Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the...Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME screening.The network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory diseases.These results indicated the potential pharmacological effects of the active components in’Chuju’.展开更多
Agricultural production is considered one of the most important sources of water quality deterioration in the Taihu Lake Basin,China.Crop farming,livestock&poultry breeding and aquaculture are primary agricultural...Agricultural production is considered one of the most important sources of water quality deterioration in the Taihu Lake Basin,China.Crop farming,livestock&poultry breeding and aquaculture are primary agricultural non-point sources and their impacts on the water environment are,in most cases,evaluated separately.Therefore,it is a challenge for current research to consider all of the different agricultural non-point sources as a whole and assess their combined influence on the water environment.The purpose of this paper is to evaluate the conjoint impact that agricultural non-point sources such as crop farming,livestock&poultry breeding and aquaculture have had on the local water environment in the Taihu Lake Basin by taking Huzhou City of Zhejiang Province as a case study.To achieve this,a new,innovative approach named the“Waste Absorption Footprint”(WAF)is applied.The results show that nitrogen and phosphorus pollution generated by agricultural production are more serious than that of organic substances,while aquaculture and crop farming are more critical pollution sources compared with livestock and poultry breeding,and so they should be the focus of environmental management and pollution control initiatives.There is a regional discrepancy in the spatial distribution of agricultural non-point source pollution across counties and districts,which provides information for determining the key regions for the treatment of agricultural pollution.This study demonstrates that the WAF method can make a comprehensive assessment of the influence of agricultural production on the water environment and provide references for the control and management of agricultural non-point source pollution,which is of great importance for management of the water environment.展开更多
基金Key Project of Natural Science Research in Colleges and Universities in Anhui Province(Grant No.KJ2019A0639,KJ2020A0715)Open Foundation of the Key Laboratory of Crop Gene Resources and Germplasm Creation in East China,Ministry of Agriculture(Grant No.ECG2018001)+1 种基金the Key Project of Excellent Young Talents Support Program in Universities of Anhui Province(Grant No.gxyq ZD2021133)Chuzhou Science and Technology Plan Project(Grant No.2020ZN013)。
文摘Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME screening.The network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory diseases.These results indicated the potential pharmacological effects of the active components in’Chuju’.
基金The National Natural Science Foundation of China(41861022,41961008,41801204)The Science and Technology Project in Jiangxi Province Department of Education(GJJ180903)The Consulting Research Project of Chinese Academy of Engineering(2021-XBZD-8)。
文摘Agricultural production is considered one of the most important sources of water quality deterioration in the Taihu Lake Basin,China.Crop farming,livestock&poultry breeding and aquaculture are primary agricultural non-point sources and their impacts on the water environment are,in most cases,evaluated separately.Therefore,it is a challenge for current research to consider all of the different agricultural non-point sources as a whole and assess their combined influence on the water environment.The purpose of this paper is to evaluate the conjoint impact that agricultural non-point sources such as crop farming,livestock&poultry breeding and aquaculture have had on the local water environment in the Taihu Lake Basin by taking Huzhou City of Zhejiang Province as a case study.To achieve this,a new,innovative approach named the“Waste Absorption Footprint”(WAF)is applied.The results show that nitrogen and phosphorus pollution generated by agricultural production are more serious than that of organic substances,while aquaculture and crop farming are more critical pollution sources compared with livestock and poultry breeding,and so they should be the focus of environmental management and pollution control initiatives.There is a regional discrepancy in the spatial distribution of agricultural non-point source pollution across counties and districts,which provides information for determining the key regions for the treatment of agricultural pollution.This study demonstrates that the WAF method can make a comprehensive assessment of the influence of agricultural production on the water environment and provide references for the control and management of agricultural non-point source pollution,which is of great importance for management of the water environment.
