目的:观察肿瘤转移相关基因及转移抑制基因在DEN诱发大鼠肝癌组织中的表达及不同治法对其影响。方法:DEN诱发大鼠肝癌,经西药喃氟啶和不同中药治疗,取大鼠肝(含肝癌)组织抽提RNA,Affymetrix Rat 230A GeneChip检测基因表达的差异。结果...目的:观察肿瘤转移相关基因及转移抑制基因在DEN诱发大鼠肝癌组织中的表达及不同治法对其影响。方法:DEN诱发大鼠肝癌,经西药喃氟啶和不同中药治疗,取大鼠肝(含肝癌)组织抽提RNA,Affymetrix Rat 230A GeneChip检测基因表达的差异。结果:肝癌表达增加者55个,减少者8个,不同中西医治法有一定的调节作用。分析:肿瘤转移相关基因及转移抑制基因在肝癌中表达的改变和不同治法作用的差异,其具体调节途径和意义有待进一步研究。展开更多
Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible p...Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible patients will be randomly assigned to the intervention group(acupuncture)or the control group(sham acupuncture).All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks(5 times per week in the first 2 weeks,3 times per week during weeks 3-6,and 2 times per week during weeks 7 and 8).Each treatment will last for 20 min.The primary outcome is the change in mean complete spontaneous bowel movements(CSBMs)per week.The secondary out?comes are patient assessment of constipation quality of life questionnaire(PAC-QOL),self-rating anxiety scale(SAS),and the dosage of the medication.All adverse events will be recorded in detail and managed by corresponding researchers as quickly as possible.Outcomes will be evaluated at baseline(1 week before treatment),2 weeks after intervention begins,6 weeks after intervention begins,8 weeks after intervention begins,4 weeks follow-up,and 12 weeks follow-up.Discussion:The results of this study will provide the evidence of the efficacy and safety of acupuncture as a traditional treatment methods for functional constipation.Trial registration:Chinese Clinical Trial Registry,ChiCTR-INR-17011472.Registered on 23 May 2017.展开更多
文摘目的:观察肿瘤转移相关基因及转移抑制基因在DEN诱发大鼠肝癌组织中的表达及不同治法对其影响。方法:DEN诱发大鼠肝癌,经西药喃氟啶和不同中药治疗,取大鼠肝(含肝癌)组织抽提RNA,Affymetrix Rat 230A GeneChip检测基因表达的差异。结果:肝癌表达增加者55个,减少者8个,不同中西医治法有一定的调节作用。分析:肿瘤转移相关基因及转移抑制基因在肝癌中表达的改变和不同治法作用的差异,其具体调节途径和意义有待进一步研究。
基金supported by the Shanghai Municipal Commission of Health and Family Planning(Grant No.2016LQ015)
文摘Objective:This trial is aimed at evaluating the efficacy and safety of acupuncture on treating FC.Methods:We describe the protocol for a randomized,patient-assessor-blinded,sham controlled trial.Seventy-two eligible patients will be randomly assigned to the intervention group(acupuncture)or the control group(sham acupuncture).All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks(5 times per week in the first 2 weeks,3 times per week during weeks 3-6,and 2 times per week during weeks 7 and 8).Each treatment will last for 20 min.The primary outcome is the change in mean complete spontaneous bowel movements(CSBMs)per week.The secondary out?comes are patient assessment of constipation quality of life questionnaire(PAC-QOL),self-rating anxiety scale(SAS),and the dosage of the medication.All adverse events will be recorded in detail and managed by corresponding researchers as quickly as possible.Outcomes will be evaluated at baseline(1 week before treatment),2 weeks after intervention begins,6 weeks after intervention begins,8 weeks after intervention begins,4 weeks follow-up,and 12 weeks follow-up.Discussion:The results of this study will provide the evidence of the efficacy and safety of acupuncture as a traditional treatment methods for functional constipation.Trial registration:Chinese Clinical Trial Registry,ChiCTR-INR-17011472.Registered on 23 May 2017.
