follow-up will be ended until December, 2023. Trial registration： ClinicalTrials.gov, identifier： NCT02867839. Registered on August 4, 2016.
基金Supported by National Natural Science Foundation of China (No.11075198)
文摘As a third generation light source, Shanghai Synchrotron Radiation Facility (SSRF) has up to 140 beam position monitors (BPM) installed to monitor the beam dynamics on its storage ring. Once the operation mode is chosen, the betatron functions are determined. Since the sinusoidal betatron oscillation is the dominant component of the transverse motion, these BPMs can be used to measure the motion to get the betatron functions. Three methods are compared to calculate the phase advance among the BPMs in this paper, aiming to find one or more feasible ways to check the beam optics in SSRF. Some experiments have also been made to verify the practicality of the phase information.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11475022 and 11675001)the Scientific Research Funds of Huaqiao University,China(Grant No.15BS401)
文摘Oscillatory behaviors can be ubiquitously observed in various systems. Biological rhythms are significant in governing living activities of all units. The emergence of biological rhythms is the consequence of large numbers of units. In this paper we discuss several important examples of sustained oscillations in biological media, where the unit composed in the system does not possess the oscillation behavior. The dominant phase-advanced driving method is applied to study the skeletons and oscillatory organizing motifs in excitable networks and gene regulatory networks.
基金Project(51071181)supported by the National Natural Science Foundation of ChinaProject(2013FJ4043)supported by the Natural Science Foundation of Hunan Province,China
文摘Taking Au?Cu system as an example, three discoveries and two methods were presented. First, a new way for boosting sustainable progress of systematic metal materials science (SMMS) and alloy gene engineering (AGE) is to establish holographic alloy positioning design (HAPD) system, of which the base consists of measurement and calculation center, SMMS center, AGE center, HAPD information center and HAPD cybernation center; Second, the resonance activating-sychro alternating mechanism of atom movement may be divided into the located and oriented diffuse modes; Third, the equilibrium and subequilibrium holographic network phase diagrams are blueprints and operable platform for researchers to discover, design, manufacture and deploy advanced alloys, which are obtained respectively by the equilibrium lever numerical method and cross point numerical method of isothermal Gibbs energy curves. As clicking each network point, the holographic information of three structure levels for the designed alloy may be readily obtained: the phase constitution and fraction, phase arranging structure and properties of organization; the composition, alloy gene arranging structure and properties of each phase and the electronic structures and properties of alloy genes. It will create a new era for network designing advanced alloys.
基金sponsored by EOC Pharmaceutical CO,and CAMS Innovation Fund for Medical Sciences(CIFMS,2021I2M-1-014,China)Taizhou EOC Pharma Co.,Ltd.for supporting,developing and sponsoring this trial。
文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171).
文摘As cyber threats keep changing and business environments adapt, a comprehensive approach to disaster recovery involves more than just defensive measures. This research delves deep into the strategies required to respond to threats and anticipate and mitigate them proactively. Beginning with understanding the critical need for a layered defense and the intricacies of the attacker’s journey, the research offers insights into specialized defense techniques, emphasizing the importance of timely and strategic responses during incidents. Risk management is brought to the forefront, underscoring businesses’ need to adopt mature risk assessment practices and understand the potential risk impact areas. Additionally, the value of threat intelligence is explored, shedding light on the importance of active engagement within sharing communities and the vigilant observation of adversary motivations. “Beyond Defense: Proactive Approaches to Disaster Recovery and Threat Intelligence in Modern Enterprises” is a comprehensive guide for organizations aiming to fortify their cybersecurity posture, marrying best practices in proactive and reactive measures in the ever-challenging digital realm.
基金Supported by the National Key Research and Development Program of China(No.2016YFC1402000)
文摘Because of the special topography and large tidal range in the South Yellow Sea,the dynamic process of tide and storm surge is very complicated.The shallow water circulation model Advanced Circulation(ADCIRC)was used to simulate the storm surge process during typhoon Winnie,Prapiroon,and Damrey,which represents three types of tracks attacking the South Yellow Sea,which are,moving northward after landing,no landing but active in offshore areas,and landing straightly to the coastline.Numerical experiments were carried out to investigate the effects of tidal phase on the tide-surge interaction as well as storm surge.The results show that the peak surge caused by Winnie and Prapiroon occurs 2-5 h before the high tide and its occurring time relative to high tide has little change with tidal phase variations.On the contrary,under the action of Damrey,the occurring time of the peak surge relative to high tide varies with tidal phase.The variation of tide-surge interaction is about 0.06-0.37 m,and the amplitude variations of interaction are smooth when tidal phase changes for Typhoon Winnie and Prapiroon.While the interaction is about 0.07-0.69 m,and great differences exists among the stations for Typhoon Damrey.It can be concluded that the tide-surge interaction of the former is dominated by the tidal phase modulation,and the time of surge peak is insensitive to the tidal phase variation.While the interaction of the latter is dominated by storm surge modulation due to the water depth varying with tide,the time of surge peak is significantly affected by tidal phase.Therefore,influence of tidal phase on storm surge is related to typhoon tracks which may provide very useful information at the design stage of coastal protection systems.
