阴极射线管(cathode ray tube,CRT)玻璃附加值极低,毒性浸出实验表明CRT玻璃为危险废物,是当前我国电子垃圾处理处置中首要的必须解决的难题。废弃CRT玻璃安全处理处置的关键在于其含铅锥玻璃的处理处置。文章从锥玻璃的组成出发,探讨...阴极射线管(cathode ray tube,CRT)玻璃附加值极低,毒性浸出实验表明CRT玻璃为危险废物,是当前我国电子垃圾处理处置中首要的必须解决的难题。废弃CRT玻璃安全处理处置的关键在于其含铅锥玻璃的处理处置。文章从锥玻璃的组成出发,探讨真空碳热还原除铅的可能性及可行性,计算表明真空碳热还原除铅完全可能,实验结果表明900℃,10 Pa下反应4 h铅的去除率可达93.53%,残余物中铅的质量分数仅为0.9%。该法为解决废弃危险电子垃圾CRT玻璃问题提供了新的思路,具有较强的应用价值。展开更多
Industrial activities such as smelting emissions,mineral combustion and industrial wastewater discharge might lead to copper pollution in the environment.This kind of copper pollution has harmful effects on aquatic o ...Industrial activities such as smelting emissions,mineral combustion and industrial wastewater discharge might lead to copper pollution in the environment.This kind of copper pollution has harmful effects on aquatic o rganisms,plants and animals through direct or indirect exposure.However,the current understanding of the toxicity of copper is rather limited.Copper overload can perturb intracellular homeostasis and induce oxidative stress and e ven cell death.Recently,cuproptosis has been identified as a copper-dependent form of cell death induced by o xidative stress in mitochondria.We uncover here that zinc transporter 1(ZNT1)is an important regulator involved in cuproptosis.Firstly,we established the copper overload-induced cell death model with the overexpression of copper importer SLC31A1 in HeLa cells.Using this model,we conducted unbiased genome-wide CRISPR-Cas9 screens in cells treated with copper.Our results revealed a significant enrichment of ZNT1 gene in both library A and library B plasmids.Knocking out of ZNT1 in HeLa cells notably prevented cuproptosis.Subsequent knockout of metal transcription factor 1(MTF1)in ZNT1-deficient cells nearly abolished their ability to resist copper-induced cell death.However,overexpression of metallothionein 1X(MT1X)in the double-knockout cells could p artially restored the resistance to cuproptosis by loss of MTF1.Mechanistically,knockout of ZNT1 could promote MT1X expression by activating MTF1.As a consequence,the interaction between MT1X and copper was e nhanced,reducing the flow of copper into mitochondria and eliminating mitochondria damage.Taken together,this study reveals the important role of ZNT1 in cuproptosis and shows MTF1-MT1X axis mediated resistance to c uproptosis.Moreover,our study will help to understand the regulatory mechanism of cellular and systemic copper homeostasis under copper overload,and present insights into novel treatments for damages caused by both genetic copper overload diseases and environmental copper contamination.展开更多
In the context of the“Belt and Road Initiative”,the sustainable development of border cities is paramount for facilitating intergovernmental exchanges.Using the system dynamics approach,we integrated border policy f...In the context of the“Belt and Road Initiative”,the sustainable development of border cities is paramount for facilitating intergovernmental exchanges.Using the system dynamics approach,we integrated border policy factors to create the Border City Coordinated Development(BCCD-SD)model,encompassing three dimensions:Economic,Social,and Resource-Environment.Furthermore,a comprehensive evaluation indicator,the City Coordinated Development Index(CCDI),was devised.Using Lincang City in Southwest China as a case study,this article examines the trends in city development under three scenarios:Inertial Development,Rapid Development,and Green Development.The research findings demonstrate that the model adeptly captures trends in the city coordinated development indicators.Among the three scenarios,the rapid development scenario stands out,yielding the most favorable economic indicators,superior public infrastructure,and the highest employed population.However,the rapid development path,which is heavily focused on economic growth,intensifies resource and environmental pressures,giving rise to sustainability challenges.In contrast,although the green development scenario trails slightly in economic performance compared to rapid development,it fosters a larger urban population and transition of the employed population into citizens while excelling in resource and environmental aspects.Overall,the CCDI attains its highest score under the green development scenario,surpassing those of rapid and inertia development,signifying superior city development coordination along the green path.This scenario effectively combines economic growth,social progress,and resource-environment protection.This study also emphasizes the pivotal role of ports in the coordinated development of border cities and underscores the necessity of expediting the transition from a“gateway”economy to a“port+”economy.One objective of this article is to encourage border cities to serve as more effective windows to the outside world,promote regional coordination,and achieve high-quality development.展开更多
文摘阴极射线管(cathode ray tube,CRT)玻璃附加值极低,毒性浸出实验表明CRT玻璃为危险废物,是当前我国电子垃圾处理处置中首要的必须解决的难题。废弃CRT玻璃安全处理处置的关键在于其含铅锥玻璃的处理处置。文章从锥玻璃的组成出发,探讨真空碳热还原除铅的可能性及可行性,计算表明真空碳热还原除铅完全可能,实验结果表明900℃,10 Pa下反应4 h铅的去除率可达93.53%,残余物中铅的质量分数仅为0.9%。该法为解决废弃危险电子垃圾CRT玻璃问题提供了新的思路,具有较强的应用价值。
文摘Industrial activities such as smelting emissions,mineral combustion and industrial wastewater discharge might lead to copper pollution in the environment.This kind of copper pollution has harmful effects on aquatic o rganisms,plants and animals through direct or indirect exposure.However,the current understanding of the toxicity of copper is rather limited.Copper overload can perturb intracellular homeostasis and induce oxidative stress and e ven cell death.Recently,cuproptosis has been identified as a copper-dependent form of cell death induced by o xidative stress in mitochondria.We uncover here that zinc transporter 1(ZNT1)is an important regulator involved in cuproptosis.Firstly,we established the copper overload-induced cell death model with the overexpression of copper importer SLC31A1 in HeLa cells.Using this model,we conducted unbiased genome-wide CRISPR-Cas9 screens in cells treated with copper.Our results revealed a significant enrichment of ZNT1 gene in both library A and library B plasmids.Knocking out of ZNT1 in HeLa cells notably prevented cuproptosis.Subsequent knockout of metal transcription factor 1(MTF1)in ZNT1-deficient cells nearly abolished their ability to resist copper-induced cell death.However,overexpression of metallothionein 1X(MT1X)in the double-knockout cells could p artially restored the resistance to cuproptosis by loss of MTF1.Mechanistically,knockout of ZNT1 could promote MT1X expression by activating MTF1.As a consequence,the interaction between MT1X and copper was e nhanced,reducing the flow of copper into mitochondria and eliminating mitochondria damage.Taken together,this study reveals the important role of ZNT1 in cuproptosis and shows MTF1-MT1X axis mediated resistance to c uproptosis.Moreover,our study will help to understand the regulatory mechanism of cellular and systemic copper homeostasis under copper overload,and present insights into novel treatments for damages caused by both genetic copper overload diseases and environmental copper contamination.
基金The National Natural Science Foundation of China(42130508).
文摘In the context of the“Belt and Road Initiative”,the sustainable development of border cities is paramount for facilitating intergovernmental exchanges.Using the system dynamics approach,we integrated border policy factors to create the Border City Coordinated Development(BCCD-SD)model,encompassing three dimensions:Economic,Social,and Resource-Environment.Furthermore,a comprehensive evaluation indicator,the City Coordinated Development Index(CCDI),was devised.Using Lincang City in Southwest China as a case study,this article examines the trends in city development under three scenarios:Inertial Development,Rapid Development,and Green Development.The research findings demonstrate that the model adeptly captures trends in the city coordinated development indicators.Among the three scenarios,the rapid development scenario stands out,yielding the most favorable economic indicators,superior public infrastructure,and the highest employed population.However,the rapid development path,which is heavily focused on economic growth,intensifies resource and environmental pressures,giving rise to sustainability challenges.In contrast,although the green development scenario trails slightly in economic performance compared to rapid development,it fosters a larger urban population and transition of the employed population into citizens while excelling in resource and environmental aspects.Overall,the CCDI attains its highest score under the green development scenario,surpassing those of rapid and inertia development,signifying superior city development coordination along the green path.This scenario effectively combines economic growth,social progress,and resource-environment protection.This study also emphasizes the pivotal role of ports in the coordinated development of border cities and underscores the necessity of expediting the transition from a“gateway”economy to a“port+”economy.One objective of this article is to encourage border cities to serve as more effective windows to the outside world,promote regional coordination,and achieve high-quality development.
