1文献来源研究一:Babaei M,Jansen L,Balavarca Y,et al.Neoadjuvant therapy in rectal cancer patients with clinical stageⅡtoⅢacross European countries:Variations and outcomes[J].Clin Colorectal Cancer,2018,17(1):e129-e1...1文献来源研究一:Babaei M,Jansen L,Balavarca Y,et al.Neoadjuvant therapy in rectal cancer patients with clinical stageⅡtoⅢacross European countries:Variations and outcomes[J].Clin Colorectal Cancer,2018,17(1):e129-e142.研究二:Takiyama H,Kawai K,Ishihara S,et al.Different impacts of preoperative radiotherapy and chemoradiotherapy on oncological outcomes in patients with stagesⅡandⅢlower rectal cancer:A propensity score analysis[J].Dig Surg,2018,35(3):212-219.2证据水平2b。3背景研究一:新辅助放化疗,全直肠系膜切除术(total mesorectal excision,TME),术后辅助化疗被用于局部进展期直肠癌(local advanced rectal cancer,LARC)的治疗。更好的使用直肠癌新辅助治疗的办法是,将直肠癌分为低等、中等、高等危险特征。对于LARC,术前新辅助治疗被认为可以提高手术切除的可能性,降低局部区域复发,并且潜在提高生存率。直肠癌的治疗建议来自一些指南,比如英国、欧洲其他国家、美国的指南,但各指南间却有很大差别。展开更多
1文献来源研究一:Erlandsson J,Holm T,Pettersson D,et al.Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer(StockholmⅢ):A multicentre,randomised,non-blinded,phase 3,non-inferiori...1文献来源研究一:Erlandsson J,Holm T,Pettersson D,et al.Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer(StockholmⅢ):A multicentre,randomised,non-blinded,phase 3,non-inferiority trial[J].Lancet Oncol,2017,18(3):336-346.研究二:Bujko K,Wyrwicz L,Rutkowski A,et al.Long-course Oxaliplatin-based preoperative chemoradiation versus 5×5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer:Results of a randomized phaseⅢstudy[J].Ann Oncol,2016,27(5):834-842.2证据水平1b。3背景研究一:术前长程放疗[(long course radiotherapy,LRT),每周5次,每次1.8~2 Gy,连续5~6周]加延迟手术和短程放疗[(short course radiotherapy,SRT),每周5次,每次5 Gy,持续1周]加即刻手术是临床常用的治疗方案。展开更多
1文献来源Schuler M,Wu YL,Hirsh V,et al.First-lineAfatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growthfactor receptor gene mutations and brain metastases[J].J Thorac Onco...1文献来源Schuler M,Wu YL,Hirsh V,et al.First-lineAfatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growthfactor receptor gene mutations and brain metastases[J].J Thorac Oncol,2016,11（3）：380-390.2证据水平2a。3背景EGFR阳性的非小细胞肺癌（non-small celllung cancer,NSCLC）出现脑转移的概率高达44%~63%,但目前极少有针对此类患者的前瞻性临床研究。展开更多
1文献来源Johung KL,Yeh N,Desai NB,et al.Extendedsurvival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis[J].J Clin Oncol,2016,34（2）：123-129.2证据水平2A。3背景...1文献来源Johung KL,Yeh N,Desai NB,et al.Extendedsurvival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis[J].J Clin Oncol,2016,34（2）：123-129.2证据水平2A。3背景·中枢神经系统转移在晚期肺腺癌的发生率约为30%,中位总生存期（overall survival,OS）为3~14.8个月。展开更多
文摘1文献来源研究一:Babaei M,Jansen L,Balavarca Y,et al.Neoadjuvant therapy in rectal cancer patients with clinical stageⅡtoⅢacross European countries:Variations and outcomes[J].Clin Colorectal Cancer,2018,17(1):e129-e142.研究二:Takiyama H,Kawai K,Ishihara S,et al.Different impacts of preoperative radiotherapy and chemoradiotherapy on oncological outcomes in patients with stagesⅡandⅢlower rectal cancer:A propensity score analysis[J].Dig Surg,2018,35(3):212-219.2证据水平2b。3背景研究一:新辅助放化疗,全直肠系膜切除术(total mesorectal excision,TME),术后辅助化疗被用于局部进展期直肠癌(local advanced rectal cancer,LARC)的治疗。更好的使用直肠癌新辅助治疗的办法是,将直肠癌分为低等、中等、高等危险特征。对于LARC,术前新辅助治疗被认为可以提高手术切除的可能性,降低局部区域复发,并且潜在提高生存率。直肠癌的治疗建议来自一些指南,比如英国、欧洲其他国家、美国的指南,但各指南间却有很大差别。
文摘1文献来源研究一:Erlandsson J,Holm T,Pettersson D,et al.Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer(StockholmⅢ):A multicentre,randomised,non-blinded,phase 3,non-inferiority trial[J].Lancet Oncol,2017,18(3):336-346.研究二:Bujko K,Wyrwicz L,Rutkowski A,et al.Long-course Oxaliplatin-based preoperative chemoradiation versus 5×5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer:Results of a randomized phaseⅢstudy[J].Ann Oncol,2016,27(5):834-842.2证据水平1b。3背景研究一:术前长程放疗[(long course radiotherapy,LRT),每周5次,每次1.8~2 Gy,连续5~6周]加延迟手术和短程放疗[(short course radiotherapy,SRT),每周5次,每次5 Gy,持续1周]加即刻手术是临床常用的治疗方案。
文摘1文献来源Schuler M,Wu YL,Hirsh V,et al.First-lineAfatinib versus chemotherapy in patients with non-small cell lung cancer and common epidermal growthfactor receptor gene mutations and brain metastases[J].J Thorac Oncol,2016,11（3）：380-390.2证据水平2a。3背景EGFR阳性的非小细胞肺癌（non-small celllung cancer,NSCLC）出现脑转移的概率高达44%~63%,但目前极少有针对此类患者的前瞻性临床研究。
文摘1文献来源Johung KL,Yeh N,Desai NB,et al.Extendedsurvival and prognostic factors for patients with ALK-rearranged non-small-cell lung cancer and brain metastasis[J].J Clin Oncol,2016,34（2）：123-129.2证据水平2A。3背景·中枢神经系统转移在晚期肺腺癌的发生率约为30%,中位总生存期（overall survival,OS）为3~14.8个月。
