不同病因的间质性肺疾病患者普遍展现出一些共同的临床表现,包括不同程度的呼吸困难、咳嗽以及运动耐量的显著下降等。这些症状严重影响了患者的生活质量。心肺运动试验是目前评估运动耐量的“金标准”,该试验能够全面揭示运动过程中患...不同病因的间质性肺疾病患者普遍展现出一些共同的临床表现,包括不同程度的呼吸困难、咳嗽以及运动耐量的显著下降等。这些症状严重影响了患者的生活质量。心肺运动试验是目前评估运动耐量的“金标准”,该试验能够全面揭示运动过程中患者呼吸、心血管、骨骼肌、神经感觉等多个系统综合功能的异常,从而为慢性呼吸系统疾病(包括间质性肺疾病)患者的诊断提供线索、进一步指导治疗方案、制定运动处方及后期康复训练计划。初步证据表明,该项检查还可用于揭示间质性肺疾病患者中相关肺动脉高压的存在。本文就心肺运动试验在间质性肺疾病中临床应用及研究进展作一综述。Patients with interstitial lung disease caused by different etiologies exhibit, have some common clinical manifestations, including dyspnea, significant reduced exercise tolerance, persistent cough, and pronounced fatigue, which severely impact their quality of life. Cardiopulmonary Exercise Testing is currently the “gold standard” for assessing exercise tolerance. This test can reveal abnormalities in the comprehensive functions of multiple systems, including respiratory, cardiovascular, skeletal muscle, and neurosensory systems. It provides clues for the diagnosis of these patients with chronic respiratory diseases, further guiding treatment plans, formulating exercise prescriptions, and making later rehabilitation training plans. Preliminary evidence suggests that this test can also be used to shed light on the presence of associated pulmonary hypertension. This article reviews the clinical application and research progress of Cardiopulmonary Exercise Testing in Interstitial Lung Disease.展开更多
无创产前检测(Non-Invasive Prenatal Testing, NIPT)自临床应用以来,因其方便快捷、无需侵入的特点于全球迅速开展。胎儿游离DNA浓度(Fetal Fraction, FF)是NIPT的质控参数,同时也可作为预测不良妊娠结局的重要指标。本文旨在分析总结F...无创产前检测(Non-Invasive Prenatal Testing, NIPT)自临床应用以来,因其方便快捷、无需侵入的特点于全球迅速开展。胎儿游离DNA浓度(Fetal Fraction, FF)是NIPT的质控参数,同时也可作为预测不良妊娠结局的重要指标。本文旨在分析总结FF的影响因素及与胎盘相关性不良妊娠结局的关系,以期发挥FF在临床应用中的价值。Non-invasive prenatal testing (NIPT) has been rapidly developed worldwide due to its characteristics, including convenience and non-invasive. Fetal fraction (FF) is a parameter of sample quality control for NIPT and can also be used as an important indicator for predicting adverse pregnancy outcomes. This article aims to analyze and summarize the influencing factors of FF and the relationship between FF with placenta-related adverse pregnancy outcomes, in order to exert the value of FF in clinical application.展开更多
目的:系统评价音乐疗法在早产儿中应用的效果。方法:计算机检索Cochrane Central of Registration Controlled Trials(CENTRAL)、EMBASE、Pub Med、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)和万方数据...目的:系统评价音乐疗法在早产儿中应用的效果。方法:计算机检索Cochrane Central of Registration Controlled Trials(CENTRAL)、EMBASE、Pub Med、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)和万方数据资源系统中有关音乐疗法应用于早产儿的随机对照试验。2名评价者独立检索、筛查文献、提取数据、评价纳入文献的方法学质量并进行交叉核对后,用Rev Man5.3软件行Meta分析。结果:最终纳入11项随机对照试验,包括1182例研究对象,Meta分析结果显示,音乐疗法组早产儿的平均每日体质量增长、第2周体质量、第5天进奶量及第10天进奶量高于对照组,差异有统计学意义(P<0.05);住院时间及干预后心率低于对照组(P<0.05);干预后血氧饱和度与对照组相比,差异没有统计学意义(P>0.05)。结论:音乐疗法是一种非药物性、非侵入性、成本较低的疗法,有助于提升早产儿进奶量、改善第2周体质量、缩短住院时间及降低心率,但对早产儿的血氧饱和度的提升作用不大。展开更多
文摘不同病因的间质性肺疾病患者普遍展现出一些共同的临床表现,包括不同程度的呼吸困难、咳嗽以及运动耐量的显著下降等。这些症状严重影响了患者的生活质量。心肺运动试验是目前评估运动耐量的“金标准”,该试验能够全面揭示运动过程中患者呼吸、心血管、骨骼肌、神经感觉等多个系统综合功能的异常,从而为慢性呼吸系统疾病(包括间质性肺疾病)患者的诊断提供线索、进一步指导治疗方案、制定运动处方及后期康复训练计划。初步证据表明,该项检查还可用于揭示间质性肺疾病患者中相关肺动脉高压的存在。本文就心肺运动试验在间质性肺疾病中临床应用及研究进展作一综述。Patients with interstitial lung disease caused by different etiologies exhibit, have some common clinical manifestations, including dyspnea, significant reduced exercise tolerance, persistent cough, and pronounced fatigue, which severely impact their quality of life. Cardiopulmonary Exercise Testing is currently the “gold standard” for assessing exercise tolerance. This test can reveal abnormalities in the comprehensive functions of multiple systems, including respiratory, cardiovascular, skeletal muscle, and neurosensory systems. It provides clues for the diagnosis of these patients with chronic respiratory diseases, further guiding treatment plans, formulating exercise prescriptions, and making later rehabilitation training plans. Preliminary evidence suggests that this test can also be used to shed light on the presence of associated pulmonary hypertension. This article reviews the clinical application and research progress of Cardiopulmonary Exercise Testing in Interstitial Lung Disease.
文摘无创产前检测(Non-Invasive Prenatal Testing, NIPT)自临床应用以来,因其方便快捷、无需侵入的特点于全球迅速开展。胎儿游离DNA浓度(Fetal Fraction, FF)是NIPT的质控参数,同时也可作为预测不良妊娠结局的重要指标。本文旨在分析总结FF的影响因素及与胎盘相关性不良妊娠结局的关系,以期发挥FF在临床应用中的价值。Non-invasive prenatal testing (NIPT) has been rapidly developed worldwide due to its characteristics, including convenience and non-invasive. Fetal fraction (FF) is a parameter of sample quality control for NIPT and can also be used as an important indicator for predicting adverse pregnancy outcomes. This article aims to analyze and summarize the influencing factors of FF and the relationship between FF with placenta-related adverse pregnancy outcomes, in order to exert the value of FF in clinical application.
文摘目的:系统评价音乐疗法在早产儿中应用的效果。方法:计算机检索Cochrane Central of Registration Controlled Trials(CENTRAL)、EMBASE、Pub Med、Web of Science、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)和万方数据资源系统中有关音乐疗法应用于早产儿的随机对照试验。2名评价者独立检索、筛查文献、提取数据、评价纳入文献的方法学质量并进行交叉核对后,用Rev Man5.3软件行Meta分析。结果:最终纳入11项随机对照试验,包括1182例研究对象,Meta分析结果显示,音乐疗法组早产儿的平均每日体质量增长、第2周体质量、第5天进奶量及第10天进奶量高于对照组,差异有统计学意义(P<0.05);住院时间及干预后心率低于对照组(P<0.05);干预后血氧饱和度与对照组相比,差异没有统计学意义(P>0.05)。结论:音乐疗法是一种非药物性、非侵入性、成本较低的疗法,有助于提升早产儿进奶量、改善第2周体质量、缩短住院时间及降低心率,但对早产儿的血氧饱和度的提升作用不大。
