内消连翘丸治疗甲状腺结节的临床疗效回顾性队列研究

目的 回顾性评价应用内消连翘丸治疗甲状腺结节的临床疗效。方法 选取2013年—2020年就诊于北京中医医院内分泌科诊断为结节性甲状腺肿的患者729例。暴露组符合纳排标准,应用内消连翘丸共421例;对照组符合纳排标准,未应用内消连翘丸共308例。疗程6个月及以上。观察甲状腺最大结节体积、甲状腺结节性质评分以及各风险指标、症状积分、甲状腺相关抗体。结果 治疗后治疗组甲状腺最大结节体积较治疗前降低,且治疗组均低于对照组(P<0.05)。治疗后治疗组甲状腺结节性质评分较治疗前降低,且治疗组均低于对照组(P<0.05);治疗后治疗组边缘不规则、点状强回声细小钙化灶、结节纵横比>1风险指标较治疗前降低,且治疗组均低于对照组(P<0.05);低回声实性结节、甲状腺被膜受侵状态差异无统计学意义(P>0.05)。治疗后治疗组症状积分均较治疗前降低,且治疗组症状积分均低于对照组(P<0.05)。治疗后治疗组TGAb、TPOAb较治疗前降低,且治疗组均低于对照组(P<0.05)。结论 内消连翘丸在治疗甲状腺结节上可降低甲状腺结节性质评分、缩小结节,改善结节性质及调节甲状腺免疫状态。

中医经典海外传播研究——以《黄帝内经》海外课堂为例

中医经典海外传播对中医药国际化具有重要意义,然而目前中医经典海外传播存在课程覆盖面有限、语言障碍、师资明显不足等困境。通过考察法国汉学家伊丽莎白(Elisabeth Rochat de la Vallée,中文名罗姹)在美国科罗拉中医教学时的《黄帝内经》课堂,发现其以“汉字立论”的跨国际授课方式对中医经典的海外传播与教授具有借鉴意义。未来,中医经典海外传播应加大人才培养力度,保持积极的开放态度,并与更多海外汉学家建立联系。

Superposition of dual electric fields in covalent organic frameworks for efficient photocatalytic hydrogen evolution

Covalent organic frameworks(COFs)are promising materials for converting solar energy into green hydrogen.However,limited charge separation and transport in COFs impede their application in the photocatalytic hydrogen evolution reaction(HER).In this study,the intrinsically tunable inter-nal bond electric field(IBEF)at the imine bonds of COFs was manipulated to cooperate with the internal molecular electric field(IMEF)induced by the donor-acceptor(D-A)structure for an effi-cient HER.The aligned orientation of IBEF and IMEF resulted in a remarkable H_(2)evolution rate of 57.3 mmol·g^(-1)·h^(-1)on TNCA,which was approximately 520 times higher than that of TCNA(0.11 mmol·g^(-1)·h^(-1))with the opposing electric field orientation.The superposition of the dual electric fields enables the IBEF to function as an accelerating field for electron transfer,kinetically facilitat-ing the migration of photogenerated electrons from D to A.Furthermore,theoretical calculations indicate that the inhomogeneous charge distribution at the C and N atoms in TNCA not only pro-vides a strong driving force for carrier transfer but also effectively hinders the return of free elec-trons to the valence band,improving the utilization of photoelectrons.This strategy of fabricating dual electric fields in COFs offers a novel approach to designing photocatalysts for clean energy synthesis.

秦仁昌在甘肃和内蒙古的植物考察活动考述

1923年3月,秦仁昌参加美国国家地理学会资助的科学考察队,前往甘肃收集植物标本,途经内蒙古、宁夏、甘肃和青海,共得植物标本1158号。不同国家的40余位植物学家参与了这批标本的鉴定工作,完整的标本名录于1941年由美国学者和嘉发表,秦仁昌也曾著文介绍沿途人文景致和植物采集情形,并对所经之地的植物地理情况进行初步探究。秦仁昌是对这些地区进行植物学考察的第一位中国人,他的工作表明本土培养的植物学者已经开始在将中国植物纳入现代植物学体系的实践中发挥重要作用。

Long TR three-dimensional inversion recovery sequence with real reconstruction(3D real IR)for quantifying inner ear endolymphatic hydrops

Objective To observe the value of long TR three-dimensional inversion recovery sequence with real reconstruction(3D real IR)for quantifying inner ear endolymphatic hydrops(EH).Methods Totally 46 Ménière's disease(MD)patients and 21 healthy volunteers were prospectively enrolled.MR scanning for inner ear based on 3D real IR and 3D fluid attenuated inversion recovery(3D FLAIR)sequence 4—6 h after administration of contrast agents were performed.The imaging qualities were scored and compared between groups.The endolymphatic space area and the membranous labyrinth area of cochlea and vestibule,as well as endolymph/membranous labyrinth area percentage were calculated,the present or not of EH and the grade of EH were evaluated.EH inner ears of MD patients were enrolled in EH group,while inner ears of healthy volunteers were taken as controls(control group).The endolymphatic space area,membranous labyrinth area and endolymph/membranous labyrinth area percentage of cochlea and vestibule were compared between groups.The receiver operating characteristic(ROC)curve was drawn to calculate the diagnostic efficacy of the above indexes.Results Cochlear and/or vestibular EH were detected in 56 ears,including cochlear EH in 52 ears and vestibular EH in 45 ears among 46 MD patients(EH group),but not in 42 ears in control group.The subjective quality scores of 3D real IR images were higher than those of 3D-FLAIR(both P<0.05).Quantitative analysis based on 3D real IR images revealed that,compared with control group,significantly larger endolymph areas and endolymph/membranous labyrinth area percentages in both cochlea and vestibule were found in EH group(all P<0.001).The area under the curve(AUC)of cochlear or vestibular endolymph/membranous labyrinth area percentage for identifying inner ear EH was 0.999 and 0.985,respectively.Taken 13.64%and 24.13%as the critical value of cochlear or vestibular endolymph,the specificity was 100%and 92.86%,respectively,and the sensitivity was 96.43%and 96.43%,respectively.Conclusion MR long TR 3D real IR was helpful to quantifying inner ear EH.

Research and development on mechanism of removal of indoor volatile organic compounds by plants

Background,aim,and scope Owing to the rapid development of modernisation and urbanisation,living standards have gradually improved.However,the widespread use of high-energy-consuming indoor appliances and furniture has made indoor environments a primary environmental problem affecting human health.Sick building syndrome(SBS)and building-related illness(BRI)have occurred,and indoor air conditions have been extensively studied.Common indoor pollutants include CO,CO_(2),volatile organic compounds(VOCs)(such as the formaldehyde and benzene series),NOx(NO and NO_(2)),and polycyclic aromatic hydrocarbons(PAHs).VOCs have replaced SO_(2)as the“The Fourteenth Five-Year Plan”urban air quality assessment new indicators.Indoor VOCs can cause diseases such as cataract,asthma,and lung cancer.To protect human health,researchers have proposed several indoor air purification technologies,including adsorption,filtration,electrostatic dust removal,ozonation,and plant purification.However,each technology has drawbacks,such as high operating costs,high energy consumption,and the generation of secondary waste or toxic substances.Plant degradation of VOCs as a bioremediation technology has the characteristics of low cost,high efficiency,and sustainability,thereby becoming a potential green solution for improving indoor air quality.This study introduces the research status and mechanism of plant removal of indoor VOCs and provides an experimental basis and scientific guidance for analysing the mechanism of plant degradation of pollutants.Materials and methods This study reviews studies on the harm caused by indoor pollutants to human health and related sources,mainly investigating the degradation of indoor formaldehyde,BTEX(benzene,toluene,ethylbenzene,and xylene)plant mechanisms,and research results.Results Plants can remove VOCs via stomatal and non-stomatal adsorption,interfoliar microbial,rhizosphere microbial,and growth media.Benzene,toluene,and xylene(BTX)are adsorbed by pores,hydroxylated into fumaric acid,and then removed into CO_(2)and H2O by TCA.Formaldehyde enters plant leaves through the stomata and epidermal waxy substances and is adsorbed.After the two steps of enzymatic oxidation,formic acid and CO_(2)are generated.Finally,it enters the Calvin cycle and removes glucose and other nontoxic compounds.Discussion The non-stomatal degradation of VOCs can be divided into adsorption by cuticular wax and active adsorption by plant surface microorganisms.The leaf epidermal waxy matter content and the lipid composition of the epidermal membrane covering the plant surface play important roles in the non-stomatal adsorption of indoor air pollutants.The leaf margin of a plant is an ecological environment containing various microbial communities.The endophytic and inoculated microbiota in plant buds and leaves can remove VOCs(formaldehyde and BTEX).Formaldehyde can be directly absorbed by plant leaves and converted into organic acids,sugars,CO_(2)and H2O by microbes.Bioremediation of indoor VOCs is usually inefficient,leading to plant toxicity or residual chemical substance volatilisation through leaves,followed by secondary pollution.Therefore,plants must be inoculated with microorganisms to improve the efficiency of plant degradation of VOCs.However,the effectiveness of interfoliar microbial removal remains largely unknown and several microorganisms are not culturable.Therefore,methods for collecting,identifying,and culturing microorganisms must be developed.As the leaf space is a relatively unstable environment,the degradation of VOCs by rhizosphere microorganisms is equally important,and formaldehyde is absorbed more by rhizosphere microorganisms at night.The inoculation of bacteria into the rhizosphere improves the efficiency of plants in degrading VOCs.However,most of these studies were conducted in simulation chambers.To ensure the authenticity of these conclusions,the ability of plants to remove indoor air pollutants must be further verified in real situations.Conclusions Plant purification is an economical,environment-friendly,and sustainable remediation technology.This review summarises the mechanisms of VOC plant degradation and presents its limitations.Simultaneously,it briefly puts forward a plant selection scheme according to different temperatures,light,and specific VOCs that can be absorbed to choose the appropriate plant species.However,some studies have denied the purification effect of plants and proposed that numerous plants are required to achieve indoor ventilation effects.Therefore,determining the ability of plants to remove indoor VOCs requires a combination of realistic and simulated scenarios.Recommendations and perspectives Plants and related microorganisms play an important role in improving indoor air quality,therefore,the effect of plants and the related microorganisms on improving indoor air quality must be studied further and the effect of plants on indoor VOCs will be the focus of future research.

A Comparative Study of the L2 Pragmatic Competence of University Students in Hong Kong and the Chinese Mainland:The Contributions of Sociocultural Context and Linguistic Proficiency

This study investigates the differences in pragmatic competence between Hong Kong and Chinese mainland university students.Participants included 19 native speakers of English,115 Chinese mainland students,divided into those who had spent time abroad in an English-speaking country(CM A)and those who had not(CM NA),and 97 Hong Kong students,divided into those from an English-medium secondary school(Hong Kong EMI)and those from a Chinese-medium school(Hong Kong CMI).Linguistic proficiency was measured by a C-test,and pragmatic competence by a Metapragmatic Knowledge Test,an Irony Test and a Monologic Role Play.Group scores were compared using ANCOVAs to control for differences in proficiency.The results point to a continuum of pragmatic competence—EMI>CMI>CM A>CM NA—reflecting the groups’access to English in real-life contexts.The differences between the Hong Kong groups and the Chinese mainland groups were clearest in those tests measuring processing capacity(i.e.,Irony Response Time and the Monologic Role Play).CM A,but not CM NA,performed as well as the Hong Kong groups on measures of metapragmatic awareness.The results are discussed in terms of Bialystok’s(1993)distinction between analyzed representation and control of processing.

Impact of correlated private signals on continuous-time insider trading

A model of continuous-time insider trading in which a risk-neutral in-sider possesses two imperfect correlated signals of a risky asset is studied.By conditional expectation theory and filtering theory,we first establish three lemmas:normal corre-lation,equivalent pricing and equivalent profit,which can guarantee to turn our model into a model with insider knowing full information.Then we investigate the impact of the two correlated signals on the market equilibrium consisting of optimal insider trading strategy and semi-strong pricing rule.It shows that in the equilibrium,(1)the market depth is constant over time;(2)if the two noisy signals are not linerly correlated,then all private information of the insider is incorporated into prices in the end while the whole information on the asset value can not incorporated into prices in the end;(3)if the two noisy signals are linear correlated such that the insider can infer the whole information of the asset value,then our model turns into a model with insider knowing full information;(4)if the two noisy signals are the same then the total ex ant profit of the insider is increasing with the noise decreasing,while down to O as the noise going up to infinity;(5)if the two noisy signals are not linear correlated then with one noisy signal fixed,the total ex ante profit of the insider is single-peaked with a unique minimum with respect to the other noisy signal value,and furthermore as the noisy value going to O it gets its maximum,the profit in the case that the real value is observed.

《庄子·内篇》“VP_(1)而VP_(2)”“NP之VP”结构研究

连词“而”是一个高频虚词,当它连接两个动词性词语VP_(1)、VP_(2)时,用法较为复杂。根据两个VP之间的句法语义关系,《庄子·内篇》中的“VP_(1)而VP_(2)”结构可以分析为四种类型:连谓、偏正、联合、紧缩。“NP之VP”结构在《内篇》中的出现频率也比较高。结构助词“之”置于主谓结构“NP+VP”中间,形成体词性偏正结构“NP之VP”,相当于现代汉语“NP的VP”。该结构在句法上只能分布于主、宾位;在语义上不具有独立性,是谓语核心动词的论元成分;在语用上具有指称功能。

Effect of acetyl L-carnitine on human retinal pigment epithelium-19 cells in hypoxic conditions

AIM:To investigate the effect of acetyl-L-carnitine(ALCAR)on cell viability,morphological integrity,and vascular endothelial growth factor(VEGF)expression in human retinal pigment epithelium(ARPE-19)cells using a hypoxic model.METHODS:In the first set of experiments,the optimal CoCl_(2) dose was determined by exposing ARPE-19 cell cultures to different concentrations.To evaluate the effect of ALCAR on cell viability,five groups of ARPE-19 cell culture were established that included a control group,a sham group(200μM CoCl_(2)),and groups that received 1,10 and 100 mM doses of ALCAR combined with 200μM CoCl_(2),respectively.The cell viability was measured by MTT assay.The morphological characteristics of cells were observed by an inverted phase contrast microscope.The levels of VEGF and HIF-1α secretion by ARPE-19 cells were detected by enzyme linked immunosorbent assay(ELISA)assay.RESULTS:ARPE-19 cells were exposed to different doses of CoCl_(2) in order to create a hypoxia model.Nevertheless,when exposed to a concentration of 200μM CoCl_(2),a notable decrease in viability to 83% was noted.ALCAR was found to increase the cell viability at 1 mM and 10 mM concentrations,while the highest concentration(100 mM)did not have an added effect.The cell viability was found to be significantly higher in the groups treated with a concentration of 1 mM and 10 mM ALCAR compared to the Sham group(P=0.041,P=0.019,respectively).The cell viability and morphology remained unaffected by the greatest dose of ALCAR(100 mM).The administration of 10 mM ALCAR demonstrated a statistically significant reduction in the levels of VEGF and HIF-1α compared with the Sham group(P=0.013,P=0.033,respectively).CONCLUSION:The findings from the current study indicate that ALCAR could represent a viable therapeutic option with the potential to open up novel treatment pathways for retinal diseases,particular relevance for age-related macular degeneration(AMD).However,to fully elucidate ALCAR’s application potential in retinal diseases,additional investigation is necessary to clearly define the exact mechanisms involved.

微管壳式换热器在能量转换循环中的应用

目前,超临界二氧化碳(S-CO_(2))布雷顿循环普遍采用印刷电路板换热器(PCHE)来保证其相对其他能量转换循环的紧凑性优势。PCHE芯体为整体结构,若内部出现泄漏或结垢等问题,很难进行维护与检修。本文提出了一种微管壳式换热器(MSTE),其结构与传统管壳式换热器类似,但其管径缩小至微通道级。由于MSTE的流道横截面积占总截面积之比较PCHE大,在典型的回热器与冷却器设计工况下,相对PCHE而言,采用MSTE可将体积与质量均减小30%以上。灵敏性分析结果显示,采用本文设计的MSTE结构的回热器与冷却器,回热器冷热流道入口温度升高20℃左右,压缩机入口温度变化均不超过1℃,说明该种结构换热器的换热能力足够支撑能量转换循环的一般工况波动。

浮针联合贴扎疗法治疗颈型颈椎病临床观察

目的:观察浮针联合贴扎疗法治疗颈型颈椎病的临床疗效。方法:选取2020年1月至2022年4月泰州市第四人民医院收治的颈型颈椎病患者80例为研究对象,按照随机数字表法分为观察组和对照组,每组40例。对照组给予塞来昔布胶囊、甲钴胺片联合贴扎疗法治疗,观察组在对照组治疗的基础上给予浮针治疗。观察两组患者治疗前后颈椎曲度值、疼痛视觉模拟评分(visual analogue scale,VAS)、颈椎功能障碍指数(neck disability index,NDI)、颈椎肌力评分、颈椎活动度评分变化情况及临床疗效。结果:观察组有效率为92.5%,对照组有效率为72.5%,观察组有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后VAS评分、NDI评分、颈椎活动度评分低于对照组,颈椎肌力评分高于对照组,差异具有统计学意义(P<0.05)。观察组治疗后颈椎曲度值高于对照组,差异有统计学意义(P<0.05).结论:浮针联合贴扎疗法治疗颈型颈椎病,可有效减轻患者颈部神经的压迫,缓解疼痛,改善颈椎肌力和活动度。

依达拉奉右莰醇治疗缺血性脑卒中的有效性和安全性研究进展

急性缺血性脑卒中特异性治疗策略包括改善脑血循环、他汀药物及神经保护等。神经保护剂理论上可以阻断缺血级联反应并阻止神经细胞死亡,在缺血性脑卒中的治疗中有很大的应用前景,但是既往对神经保护剂的临床研究结论并不一致。近期,越来越多临床研究结果显示,与依达拉奉相比,依达拉奉右莰醇改善缺血性脑卒中患者神经功能缺损的远期疗效更好,安全性相似,临床应用价值更优。本文将对多靶点神经保护剂依达拉奉右莰醇的作用机制、治疗缺血性脑卒中的有效性及安全性进行综述,以期为该药的临床合理应用提供参考。

《黄帝内经》中的形近讹误字

《黄帝内经》中存在不少异文现象,有些异文是由形近讹误所造成的。依据《黄帝内经太素》萧延平按语、《天回医简》等相关语言文献材料,对部分异文进行分析,揭示了15组形近讹误字,如“摶”与“搏”、“蛂”与“蛟”、“内”与“肉”、“乃”与“及”、“温”与“湿”、“感”与“惑”等。对《黄帝内经》中既往关注较少的文字讹误现象进行探析,可以校订传世医籍中的误字,补充形近讹误字例证,这对解决相关问题、解读《黄帝内经》均有所助益。

读马王堆帛书医方札记四则

通过对马王堆帛书《五十二病方》《房内记》医方中的四个问题进行探讨,提出以下论点:“以汁【□】之”的缺文不能补作“■(歠)”或“■(飲)”,而应补作“洒”或“沃”“■(洗)”等字;“枣种”不是指大枣,而是指大枣的种子,即枣仁;“澡石”不是一味药,而是处理药石的一种方法;桑枝不是桑枝汁,二者在医疗活动中的运用各有不同。

内河限制性航道护岸工程BIM正向设计方法研究

针对内河限制性航道护岸工程传统二维设计精细度不高,设计效率低下等问题,本文基于Civil3D开展内河限制性航道护岸工程BIM正向设计研究,包括三维地形曲面建立、护岸要素线确定、参数化横断面设计、护岸模型建立等内容,并基于Civil3D进行二次开发,实现护岸基础结构批量快速建模、护岸结构工程量快速提取、模型出图,可有效提高设计效率,为护岸工程正向设计提供思路。研究成果在浙北某内河限制性航道工程进行了应用验证,可为内河限制性航道工程BIM技术应用提供借鉴。

The Effects of Increasing Production of Endophytes Phomopsis B3 on Rice

After insufflating extended endophytes phomopsis B3 ferment diluent on seedling bed of rice, the effect of microbial inoculum on rice growth was studied. The investigation result of seedlings before transplanting seedling showed that leaf age,the number of green leaves,the number of tiller of individual plant and the weight of per 100 fresh plants in microbial inoculum treatment group increased 0.11,0.12 ,0. 03 and 2.6 g respectively compared with those of control group. 20 days after transplanting, increased tiller number in microbial inoculum treatment group was 55 500 hm^2 more than that in control group. 30 days after transplanting, tiller number in microbial inoculum treatment group was 42 000 hm^2 more than that in control group. In harvest season, the yield ,weight of I 0130 grain and seed-setting rate increased 300 kg/hm2, 0. 7 g and 0. 23% respectively compared with these in control group. The result of preliminary study demonstrated that microbial inoculum confected by endophytes phomopsis B3 could increase the number of strong seedling and yield.

Selection of Reference Genes in Transcription Analysis of Gene Expression of the Mandarin Fish, Siniperca chuasti

At present, transcription analysis of gene expression commonly uses housekeeping genes as control for normalization. In this study, the expression levels of three housekeeping genes including GAPDH, β-actin, and 18S rRNA in six tissues and five developmental stages of the Mandarin fish Siniperca chuatsi were assayed with quantitative real-time PCR （qPCR）. Differences in expression levels were analyzed using geNorm program. The results demonstrate that β-actin is the most stable gene at developmental stages and GAPDH is the most stable in different tissues. While 18S rRNA expression during development is differentially regulated, which indicates it is suitable as an internal control for gene expression normalization at the developmental level. Overall, the data suggest that the two most stable housekeeping genes are enough to accurately calibrate gene expression in S. chuatsi. The significance of this study provided convincing references and methodology for housekeeping gene selection and normalization in gene expression analysis with regular PCR or qPCR.

Feasibility of enhanced phytoextraction of Zn contaminated soil with Zn mobilizing and plant growth promoting endophytic bacteria

Three bacterial endophytes of Sedum alfredii, VI8L2, II8L4 and VI8R2, were examined for promoting soil Zn bioavailability and Zn accumulation in S. alfredii. Results showed that three strains were re-introduced into S. alfredii rhizosphere soils under Zn stress and resulted in better plant growth, as roots biomass increased from 80% to 525% and shoot biomass from 11% to 47% compared with the uninoculated ones. Strains IVsLz, II8L4 and IVsR2 significantly increased shoot and root Zn concentrations in the ZnCO3 contaminated soil. Inoculation with strain IVsL2 resulted in 44% and 39% higher shoot and root Zn concentrations, while strain IV8R2 significantly decreased shoot Zn concentration in the Zn3（PO4）2 contaminated soils. In the aged contaminated soil, isolates IVsL2, IIsL4 and IVsR2 significantly increased root Zn concentration, but decreased shoot Zn concentration of Sedum alfredii. It suggested that endophytes might be used for enhancing phytoextraction efficiency.

Chemical Constituents of Roots of Ranunculus ternatus Thunb.

Ranunculus ternatus is culus, which is distributed a species of genus Ranunmainly in Henan, Hubei, Guangxi, Sichuan, and Yunnan provinces in China. The root of Ranunculus ternatus has been used for the treatment of faucitis, tuberculosis, neck scrofula, etc in traditional Chinese medicine. Pharmacological experiment indicated that the water extract of Ranunculus ternatus inhibits not only Staphylococcus aureus and pseudomonas aeruginosa, but also S-180, and S37 remarkablely.