In order to confirm which process is the most important in the blood coagulation cascade,a dynamic model on the function of platelets in blood coagulation is presented based on biochemical experiments.Based on qualita...In order to confirm which process is the most important in the blood coagulation cascade,a dynamic model on the function of platelets in blood coagulation is presented based on biochemical experiments.Based on qualitative analysis and mathematical simulation,a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin(IIa)are drawn.It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade.The value is related to the binding constant d_2 of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on thrombin.The proportion of platelets activated at any given time is designated c.To each c,we obtain a maximum concentration of thrombin.It is evident that when the level of factor IX is below 1% of the normal level,the rate of thrombin generation reduces dramatically,resulting in severe bleeding tendency.展开更多
Nowadays, many kinds of computer network data management systems have been built widely in China. People have realized widely that management information system (MIS) has brought a revolution to the management mechani...Nowadays, many kinds of computer network data management systems have been built widely in China. People have realized widely that management information system (MIS) has brought a revolution to the management mechanism. Moreover, the managers of company need wide-range and comprehensive decision information more and more urgently which is the character of information explosion era. The needs of users become harsher and harsher in the design of MIS, and these needs have brought new problems to the general designers of MIS. Furthermore, the current method of traditional database development can't solve so big and complex problems of wide-range and comprehensive information processing. This paper proposes the adoption of parallel processing mode, the built of new decision support system (DSS) is to discuss and analyze the problems of information collection, processing and the acquirement of full-merit information with cross-domain and cross-VLDB (very-large database).展开更多
When querying on a large-scale knowledge base, a major technique of im-proving performance is to preload knowledge to minimize the number of roundtrips to theknowledge base. In this paper, an ontology-based semantic c...When querying on a large-scale knowledge base, a major technique of im-proving performance is to preload knowledge to minimize the number of roundtrips to theknowledge base. In this paper, an ontology-based semantic cache is proposed for an agentand ontology-oriented knowledge base (AOKB). In AOKB, an ontology is the collection of re-lationships between a group of knowledge units (agents and/or other sub-ontologies). Whenloading some agent A, its relationships with other knowledge units are examined, and thosewho have a tight semantic tie with A will be preloaded at the same time, including agents andsub-ontologies in the same ontology where A is. The preloaded agents and ontologies are savedat a semantic cache located in the memory. Test results show that up to 50% reduction inrunning time is achieved.展开更多
基金The project supported by The Beijing Municipal Natural Sciences Foundation (3982005)
文摘In order to confirm which process is the most important in the blood coagulation cascade,a dynamic model on the function of platelets in blood coagulation is presented based on biochemical experiments.Based on qualitative analysis and mathematical simulation,a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin(IIa)are drawn.It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade.The value is related to the binding constant d_2 of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on thrombin.The proportion of platelets activated at any given time is designated c.To each c,we obtain a maximum concentration of thrombin.It is evident that when the level of factor IX is below 1% of the normal level,the rate of thrombin generation reduces dramatically,resulting in severe bleeding tendency.
文摘Nowadays, many kinds of computer network data management systems have been built widely in China. People have realized widely that management information system (MIS) has brought a revolution to the management mechanism. Moreover, the managers of company need wide-range and comprehensive decision information more and more urgently which is the character of information explosion era. The needs of users become harsher and harsher in the design of MIS, and these needs have brought new problems to the general designers of MIS. Furthermore, the current method of traditional database development can't solve so big and complex problems of wide-range and comprehensive information processing. This paper proposes the adoption of parallel processing mode, the built of new decision support system (DSS) is to discuss and analyze the problems of information collection, processing and the acquirement of full-merit information with cross-domain and cross-VLDB (very-large database).
基金科技部资助项目，国家自然科学基金，Innovation Foundation of AMSS, IOM and ICT,and MADIS Lab
文摘When querying on a large-scale knowledge base, a major technique of im-proving performance is to preload knowledge to minimize the number of roundtrips to theknowledge base. In this paper, an ontology-based semantic cache is proposed for an agentand ontology-oriented knowledge base (AOKB). In AOKB, an ontology is the collection of re-lationships between a group of knowledge units (agents and/or other sub-ontologies). Whenloading some agent A, its relationships with other knowledge units are examined, and thosewho have a tight semantic tie with A will be preloaded at the same time, including agents andsub-ontologies in the same ontology where A is. The preloaded agents and ontologies are savedat a semantic cache located in the memory. Test results show that up to 50% reduction inrunning time is achieved.
