Objective To evaluate the safety of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation. Methods multiple centers, random and double blind procedure. 144 adault patients, ASA gradeⅠ-Ⅱ, schedule...Objective To evaluate the safety of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation. Methods multiple centers, random and double blind procedure. 144 adault patients, ASA gradeⅠ-Ⅱ, scheduled for selective surgery. Both the test group(6% hydroxyethyl starch group)and the control group(HES group) are all 72 patients. The liver functions, renal functions, acid-base changes and coagulation variables were observed after administration. Results There are no significant difference between test group and control group in liver functions, renal functions, acid-base changes and coagulation variables (P> 0.05 ), with significant difference only in FⅧ:C activity between test group and control group (P<0.05) after volume treatment. but the numerical value of FⅧ:C in both groups are all in normal range in clinic. Conclusion 6% hydroxyethyl starch (200/0.5) is safe for expand plasma volume during operation.展开更多
文摘Objective To evaluate the safety of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation. Methods multiple centers, random and double blind procedure. 144 adault patients, ASA gradeⅠ-Ⅱ, scheduled for selective surgery. Both the test group(6% hydroxyethyl starch group)and the control group(HES group) are all 72 patients. The liver functions, renal functions, acid-base changes and coagulation variables were observed after administration. Results There are no significant difference between test group and control group in liver functions, renal functions, acid-base changes and coagulation variables (P> 0.05 ), with significant difference only in FⅧ:C activity between test group and control group (P<0.05) after volume treatment. but the numerical value of FⅧ:C in both groups are all in normal range in clinic. Conclusion 6% hydroxyethyl starch (200/0.5) is safe for expand plasma volume during operation.
