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Effect of Co-administration of Morphine and Cholinergic Antagonists on Y-maze Spatial Recognition Memory Retrieval and Locomotor Activity in Mice 被引量:1
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作者 何静 陈艳梅 +1 位作者 王建红 马原野 《Zoological Research》 CAS CSCD 北大核心 2008年第6期613-620,共8页
The interaction of morphine and cholinergic system was shown in previous studies. In the present study, we investigated whether morphine would interact with the cholinergic antagonists, scopolamine and atropine in a Y... The interaction of morphine and cholinergic system was shown in previous studies. In the present study, we investigated whether morphine would interact with the cholinergic antagonists, scopolamine and atropine in a Y-maze spatial recognition memory. Pre-test treatments of morphine (5, 1.5, 0.5 mg/kg), scopolamine (1, 0.1 mg/kg), atropine (0.5, 0.1 mg/kg) were used in the experiments, relatively high or low doses were paired respectively as co-administration measures. The results showed that co-administration of morphine 0.Smg/kg ~ scopolamine 0.1 mg/kg and morphine 0.5 mg/kg + atropine 0.1 mg/kg disturbed the inspective exploratory behavior (percent of arm duration) but not the inquisitive behavior (percent of arm visits) of the spatial memory retrieval, while the drugs didn't cause amnesia when single administered of the concerned low doses. Distinct interaction was found between scopolamine and morphine on increasing locomotor activity. 展开更多
关键词 RETRIEVAL MORPHINE SCOPOLAMINE ATROPINE Y-MAZE
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