目的:运用meta分析方法系统评价中医药治疗男性免疫性不育的有效性和安全性。方法:检索万方数据库、中国生物医学文献数据库、Cochrane Library、维普数据库、PubMed数据库、CNKI(China National Knowledge Infrastructure)数据库,搜集...目的:运用meta分析方法系统评价中医药治疗男性免疫性不育的有效性和安全性。方法:检索万方数据库、中国生物医学文献数据库、Cochrane Library、维普数据库、PubMed数据库、CNKI(China National Knowledge Infrastructure)数据库,搜集中医药治疗男性免疫性不育的随机对照试验(RCT),并进行方法学质量评价,采用RevMan5.4软件进行统计分析与发表偏倚评估。结果:有25篇RCT文献纳入本项研究,总共纳入病例2563例,其中试验组1407例,对照组1155例。meta分析显示中医药治疗男性免疫性不育总有效率(OR=6.35,95%CI:4.96~8.13,P<0.00001)、精浆抗精子抗体转阴率(OR=4.52,95%CI:2.72~7.51,P<0.00001)、血清抗精子抗体转阴率(OR=2.98,95%CI:2.23~3.96,P<0.00001)、精液浓度(MD=15.56,95%CI:11.32~19.79,P<0.00001)、a级精子百分率(MD=3.85,95%CI:1.91~5.79,P=0.00001)、a+b级精子百分率(MD=13.77,95%CI:7.06~20.48,P<0.0001)、精子存活率(MD=10.32,95%CI:6.78~13.86,P<0.00001)、妊娠率(OR=3.53,95%CI:2.68~4.63,P<0.00001)、不良反应(OR=0.06,95%CI:0.01~0.23,P<0.00001)均显著优于单纯西药治疗。中医药治疗男性免疫性不育的精子畸形率与单纯使用西药组疗效差异不明显(MD=-7.53,95%CI:-15.50~0.44,P=0.06)。结论:中医药治疗男性免疫性不育疗效确切、安全性高,是治疗男性免疫性不育的有效方法。展开更多
流涎是帕金森病常见的消化道症状之一,可出现在帕金森病的整个病程中,同时可能与运动症状及非运动症状的严重程度相关,晚期帕金森病患者常伴有严重的流涎,甚至出现感染、吸入性肺炎等危及生命的严重并发症。目前认为帕金森病流涎可能与...流涎是帕金森病常见的消化道症状之一,可出现在帕金森病的整个病程中,同时可能与运动症状及非运动症状的严重程度相关,晚期帕金森病患者常伴有严重的流涎,甚至出现感染、吸入性肺炎等危及生命的严重并发症。目前认为帕金森病流涎可能与唾液分泌过多及唾液清除障碍相关,西医治疗以改善症状为主。中医认为本病主因肝脾肺肾功能失调,水液代谢失常所致,在治疗上具有个体化优势。本文旨在结合帕金森病流涎的病理机制及相关危险因素,对其中医药治疗进行阐述。Drooling is one of the common gastrointestinal symptoms of Parkinson’s disease, which can appear throughout the course of Parkinson’s disease, and may be related to the severity of motor symptoms and non-motor symptoms. At present, it is believed that salivation in Parkinson’s disease may be related to excessive saliva secretion and saliva clearance disorders, and Western medicine treatment is mainly to improve symptoms. Traditional Chinese medicine believes that this disease is mainly caused by the dysfunction of the liver, spleen, lungs and kidneys, and the abnormal metabolism of water and fluid, and has an individualized advantage in treatment. The purpose of this article is to elaborate on the pathological mechanism and related risk factors of salivation in Parkinson’s disease and its traditional Chinese medicine treatment.展开更多
目的:通过数据挖掘及分析探讨中医药治疗异位妊娠的临床运用现况及规律。方法:系统搜集中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普(CQVIP)等数据库自2010年1月~2023年12月中医药治疗异位妊娠的临床研究文献,运用Excel...目的:通过数据挖掘及分析探讨中医药治疗异位妊娠的临床运用现况及规律。方法:系统搜集中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普(CQVIP)等数据库自2010年1月~2023年12月中医药治疗异位妊娠的临床研究文献,运用Excel进行规范化统计,并将规范化后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析,对用药频次、性味归经、组方规律和新处方的统算剖析,总结并研究中医药治疗异位妊娠的用药规律。结果:共筛选纳入相关方剂125首,涉及不同中药153味,其中频次 ≥ 30次的有12味,用药以活血化瘀药为主,兼以清热解毒类药、补益气血类药,对所有药物进行四气五味的分析,性味多寒、平、温、凉,部分动物类药味咸,主入心、肝、脾三经;其中使用频率最高的前十味药为:丹参、桃仁、赤芍、莪术、三棱、天花粉、蜈蚣、红花、紫草、当归。结论:中医药治疗异位妊娠主要以活血化瘀、清热解毒类物为主,中药治疗异位妊娠优选丹参、桃仁、赤芍、莪术、三棱、天花粉、蜈蚣、红花、紫草、当归,为临床诊疗提供一定理论依据。Objective: To explore the current clinical application status and patterns of traditional Chinese medicine in the treatment of ectopic pregnancy through data mining and analysis. Method: The system collected clinical research literature on the treatment of ectopic pregnancy with traditional Chinese medicine from databases such as China National Knowledge Infrastructure (CNKI), Wanfang Data, and CQVIP from January 2010 to December 2023. Excel was used for standardized statistics, and the standardized prescription materials were input into the “Traditional Chinese Medicine Inheritance Assistance Platform (V2.5)” for statistical analysis. The frequency of medication, sexual and taste meridian differentiation, prescription rules, and new prescriptions were analyzed, and the medication rules of traditional Chinese medicine in the treatment of ectopic pregnancy were summarized and studied. As a result, a total of 125 relevant prescriptions were screened and included, involving 153 different traditional Chinese medicines. Among them, 12 herbs were used with a frequency of ≥ 30 times. The main drugs used were blood activating and stasis removing herbs, as well as heat clearing and detoxifying herbs and tonifying Qi and blood herbs. The analysis of the four qi and five flavors of all herbs showed that their properties were mostly cold, calm, warm, and cool, and some animal medicines had salty flavors, mainly entering the heart, liver, and spleen meridians;The top ten medicines with the highest frequency of use are: Danshen, Taoren, Chishao, Curcuma, Sanjing, Tianfen, Centipede, Honghua, Zicao, and Danggui. Conclusion: Traditional Chinese medicine mainly focuses on promoting blood circulation, removing blood stasis, clearing heat and detoxifying substances for the treatment of ectopic pregnancy. Danshen, Taoren, Chishao, Curcuma, Sanjing, Tianfen, Centipede, Honghua, Zicao, and Danggui are preferred for the treatment of ectopic pregnancy, providing a certain theoretical basis for clinical diagnosis and treatment.展开更多
目的 使用数据挖掘探索中医药治疗精索静脉曲张(VC)的临床用药规律。方法搜寻中国知网(CNKI)、万方数据知识服务平台(Wanfang Data Knowledge Service Platform)、维普(CQVIP)自建库起至2023年8月的中医药治疗VC的文献,通过挑选并运用Ex...目的 使用数据挖掘探索中医药治疗精索静脉曲张(VC)的临床用药规律。方法搜寻中国知网(CNKI)、万方数据知识服务平台(Wanfang Data Knowledge Service Platform)、维普(CQVIP)自建库起至2023年8月的中医药治疗VC的文献,通过挑选并运用Excel规范后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析,对中医证候、用药频次、性味归经、组方规律和新处方进行统算剖析,总结并研究中医药治疗VC的用药规律。结果共纳入60篇文献中的80首合格处方,包括147味中药,出现频次较高的中医证候依次是肾虚血瘀证、瘀血阻络证、气虚血瘀证、气滞血瘀证;频次≥20的中药共有11味;性味多为温、甘,归经多是肝、肾、脾;频次较高的药对是“菟丝子-枸杞子”“丹参-当归”,置信度最高药物为淫羊藿、枸杞子与菟丝子;最后重组13个新药方。结论 目前中医药治疗VC以活血祛瘀为主,同时兼顾补肾、疏肝、健脾、理气、补气等治法。展开更多
文摘目的:运用meta分析方法系统评价中医药治疗男性免疫性不育的有效性和安全性。方法:检索万方数据库、中国生物医学文献数据库、Cochrane Library、维普数据库、PubMed数据库、CNKI(China National Knowledge Infrastructure)数据库,搜集中医药治疗男性免疫性不育的随机对照试验(RCT),并进行方法学质量评价,采用RevMan5.4软件进行统计分析与发表偏倚评估。结果:有25篇RCT文献纳入本项研究,总共纳入病例2563例,其中试验组1407例,对照组1155例。meta分析显示中医药治疗男性免疫性不育总有效率(OR=6.35,95%CI:4.96~8.13,P<0.00001)、精浆抗精子抗体转阴率(OR=4.52,95%CI:2.72~7.51,P<0.00001)、血清抗精子抗体转阴率(OR=2.98,95%CI:2.23~3.96,P<0.00001)、精液浓度(MD=15.56,95%CI:11.32~19.79,P<0.00001)、a级精子百分率(MD=3.85,95%CI:1.91~5.79,P=0.00001)、a+b级精子百分率(MD=13.77,95%CI:7.06~20.48,P<0.0001)、精子存活率(MD=10.32,95%CI:6.78~13.86,P<0.00001)、妊娠率(OR=3.53,95%CI:2.68~4.63,P<0.00001)、不良反应(OR=0.06,95%CI:0.01~0.23,P<0.00001)均显著优于单纯西药治疗。中医药治疗男性免疫性不育的精子畸形率与单纯使用西药组疗效差异不明显(MD=-7.53,95%CI:-15.50~0.44,P=0.06)。结论:中医药治疗男性免疫性不育疗效确切、安全性高,是治疗男性免疫性不育的有效方法。
文摘流涎是帕金森病常见的消化道症状之一,可出现在帕金森病的整个病程中,同时可能与运动症状及非运动症状的严重程度相关,晚期帕金森病患者常伴有严重的流涎,甚至出现感染、吸入性肺炎等危及生命的严重并发症。目前认为帕金森病流涎可能与唾液分泌过多及唾液清除障碍相关,西医治疗以改善症状为主。中医认为本病主因肝脾肺肾功能失调,水液代谢失常所致,在治疗上具有个体化优势。本文旨在结合帕金森病流涎的病理机制及相关危险因素,对其中医药治疗进行阐述。Drooling is one of the common gastrointestinal symptoms of Parkinson’s disease, which can appear throughout the course of Parkinson’s disease, and may be related to the severity of motor symptoms and non-motor symptoms. At present, it is believed that salivation in Parkinson’s disease may be related to excessive saliva secretion and saliva clearance disorders, and Western medicine treatment is mainly to improve symptoms. Traditional Chinese medicine believes that this disease is mainly caused by the dysfunction of the liver, spleen, lungs and kidneys, and the abnormal metabolism of water and fluid, and has an individualized advantage in treatment. The purpose of this article is to elaborate on the pathological mechanism and related risk factors of salivation in Parkinson’s disease and its traditional Chinese medicine treatment.
文摘目的:通过数据挖掘及分析探讨中医药治疗异位妊娠的临床运用现况及规律。方法:系统搜集中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普(CQVIP)等数据库自2010年1月~2023年12月中医药治疗异位妊娠的临床研究文献,运用Excel进行规范化统计,并将规范化后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析,对用药频次、性味归经、组方规律和新处方的统算剖析,总结并研究中医药治疗异位妊娠的用药规律。结果:共筛选纳入相关方剂125首,涉及不同中药153味,其中频次 ≥ 30次的有12味,用药以活血化瘀药为主,兼以清热解毒类药、补益气血类药,对所有药物进行四气五味的分析,性味多寒、平、温、凉,部分动物类药味咸,主入心、肝、脾三经;其中使用频率最高的前十味药为:丹参、桃仁、赤芍、莪术、三棱、天花粉、蜈蚣、红花、紫草、当归。结论:中医药治疗异位妊娠主要以活血化瘀、清热解毒类物为主,中药治疗异位妊娠优选丹参、桃仁、赤芍、莪术、三棱、天花粉、蜈蚣、红花、紫草、当归,为临床诊疗提供一定理论依据。Objective: To explore the current clinical application status and patterns of traditional Chinese medicine in the treatment of ectopic pregnancy through data mining and analysis. Method: The system collected clinical research literature on the treatment of ectopic pregnancy with traditional Chinese medicine from databases such as China National Knowledge Infrastructure (CNKI), Wanfang Data, and CQVIP from January 2010 to December 2023. Excel was used for standardized statistics, and the standardized prescription materials were input into the “Traditional Chinese Medicine Inheritance Assistance Platform (V2.5)” for statistical analysis. The frequency of medication, sexual and taste meridian differentiation, prescription rules, and new prescriptions were analyzed, and the medication rules of traditional Chinese medicine in the treatment of ectopic pregnancy were summarized and studied. As a result, a total of 125 relevant prescriptions were screened and included, involving 153 different traditional Chinese medicines. Among them, 12 herbs were used with a frequency of ≥ 30 times. The main drugs used were blood activating and stasis removing herbs, as well as heat clearing and detoxifying herbs and tonifying Qi and blood herbs. The analysis of the four qi and five flavors of all herbs showed that their properties were mostly cold, calm, warm, and cool, and some animal medicines had salty flavors, mainly entering the heart, liver, and spleen meridians;The top ten medicines with the highest frequency of use are: Danshen, Taoren, Chishao, Curcuma, Sanjing, Tianfen, Centipede, Honghua, Zicao, and Danggui. Conclusion: Traditional Chinese medicine mainly focuses on promoting blood circulation, removing blood stasis, clearing heat and detoxifying substances for the treatment of ectopic pregnancy. Danshen, Taoren, Chishao, Curcuma, Sanjing, Tianfen, Centipede, Honghua, Zicao, and Danggui are preferred for the treatment of ectopic pregnancy, providing a certain theoretical basis for clinical diagnosis and treatment.
文摘目的 使用数据挖掘探索中医药治疗精索静脉曲张(VC)的临床用药规律。方法搜寻中国知网(CNKI)、万方数据知识服务平台(Wanfang Data Knowledge Service Platform)、维普(CQVIP)自建库起至2023年8月的中医药治疗VC的文献,通过挑选并运用Excel规范后的药方材料输入“中医传承辅助平台(V2.5)”后予统算剖析,对中医证候、用药频次、性味归经、组方规律和新处方进行统算剖析,总结并研究中医药治疗VC的用药规律。结果共纳入60篇文献中的80首合格处方,包括147味中药,出现频次较高的中医证候依次是肾虚血瘀证、瘀血阻络证、气虚血瘀证、气滞血瘀证;频次≥20的中药共有11味;性味多为温、甘,归经多是肝、肾、脾;频次较高的药对是“菟丝子-枸杞子”“丹参-当归”,置信度最高药物为淫羊藿、枸杞子与菟丝子;最后重组13个新药方。结论 目前中医药治疗VC以活血祛瘀为主,同时兼顾补肾、疏肝、健脾、理气、补气等治法。
