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表观遗传学如何诠释人肿瘤转移microRNA的新作用 被引量:11
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作者 Amaia Lujambio Manel Esteller +2 位作者 南娟(翻译) 丁燕(翻译) 孙丹(校对) 《中国肺癌杂志》 CAS 2009年第8期907-914,共8页
转移过程的特征是肿瘤细胞可通过血液系统播散到远端组织,然后这些变异的细胞在那里增殖,并形成继发性肿瘤,这也是肿瘤患者死亡最主要的原因。近年来,一系列重要的肿瘤相关基因陆续被报道,如钙粘素、层粘连蛋白、乙酰肝素硫酸盐、... 转移过程的特征是肿瘤细胞可通过血液系统播散到远端组织,然后这些变异的细胞在那里增殖,并形成继发性肿瘤,这也是肿瘤患者死亡最主要的原因。近年来,一系列重要的肿瘤相关基因陆续被报道,如钙粘素、层粘连蛋白、乙酰肝素硫酸盐、蛋白水解酶、血管生成抑制剂等。但是,这些基因在肿瘤转移中发生改变的机制尚不明了,因为尽管它们的表达普遍下调, 展开更多
关键词 转移 表观遗传学 DNA甲基化 组蛋白修饰 MICRORNAS DNA去甲基化药物 组蛋白去乙酰 化抑制剂 表观遗传学药物
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Dietary intake of advanced glycation endproducts(AGEs)and cancer risk across more than 20 anatomical sites:A multinational cohort study
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作者 Reynalda Córdova Ana-Lucia Mayén +30 位作者 Viktoria Knaze Elom Kouassivi Aglago Casper Schalkwijk Karl-Heinz Wagner Kim Overvad Anne Tjønneland Cecilie Kyrø Verena Andrea Katzke Charlotte Le Cornet Matthias Bernd Schulze Anna Birukov Domenico Palli Sara Grioni Fabrizio Pasanisi Alberto Catalano Torkjel Manning Sandanger Inger Torhild Gram Guri Skeie Marta Crous-Bou Esther Molina-Montes Pilar Amiano Sandra Milena Colorado-Yohar Eva Ardanaz Isabel Drake Jonas Manjer Ingegerd Johansson Anders Esberg Aurora Perez-Cornago Elisabete Weiderpass Mazda Jenab Heinz Freisling 《Cancer Communications》 SCIE 2022年第10期1041-1045,共5页
Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons... Dear Editor,In the European region,which shares 22.8%of the global cancer burden for 10%of the global population,there were around 4.4 million new cancer cases and 1.9 million deaths from cancer in 2020[1].The reasons for the high cancer incidence rates are complex;however,diet and dietary components are among the main contributors to cancer risk[2].In modern-day living,a growing proportion of people include in their diets ultra-processed foods.Byproducts of food processing and home-prepared foods are so-called dietary advanced glycation endproducts(AGEs),which are reactive metabolites emerging during the breakdown of reducing sugar.AGEs production is preponderant in dry high-heat processes(e.g.,baking,roasting);hence foods such as cakes,crisps,crackers,cereal products,meat and meat-derived products represent a major source of dietary AGEs[3]. 展开更多
关键词 dietary INTAKE hence
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