TRPC1 Regulates Mechanical Stretch-Induced Proliferation of Bone Marrow-Derived Mesenchymal Stem Cells via Calcium-Dependent Signaling

Objective Compelling evidence shows that mechanical stimulation regulates the proliferation of mesenchymal stem cells(MSCs),but the underlying mechanism is still unknown.Transient receptor potential channel classic subfamily members 1(TRPC1)is mechanosentive and engaged in MSC proliferation.

IKCa与TRPC1的钙信号互动在血管平滑肌细胞增殖中的作用

目的血管平滑肌细胞(vscular smooth muscle cells,VSMCs)的过度增殖与许多血管疾病的发生发展密切相关。研究表明,中电导钙激活钾离子通道(Intermediate-conductance Ca^(2+)-activated K^(+)channels,IKCa)与VSMCs的增殖,但其机制尚未明确。探索IKCa通道与经典瞬时受体电位通道1(transient receptor potential channel classic subfamily members1 TRPC1)。