The genomic landscapes of histone H3-Lys9 modifications of gene promoter regions and expression profiles in human bone marrow mesenchymal stem cells

Mesenchymal stem cells （MSCs） of nonembryonic origins possess the proliferation and multi-lineage differentiation potentials. It has been established that epigenetic mechanisms could be critical for determining the fate of stem cells, and MSCs derived from different origins exhibited different expression profiles individually to a certain extent. In this study, ChiP-on-chip was used to generate genome-wide histone H3-Lys9 acetylation and dimethylation profiles at gene promoters in human bone marrow MSCs. We showed that modifications of histone H3-Lys9 at gene promoters correlated well with mRNA expression in human bone marrow MSCs. Functional analysis revealed that many key cellular pathways in human bone marrow MSC self-renewal, such as the canonical signaling pathways, cell cycle pathways and cytokine related pathways may be regulated by H3-Lys9 modifications. These data suggest that gene activation and silencing affected by H3-Lys9 acetylation and dimethylation, respectively, may be essential to the maintenance of human bone marrow MSC self-renewal and multi-potency.

On the maximin distance properties of orthogonal designs via the rotation

Space-filling designs are widely used in computer experiments.They are frequently evaluated by the orthogonality and distance-related criteria.Rotating orthogonal arrays is an appealing approach to constructing orthogonal space-filling designs.An important issue that has been rarely addressed in the literature is the design selection for the initial orthogonal arrays.This paper studies the maximin L_(2)-distance properties of orthogonal designs generated by rotating two-level orthogonal arrays under three criteria.We provide theoretical justifications for the rotation method from a maximin distance perspective and further propose to select initial orthogonal arrays by the minimum G_(2)-aberration criterion.New infinite families of orthogonal or 3-orthogonal U-type designs,which also perform well under the maximin distance criterion,are obtained and tabulated.Examples are presented to show the effectiveness of the constructed designs for building statistical surrogate models.

A review of 20 years of naive tests of significance for high-dimensional mean vectors and covariance matrices

We introduce the so-called naive tests and give a brief review of the new developments. Naive testing methods are easy to understand and perform robustly, especially when the dimension is large. We focus mainly on reviewing some naive testing methods for the mean vectors and covariance matrices of high-dimensional populations, and we believe that this naive testing approach can be used widely in many other testing problems.

BOUNDS ON AVERAGE CONTROLLED DIRECT EFFECTS WITH AN UNOBSERVED RESPONSE VARIABLE

这份报纸考虑在一般水准上估计界限的问题面对在一个中间的变量和反应变量之间的未被遵守的 confounders 在一个未被遵守的反应变量上控制了一个处理变量的直接效果(ACDE ) 。当反应变量被观察时，蔡，等(2008 ) 在 ACDE 上为锋利的界限导出公式。当反应变量是未被遵守的时，作者为选择反应变量假装在 ACDE 上为界限导出公式的变量建议一个图形的标准，它是 Kuroki (2005 ) 的结果的延期到 ACDE。结果使我们能不仅当反应变量是未被遵守的时，从图结构判定 ACDE 上的界限是否能通过观察变量被表示，而且当答案肯定时，提供他们的公式。