A protocol for extracting chlorogenic acid from Eucommia ulmoides leaf was optimized by orthogonal test on the base of noticeable factors test.The preventing effect of extract of Eucommia ulmoides leaf on mice suffere...A protocol for extracting chlorogenic acid from Eucommia ulmoides leaf was optimized by orthogonal test on the base of noticeable factors test.The preventing effect of extract of Eucommia ulmoides leaf on mice suffered from high lipid serum was evaluated.High lipid serum was induced by gavaging fat emulsion to mice everyday.The TC,TG,LDL-C and HDL-C level in the serum of different animal groups were monitored.The result showed that the optimum process was to extract the chlorogenicacid at 90 ℃ with 70% ethanol for 2 h,with solid-liquid ratio 1∶16,and the extract rate was able to reach to 4%.The extract was efficient in defending high lipid serum.展开更多
文摘合成了一系列分子量较低的聚乙二醇-聚己内酯-聚乙二醇(Poly(ethylene glycol)-Polycaprolactone-Poly(ethylene glycol),PEG-PCL-PEG)三嵌段共聚物。分别采用FTIR和1H-NMR对其结构进行了表征。所合成的PEG-PCL-PEG共聚物具有良好的水溶性,当水溶液浓度高于临界凝胶浓度(Critical gel concentration,CGC)时,随着温度的变化聚合物水溶液会呈现特有的凝胶-溶胶转变。研究了共聚物亲水疏水链段的比例和长度,以及热历史等对凝胶-溶胶转变行为的影响。通过调节上述条件,可以在一定程度上拓宽凝胶-溶胶转变温度范围,有助于PEG-PCL-PEG水凝胶在可注射药物控制释放系统等方面的应用。
文摘A protocol for extracting chlorogenic acid from Eucommia ulmoides leaf was optimized by orthogonal test on the base of noticeable factors test.The preventing effect of extract of Eucommia ulmoides leaf on mice suffered from high lipid serum was evaluated.High lipid serum was induced by gavaging fat emulsion to mice everyday.The TC,TG,LDL-C and HDL-C level in the serum of different animal groups were monitored.The result showed that the optimum process was to extract the chlorogenicacid at 90 ℃ with 70% ethanol for 2 h,with solid-liquid ratio 1∶16,and the extract rate was able to reach to 4%.The extract was efficient in defending high lipid serum.
