Mesenchymal stem cells in wound healing:A bibliometric analysis as a powerful research tool

Bibliographic analysis is still very rarely used in experimental basic study papers.The comprehensive bibliometric analysis of scientific literature on research progress and challenges in stem cell therapy for diabetic chronic wounds,which was conducted in the work of Shi et al can be a case study and a source of valuable information for writing reviews and experimental papers in this field.Basic experimental studies on a role of mesenchymal stem cells(MSCs)in wound healing that are published in 2023-2024,such as Zhang et al in 2023,Hu et al in 2023,Wang et al in 2023 are certainly also subjects for applying this powerful tool to analyze current research,challenges and perspectives in this field.This is due to the fact that these studies have addressed a great variety of aspects of the application of MSCs for the treatment of chronic wounds,such as using both the cells themselves and their various products:Sponges,hydrogels,exosomes,and genetic constructions.Such a wide variety of directions in the field of study and biomedical application of MSCs requires a deep understanding of the current state of research in this area,which can be provided by bibliometric analysis.Thus,the use of such elements of bibliographic analysis as publication count by year and analysis of top-10 keywords calculated independently or cited from bibliometric analysis studies can be safely recommended for every basic study manuscripts,primarily for the“Introduction”section,and review.

Nanodiamond-Assisted High Performance Lithium and Sodium Ions Co-Storage

While lithium resources are scarce for high energy-dense lithium-ion batteries(LIBs),sodium-ion batteries(SIBs),serving as an alternative,inherently suffer from low capacity and the high-cost use of non-graphite anodes.Combining Li-and Na-ions within a single battery system is expected to mitigate the shortcomings of both systems while leveraging their respective advantages.In this study,we developed and assembled a nanodiamonds(NDs)-assisted co-Li/Na-ion battery(ND–LSIB).This innovative battery system comprised a commercial graphite anode,an ND-modified polypropylene(DPP)separator,a hybrid lithium/sodium-based electrolyte,and a cathode.It is theoretically and experimentally demonstrated that the ND/Li co-insertion can serve as an ion-drill opening graphite layers and reconstructing graphite anodes into few-layered graphene with expanding interlayer space,achieving highly efficient Li/Na storage and the theoretical maximum of LiC_(6)for Li storage in graphite.In addition,ND is helpful for creating a LiF-/NaF-rich hybrid solid electrolyte interface with improved ionic mobility,mechanical strength,and reversibility.Consequently,ND–LSIBs have higher specific capacities~1.4 times the theoretical value of LIBs and show long-term cycling stability.This study proposes and realizes the concept of Li/Na co-storage in one ion battery with compatible high-performance,cost-effectiveness,and industrial prospects.

Sequential disruption of ALV host receptor genes reveals no sharing of receptors between ALV subgroups A, B, and J

Background: Previously, we showed that targeted disruption of viral receptor genes in avian leukosis virus(ALV)subgroups using clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9))-based genome editing confers resistance to ALV subgroups B and J. Here, we used the same strategy to target the receptor expressed by ALV subgroup A(TVA) and generate chicken cells resistant to infection by this virus.Results: CRISPR/Cas9-based disruption of exon 2 within the tva gene of DF-1 fibroblasts conferred resistance to infection by ALV subgroup A regardless of whether frameshift mutations were introduced during editing. Conversely,overexpression of the wild-type TVA receptor(wtTVA) by tva-modified DF-1 clones restored susceptibility to ALV subgroup A. The results confirm that exon 2, which contains the low-density lipoprotein receptor class A domain of TVA, is critical for virus entry. Furthermore, we sequentially modified DF-1 cells by editing the tva, tvb, and Na^+/H^+ exchange 1(chNHE1) genes, which are the specific receptors for ALV subgroups A, B, and J, respectively.Conclusions: Simultaneous editing of multiple receptors to block infection by different subgroups of ALV confirmed that ALV subgroups A, B, and J do not share host receptors. This strategy could be used to generate cells resistant to multiple viral pathogens that use distinct receptors for cell entry.

Evolving role of adiponectin in cancer-controversies and update

Adiponectin(APN), an adipokine produced by adipocytes, has been shown to have a critical role in the pathogenesis of obesityassociated malignancies. Through its receptor interactions, APN may exert its anti-carcinogenic effects including regulating cell survival, apoptosis and metastasis via a plethora of signalling pathways. Despite the strong evidence supporting this notion, some work may indicate otherwise. Our review addresses all controversies critically. On the whole, hypoadiponectinaemia is associated with increased risk of several malignancies and poor prognosis. In addition, various genetic polymorphisms may predispose individuals to increased risk of obesity-associated malignancies. We also provide an updated summary on therapeutic interventions to increase APN levels that are of key interest in this field. To date efforts to manipulate APN levels have been promising, but much work remains to be done.

口蹄疫病毒受体整联蛋白在绵羊不同发育阶段组织中mRNA转录水平的分析

口蹄疫病毒野毒株利用整联蛋白(integrin)αvβ1、αvβ3、αvβ6和αvβ8作为受体侵入细胞。本研究采用实时逆转录聚合酶链反应(qRT-PCR)技术,定量检测绵羊胎儿(45、75和110 d的绵羊胎儿)、新生羔羊和成年绵羊组织中整联蛋白亚单位αv、β3、β6和β8转录水平。比较分析发现,在蹄冠上皮组织中,成年绵羊和新生羔羊的β6 mRNA水平低于75和110 d胎儿的;在心组织中,成年绵羊、新生羔羊和110 d胎儿的β6 mRNA高于45和75 d胎儿的;在肌肉组织中,胎儿和新生羔羊的β6以及β8 mRNA水平高于成年绵羊的;在舌上皮组织中,成年绵羊的β3 mRNA水平低于其他发育时期的。在软腭组织、扁桃体中整联蛋白mRNA水平在胎儿、新生儿和成年绵羊之间变化不大。本研究首次获得相关整联蛋白mRNA在绵羊不同发育阶段组织中分布的定量数据,为了解整联蛋白在口蹄疫病毒感染组织嗜性中的作用机制提供新的科学依据。

Minimizing the risk of small-for-size syndrome after liver surgery

Background: Primary and secondary liver tumors are not always amenable to resection due to location and size. Inadequate future liver remnant(FLR) may prevent patients from having a curative resection or may result in increased postoperative morbidity and mortality from complications related to small-forsize syndrome(SFSS). Data sources: This comprehensive review analyzed the principles, mechanism and risk factors associated with SFSS and presented current available options in the evaluation of FLR when planning liver surgery. In addition, it provided a detailed description of specifc modalities that can be used before, during or after surgery, in order to optimize the conditions for a safe resection and minimize the risk of SFSS. Results: Several methods which aim to reduce tumor burden, preserve healthy liver parenchyma, induce hypertrophy of FLR or prevent postoperative complications help minimize the risk of SFSS. Conclusions: With those techniques the indications of radical treatment for patients with liver tumors have signifcantly expanded. The successful outcome depends on appropriate patient selection, the individualization and modifcation of interventions and the right timing of surgery.

两种基于向量化策略SVM分类器的对比分析

以股票涨跌趋势预测精度为评价指标,针对传统股票数据特征训练过程中预测精度不高的情况,考虑引入两种不同的向量化策略对股民评论、新闻关键词等文本信息进行非结构化数据特征的捕捉,利用词意的积极、消极程度对客观因素进行处理,进而将向量化后的特征作为新的非线性特征项扩充原有的结构化特征集合。文中分别以词向量化和句向量化为出发点设计两种启发式的SVM分类器,其目标是在拟合每支股票的情况下尽可能预测出其未来的走势,挖掘出更具有增长潜力的股票样本。经过2018年6月至12月半年沪市股票数据集的实验结果表明,相比于词向量化策略,采用句向量化策略设计的SVM分类器不仅能够更好地预测股票涨跌,并且能够更有效地挑选出潜在增长的股票样本。

Assessment of the binding interactions of SARS-CoV-2 spike glycoprotein variants

Severe acute respiratory syndrome-associated coronavirus 2 is a major global health issue and is driving the need for new therapeutics.The surface spike protein,which plays a central role in virus infection,is currently the target for vaccines and neutralizing treatments.The emergence of novel variants with multiple mutations in the spike protein may reduce the effectiveness of neutralizing antibodies by altering the binding activity of the protein with angiotensin-converting enzyme 2(ACE2).To understand the impact of spike protein mutations on the binding interactions required for virus infection and the effectiveness of neutralizing monoclonal antibody(mAb)therapies,the binding activities of the original spike protein receptor binding domain(RBD)sequence and the reported spike protein variants were investigated using surface plasmon resonance.In addition,the interactions of the ACE2 receptor,an antispike mAb(mAb1),a neutralizing mAb(mAb2),the original spike RBD sequence,and mutants D614G,N501Y,N439K,Y453F,and E484K were assessed.Compared to the original RBD,the Y453F and N501Y mutants displayed a significant increase in ACE2 binding affinity,whereas D614G had a substantial reduction in binding affinity.All mAb-RBD mutant proteins displayed a reduction in binding affinities relative to the original RBD,except for the E484K-mAb1 interaction.The potential neutralizing capability of mAb1 and mAb2 was investigated.Accordingly,mAb1 failed to inhibit the ACE2-RBD interaction while mAb2 inhibited the ACE2-RBD interactions for all RBD mutants,except mutant E484K,which only displayed partial blocking.

Aggressive behavioural interactions between swans(Cygnus spp.)and other waterbirds during winter:a webcam-based study

Background:Our understanding of any impacts of swans on other waterbirds(including other swans),and potential effects on waterbird community structure,remain limited by a paucity of fundamental behavioural and ecological data,including which species swans interact aggressively with and how frequently such interactions occur.Methods:Behavioural observations of aggression by swans and other waterbirds in winters 2018/2019 and 2019/2020,were carried out via live-streaming webcams at two wintering sites in the UK.All occurrence sampling was used to identify all aggressive interactions between conspecific or heterospecifics individuals,whilst focal observations were used to record the total time spent by swans on aggressive interactions with other swans.Binomial tests were then used to assess whether the proportion of intraspecific aggressive interactions of each species differed from 0.5(which would indicate equal numbers of intraspecific and interspecific interactions).Zero-inflated generalized linear mixed effects models(ZIGLMMs)were used to assess between-individual variation in the total time spent by swans on aggressive interactions with other swans.Results:All three swan species were most frequently aggressive towards,and received most aggression from,their conspecifics.Our 10-min focal observations showed that Whooper(Cygnus cygnus)and Bewick’s Swans(C.columbianus bewickii)spent 13.8±4.7 s(means±95%CI)and 1.4±0.3 s,respectively,on aggression with other swans.These durations were equivalent to 2.3%and 0.2%of the Whooper and Bewick’s Swan time-activity budgets,respectively.Model selection indicated that the time spent in aggressive interactions with other swans was best-explained by the number of other swans present for Whooper Swans,and an interactive effect of time of day and winter of observation for Bewick’s Swans.However,the relationship between swan numbers and Whooper Swan aggression times was not strong(R2=19.3%).Conclusions:Whilst swans do exhibit some aggression towards smaller waterbirds,the majority of aggression by swans is directed towards other swans.Aggression focused on conspecifics likely reflects greater overlap in resource use,and hence higher potential for competition,between individuals of the same species.Our study provides an example of how questions relating to avian behaviour can be addressed using methods of remote data collection such as live-streaming webcams.

高分子材料的远红外加工

远红外加热源的有效波段与液晶、PDP、CD、DVD以及各种电子器件的有机高分子材料的远红外吸收波长相一致。因而,现在就应该研究利用远红外技术来提高它们的质量和生产率。本文主要研究以往的热风加热装置和热风、远红外并用装置,以及远红外主体装置的加热效果比较,并阐述利用远红外热加工高分子材料的概要。

缺水、海水淡化与污染

全世界快速的人口增长、城市化和高标准生活加剧了水的短缺，已经导致许多国家(特别是在干旱与半干旱地区)不得不采用海水淡化技术，首要满足家庭需求．在1950与1960年代，海水淡化业商业化．随着成本的大幅度降低和效率的提高，特别是自从1970年代以来，海水淡化已经变成满足家庭需要的一项战略和可靠来源．

Nature Reserve and Ecotourism Development in China’s Wuzhishan Mountain Region

As the protected areas of land and coastal environment, nature reserves are designed to address how to reconcile the conservation of biodiversity, the quest for economic and social development and the maintenance of cultural values. This paper establishes a framework for nature reserve development that seeks to incorporate ecotourism into its strategies. The overall purpose was to identify the information needs required for a comprehensive nature reserve that incorporates ecotourism related values. It also illustrates the utility of this framework in the context of the Wuzhishan Mountain Region of China. A literature review, the first phase of a visionary strategy and a subsequent gap analysis for available management information were undertaken in order to achieve this paper＇s purpose. Finally, recommendations axe pre-sented for integrating ecotourism into nature reserve development in the Wuzhishan Mountain Region.

Novel treatment of coronary artery fistulae concealing severe coronary artery lesion： using thrombus aspiration catheter as a delivery guide

In this case report, we present the occlusion of multiple coronary artery fistulaes originating from proximal left anterior descending （LAD） and fight sinus valsavla and empting to the pulmonary artery at the same place. We occluded LAD fistulae by using thrombus aspira- tion catheter as a delivery guide. To the best of our knowlege, this is the first case of occlusion of coronary fistulaes with the help of throm- bus aspiration catheter. Our experience may suggest that thrombus aspiration catheters can be used in treating coronary artery fistulaes with difficult anotomv.

Influence of Bitumen Emulsion Spray on Pavement Performance

Bitumen emulsion sprays have an important part to play in the achievement of durable,efficient road pavement construction.Clearly,spraying of bond coats or tack coats at the interface of the bound layers should improve the likelihood of full bond and of resistance to the entry of water through the layers,both of which are needed to meet the design objectives and for the pavement to continue to function properly.BS 594987 recommends bond coats,which are typically polymer modified bitumen emulsion,as best practice and their use is prevalent for the whole range of paved areas in the UK.Recent work examines the effect of different rates of spread of bitumen emulsion sprays on interlayer adhesion and permeability,and attempts to ascertain whether there are optimum quantities to obtain the desired effects.

The Pivotal Role of TNF -α in Rheumatoid Arthritis

As a main pro-inflammatory factor, the up-regulation of TNF-α in RA patients plays a pivotal role in RA pathogenesis. The process of TNF production starts with the binding of a ligand( which is commonly a microbial product) to a cell surface Toll receptor, which stimulates a signal transduction pathway that activates NF - κB transcription factors. Activated NF - κB enters nuclei and induces the transcription of genes associated with inflammation, including those coding for TNF. The production of TNF and other inflammatory cytokines serves to recruit other inflammatory cells, which in turn release cytokines and subsequently amplify the immune response. TNF exerts its effect via binding of TNFRland TNFR2 receptors. Many experimental and clinical study have proved the effectiveness of TNF - αa ctivity blockade. Recent therapeutic interventions, including TNF - α and IL - 1 inhibitors, strongly support the importance of cytokines in RA. The mechanism of anti - TNF - α action in vivo is complex and probably includes suppression of other pro - inflammatory cytokines, decreased synovial cellular infiltration, interference with osteoclast activation, and decreased angiogenisis. Studies using anti -TNF agents clearly show that they can slow or prevent the progression of bone and cartilage damage in RA. This activity probably involves suppression of osteoclasts in joint lesions. Etanereept, Infliximab and adalimumab are the three main biologic agents that were fo-cused on clinically at present.

英国整体人生满意程度和何种因素相关

人生满意程度逐渐成为衡量英国社会与经济现状的最重要指标之一。Buetell(2006)指出,人生满意程度也成为幸福指数或快乐指数。这是人们对未来和现在的感受和语气。根据英国卫报(2014)的报道显示,77%的英国成年人对他们的生活非常满意。相比于2011/12的调查,这个数字增长了1.1%。ONS最近总结来看英国人对他们的生活是比较满意的。然而,人生满意程度是一个主观的变量,幸福的程度是受到很多因素共同影响的。如果政府想要增加人民的幸福程度,那么决定人生满意程度的变量就应该被探索和研究。

Measurement and Simulation of the Flow Field around a Triangular Lattice Meteorological Mast

The international standard IEC 61400-12-1 Wind turbines--Part 12-1： Power performance measurements of electricity producing wind turbines＂ aims to provide a uniform methodology that will ensure consistency, accuracy and reproducibility in the measurement and analysis of power performance by wind turbines. Annex G of this standard provides a methodology for the appropriate arrangement of instruments on the meteorological mast to ensure accurate measurement. For cup anemometers it provides recommendations about their location relative to the mast so that the effect of mast and boom interference on their output may be minimised. These recommendations are given for both tubular masts and lattice masts. This paper compares the flow distortion predicted by the IEC standard and the results of a 3D CFD （computational fluid dynamics） simulation of a triangular lattice mast. Based on the results of wind tunnel and CFD simulation it was found that the flow distortion surrounding the lattice mast was overpredicted by the method suggested in appendix G oflEC61400-12-1. Using the CFD data it was possible to determine, for a range of flow directions and mast heights, the distance from the mast that anemometers would need to be in order to be outside the flow distortion field.

The Global Stratotype Section and Point （GSSP） for the base of the Holocene Series/Epoch （Quaternary System/Period） in the NGRIP ice core

The Greenland ice core from NorthGRIP （NGRIP） contains a proxy climate record across the Pleistocene-Holocene boundary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enables the base of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/Greenland Stadial 1 cold phase, to be located with a high degree of precision.

Self-efficacy for managing hypertension and comorbid conditions

BACKGROUND Self-efficacy is defined an individual’s belief in completing necessary actions to achieve the desired goal.For individuals with hypertension and other chronic conditions,self-efficacy has been an essential factor to predict adherence to treatment behaviors.AIM To examine self-efficacy for managing chronic conditions in individuals with hypertension.METHODS A total of 1087 individuals with chronic conditions in two groups(hypertension and non-hypertension groups)were selected in this study.The two groups’selfefficacy for managing chronic conditions were investigated using the five domains of patient reported outcomes measurement information system selfefficacy for managing chronic conditions measures(PROMIS-SE);daily activities,emotions,medication and treatment,social interactions,and symptoms.Also,the relationships between self-efficacy and other health-related outcomes for the hypertension group were examined using structural equation modeling.RESULTS Among 1087 participants,437 reported having hypertension.The hypertension and non-hypertension groups were statistically different in self-efficacy for managing daily activities[F(1,598)=5.63,P<0.05].Structural equation modeling indicated that for individuals with hypertension,two domains of PROMIS-SE(managing daily activities and emotions)significantly predict global physical health(P<0.001 and P<0.01 sequentially),and one domain(managing emotions)significantly predicts mental health(P<0.001).Hypertension patients’general quality of life was significantly predicted by global physical health(P<0.001)and mental health(P<0.001).CONCLUSION The hypertension group reported deficits in self-efficacy in managing daily activities as compared to the non-hypertension group.In this hypertension group,self-efficacy functioned as an indirect predictor of general quality of life,mediated by global physical and mental health.

Synthesis of silicone blocked bio-polyurethane and its application in highly stretchable fiber-shaped strain sensor

Flexible strain sensors have become a key component of intelligent wearable electronics.However,the fabrication of strain sensors with wide workable strain ranges and high sensitivity remains a great challenge.Additionally,the rapid development of polymer composites based strain sensors has produced a large amount of e-waste.Therefore,the development of strain sensors with wide strain sensing ranges and high sensitivity based on degradable materials is necessary.In this work,a silicone blocked polyurethane(Si-BPU)with high stretchability and degradability was synthesized and composited with carbon nanotubes(CNTs)to fabricate fibrous strain sensors.The synthesized 0.5%Si-BPU exhibited good biodegradability with a weight loss of 16.47%in 42 days.The Si-BPU/12CNTs fiber based strain sensor achieved a sensing range of 0%–353.3%strain,gauge factor(GF)of 206.3 at 250%strain and of 4,513.2 at 353.3%strain,reliable stability under 10,000 repeated stretching–releasing cycles.Moreover,the Si-BPU/12CNTs strain sensor showed rapid response time(<163 ms)and was capable of monitoring various human body movements(elbow bending,finger bending,breath,swallow).In consequence,this work provides a new and effective strategy for the development of sustainable wearable electronic devices.