Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in tota...Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in total has been achieved.Herein,the simplified analog of elansolid A,featured with a cyclohexyl-fused 19-memebered macrolactone,was proposed,and its asymmetric total synthesis based on a convergent strategy and key reactions exemplified by desymmetric alcoholysis of anhydride,Pd-catalyzed Stille coupling,Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished.展开更多
A total of 21 compounds were isolated from the seeds of Capparis masaikai and identified as oxazolidine-2-thione(1), succinimide(2), catechol(3), octathiocane(4), monoethanolamine(5), 3-hydroxypropanenitrile(6), L-ara...A total of 21 compounds were isolated from the seeds of Capparis masaikai and identified as oxazolidine-2-thione(1), succinimide(2), catechol(3), octathiocane(4), monoethanolamine(5), 3-hydroxypropanenitrile(6), L-arabinose(7), 1,2,3-propanetriol(8), drummondol(9), spionoside B(10), adenosine(11), corchoionoside C(12), coniferin(13), syringin(14), cis-syringin(15), dihydrosyringin(16), indole-3-carboxylic acid(17), β-D-glucopyranosyl indole-3-carboxylic acid(18), 6-hydroxyindole-3-carboxylic acid β-D-glucopyranosyl ester(19), linoleis monoglyceride(20), and triolein(21). Their structures were identified based on physicochemical property and spectroscopic analysis, including MS, NMR, and single-crystal X-ray crystallographic data. Compounds 2–10 and 12–21 were isolated from C. masaikai for the first time.展开更多
基金Project supported by the High-Level Talent Program of Yunnan Province(No.Y93D321261)the Regional Development Program for Young Scholars,Chinese Academy of Sciences(CAS)(No.E323521311)the Science and Technology Department of Yunan Province(Nos.202305AH34005,202401AS070096)。
文摘Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic activity.Pre-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in total has been achieved.Herein,the simplified analog of elansolid A,featured with a cyclohexyl-fused 19-memebered macrolactone,was proposed,and its asymmetric total synthesis based on a convergent strategy and key reactions exemplified by desymmetric alcoholysis of anhydride,Pd-catalyzed Stille coupling,Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished.
基金National Science and Technology Major Project(Major New Drug Development,Grant No.2016ZX09101069)。
文摘A total of 21 compounds were isolated from the seeds of Capparis masaikai and identified as oxazolidine-2-thione(1), succinimide(2), catechol(3), octathiocane(4), monoethanolamine(5), 3-hydroxypropanenitrile(6), L-arabinose(7), 1,2,3-propanetriol(8), drummondol(9), spionoside B(10), adenosine(11), corchoionoside C(12), coniferin(13), syringin(14), cis-syringin(15), dihydrosyringin(16), indole-3-carboxylic acid(17), β-D-glucopyranosyl indole-3-carboxylic acid(18), 6-hydroxyindole-3-carboxylic acid β-D-glucopyranosyl ester(19), linoleis monoglyceride(20), and triolein(21). Their structures were identified based on physicochemical property and spectroscopic analysis, including MS, NMR, and single-crystal X-ray crystallographic data. Compounds 2–10 and 12–21 were isolated from C. masaikai for the first time.
