扩散系数Holder连续的随机微分方程的截断Euler-Maruyama方法

本文研究漂移系数超线性增长和扩散系数Holder连续的随机微分方程的截断Euler-Maruyama方法的强收敛性.研究结果显示强收敛率依赖于Holder指数.本文给出一个例子验证所得的结果.

Minkowski容量参数化下SLE8的Holder连续性

在已知κ∈(0,4]时,SLE_(κ)曲线η不是局部d/1−Holder连续基础之上,研究了SLE8的Holder连续性问题.通过运用Koebe失真定理和Radon-Nikodym导数,分析将双边全平面SLE_(κ)的曲线η(在d维Minkowski容量参数下)转变为指数为d 1的带有固定增量的自我相似过程.同时,证明了带有固定增量的自我相似SLE8曲线η,在任意开区间上都不是d/1−Holder连续的,即SLE8曲线η在任意开区间上不是d/1−Holder连续的.研究结果可为SLE8的Holder连续性研究提供参考.

Research on Construction of Pharmacovigilance System for Marketing Authorization Holders in China

Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the multinational pharmaceutical companies were analyzed based on the requirements of regulations and laws.Results and Conclusion There are some gaps between local and multinational pharmaceutical companies in the construction of pharmacovigilance system.We can learn from the experience of multinational pharmaceutical companies to improve the pharmacovigilance system,which includes building a sound pharmacovigilance organizational structure,establishing a series of operational system files and cultivating professional talents.MAHs of China should improve the structure of enterprise pharmacovigilance system.Besides,members of Drug Safety Committee should be department managers with higher position so that they can fulfil the responsibilities of risk assessment.If MAHs possess a large variety and quantity of products,a Drug Safety Committee should be established to ensure the timely discovery of risks.In addition,MAHs should pay attention to the implementation of related regulations and laws on pharmacovigilance and establish compliant,effective and operatable files combing with the actual operation of pharmacovigilance system.Finally,MAHs should introduce and train pharmacovigilance talents,and hire pharmacovigilance experts as consultants to solve the problem of talent shortage.

Method for eliminating zero-order image in digital holography

For eliminating the zero-order image in digital holography, a new method using the differential of the hologram intensity instead of the hologram itself for numerical reconstruction is proposed. This method is based on digital image processing. By analyzing the spatial spectrum of the off-axis digital hologram, it theoretically proves that the zero-order image can be effectively eliminated by differential before reconstruction. Then, the detected hologram is processed in the program with differential and reconstruction. Both the theoretical analysis and digital reconstruction results show that it can effectively eliminate the large bright spot in the center of the reconstructed image caused by the zero-order image, improve the image quality significantly, and render a better contrast of the reconstructed image. This method is very simple and convenient due to no superfluous optical elements and requiring only one time record.

Axial acoustic radiation force on an elastic spherical shell near an impedance boundary for zero-order quasi-Bessel-Gauss beam

Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various circumstances to improve the system efficiency.The acoustic radiation force exerted by a zero-order quasi-Bessel-Gauss beam on an elastic spherical shell near an impedance boundary is theoretically and numerically studied in this study.By means of the finite series method and the image theory,a zero-order quasi-Bessel-Gauss beam is expanded in terms of spherical harmonic functions,and the exact solution of the acoustic radiation force is derived based on the acoustic scattering theory.The acoustic radiation force function,which represents the radiation force per unit energy density and per unit cross-sectional surface,is especially investigated.Some simulated results for a polymethyl methacrylate shell and an aluminum shell are provided to illustrate the behavior of acoustic radiation force in this case.The simulated results show the oscillatory property and the negative radiation force caused by the impedance boundary.An appropriate relative thickness of the shell can generate sharp peaks for a polymethyl methacrylate shell.Strong radiation force can be obtained at small half-cone angles and the beam waist only affects the results at high frequencies.Considering that the quasi-Bessel-Gauss beam possesses both the energy focusing property and the non-diffracting advantage,this study is expected to be useful in the development of acoustic tweezers,contrast agent micro-shells,and drug delivery applications.

Improved Grid Relaxation with Zero-Order Integrators

In this research, we have improved a relaxation method for triangular meshes intended for finite element fluid simulations which contain discrete element particles. The triangle edges are treated as springs which relax their lengths towards a “better” force equilibrium where the triangles are closer to equilateral shape. The actual kernel is an improved zero order integrator which is able to follow reconfigurations of the particles faster than earlier methods. The improved relaxation allows larger timesteps in the flow simulation and leads to more stable, faster mesh reconfigurations for fast moving particles in the flow. Additionally, this demonstrates how integrators of the same order zero can nevertheless have different convergence speeds towards

SIMULTANEOUS DETERMINATION OF NEODYMIUM AND PRASEODYMIUM BY ZERO-ORDER AND FOURTH-ORDER DFRIVATIVE SPECTROPHOTOMETRY

With derivative spectrophotometric method,the complexes of lanthanides with 2-(5-bromo-2-pyridylazo)-5-diethylaminophen- ol(5-Br-PADAP)in the presence of octylphenol poly(ethyleneg- lycol)ether(TX-100)were studied.It is found that the maximum absorption of fourth-order derivative spectra of the neodymium complex by 4f electron transitions is at 579(+)nm and 582(-)nm with molar derivative absorptivities of 5.2×10~3 1.mol^(-1).cm^(-1). The maximum absorption of the zero-order derivative spectra of the complexes for neodymium and praseodymium is at 580hm,the molar absorptivities are 1.47×10~5 l.mol^(-1).cm^(-1)for Nd and 1.26 ×10~5 l.mol^(-1).cm^(-1)for Pr.The component ratio of the complex is Nd:5-Br-PADAP=1:4.Beer's law is obeyed in the range of 0-3.75μg of Nd and Pr in 25ml of solution.The method has been used for the simultaneous determination of Nd and Pr in four synthetic samples and the results obtained are satisfactory.

一类椭圆方程Dirichlet问题弱解的全局Holder连续性

本文研究一类具有可变指数的散度型椭圆方程Dirichlet问题弱解的全局Holder连续性.通过建立反向Holder不等式,并利用比较估计的方法,获得了所考虑问题弱解的全局C1,α连续性,推广了已有结论.

基于非线性修饰和零阶保持器的船舶航向保持控制

[目的]为了解决船舶在海上航行时控制器舵角输出大、打舵频率高、控制速度较慢以及控制精度较低的问题,利用三阶闭环增益成形算法设计鲁棒控制器。[方法]首先,利用三阶闭环增益成形算法设计出线性鲁棒控制器,然后,在控制策略中加入双曲正切非线性修饰以及零阶保持器,在不同海况下对该控制器的性能进行仿真实验。[结果]仿真结果表明,相比于基于非线性修饰的传统PID控制器,在一般海况下,所提控制器在延迟时间、控制精度以及能量输出上分别改进了36%,14%和32%;在恶劣海况下,分别改进了27%,7%和16%。此外,不同海况下该控制器的仿真结果都具有稳定的舵角输出,并可以较快地稳定在临界值附近,证明了其具有较好的鲁棒性。[结论]改进的控制器符合工程实践,对于智能船舶的控制具有较好的应用参考价值。

Some Refinement of Holder’s and Its Reverse Inequality

Holder’s inequality, its refinement, and reverse have received considerable attention in the theory of mathematical analysis and differential equations. In this paper, we give some refinements of Holder’s inequality and its reverse using a simple analytical technique of algebra and calculus. Our results show many results related to holder’s inequality as special cases of the inequalities presented.

汽车车灯支架压铸工艺CAE分析及模具设计

分析了汽车车灯支架的结构特点,进行了压铸工艺设计,并应用ProCAST软件对该铝合金压铸件的充型过程、压铸模具热平衡和温度场进行了数值模拟分析,预测缺陷产生的位置及原因,根据预测结果对模具结构进行了优化。实际生产表明,采用优化后的模具设计方案提升了铸件质量。

一类由空间粗糙高斯噪声驱动分数阶动力学方程的性质研究

本文主要研究了一类空间粗糙高斯噪声驱动的分数阶动力学方程,其中高斯噪声关于时间是白色的,关于空间的相依结构由Hurst指数小于1/2的分数布朗运动的协方差刻画.基于Malliavin分析技巧,我们证明了该类方程温和解在Skorohod意义下的存在性.同时证明了其温和解矩的上、下界的估计.最后证明了其温和解关于时间和空间变量的Holder连续性.

Credit Card Fraud Detection on Original European Credit Card Holder Dataset Using Ensemble Machine Learning Technique

The proliferation of digital payment methods facilitated by various online platforms and applications has led to a surge in financial fraud,particularly in credit card transactions.Advanced technologies such as machine learning have been widely employed to enhance the early detection and prevention of losses arising frompotentially fraudulent activities.However,a prevalent approach in existing literature involves the use of extensive data sampling and feature selection algorithms as a precursor to subsequent investigations.While sampling techniques can significantly reduce computational time,the resulting dataset relies on generated data and the accuracy of the pre-processing machine learning models employed.Such datasets often lack true representativeness of realworld data,potentially introducing secondary issues that affect the precision of the results.For instance,undersampling may result in the loss of critical information,while over-sampling can lead to overfitting machine learning models.In this paper,we proposed a classification study of credit card fraud using fundamental machine learning models without the application of any sampling techniques on all the features present in the original dataset.The results indicate that Support Vector Machine(SVM)consistently achieves classification performance exceeding 90%across various evaluation metrics.This discovery serves as a valuable reference for future research,encouraging comparative studies on original dataset without the reliance on sampling techniques.Furthermore,we explore hybrid machine learning techniques,such as ensemble learning constructed based on SVM,K-Nearest Neighbor(KNN)and decision tree,highlighting their potential advancements in the field.The study demonstrates that the proposed machine learning models yield promising results,suggesting that pre-processing the dataset with sampling algorithm or additional machine learning technique may not always be necessary.This research contributes to the field of credit card fraud detection by emphasizing the potential of employing machine learning models directly on original datasets,thereby simplifying the workflow and potentially improving the accuracy and efficiency of fraud detection systems.

Analyzing the Effects of Tool Holder Stiffness on Chatter Vibration Reduction in Turning

This paper investigates the effects of tool holder materials on chatter vibration in turning operations.The study uses a complex dynamic turning model with two degrees of freedom for the orthogonal cutting system.Tool holders made from different materials,including Al 5083,Al 6082,Al 7012,and a standard 4140 material,were subjected to chatter vibration to investigate their process damping capabilities.The study found that the standard tool holder 4140 allows for higher stable depths of cut and produces similar process damping values compared to the other tool holders.Finite element analyses(FEA)were performed to verify the experimental results,and the modal and FEA analyses produced very similar results.The study concludes that future research should investigate the effects of tool holders made from high alloy steel alloys on process damping.Overall,this paper provides important insights into the effects of tool hold-er materials on chatter vibration and process damping in turning operations,which can help in the design of more effi-cient and effective cutting systems.

国内民事诉讼律师调查令制度建设存在的若干问题探讨

我国法院经过不断探索,建立了律师调查令制度。目前,律师调查令制度存在着需要进一步完善的若干问题。律师持令调查行为的性质、调查令申请条件、听取证据持有人意见、调查令跨省适用等若干方面均有必要进一步厘清或改进。关于律师持令调查行为的性质,需要在“公的性质”基础上,从证据持有人维护司法秩序义务之角度加以审视。调查令的申请条件有必要取消“因客观原因无法自行调查收集证据”的规定,避免制度上的逻辑性矛盾。应当建立听取证据持有人意见的程序,维护证据持有人的合法权益。律师调查令制度应当允许跨省适用,提高律师证据调查收集的效率与实效性。

Design of High Precision CNC Vertical Lathe Turning Tool Holder

A large aspect ratio vibration reducing tool holder based on passive damping vibration reduction technology is designed to solve the vibration problem that occurs in deep hole machining of vertical lathes.A dynamic model of passive damping vibration reduction tool holder was established,and the optimal damping ratio,optimal frequency ratio,and maximum relative amplitude were derived.Modal analysis of the passive damping vibrationreduction tool holder was conducted using software.The results showed that the maximum response amplitude of the passive damping vibration reduction tool holder decreased significantly compared to the original one.

热重分析仪样品支架的改进

热重分析仪的样品支架,有可能受到一些特殊样品的分解产物的污染而损坏,为了减少支架污染,扩展仪器的使用范围,增加仪器支架的使用寿命,有必要对热重分析仪的支架进行改进。采用在坩埚底部和样品支架平台之间加铂垫片或氧化铝垫片的方式,对支架进行改进。实验结果表明,添加垫片后对温度的影响可以通过校准进行消除,改进前后一水合草酸钙的测试结果一致。说明仪器支架改进后,仪器的性能没有改变,但是可以有效防止热电偶的损坏或支架与坩埚发生粘连,从而增加仪器的使用寿命和使用范围。

放射性药品的药物警戒

放射性药品在医疗领域发挥着重要作用,但同时也存在一定的风险和安全隐患。医疗机构实行药物警戒,保障患者用药安全,包括放射性药品的药物使用安全。美国和欧盟药物警戒体系的运行及管理等方面较为成熟,中国可以借鉴其先进理念,建立适合自己的放射性药物警戒体系。

基于双信号融合的主轴/刀柄结合面刚度退化程度预测

为了预测主轴/刀柄结合面刚度退化程度,提出了一种基于激励和响应信号融合的主轴/刀柄结合面刚度退化程度预测方法。首先进行钛合金矩形工件侧铣实验,采集瞬时铣削力信号和主轴/刀柄结合面附近的响应振动信号,构建反映主轴/刀柄结合面刚度退化的数据库。然后根据数据库中瞬时铣削力和振动信号各方向的时域、频域和时频域特征,基于相关性分析优选出瞬时铣削力信号和振动信号的时域均值、频域中心频率、时频域一阶小波包能量3个特征,分别使用低频滤波卷积核和高频滤波卷积核对优选后的特征矩阵进行双通道卷积池化处理,获取深度融合的主轴/刀柄结合面刚度退化程度特征向量。最后以支持向量机模型(SVM)的概率模式转化为朴素贝叶斯分类器(NBC)的条件概率,构建混合分类器模型(NBC-SVM),提高了分类器的分类性能。在主轴/刀柄结合面刚度退化数据库的基础上,基于双通道卷积池化的特征融合方法(CP-FF)和NBC-SVM模型实现了主轴/刀柄结合面刚度退化程度的预测,预测精度达96%。

中医药传统知识专门保护制度构建研究

中医药传统知识是中医药的核心内容,兼具卫生、经济、科技、文化、生态五重资源价值。目前中医药传统知识面临国外不当占有、盗用,国内传承、保护不力的双重困局,现行法律制度无法实现全面、系统保护,建立专门保护制度已成为必然选择。专门保护制度需要解决四个核心问题:对外防御侵占和不当占有,对内保护持有人权利并规范知识的获取与利用,化解持有人利益与社会公共利益之间的矛盾,处理与现行法律制度的衔接。在此基础上,提出构建中医药传统知识专门保护制度的四个机制,即阻却外国不当专利申请的防御机制、持有人权利保护机制、持有人利益与社会公共利益平衡机制、与现行法律制度的衔接机制,以更好促进中医药传统知识的保护、传承、创新、发展。