糖尿病是一种严重威胁人类健康的疾病,其并发症的研究也越来越受到关注,其中糖尿病认知功能障碍(Diabetes cognitive impairment, DCI)是糖尿病非常重要的并发症之一。认知功能障碍的发病机制复杂,且尚未完全阐明,可能与胰岛素抵抗与缺...糖尿病是一种严重威胁人类健康的疾病,其并发症的研究也越来越受到关注,其中糖尿病认知功能障碍(Diabetes cognitive impairment, DCI)是糖尿病非常重要的并发症之一。认知功能障碍的发病机制复杂,且尚未完全阐明,可能与胰岛素抵抗与缺乏、血糖控制不佳、血管疾病、炎症和心理因素等相关。这些因素可导致认知速度减慢、反应时间延长、神经退行性变、脑老化和痴呆等。Diabetes is a serious threat to human health, and the study of its complications is also getting more and more attention. Among them, diabetes cognitive impairment (DCI) is one of the most important complications of diabetes. The pathogenesis of cognitive impairment is complex and not fully understood, and may be related to insulin resistance and deficiency, poor blood sugar control, vascular diseases, inflammation, and psychological factors. These factors can lead to cognitive slowdown, prolonged reaction time, neurodegeneration, brain aging, and dementia.展开更多
糖尿病是一种慢性疾病,通过改变身体使用糖的方式,引起机体一系列的代谢变化。糖尿病是全球性的疾病。据最新报道显示,糖尿病患病人群总数仍在逐年增加,当前全球糖尿病患病率为6.1%,其会导致残疾甚至死亡的恶果。糖尿病心血管并发症是...糖尿病是一种慢性疾病,通过改变身体使用糖的方式,引起机体一系列的代谢变化。糖尿病是全球性的疾病。据最新报道显示,糖尿病患病人群总数仍在逐年增加,当前全球糖尿病患病率为6.1%,其会导致残疾甚至死亡的恶果。糖尿病心血管并发症是糖尿病最严重的慢性并发症之一,发病率高,致残、致死率高,预后差。其确切的发病机制尚且没有明确的定论,仍是需要探讨的问题。目前有研究表明,糖尿病心肌性疾病出现前期,患者的心脏相关功能已经出现异常。临床上通常将超声心动图技术作为检测左心室功能的重要手段。本文对国内外近年来有关国内外糖尿病趋势以及糖尿病心肌病左心室收缩功能障碍的发生背景、发病机制以及辅助检查手段的研究进展予以综述。Diabetes is a chronic disease that causes a series of metabolic changes by changing the way the body uses sugar. Diabetes is a global disease. According to the latest report, the total number of people with diabetes is still increasing year by year, and the current global prevalence of diabetes is 6.1%, which can lead to disability and even death. Cardiovascular complications of diabetes mellitus are one of the most serious chronic complications of diabetes mellitus, with high incidence, high disability, high mortality and poor prognosis. The exact pathogenesis of the disease has not been clearly determined, and it is still a problem that needs to be discussed. At present, studies have shown that in the early stage of diabetic myocardial disease, patients have abnormal heart-related functions. Echocardiography is usually used as an important means to detect left ventricular function in clinic. In this paper, the trend of diabetes at home and abroad in recent years, the background of left ventricular systolic dysfunction in diabetic cardiomyopathy, the pathogenesis and the research progress of auxiliary examination are reviewed.展开更多
目的了解2型糖尿病家系人群胰岛素抵抗与血清抵抗素水平的相关性,初步阐述抵抗素在胰岛素抵抗发病机制中的作用。方法检测2型糖尿病家系一级亲属89例(实验组)的血清抵抗素、血脂、胰岛素等水平,并与血糖正常的非糖尿病家系者(对照组)进...目的了解2型糖尿病家系人群胰岛素抵抗与血清抵抗素水平的相关性,初步阐述抵抗素在胰岛素抵抗发病机制中的作用。方法检测2型糖尿病家系一级亲属89例(实验组)的血清抵抗素、血脂、胰岛素等水平,并与血糖正常的非糖尿病家系者(对照组)进行对比分析,考察其血清抵抗素水平变化与胰岛素抵抗的相关性。结果 2型糖尿病家系一级亲属FINS、2h INS、TG、血清抵抗素、HOMA-IR的水平显著高于对照组(P<0.01),一级亲属的HDL-C水平显著低于对照组(P<0.05),两组的FPG、2h PG、TC、LDL-C水平的比较无显著性差异(P>0.05)。血清抵抗素与BMI、FINS、2h INS、TC、HOMA-IR呈正相关(P<0.01),与2 h PG呈负相关(P<0.05),与FPG、TG、HDL-C、LDL-C无显著相关性(P>0.05)。BMI、FPG、2 h PG、血清抵抗素为2型糖尿病家系一级亲属胰岛素抵抗的危险因素。结论 2型糖尿病家系血糖正常的一级亲属存在显著的胰岛素抵抗,其抵抗素对胰岛素抵抗程度有明显的影响。展开更多
文摘糖尿病是一种严重威胁人类健康的疾病,其并发症的研究也越来越受到关注,其中糖尿病认知功能障碍(Diabetes cognitive impairment, DCI)是糖尿病非常重要的并发症之一。认知功能障碍的发病机制复杂,且尚未完全阐明,可能与胰岛素抵抗与缺乏、血糖控制不佳、血管疾病、炎症和心理因素等相关。这些因素可导致认知速度减慢、反应时间延长、神经退行性变、脑老化和痴呆等。Diabetes is a serious threat to human health, and the study of its complications is also getting more and more attention. Among them, diabetes cognitive impairment (DCI) is one of the most important complications of diabetes. The pathogenesis of cognitive impairment is complex and not fully understood, and may be related to insulin resistance and deficiency, poor blood sugar control, vascular diseases, inflammation, and psychological factors. These factors can lead to cognitive slowdown, prolonged reaction time, neurodegeneration, brain aging, and dementia.
文摘糖尿病是一种慢性疾病,通过改变身体使用糖的方式,引起机体一系列的代谢变化。糖尿病是全球性的疾病。据最新报道显示,糖尿病患病人群总数仍在逐年增加,当前全球糖尿病患病率为6.1%,其会导致残疾甚至死亡的恶果。糖尿病心血管并发症是糖尿病最严重的慢性并发症之一,发病率高,致残、致死率高,预后差。其确切的发病机制尚且没有明确的定论,仍是需要探讨的问题。目前有研究表明,糖尿病心肌性疾病出现前期,患者的心脏相关功能已经出现异常。临床上通常将超声心动图技术作为检测左心室功能的重要手段。本文对国内外近年来有关国内外糖尿病趋势以及糖尿病心肌病左心室收缩功能障碍的发生背景、发病机制以及辅助检查手段的研究进展予以综述。Diabetes is a chronic disease that causes a series of metabolic changes by changing the way the body uses sugar. Diabetes is a global disease. According to the latest report, the total number of people with diabetes is still increasing year by year, and the current global prevalence of diabetes is 6.1%, which can lead to disability and even death. Cardiovascular complications of diabetes mellitus are one of the most serious chronic complications of diabetes mellitus, with high incidence, high disability, high mortality and poor prognosis. The exact pathogenesis of the disease has not been clearly determined, and it is still a problem that needs to be discussed. At present, studies have shown that in the early stage of diabetic myocardial disease, patients have abnormal heart-related functions. Echocardiography is usually used as an important means to detect left ventricular function in clinic. In this paper, the trend of diabetes at home and abroad in recent years, the background of left ventricular systolic dysfunction in diabetic cardiomyopathy, the pathogenesis and the research progress of auxiliary examination are reviewed.
文摘目的了解2型糖尿病家系人群胰岛素抵抗与血清抵抗素水平的相关性,初步阐述抵抗素在胰岛素抵抗发病机制中的作用。方法检测2型糖尿病家系一级亲属89例(实验组)的血清抵抗素、血脂、胰岛素等水平,并与血糖正常的非糖尿病家系者(对照组)进行对比分析,考察其血清抵抗素水平变化与胰岛素抵抗的相关性。结果 2型糖尿病家系一级亲属FINS、2h INS、TG、血清抵抗素、HOMA-IR的水平显著高于对照组(P<0.01),一级亲属的HDL-C水平显著低于对照组(P<0.05),两组的FPG、2h PG、TC、LDL-C水平的比较无显著性差异(P>0.05)。血清抵抗素与BMI、FINS、2h INS、TC、HOMA-IR呈正相关(P<0.01),与2 h PG呈负相关(P<0.05),与FPG、TG、HDL-C、LDL-C无显著相关性(P>0.05)。BMI、FPG、2 h PG、血清抵抗素为2型糖尿病家系一级亲属胰岛素抵抗的危险因素。结论 2型糖尿病家系血糖正常的一级亲属存在显著的胰岛素抵抗,其抵抗素对胰岛素抵抗程度有明显的影响。
