Constitution identification model in traditional Chinese medicine based on multiple features

Objective To construct a precise model for identifying traditional Chinese medicine(TCM)constitutions;thereby offering optimized guidance for clinical diagnosis and treatment plan-ning;and ultimately enhancing medical efficiency and treatment outcomes.Methods First;TCM full-body inspection data acquisition equipment was employed to col-lect full-body standing images of healthy people;from which the constitutions were labelled and defined in accordance with the Constitution in Chinese Medicine Questionnaire(CCMQ);and a dataset encompassing labelled constitutions was constructed.Second;heat-suppres-sion valve(HSV)color space and improved local binary patterns(LBP)algorithm were lever-aged for the extraction of features such as facial complexion and body shape.In addition;a dual-branch deep network was employed to collect deep features from the full-body standing images.Last;the random forest(RF)algorithm was utilized to learn the extracted multifea-tures;which were subsequently employed to establish a TCM constitution identification mod-el.Accuracy;precision;and F1 score were the three measures selected to assess the perfor-mance of the model.Results It was found that the accuracy;precision;and F1 score of the proposed model based on multifeatures for identifying TCM constitutions were 0.842;0.868;and 0.790;respectively.In comparison with the identification models that encompass a single feature;either a single facial complexion feature;a body shape feature;or deep features;the accuracy of the model that incorporating all the aforementioned features was elevated by 0.105;0.105;and 0.079;the precision increased by 0.164;0.164;and 0.211;and the F1 score rose by 0.071;0.071;and 0.084;respectively.Conclusion The research findings affirmed the viability of the proposed model;which incor-porated multifeatures;including the facial complexion feature;the body shape feature;and the deep feature.In addition;by employing the proposed model;the objectification and intel-ligence of identifying constitutions in TCM practices could be optimized.

补肾活血中药对体外培养成骨细胞活性的影响

目的 研究补肾活血中药对体外培养成骨细胞活性的影响。方法 取二次酶消化法培养的胎鼠颅骨第三代成骨细胞,随机分为 5 组,即:细胞对照组、空白血清组、含药血清组、原药组、阳性对照药αD3 组,分别加入普通细胞培养液、含空白血清及不同浓度补肾活血中药含药血清、补肾活血中药原药液、阳性对照药(αD3)的条件培养液,分别在培养第 3 天和第 6 天进行各试验组成骨细胞碱性磷酸酶及骨钙蛋白分泌量测定,观察补肾活血中药含药血清及原药液对成骨细胞活性的影响。结果 含药血清组成骨细胞活性指标碱性磷酸酶(ALP)值在培养第3 天均低于空白血清组,且与含药血清浓度呈负相关关系;第 6 天,含药血清组各浓度组 ALP 值明显升高,均显著高于空白血清组,ALP 值与含药血清浓度存在正相关关系;空白血清组 ALP 值在培养第 6 天时下降,其均值低于培养第 3 天 ALP 值。培养第 3 天及第 6 天,各浓度原药组 ALP 值均高于细胞对照组及αD3 组;ALP 值与原药浓度呈正相关关系。含药血清组及中药原药组骨钙素(OC)含量显著高于空白血清及其他各对照组。结论 补肾活血中药含药血清及原药能够直接作用于体外培养的成骨细胞,促进成骨细胞增殖,增强其分泌活性;可延长成骨细胞活性分泌期,使其活性分泌高峰后移而峰值升高。

Relationship between syndrome elements and anterior communicating artery opening in patients with smptomatic severe carotid artery stenosis/occlusion

Objective To study the relationship between syndrome elements and anterior communicating artery(ACoA)opening in patients with symptomatic severe carotid artery stenosis/occlusion.Methods Thirty-six patients with symptomatic severe carotid stenosis/occlusion were collected,including 26 patients with cerebral infarction and 10 patients with transient ischemic attack(TIA).Syndrome elements at five time points were collected.Computer tomography angiography(CTA)combined with magenic resonance angiograp(MRA)was used to evaluate the primary collateral circulation,and the prognosis and syndrome elements were statistically analyzed according to whether the ACoA was open or not.Results The ACoA was open more in the primary collateral circulation among patients with symptomatic severe carotid stenosis/occlusion.There was a statistically significant difference in national institute of health stroke scale(NIHSS)score improvement and good prognosis[the modified rankin scale(mRS)≤2]between the ACoA open group and the ACoA nonopen group on the 90th day(P<0.05).The proportion of patients with internal wind syndrome,blood stasis syndrome,Qi deficiency syndrome,and Yin deficiency syndrome in the ACoA non-open group was higher than that in the open group.Conclusion In the patients with severe carotid artery stenosis/occlusion,the group with presence of anterior communicating artery had better prognosis.The syndrome elements are more complex in the group without the presence of anterior communicating artery.The proportion of Qi deficiency syndrome was positively correlated with the non-opening of anterior communicating artery.The imaging evaluation of collateral circulation can provide guidance for syndrome differentiation and treatment.