呼和浩特地区部分土制海洛因的分析

对呼和浩特地区缴获的部分海洛因的外观、含量、杂质进行了分析,结果显示土制海洛因与东南亚海洛因在外观上有区别,与公安部禁毒局发布的相关数据相比,土制海洛因的纯度较东南亚海洛因高,两者在杂质特征上明显不同。

可疑片剂中新型喹酮类物质的鉴定

通过气相色谱–质谱法(gas chromatography-mass spectrometry, GC-MS)发现一种可疑新型喹酮类物质,进一步利用超高效液相色谱–四极杆飞行时间质谱(ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry, UPLC-QTOF-MS)对甲喹酮、依他喹酮和未知化合物进行结构解析,最后采用核磁共振(nuclear magnetic resonance, NMR)进行验证,建立对可疑片剂中未知喹酮类物质的定性分析。对甲喹酮、依他喹酮和疑似喹酮类物质的UPLC-QTOF-MS谱图进行解析后,预测疑似喹酮类物质的结构式可能为2-甲基-3-(2-甲氧苯基)-4-(3H)-喹唑酮[2-methyl-3-(2-methoxyphenyl)-4(3H)-quinazolinone],NMR分析结果验证了该结构式,建议新喹酮类物质应命名为甲氧喹酮。

GC-MS法检验利多卡因代谢物单乙基甘氨酰二甲苯胺

Proadifen (SKF525A)or procaine was inner standard and the mean of testing monoethylglycinedixylidide (MEGX) which is metabolization of the lidocaine by optimizing condition of chromatogram and dealing sample with acetic anhydride was found. We test sample by GC-MS/SIM referring to reserve time of gas chromatogram and diagraph which is fragment of mass spectrum.