Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial

Background： The ACTS-GC study had shown postoperative adiuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer. Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision. Methods： We have commenced a randomized phase III trial in December 2016 to evaluate S-I plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer. A total of 564 patients will be accrued from 13 Chinese institutions in two years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are 5-year overall survival, proportion of patients who complete the postoperative chemotherapy and incidence of adverse events. Ethic and dissemination： The trial has been approved by the institutional review board of each participating institution and it was activated on December, 2016. The enrollment will be finished in December, 2018. Patient＇s follow-up will be ended until December, 2023. Trial registration： ClinicalTrials.gov, identifier： NCT02867839. Registered on August 4, 2016.

Study of algorithms of phase advance measurement between BPMs and its application in SSRF

As a third generation light source, Shanghai Synchrotron Radiation Facility (SSRF) has up to 140 beam position monitors (BPM) installed to monitor the beam dynamics on its storage ring. Once the operation mode is chosen, the betatron functions are determined. Since the sinusoidal betatron oscillation is the dominant component of the transverse motion, these BPMs can be used to measure the motion to get the betatron functions. Three methods are compared to calculate the phase advance among the BPMs in this paper, aiming to find one or more feasible ways to check the beam optics in SSRF. Some experiments have also been made to verify the practicality of the phase information.

A cloud optical and microphysical property product for the advanced geosynchronous radiation imager onboard China's Fengyun-4 satellites: The first version

风云四号作为中国新一代静止气象卫星,提供了高时空分辨率的监测产品。本文介绍风云四号搭载的先进地球同步轨道辐射成像仪AGRI的云光学和微物理特性产品.该产品包含了基于双光谱通道反演的云光学厚度和云粒子有效半径产品,以及基于机器学习的云识别和云相态产品。与时空匹配的主动卫星观测结果对比显示,该产品的云识别和云相态的准确率分别在95%和85%;该产品提供的云光学厚度和云有效粒径与经典的MODIS产品的相关系数达到0.76和0.63.团队将持续优化和更新该云光学和微物理特性定量产品,服务风云四号卫星定量应用。

Dominant phase-advanced driving analysis of self-sustained oscillations in biological networks

Oscillatory behaviors can be ubiquitously observed in various systems. Biological rhythms are significant in governing living activities of all units. The emergence of biological rhythms is the consequence of large numbers of units. In this paper we discuss several important examples of sustained oscillations in biological media, where the unit composed in the system does not possess the oscillation behavior. The dominant phase-advanced driving method is applied to study the skeletons and oscillatory organizing motifs in excitable networks and gene regulatory networks.

Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial

Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171).

阶段性护理干预在初治局部晚期宫颈癌患者CT引导下三维后装放疗中的应用

目的评价在初治局部晚期宫颈癌患者CT导引三维后装放疗中应用阶段性护理干预的效果。方法选取九江市第三人民医院2020年7月至2021年6月收治的68例局部晚期宫颈癌患者作为研究对象,按住院时间不同分为研究组(2020年7月至12月)和对照组(2021年1月至6月),每组34例。两组患者采用四野盒式放射和三维后装放疗,对照组采用常规护理干预,研究组采用阶段性护理干预。比较两组患者焦虑自评量表(SAS)、抑郁自评量表(SDS)、视觉模拟评分法(VAS)、Piper疲乏评估修订量表(PFS-R)评分以及护理满意度。结果两组护理后SAS、SDS、VAS、PFS-R评分低于本组护理前,研究组SAS、SDS、VAS、PFS-R评分低于对照组,研究组的护理满意度高于对照组,差异有统计学意义(P<0.05)。结论早期局部晚期宫颈癌患者在临床的治疗当中,护理干预是必需的环节,尤其是在接受CT导向三维后装放疗中,阶段性护理干预可以减轻患者的精神应激,减轻患者的痛苦和癌性疲劳,提高患者的护理满意度。

Beyond Defense: Proactive Approaches to Disaster Recovery and Threat Intelligence in Modern Enterprises

As cyber threats keep changing and business environments adapt, a comprehensive approach to disaster recovery involves more than just defensive measures. This research delves deep into the strategies required to respond to threats and anticipate and mitigate them proactively. Beginning with understanding the critical need for a layered defense and the intricacies of the attacker’s journey, the research offers insights into specialized defense techniques, emphasizing the importance of timely and strategic responses during incidents. Risk management is brought to the forefront, underscoring businesses’ need to adopt mature risk assessment practices and understand the potential risk impact areas. Additionally, the value of threat intelligence is explored, shedding light on the importance of active engagement within sharing communities and the vigilant observation of adversary motivations. “Beyond Defense: Proactive Approaches to Disaster Recovery and Threat Intelligence in Modern Enterprises” is a comprehensive guide for organizations aiming to fortify their cybersecurity posture, marrying best practices in proactive and reactive measures in the ever-challenging digital realm.

先进高强度双相钢弯扭复合回弹补偿控制研究

针对先进高强度双相钢弯扭复合回弹的预测与补偿问题,在弯扭复合回弹试验的基础上建立了有限元模型并进行了仿真模拟。首先,利用DP600材料在弯扭复合回弹试验中回弹量较大的特点,进行了单向拉伸试验和加载-卸载-反向加载的拉压试验以测定DP600的力学特性。其次,分别采用Ls-dyna提供的4种弹塑性材料模型建立了单向拉伸和拉压试验有限元模型,通过Ls-opt迭代求解筛选出合适的材料模型及参数,结果表明,采用MAT125材料模型预测的数值更接近弯扭复合回弹试验数据。最后,通过反向截面补偿法推导出底部支撑距离移动公式,通过反向位移补偿法和偏置曲面得到模具面,对弯扭复合回弹结果分别进行补偿。发现利用反向位移补偿法,并通过偏置曲面的方式,能够对在上压杆偏转角度增加时诱发的弯扭复合回弹进行有效补偿控制。

基于海上油气田的燃气主机防进相运行改造研究

主要描述了海上平台滚动开发接入新平台,造成原平台发电机组进相运行后,机组控制容易失稳,造成电网振荡甚至崩溃事故的现象。通过对机组进相运行进行分析,得出机组长时间进相运行是供电海缆呈容性,新平台无大型电机等感性负载,电网无功为负导致的。机组本身的定子线圈及励磁系统高温发热,同时机组进相运行造成电网母线电压降低,电网内设备电流增大,持续发热高温,损害设备绝缘。针对进相运行造成局部温升过高烧毁,严重影响电网的稳定运行给出了三种优化办法并对其应用推广及效益情况进行总结。

Numerical study on effect of tidal phase on storm surge in the South Yellow Sea

Because of the special topography and large tidal range in the South Yellow Sea,the dynamic process of tide and storm surge is very complicated.The shallow water circulation model Advanced Circulation(ADCIRC)was used to simulate the storm surge process during typhoon Winnie,Prapiroon,and Damrey,which represents three types of tracks attacking the South Yellow Sea,which are,moving northward after landing,no landing but active in offshore areas,and landing straightly to the coastline.Numerical experiments were carried out to investigate the effects of tidal phase on the tide-surge interaction as well as storm surge.The results show that the peak surge caused by Winnie and Prapiroon occurs 2-5 h before the high tide and its occurring time relative to high tide has little change with tidal phase variations.On the contrary,under the action of Damrey,the occurring time of the peak surge relative to high tide varies with tidal phase.The variation of tide-surge interaction is about 0.06-0.37 m,and the amplitude variations of interaction are smooth when tidal phase changes for Typhoon Winnie and Prapiroon.While the interaction is about 0.07-0.69 m,and great differences exists among the stations for Typhoon Damrey.It can be concluded that the tide-surge interaction of the former is dominated by the tidal phase modulation,and the time of surge peak is insensitive to the tidal phase variation.While the interaction of the latter is dominated by storm surge modulation due to the water depth varying with tide,the time of surge peak is significantly affected by tidal phase.Therefore,influence of tidal phase on storm surge is related to typhoon tracks which may provide very useful information at the design stage of coastal protection systems.

Availability of MCNP & MATLAB for reconstructing the water-vapor two-phase flow pattern in neutron radiography

The China Advanced Research Reactor (CARR) is scheduled to be operated in the autumn of 2008.In this paper,we report preparations for installing the neutron radiography instrument (NRI) and for utilizing it efficiently. The 2-D relative neutron intensity profiles for the water-vapor two-phase flow inside the robe were obtained using the MCNP code without influence of y-ray and electronic-noise.The MCNP simulation of the 2-D neutron intensity profile for the water-vapor two-phase flow was demonstrated.The simulated 2-D neutron intensity profiles could be used as the benchmark data base by calibrating part of the data measured by the CARR-NRI.The 3-D objective images allow us to understand the flow pattern more clearly and it is reconstructed using the MATLAB through the threshold transformation techniques.And thus it is concluded that the MCNP code and the MATLAB are very useful for constructing the benchmark data base for the investigation of the water-vapor two-phase flow using the CARR-NRI.

基于LSTM和改进TTR算法的车辆辅助驾驶侧翻预警

以提高侧翻预警中对侧翻风险的预测和判断为目标,为了给驾驶员或其他驾驶辅助系统确定对车辆进行控制的介入时机提供重要依据,提出了一种更高效准确的侧翻预警算法.首先建立三自由度车辆预警参考模型;选取相平面法划分侧倾稳定域为侧翻指标,根据三自由度模型响应,设计改进侧翻预测时间(TTR)算法并计算TTR.分析结果表明,相平面侧翻指标接近实际横向载荷转移率(LTR),比LTR常用的表达形式更准确地表述了车辆状态,且改进的TTR也更加接近实际TTR.然后建立长短期记忆网络(LSTM)模型来取代改进TTR算法,提高预警计算效率,模型输出的TTR值作为车辆预警控制的依据.最后通过驾驶员在环(DIL)试验采集数据,对LSTM模型进行训练,并在两种工况下,仿真验证了此侧翻预警方法具有对侧翻风险预测的准确性和更高的实时性.

祁县井水温固体潮现象及其机理分析

通过对山西祁县观测井水温与水位年变与多年动态曲线分析得出,水位的大幅度变化(6 m~14 m)未对水温构成较大影响;从水温潮汐与水位潮汐效应对比结果来看,水温潮汐的相位超前水位潮汐110分钟左右,两者影响关系为7.3℃/hm,明显高于地温梯度背景值.通过祁县井几次典型地震的同震响应,结合相关研究成果,水温相位超前只是一种“假象”:由于多个层位含水层、且含水层间具有不相同的特征参数,从而导致不同观测部位水温与水位的潮汐过程不一致,造成了水温相位超前于水位的假象.

COFs材料磁固相萃取-HPLC-MS/MS法测定烘焙食品中两种主要晚期糖基化终末产物

为实现烘焙食品中晚期糖基化终末产物(Advanced Glycation End Products,AGEs)的准确、高灵敏测定,建立基于磁性共价有机骨架(Covalent Organic Frameworks,COFs)材料的磁固相萃取(Magnetic Solid Phase Extraction,MSPE)技术,实现烘焙食品中两种主要AGEs,即羧甲基赖氨酸(N^(ε)-(carboxymethyl)lysine),(CML)和羧乙基赖氨酸(N^(ε)-(carboxyethyl)lysine,CEL)的选择性、高效富集,并结合高效液相色谱-串联质谱法对其进行定量分析。结果表明:所合成的磁性COFs材料具有较大的比表面积和较高的磁化强度,适合应用于MSPE技术。MSPE的适宜条件为吸附剂用量20 mg,涡旋萃取时间20 min,洗脱溶剂选用5%氨水/甲醇溶液,洗脱溶剂体积4 mL,洗脱时间15 min。CML和CEL的检出限分别为2.05 ng/mL和2.31 ng/mL,定量限分别为6.83 ng/mL和7.71 ng/mL;日内及日间精密度良好(RSD_(日内)≤4.74%,RSD_(日间)≤5.38%);在饼干、坚果2种典型样品基质中,CML和CEL的加标回收率分别为90.70%~108.74%、85.50%~113.00%。将本文所建立的分析方法应用于市售的26种烘焙食品中CML和CEL的含量测定发现,饼干、糕点类烘焙食品中二者含量分别为(9.60±0.16)~(78.10±1.12)mg/kg、(4.37±0.23)~(26.70±1.27)mg/kg;坚果类烘焙食品中二者含量分别为(6.49±0.13)~(82.00±0.98)mg/kg、(6.65±0.30)~(55.90±0.67)mg/kg,该方法能有效净化样品,显著降低基质效应,定量分析准确性较高,且所合成的磁性COFs材料可再生使用5次,适合烘焙食品中CML和CEL的检测。

单相中频逆变器中的双分数阶重复控制策略

当360~800 Hz单相变频逆变器调频时,输出频率大范围变化会使得系统采样频率与输出频率比值可能不为整数。传统重复控制器此时无法精确跟踪输入信号,输出存在较大的静差,最终会导致系统输出的电能质量变差。为此采用了一种基于有限脉冲响应(FIR)滤波器的分数阶重复控制的控制策略,该策略既能实现分数延迟也能应用到相位超前设计上,利用分数阶相位超前解决了控制系统相位超前校正精度不高的问题。给出了控制系统的结构对其进行了理论分析,也给出了控制器的设计思路。最后,在MATLAB/Simulink工具中搭建了仿真模型,将重复控制与双分数阶重复控制两种控制方案做了对比,结果表明:双分数阶重复控制系统输出稳态误差更小,输出波形质量更好。

基于分阶段转变理论的家属参与式护理模式在高龄初产妇剖宫产术后的应用效果

目的 探讨基于分阶段转变理论(TTM)的家属参与式护理模式对高龄初产妇剖宫产患者术后心理状态及母乳喂养自我效能的影响。方法 选取2019年1月至2020年7月在郑州市妇幼保健院拟行剖宫产术的96例高龄初产妇作为研究对象,按入院顺序以奇偶数依次分为对照组(48例)、试验组(48例),对照组接受常规护理措施,在前者基础上试验组接受基于TTM的家属参与式护理模式。比较两组心理状态评分[焦虑自评量表(SAS)、抑郁自评量表(SDS)]、母亲角色适应调查表(MRAQ)、新生儿护理知识掌握度、母乳喂养自我效能量表(BSES)、纯母乳喂养率及护理满意度。结果 干预后,研究组SAS、SDS评分低于对照组,MRAQ、BSES评分高于对照组(P<0.05)。干预后,研究组脐带护理、科学喂养、疾病预防、腿臀部护理及总分高于对照组(P<0.05)。术后6个月两组纯母乳喂养率比较,差异无统计学意义(P>0.05);与对照组相比,试验组术后5 d、术后1个月、术后3个月纯母乳喂养率升高(P<0.05)。试验组护理工作满意度(95.83%)高于对照组(81.25)(P<0.05)。结论 基于TTM的家属参与式护理模式能改善高龄初产妇剖宫产术后心理状态,增强其新生儿护理知识掌握度,提高母乳喂养自我效能及角色适应度,从而提高母乳喂养率,还有助于进一步提高护理满意度。

先进高强双相钢板破裂失效B-W预测模型

为研究先进高强双相钢不同型号板料的应力三轴度与断裂应变的断裂特性,建立不同应力状态下的应力三轴度与断裂极限应变B-W关系曲线,研究B-W曲线与钢种材料参数的关系,设计了4种先进高强双相钢的拉伸、剪切与胀形断裂试验,求解了应力三轴度和等效塑性应变,采用Hill′48正交各向异性模型和Modified Mohr-Coulomb破裂失效模型对拉伸、剪切与胀形断裂进行了数值模拟,建立了从剪切到双拉范围内的B-W曲线,并通过研究B-W曲线与材料参数的相关性,建立了B-W曲线与材料参数的表达式,以减少标定B-W曲线的困难。通过拉弯试验与仿真验证了所建立模型的准确性和有效性。

磁悬浮系统的相位超前校正控制器设计

针对磁悬浮系统的时滞问题,根据磁悬浮球系统的物理参数建立了单自由度磁悬浮系统的数学模型,分析了磁悬浮球系统的时滞特性,参考规定的相位裕度设计了一种磁悬浮球系统的相位超前校正控制器,采用Matlab/Simulink对相位超前校正控制器与Smith-PID控制器进行了仿真分析,并在磁悬浮球系统实验台上进行了悬浮实验。结果表明,与Smith-PID控制器相比,所设计的磁悬浮系统相位超前校正控制器具有较好的稳态性能与较小的波动范围,能很好地解决磁悬浮系统的时滞问题。

XELOX doublet regimen versus EOX triplet regimen as first-line treatment for advanced gastric cancer:An open-labeled,multicenter,randomized,prospective phase III trial(EXELOX)

Background:There is no consensus on whether triplet regimen is better than doublet regimen in the first-line treatment of advanced gastric cancer(AGC).We aimed to compare the efficacy and safety of oxaliplatin plus capecitabine(XELOX)and epirubicin,oxaliplatin,plus capecitabine(EOX)regimens in treating AGC.Methods:This phase III trial enrolled previously untreated patients with AGC whowere randomly assigned to receive the XELOXor EOXregimen.The primary endpoint was non-inferiority in progression-free survival(PFS)for XELOX as compared with EOX on an intention-to-treat basis.Results:Between April 10,2015 andAugust 20,2020,448AGCpatientswere randomized to receive XELOX(n=222)or EOX(n=226).The median PFS(mPFS)was 5.0 months(95%confidence interval[CI]=4.5-6.0 months)in the XELOX arm and 5.5 months(95%CI=5.0-6.0 months)in the EOX arm(hazard ratio[HR]=0.989,95%CI=0.812-1.203;P_(non-inferiority)=0.003).There was no significant difference inmedian overall survival(mOS)(12.0 vs.12.0months,P=0.384)or objective response rate(37.4%vs.45.1%,P=0.291)between the two groups.In patients with poorly differentiated adenocarcinoma and liver metastasis,the EOX arm had a significantly longer mOS(P=0.021)and a trend of longer mPFS(P=0.073)than the XELOX arm.The rate of grade 3/4 adverse events(AEs)was 42.2%(90/213)in the XELOX arm and 72.5%(156/215)in the EOX arm(P=0.001).The global health-related quality of life(QoL)score was significantly higher in the XELOX arm than in the EOX arm during chemotherapy.Conclusions:This non-inferiority trial demonstrated that the doublet regimen was as effective as the triplet regimen and had a better safety profile and QoL as a first-line treatment for AGC patients.However,the triplet regimen might have a survival advantage in patients with poorly differentiated adenocarcinoma and liver metastasis.

全簧片式空间大行程并联柔性微定位平台及其轨迹控制

为了解决传统微定位平台运动范围小、寄生运动和交叉轴耦合严重导致运动精度低等问题,提出了一种音圈电机驱动的全簧片式大行程、空间多自由度并联柔性解耦微定位平台。首先,介绍了含簧片型柔性球铰的大行程多自由度并联柔性机构的结构和变形原理。接着,以空间三自由度为例,推导了动平台的运动学方程,建立了机构的输入刚度模型,并基于柔度矩阵法对柔性球铰进行了柔度建模和设计,从而确定了微定位平台的参数。此外,分别对三自由度方向进行了系统动力学模型辨识,并基于模型设计了一种相位超前PI反馈控制结合滑模前馈控制的复合控制器。最后,搭建了平台实验系统来验证其轨迹跟踪性能。实验结果表明:与经典的PID控制相比,该复合控制方法能够使得轨迹跟踪性能提高95%以上,加入的滑模前馈也能够有效消除单纯反馈控制产生的相位滞后。并且,所提出的多自由度微定位平台能够实现±3.23 mm×±21.50 mrad×±20.30 mrad的运动范围,具有行程大、稳定性好和精度高等特点,可以用于许多需要大行程高精度的空间定位场合。