The cellular messenger nitric oxide（NO） has been linked to neurodegenerative disorders due to the increased expression of the enzymes that catalyze its synthesis in postmortem tissues derived from sufferers of these...The cellular messenger nitric oxide（NO） has been linked to neurodegenerative disorders due to the increased expression of the enzymes that catalyze its synthesis in postmortem tissues derived from sufferers of these diseases.Nitrated proteins have also been detected in these samples,revealing that NO is biologically active in regions damaged during neurodegeneration.Modulation of NO levels has been reported not only in the neurons of the central nervous system,but also in the glial cells（microglia and astroglia） activated during the neuroinflammatory response.Neuroinflammation has been found in some neurodegenerative conditions,and inhibition of these neuroinflammatory signals has been shown to delay the progress of such disorders.Thus NO and the pathways triggering its release are emerging as an important research focus in the search for strategies to prevent,halt or cure neurodegenerative diseases.展开更多
基金supported by an Alzheimer's Society Personal Research Fellowship (93) with support from the Henry Smith CharityAlzheimer's Society is a charity (registration no. 296645)+1 种基金a company registered in England and Wales (registration no.2115499)The University of St Andrews is a charity registered in Scotland (registration no. SC013532)
文摘The cellular messenger nitric oxide（NO） has been linked to neurodegenerative disorders due to the increased expression of the enzymes that catalyze its synthesis in postmortem tissues derived from sufferers of these diseases.Nitrated proteins have also been detected in these samples,revealing that NO is biologically active in regions damaged during neurodegeneration.Modulation of NO levels has been reported not only in the neurons of the central nervous system,but also in the glial cells（microglia and astroglia） activated during the neuroinflammatory response.Neuroinflammation has been found in some neurodegenerative conditions,and inhibition of these neuroinflammatory signals has been shown to delay the progress of such disorders.Thus NO and the pathways triggering its release are emerging as an important research focus in the search for strategies to prevent,halt or cure neurodegenerative diseases.
