The expression of phosphatase and tensin homolog (PTEN ), a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it ...The expression of phosphatase and tensin homolog (PTEN ), a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it is unknown if additional mechanisms may account for the down-regulation of PTEN expression. While neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) is believed to be a potential dual regulator of PTEN, there are conflicting reports regarding their interaction. To gain further insight into the role of NEDD4-1 and its association with PTEN in gastric carcinoma development, we measured the protein expression of NEDD4-1 and PTEN in gastric mucosae with various pathological lesions and found that NEDD4-1 increased from normal gastric mucosa to intestinal metaplasia and decreased from dysplasia to gastric carcinoma. These changes did not correlate with PTEN expression changes during gastric carcinogenesis. Moreover, we found similar results in protein levels in the primary tumors and adjacent non-tumorous tissues. These results differ from a previous report showing that expression of NEDD4-1 is up-regulated in gastric carcinomas, and show a more complex pattern of NEDD4-1 gene expression during gastric carcinogenesis.展开更多
The title complex [Cu(L)2] (HL=4-salicylideneamino-3,5-dimethanol-1,2,4-triazole) was synthesized by the reaction of Cu(CH3COO)22H2O with 4-salicylideneamino-3,5-dimethanol- 1,2,4-triazole in the methanol. The single-...The title complex [Cu(L)2] (HL=4-salicylideneamino-3,5-dimethanol-1,2,4-triazole) was synthesized by the reaction of Cu(CH3COO)22H2O with 4-salicylideneamino-3,5-dimethanol- 1,2,4-triazole in the methanol. The single-crystal X-ray study reveals that the compound crystallizes in monoclinic, space group P21/n with a = 11.746(5), b = 8.145(3), c = 12.786(5) ? b = 106.64(1), V = 1172(1) ?, Z = 2, Dc = 1.581 g/cm3, m = 0.989 mm-1, F(000) = 574, C22H22Cu- N8O6, Mr = 558.02, T = 293(2) K, R = 0.0394 and Rw = 0.0835 for 2376 observed reflections with I > 2s(I). The complex comprises a four-coordinated copper(II) center, with an N2O2 planar coordi- nation environment. The molecules are connected by hydrogen bonds to form one-dimensional chains which are further linked to form a two-dimensional plane.展开更多
A new technology for the development of optic and photonic devices and systems taking advantages of extraordinary enhancement and localization of surface plasmon may be called as “plasmonics". A noteworthy chara...A new technology for the development of optic and photonic devices and systems taking advantages of extraordinary enhancement and localization of surface plasmon may be called as “plasmonics". A noteworthy characteristic of gold nanoparticles is that they show strong absorption bands in the visible-near IR region due to localized surface plasmon oscillation. Here, I will describe the utilization of gold nanoparticles on photoelectric conversion from self-assembled monolayers, and of gold nanorods as laser writing materials.展开更多
In this works, artificial neural network is com-bined with wavelet analysis for the forecast of solar irradiance. This method is characteristic of the preprocessing of sample data using wavelet transformation for the ...In this works, artificial neural network is com-bined with wavelet analysis for the forecast of solar irradiance. This method is characteristic of the preprocessing of sample data using wavelet transformation for the forecast, i.e., the data se-quence of solar irradiance as the sample is first mapped into several time-frequency domains, and then a chaos optimization neural network is established for each domain. The forecasted so-lar irradiance is exactly the algebraic sum of all the forecasted components obtained by the re-spective networks, which correspond respec-tively the time-frequency domains. On the basis of combination of chaos optimization neural network and wavelet analysis, a model is devel-oped for more accurate forecasts of solar irradi-ance. An example of the forecast of daily solar irradiance is presented in the paper, the historical daily records of solar irradiance in Shanghai constituting the data sample. The results of the example show that the accuracy of the method is more展开更多
Of the two methods of getting the mathematical model of a given system,modeling and i-dentification,the first is of the advantage of“knowing it in the detailed inside”.In this paper,after the common technological pr...Of the two methods of getting the mathematical model of a given system,modeling and i-dentification,the first is of the advantage of“knowing it in the detailed inside”.In this paper,after the common technological process of paper making is approached,a simplified physicalimitation and the mathematical model are presented.The resulted model by means of modelingis of the same form with that through,identification by K.J.Astrom in 1970.The course ofmodel deriving is described in detail,from which one can see clearly how the minor factors ofthe dynamics are omitted and what may be included in the unmodeled dynamics.At the sametime,the limit to its usage is also given.展开更多
Cell migration plays a crucial role in a variety of physiological and pathological processes.In this study a method of capillary force lithography was used to treat poly(sodium 4-styrenesulfonate) (PSS)/poly(diallyldi...Cell migration plays a crucial role in a variety of physiological and pathological processes.In this study a method of capillary force lithography was used to treat poly(sodium 4-styrenesulfonate) (PSS)/poly(diallyldimethylammonium) chloride (PDADMAC) multilayers with a PDMS stamp before or after etching by NaC1 solution,yielding physical patterns with various features such as double thin lines,double strips,meniscus-shaped ridges,and high ridges.The ridge height is controllable in the range of 25 and 1100 nm.Migration of smooth muscle cells (SMCs) was restrained by the double-line patterns in a ridge height-dependent manner.By contrast,the mobility of SMCs was controlled by both the hydration ratio of the multilayers and the pattern features.展开更多
Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative damage.Consequently enormous efforts have been devoted to developing ar...Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative damage.Consequently enormous efforts have been devoted to developing artificial catalysts with GPx function.Besides the research on enhancing the catalytic activity of GPx mimics,the design and construction of smart GPx models has also inspired great interest.Herein,a novel photo-responsive seleniumcontaining vesicular GPx model was successfully constructed by supramolecular self-assembly of the cationic surfactant PyC10AZoC10Py with benzeneseleninic acid (PhSeO2H) through hydrophobic and electrostatic interactions in aqueous media.This selenium-containing vesicular catalyst showed remarkable GPx-like activity,which is 692times more effective than PhSeO2H for the reduction of cumene hydroperoxide (CUOOH) by 4-nitrobenzenethiol (NBT).Interestingly,when an equimolar amount of α-CD was added,the GPx-like activity of the catalytic vesicle declines remarkably due to the vesicle disaggregation in the presence ofα-CD.Whereas the biomimetic system was irradiated by UV light at 365 nm,the catalytic vesicle was formed again and the GPx-like activity recovered.展开更多
Commercial MoS2 was found to be a highly selective catalyst for the reduction of nitrobenzenes to the corre- sponding anilines with hydrazine under mild conditions. MoS2 is not only much cheaper, but also more selecti...Commercial MoS2 was found to be a highly selective catalyst for the reduction of nitrobenzenes to the corre- sponding anilines with hydrazine under mild conditions. MoS2 is not only much cheaper, but also more selective than noble metal catalysts for the reduction of functional nitrobenzenes to the corresponding anilines. Nitrobenzenes with halides （F, C1, Br and I） were reduced selectively, and the corresponding anilines were obtained in excellent yields, and no dehalogenation was detected. Functional groups such as NH2, OH, alkene groups were tolerated dur- ing the reduction of the nitro compounds. The reduction ofp-chloronitrobenzene was studied over MoS2 and Pd/C respectively with hydrazine. The yield ofp-chloroaniline was much higher with MoS2 than that with Pd/C at full conversion.展开更多
A novel biomaterial based on polyurethane (PU) was prepared through physical incorporation of lysine-containing copolymer to improve its hemocompatibility and surface recognition of plasminogen.The lysine-containing c...A novel biomaterial based on polyurethane (PU) was prepared through physical incorporation of lysine-containing copolymer to improve its hemocompatibility and surface recognition of plasminogen.The lysine-containing copolymer was synthesized via the copolymerization of 2-ethylhexyl methacrylate (EHMA),oligo (ethylene glycol)methyl ether methacrylate (OEGMA) and 6-tert-butoxycarbonyl amino-2-(2-methyl-acryloylamino)-hexanoic acid tert-butyl ester (Lys(P)MA),followed by the deprotection of COOH and ε-NH2 groups on lysine residues in the copolymer.The composition of the copolymer can be adjusted by varying the monomer feed ratio.The three components contribute to improving the compatibility with PU,resistance to nonspecific protein adsorption and specific binding of plasminogen,respectively.The binding capacity towards plasminogen increased with the lysine content in the copolymer.This approach illustrates a simple way for the generation of novel biomaterials with improved hemocompatibility and surface recognition of specific biomolecules.展开更多
The growing importance of the service economy during the last 40 years has raised the need for new tools for designing and managing services. As a result, several authors have developed service classification systems,...The growing importance of the service economy during the last 40 years has raised the need for new tools for designing and managing services. As a result, several authors have developed service classification systems, in order to better understand the nature of service operations and provide methods and tools to improve service efficiency and quality. This paper exploits the work resulting from service classification systems and identifies the principal attributes to be considered in service management. The tool introduced for this purpose is the Service Attribute-Process Matrix （SAPM）, which uses selected results from existing service classification schemes to investigate the importance of the significant service attributes to major processes of the service life cycle.展开更多
基金Supported by Grants from the National Natural Science Foundation of China, No. 81060038the Graduate Innovative Fund of Jiangxi Province, No. YC10A020
文摘The expression of phosphatase and tensin homolog (PTEN ), a tumor suppressor gene, is frequently downregulated in gastric carcinomas due to mutation, loss of heterozygosity, and promoter hypermethylation. However, it is unknown if additional mechanisms may account for the down-regulation of PTEN expression. While neuronal precursor cell-expressed developmentally down-regulated 4-1 (NEDD4-1) is believed to be a potential dual regulator of PTEN, there are conflicting reports regarding their interaction. To gain further insight into the role of NEDD4-1 and its association with PTEN in gastric carcinoma development, we measured the protein expression of NEDD4-1 and PTEN in gastric mucosae with various pathological lesions and found that NEDD4-1 increased from normal gastric mucosa to intestinal metaplasia and decreased from dysplasia to gastric carcinoma. These changes did not correlate with PTEN expression changes during gastric carcinogenesis. Moreover, we found similar results in protein levels in the primary tumors and adjacent non-tumorous tissues. These results differ from a previous report showing that expression of NEDD4-1 is up-regulated in gastric carcinomas, and show a more complex pattern of NEDD4-1 gene expression during gastric carcinogenesis.
基金This work was supported by the NNSFC (Nos. 50173011and 90101028),the NSF of Tianjin (No. 013801611) and the TRAPOYT of MOE,China
文摘The title complex [Cu(L)2] (HL=4-salicylideneamino-3,5-dimethanol-1,2,4-triazole) was synthesized by the reaction of Cu(CH3COO)22H2O with 4-salicylideneamino-3,5-dimethanol- 1,2,4-triazole in the methanol. The single-crystal X-ray study reveals that the compound crystallizes in monoclinic, space group P21/n with a = 11.746(5), b = 8.145(3), c = 12.786(5) ? b = 106.64(1), V = 1172(1) ?, Z = 2, Dc = 1.581 g/cm3, m = 0.989 mm-1, F(000) = 574, C22H22Cu- N8O6, Mr = 558.02, T = 293(2) K, R = 0.0394 and Rw = 0.0835 for 2376 observed reflections with I > 2s(I). The complex comprises a four-coordinated copper(II) center, with an N2O2 planar coordi- nation environment. The molecules are connected by hydrogen bonds to form one-dimensional chains which are further linked to form a two-dimensional plane.
文摘A new technology for the development of optic and photonic devices and systems taking advantages of extraordinary enhancement and localization of surface plasmon may be called as “plasmonics". A noteworthy characteristic of gold nanoparticles is that they show strong absorption bands in the visible-near IR region due to localized surface plasmon oscillation. Here, I will describe the utilization of gold nanoparticles on photoelectric conversion from self-assembled monolayers, and of gold nanorods as laser writing materials.
文摘In this works, artificial neural network is com-bined with wavelet analysis for the forecast of solar irradiance. This method is characteristic of the preprocessing of sample data using wavelet transformation for the forecast, i.e., the data se-quence of solar irradiance as the sample is first mapped into several time-frequency domains, and then a chaos optimization neural network is established for each domain. The forecasted so-lar irradiance is exactly the algebraic sum of all the forecasted components obtained by the re-spective networks, which correspond respec-tively the time-frequency domains. On the basis of combination of chaos optimization neural network and wavelet analysis, a model is devel-oped for more accurate forecasts of solar irradi-ance. An example of the forecast of daily solar irradiance is presented in the paper, the historical daily records of solar irradiance in Shanghai constituting the data sample. The results of the example show that the accuracy of the method is more
文摘Of the two methods of getting the mathematical model of a given system,modeling and i-dentification,the first is of the advantage of“knowing it in the detailed inside”.In this paper,after the common technological process of paper making is approached,a simplified physicalimitation and the mathematical model are presented.The resulted model by means of modelingis of the same form with that through,identification by K.J.Astrom in 1970.The course ofmodel deriving is described in detail,from which one can see clearly how the minor factors ofthe dynamics are omitted and what may be included in the unmodeled dynamics.At the sametime,the limit to its usage is also given.
基金This study is financially supported by the National Natural Science Foundation of China (Nos.20934003and 51003094),and the National Basic Research Program of China (No.2011CB606203).Z.W.Mao thanks Young Teacher Programs Foundation of Ministry of Education of China (No.20100101120034),'Qianjiang'outstanding researcher funding of Zhejiang Province (No.J20110541) and the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry.
文摘Cell migration plays a crucial role in a variety of physiological and pathological processes.In this study a method of capillary force lithography was used to treat poly(sodium 4-styrenesulfonate) (PSS)/poly(diallyldimethylammonium) chloride (PDADMAC) multilayers with a PDMS stamp before or after etching by NaC1 solution,yielding physical patterns with various features such as double thin lines,double strips,meniscus-shaped ridges,and high ridges.The ridge height is controllable in the range of 25 and 1100 nm.Migration of smooth muscle cells (SMCs) was restrained by the double-line patterns in a ridge height-dependent manner.By contrast,the mobility of SMCs was controlled by both the hydration ratio of the multilayers and the pattern features.
基金We acknowledge financial support from the National Natural Science Foundation of China (Nos.21234004,91027023,21221063,and 21004028) and the 111 project (No.B06009).
文摘Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative damage.Consequently enormous efforts have been devoted to developing artificial catalysts with GPx function.Besides the research on enhancing the catalytic activity of GPx mimics,the design and construction of smart GPx models has also inspired great interest.Herein,a novel photo-responsive seleniumcontaining vesicular GPx model was successfully constructed by supramolecular self-assembly of the cationic surfactant PyC10AZoC10Py with benzeneseleninic acid (PhSeO2H) through hydrophobic and electrostatic interactions in aqueous media.This selenium-containing vesicular catalyst showed remarkable GPx-like activity,which is 692times more effective than PhSeO2H for the reduction of cumene hydroperoxide (CUOOH) by 4-nitrobenzenethiol (NBT).Interestingly,when an equimolar amount of α-CD was added,the GPx-like activity of the catalytic vesicle declines remarkably due to the vesicle disaggregation in the presence ofα-CD.Whereas the biomimetic system was irradiated by UV light at 365 nm,the catalytic vesicle was formed again and the GPx-like activity recovered.
文摘Commercial MoS2 was found to be a highly selective catalyst for the reduction of nitrobenzenes to the corre- sponding anilines with hydrazine under mild conditions. MoS2 is not only much cheaper, but also more selective than noble metal catalysts for the reduction of functional nitrobenzenes to the corresponding anilines. Nitrobenzenes with halides （F, C1, Br and I） were reduced selectively, and the corresponding anilines were obtained in excellent yields, and no dehalogenation was detected. Functional groups such as NH2, OH, alkene groups were tolerated dur- ing the reduction of the nitro compounds. The reduction ofp-chloronitrobenzene was studied over MoS2 and Pd/C respectively with hydrazine. The yield ofp-chloroaniline was much higher with MoS2 than that with Pd/C at full conversion.
基金This work was supported by the National Natural Science Foundation of China (Nos.21204055,21344002,21174098 and 21304062) and the Natural Science Foundation of Jiangsu Province (Nos.13KJA430006 and 13KJB430020).
文摘A novel biomaterial based on polyurethane (PU) was prepared through physical incorporation of lysine-containing copolymer to improve its hemocompatibility and surface recognition of plasminogen.The lysine-containing copolymer was synthesized via the copolymerization of 2-ethylhexyl methacrylate (EHMA),oligo (ethylene glycol)methyl ether methacrylate (OEGMA) and 6-tert-butoxycarbonyl amino-2-(2-methyl-acryloylamino)-hexanoic acid tert-butyl ester (Lys(P)MA),followed by the deprotection of COOH and ε-NH2 groups on lysine residues in the copolymer.The composition of the copolymer can be adjusted by varying the monomer feed ratio.The three components contribute to improving the compatibility with PU,resistance to nonspecific protein adsorption and specific binding of plasminogen,respectively.The binding capacity towards plasminogen increased with the lysine content in the copolymer.This approach illustrates a simple way for the generation of novel biomaterials with improved hemocompatibility and surface recognition of specific biomolecules.
文摘The growing importance of the service economy during the last 40 years has raised the need for new tools for designing and managing services. As a result, several authors have developed service classification systems, in order to better understand the nature of service operations and provide methods and tools to improve service efficiency and quality. This paper exploits the work resulting from service classification systems and identifies the principal attributes to be considered in service management. The tool introduced for this purpose is the Service Attribute-Process Matrix （SAPM）, which uses selected results from existing service classification schemes to investigate the importance of the significant service attributes to major processes of the service life cycle.
