产业用地提质增效的理论辨析、深圳实践与发展策略

产业用地提质增效是构建高质量现代产业体系的关键环节,对于提升产业用地要素生产率、增强产业链竞争力及促进新质生产力发展具有重要基础支撑作用。本文从产业升级、集约利用和市场配置三大维度出发,深入阐述了产业用地提质增效的内涵与意义,并围绕规划引领、土地供应及供后利用这三个层次,系统分析了产业用地全链条提质增效的发展路径。同时,结合深圳的实践经验、现存问题及对策建议,实现了理论与实践的有机结合,旨在为其他城市在产业用地提质增效方面提供有价值的理论与实践参考。

深圳市劳务工社会支持状况调查

目的：了解深圳市劳务工的社会支持状况及其影响因素。方法采用自制一般资料调查表和社会支持量表对1038名深圳市劳务工进行调查分析。结果深圳市劳务工社会支持量表总分显著低于我国6省市5类职业人群和辽宁省城市职业人群（P＜0．01）；不同性别、年龄、婚姻状况、学历及职务社会支持量表评分比较差异有显著性（P＜0．05或0．01）；Logistic回归分析显示，性别、年龄、婚姻状况及职务进入回归模型，其中性别和年龄对劳务工的社会支持状况影响显著（P＜0．01）。结论深圳市劳务工社会支持状况较差，性别和年龄是影响劳务工社会支持状况的主要因素。

深圳市中学生自杀状况调查

目的探讨深圳市中学生自杀意念和自杀未遂的发生率及其分布情况，为制定深圳市精神卫生规划提供客观依据。方法采用分层整群抽样法抽取深圳市4177名中学生应用自杀行为问卷～修订版进行调查。结果深圳市中学生自杀意念发生率为42．40％，1a内自杀意念发生率为34．04％，自杀计划发生率为7．92％，自杀未遂发生率为1．46％，自杀威胁性发生率为7．25％，自杀可能性发生率为5．03％；男生和女生自杀的各项因子无显著性差异（P〉0．05）；随着年龄的增长、年级的增高，自杀各项因子发生率明显升高。结论深圳市中学生自杀倾向发生率高，特别是在高年级的学生中更为显著。

深圳市企业员工心理健康状况与应对方式相关性研究

目的探讨深圳市企业员工的心理健康状况和应对方式及其相关性，为提高其心身健康水平提供依据。方法对914名深圳市企业员工采用症状自评量表和应对方式问卷进行测评分析。结果企业员工症状自评量表阳性症状均分显著低于全国常模（P〈0．01），总分、总均分、阳性项目数及各因子分均显著高于全国常模（P〈0．01），采用的压力应对方式依次为解决问题、求助、退避、合理化、幻想和自责。企业员工症状自评量表各因子分与解决问题、求助因子分呈显著负相关（P〈0．01），与自责、幻想、退避和合理化因子分呈显著正相关（P〈0．01）；应对方式对心理健康水平的影响从大到小依次为自责、幻想、解决问题、求助、合理化。结论企业员工心理健康水平明显低于普通人群，其心理健康水平与应对方式密切相关。

Prenatal ultrasonic characteristics and diagnosis of fetal Currarino syndrome:Report of 2 cases and review of literature

Objective To explore prenatal ultrasonic characteristics of fetal Currarino syndrome(CS)and methods for prenatal diagnosis of CS.Methods Two fetuses with CS confirmed by genetic examination were retrospectively analyzed,while 6 CS fetuses with complete prenatal ultrasonic data in literature were reviewed.Prenatal ultrasonic characteristics of CS fetuses and the method for prenatal diagnosis of CS were discussed.Results Among 8 CS fetuses diagnosed with prenatal ultrasound,4 were female singletons with a clear family history of CS,and MNX 1 gene mutation was found in 1 fetus.The other 4 fetuses were 2 pairs of male monochorionic twins,all with MNX 1 gene mutation.Among 8 CS fetuses,complete triad(sacral agenesis abnormalities,anorectal malformation and presacral mass)were displayed only in 2 fetuses,while all 8 had sacral agenesis abnormalities and 6(6/8,75.00%)were detected with prenatal ultrasound,6 had low location of conus medullaris and 2(2/6,33.33%)detected with prenatal ultrasound.Conclusion Prenatal ultrasound was the first choice for non-invasive diagnosis of fetal CS.When one of sacral agenesis abnormalities,anorectal malformation and presacral mass was found with prenatal ultrasound,the possibility of CS should be considered,and fetal MRI,genetic examination and prenatal genetic counselling should be recommended if necessary.

Perfecting HER catalysts via defects:Recent advances and perspectives

Defect engineering has become a promising approach to improve the performance of hydrogen evolution reaction(HER)catalysts.Non-noble transition metal-based catalysts(TMCs)have shown significant promise as effective alternatives to traditional platinum-group catalysts,attracting considerable attention.However,the industrial application of TMCs in electrocatalytic hydrogen production necessitates further optimization to boost both catalytic activity and stability.This review comprehensively examines the types,fabrication methods,and characterization techniques of various defects that enhance catalytic HER activity.Key advancements include optimizing defect concentration and distribution,coupling heteroatoms with vacancies,and leveraging the synergy between bond lengths and defects.In-depth discussions highlight the electronic structure and catalytic mechanisms elucidated through in-situ characterization and density functional theory calculations.Additionally,future directions are identified,exploring novel defect types,emphasizing precision synthesis methods,industrial-scale preparation techniques,and strategies to enhance structural stability and understanding the in-depth catalytic mechanism.This review aims to inspire further research and development in defect-engineered HER catalysts,providing pathways for high efficiency and cost-effectiveness in hydrogen production.

Opto-mechanical-thermal integration analysis of Doppler asymmetric spatial heterodyne interferometer

In order to improve the detection accuracy of Doppler asymmetric spatial heterodyne(DASH)interferometer in harsh temperatures,an opto-mechanical-thermal integration analysis is carried out.Firstly,the correlation between the interference phase and temperature is established according to the working principle and the phase algorithm of the interferometer.Secondly,the optical mechanical thermal analysis model and thermal deformation data acquisition model are designed.The deformation data of the interference module and the imaging optical system at different temperatures are given by temperature load simulation analysis,and the phase error caused by thermal deformation is obtained by fitting.Finally,based on the wind speed error caused by thermal deformation of each component,a reasonable temperature control scheme is proposed.The results show that the interference module occupies the main cause,the temperature must be controlled within(20±0.05)℃,and the temperature control should be carried out for the temperature sensitive parts,and the wind speed error caused by the part is 3.8 m/s.The thermal drift between the magnification of the imaging optical system and the thermal drift of the relative position between the imaging optical system and the detector should occupy the secondary cause,which should be controlled within(20±2)℃,and the wind speed error caused by the part is 3.05 m/s.In summary,the wind measurement error caused by interference module,imaging optical system,and the relative position between the imaging optical system and the detector can be controlled within 6.85 m/s.The analysis and temperature control schemes presented in this paper can provide theoretical basis for DASH interferometer engineering applications.

Self-supervised learning artificial intelligence noise reduction technology based on the nearest adjacent layer in ultra-low dose CT of urinary calculi

Objective To observe the value of self-supervised deep learning artificial intelligence(AI)noise reduction technology based on the nearest adjacent layer applicated in ultra-low dose CT(ULDCT)for urinary calculi.Methods Eighty-eight urinary calculi patients were prospectively enrolled.Low dose CT(LDCT)and ULDCT scanning were performed,and the effective dose(ED)of each scanning protocol were calculated.The patients were then randomly divided into training set(n=75)and test set(n=13),and a self-supervised deep learning AI noise reduction system based on the nearest adjacent layer constructed with ULDCT images in training set was used for reducing noise of ULDCT images in test set.In test set,the quality of ULDCT images before and after AI noise reduction were compared with LDCT images,i.e.Blind/Referenceless Image Spatial Quality Evaluator(BRISQUE)scores,image noise(SD ROI)and signal-to-noise ratio(SNR).Results The tube current,the volume CT dose index and the dose length product of abdominal ULDCT scanning protocol were all lower compared with those of LDCT scanning protocol(all P<0.05),with a decrease of ED for approximately 82.66%.For 13 patients with urinary calculi in test set,BRISQUE score showed that the quality level of ULDCT images before AI noise reduction reached 54.42%level but raised to 95.76%level of LDCT images after AI noise reduction.Both ULDCT images after AI noise reduction and LDCT images had lower SD ROI and higher SNR than ULDCT images before AI noise reduction(all adjusted P<0.05),whereas no significant difference was found between the former two(both adjusted P>0.05).Conclusion Self-supervised learning AI noise reduction technology based on the nearest adjacent layer could effectively reduce noise and improve image quality of urinary calculi ULDCT images,being conducive for clinical application of ULDCT.

Cu single-atom electrocatalyst on nitrogen-containing graphdiyne for CO_(2) electroreduction to CH_(4)

Developing Cu single-atom catalysts(SACs)with well-defined active sites is highly desirable for producing CH4 in the electrochemical CO_(2) reduction reaction and understanding the structure-property relationship.Herein,a new graphdiyne analogue with uniformly distributed N_(2)-bidentate(note that N_(2)-bidentate site=N^N-bidentate site;N_(2)≠dinitrogen gas in this work)sites are synthesized.Due to the strong interaction between Cu and the N_(2)-bidentate site,a Cu SAC with isolated undercoordinated Cu-N_(2) sites(Cu1.0/N_(2)-GDY)is obtained,with the Cu loading of 1.0 wt%.Cu1.0/N_(2)-GDY exhibits the highest Faradaic efficiency(FE)of 80.6% for CH_(4) in electrocatalytic reduction of CO_(2) at-0.96 V vs.RHE,and the partial current density of CH_(4) is 160 mA cm^(-2).The selectivity for CH_(4) is maintained above 70% when the total current density is 100 to 300 mA cm^(-2).More remarkably,the Cu1.0/N_(2)-GDY achieves a mass activity of 53.2 A/mgCu toward CH4 under-1.18 V vs.RHE.In situ electrochemical spectroscopic studies reveal that undercoordinated Cu-N_(2) sites are more favorable in generating key ^(*)COOH and ^(*)CHO intermediate than Cu nanoparticle counterparts.This work provides an effective pathway to produce SACs with undercoordinated Metal-N_(2) sites toward efficient electrocatalysis.

Preliminary clinical application of total free-breathing cardiac MR examination

Objective To observe the clinical application value of total free-breathing cardiac MR(CMR)examination preliminarily.Methods Two patients who underwent CMR scanning under free-breathing state,including cine,motion correction T1 and T2 mapping,blood flow imaging,and late gadolinium enhancement scanning were retrospectively enrolled,and the qualities of the above images were evaluated and compared with that of conventional CMR images under breath-holding state.Results No significant difference of imaging quality was found between total free-breathing and conventional breath-holding CMR.The differences of left ventricular ejection fraction,cardiac output,left ventricular end-diastolic volume index and left ventricular mass measured based on CMR images under different breath conditions were limited.Conclusion Total free-breathing CMR was feasible in clinical practice,which could provide"one-stop"evaluation of cardiac structure,function and myocardial histological characteristics,hence having promising clinical prospects.

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent years.However,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory results.Previous studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage regeneration.OBJECTIVE:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis treatment.METHODS:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were prepared.Their efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into cells.The experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 group.Samples were collected at 4,12,and 24 weeks postoperatively.Tissue staining,including safranin O and Alcian blue,was applied after collecting articular tissue.Then,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in vivo.RESULTS AND CONCLUSION:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis treatment.Mixed cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(P<0.05).In vivo results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(P<0.05).In the present study,we also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal proportions.Decreasing either p65shRNA or BMP4 transfected cells resulted in less collagen II synthesis.This implies that inhibiting inflammation by p65shRNA and promoting regeneration by BMP4 are equally important for osteoarthritis treatment.These findings provide a new strategy for the treatment of early osteoarthritis by simultaneously inhibiting cartilage inflammation and promoting cartilage repair.

国家战略人才和急需紧缺人才实验教学培养模式的研究

战略人才和急需紧缺人才培养所面临的新挑战对实验教学提出了新要求。针对实验教学方法与学生特点不匹配、实验教学考核与培养目标相脱节、实验教学内容与产业要求有差距等问题,设置与产业相关的实验项目,开设模拟生产的创新实验,改革实验教学“小课堂”,用好产业专家、社会企业等产业“大课堂”资源,做好思政教育与实验课堂教学的融合工作,为培养更多具有创新精神与实践能力的战略人才和急需紧缺人才提供有力支持。

深圳土地整备增值收益分配机制研究及案例解析

深圳市建设开发强度在世界城市中居于前列,以小土地面积撬动大发展的模式正面临瓶颈。深圳土地整备是由政府主导的存量土地再开发的重要模式之一,其目的是实施规划并解决原农村土地的历史遗留问题。本文通过回顾深圳土地整备政策的变迁,指出深圳土地整备的实质是整备成本和整备后的土地增值收益在政府、原农村社区、权益人三者之间进行公平合理地分配和分担,并在过程中充分发挥原农村社区的作用。同时结合下围土地整备利益统筹项目实施案例,通过综合运用土地确权、用地规划、地价规则和补偿资金等多种政策手段,对土地整备利益统筹机制进行解析,对进一步完善利益统筹分配机制提出建议,也为全国农地入市土地增值收益分配提供样本。

深圳地区孤独症儿童龋齿状况调查

目的：了解深圳地区孤独症患儿罹患龋齿的状况。方法按第三次全国口腔健康流行病学抽样调查方案中龋病的调查标准对126例孤独症患儿进行口腔健康状况检查。结果孤独症儿龋齿患病率为81．0％，男性显著高于女性（ P＜0．01），好发牙位是上颌乳中切牙和下颌乳磨牙。结论孤独症患儿龋齿患病率较高，应对患儿家长进行口腔健康知识教育。

深圳市某区学龄前儿童乙型肝炎病毒感染情况和抗体水平分析

目的了解学龄前儿童乙型肝炎病毒感染情况和抗体水平。方法对深圳市某区进行健康体检的学龄前儿童的乙肝表面抗原和乙肝表面抗体阳性率进行统计分析。结果乙肝表面抗原的总阳性率为0．3％，乙肝表面抗体总阳性率为72．9％，乙肝表面抗体阳性率随着年龄的增长而升高。结论实施新生儿免费接种乙型肝炎疫苗，定时复检加强乙肝疫苗接种后抗体的浓度，提高及时接种率、全程接种率和加强复种疫苗，均可以有效控制乙肝的流行。

PPP模式在棚户区改造中应用研究综述

本文整理了中国知网中PPP模式在棚户区改造中应用研究的相关文献,从文献计量和研究内容两个角度进行分析,理清该研究主题的研究脉络和研究热点;同时,结合文献分析发现的优点和问题,采用SWOT法对棚户区改造应用PPP模式进行分析,提出发展棚户区改造项目PPP融资模式的对策建议,以便为后续相关研究提供参考。

无抽搐电休克治疗难治性精神分裂症临床疗效及其相关影响因素分析

目的 探讨无抽搐电休克治疗难治性精神分裂症临床疗效及其影响因素,为临床干预提供依据.方法 将27例行无抽搐电休克治疗的难治性精神分裂症患者依据简明精神病量表评分减分率判定临床疗效,将有效病例设为有效组,无效病例设为无效组,对两组临床资料进行回顾性分析.结果 本组病例治疗有效率为44.44%.有效组患者受教育年限、病前性格、症状特点、首发年龄、服药种类、用药是否为二苯二氮（艹卓）类、经济水平、社会支持度、无抽搐电休克治疗有效发作次数、发作时间、婚姻及简明精神病量表思维障碍、激活性、敌对猜疑因子减分等与无效组差异均有显著或极显著性（P＜0.05或0.01）.其主要影响因素有患者受教育年限、婚姻、病前性格、经济水平、无抽搐电休克治疗有效发作次数以及简明精神病量表思维障碍、激活性、敌对猜疑因子减分等.结论 无抽搐电休克治疗难治性精神分裂症患者疗效显著,但影响因素较多,在临床治疗过程中应特别重视抽搐发作质量,必要时可联合二苯二氮（艹卓）类抗精神病药物治疗.

精神活性物质所致精神病性障碍转归状况及其影响因素研究

目的：探讨精神活性物质（毒品）所致精神病性障碍转归状况及其影响因素。方法对374例精神活性物质所致精神病性障碍患者进行随访。结果72．5％患者完成了随访，随访期间复吸率达88．9％，随访前6个月内仍有吸毒行为者占17．0％；69．0％患者随访期内接受过住院治疗。患者首次入院后精神病性症状1个月内完全缓解者占62．9％（症状短暂型），6个月内精神病性症状逐渐缓解者占28．2％（症状持久型），＞6个月仍残留部分幻觉、妄想等精神病性症状者占8．9％（症状残留型）；症状残留型组吸毒年限、精神病家族史阳性率、多次住院率、随访时存在精神病性症状率均显著高于症状短暂型组及症状持久型组（P＜0．01），初次吸毒年龄显著小于症状短暂型组及症状持久型组（P＜0．01）；多种物质滥用率显著高于症状短暂型（P＜0．05）。结论多数精神活性物质所致精神病性障碍患者预后较好，但部分患者预后不良，脱离毒品后可能仍然长期残留精神病性症状。

电抽搐治疗在双相障碍混合发作中的应用进展

双相障碍混合发作在临床上不常见,且治疗起来非常困难,锂盐、抗癫痫药（如丙戊酸钠、卡马西平）以及抗精神病药（如奥氮平、齐拉西酮、阿立哌唑）都曾被报道至少部分可以控制双相障碍的临床症状,但是仍有许多患者药物治疗效果不好.Ciapparelli等[1]在对双相障碍的综述中曾提到双相障碍混合发作的治疗非常困难,与双相抑郁和双相躁狂相比,其病程更长,发作更频繁,自杀的风险更高,同时预后较差.

实质性辨认能力与刑法中辨认能力探析

长期以来精神病人刑事责任能力评定都是社会关注的焦点,争论主要集中在对我国《刑法》中'不能辨认'的认定.本文拟从不同学术界(精神医学、法学)对辨认能力的解读及《精神障碍者刑事责任能力评定指南(SF/Z JD0104002-2011)》的解释为出发点,对实质性辨认能力与辨认能力的概念予以综述,浅析两者的概念及关系,并引申出'常识性辨认能力'的概念.